Biological evaluation of levofloxacin and its thionated derivatives: antioxidant activity, aldehyde dehydrogenase enzyme inhibition, and cytotoxicity on A549 cell line

Abusara OH, Ibrahim AIM, Issa H, Hammad AM, Ismail WH (2023) In Vitro evaluation of ALDH1A3-Affinic compounds on breast and prostate Cancer cell lines as single treatments and in combination with Doxorubicin. Curr Issues Mol Biol 45:2170–2181

Article  CAS  PubMed  PubMed Central  Google Scholar 

Al-Ali L, Al-Ani RJ, Saleh MM, Hammad AM, Abuarqoub DA, Abu-Irmaileh B, Naser AY, Najdawi MM, Abbas MM, Alyoussef Alkrad J (2024) Biological evaluation of combinations of tyrosine kinase inhibitors with Inecalcitol as novel treatments for human chronic myeloid leukemia. Saudi Pharm J 32:101931

Article  CAS  PubMed  Google Scholar 

Appelbaum PC, Hunter PA (2000) The fluoroquinolone antibacterials: past, present and future perspectives. Int J Antimicrob Agents 16:5–15

Article  CAS  PubMed  Google Scholar 

Azhari S, Xu YS, Jiang QX, Xia WS (2014) Physicochemical properties and chemical composition of Seinat (Cucumis melo var. Tibish) seed oil and its antioxidant activity. Grasas Aceites 65:e008

Article  Google Scholar 

Bartlett JG, Dowell SF, Mandell LA, File TM Jr., Musher DM, Fine MJ (2000) Practice guidelines for the management of community-acquired pneumonia in adults. Infectious Diseases Society of America. Clin Infect Diseases: Official Publication Infect Dis Soc Am 31:347–382

Article  CAS  Google Scholar 

Brand-Williams W, Cuvelier ME, Berset C (1995) Use of a free radical method to evaluate antioxidant activity. LWT - Food Sci Technol 28:25–30

Article  CAS  Google Scholar 

Caritá AC, Fonseca-Santos B, Shultz JD, Michniak-Kohn B, Chorilli M, Leonardi GR (2020) Vitamin C: one compound, several uses. Advances for delivery, efficiency and stability. Nanomedicine: Nanatechnol Biology Med 24:102117

Article  Google Scholar 

Chou TC, Talalay P (1984) Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors. Adv Enzyme Regul 22:27–55

Article  CAS  PubMed  Google Scholar 

El-Demerdash FM, Ahmed MM, Baghdadi HH (2023) Punica granatum peel extract modulates levofloxacin-induced oxidative stress and testicular damage in rats. Tissue Cell 85:102227

Article  CAS  PubMed  Google Scholar 

El-Malah A, Youssef A, Ismail M, Kamel M, Mahmoud Z (2021) New promising levofloxacin derivatives: design, synthesis, cytotoxic activity screening, Topo2β polymerase inhibition assay, cell cycle apoptosis profile analysis. Bioorg Chem 113:105029

Article  CAS  PubMed  Google Scholar 

Fan F, Yin R, Wang L, Zhao S, Lv D, Yang K, Geng S, Yang N, Zhang X, Wang H (2021) ALDH3A1 driving tumor metastasis is mediated by p53/BAG1 in lung adenocarcinoma. J Cancer 12:4780–4790

Article  CAS  PubMed  PubMed Central  Google Scholar 

Feng H, Liu Y, Bian X, Zhou F, Liu Y (2018) ALDH1A3 affects colon cancer in vitro proliferation and invasion depending on CXCR4 status. Br J Cancer 118:224–232

Article  CAS  PubMed  Google Scholar 

Fisusi FA, Akala EO (2019) Drug combinations in breast Cancer therapy. Pharm Nanatechnol 7:3–23

Article  CAS  Google Scholar 

Gao F, Zhou B, Xu JC, Gao X, Li SX, Zhu GC, Zhang XG, Yang C (2015) The role of LGR5 and ALDH1A1 in non-small cell lung cancer: Cancer progression and prognosis. Biochem Biophys Res Commun 462:91–98

Article  CAS  PubMed  Google Scholar 

Haitham Abusara O, Freeman S, Aojula HS (2017) Pentapeptides for the treatment of small cell lung cancer: optimisation by N(ind)-alkyl modification of the tryptophan side chain. Eur J Med Chem 137:221–232

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hanušová V, Boušová I, Skálová L (2011) Possibilities to increase the effectiveness of doxorubicin in cancer cells killing. Drug Metab Rev 43:540–557

Article  PubMed  Google Scholar 

Hariono M, Rollando R, Yoga I, Harjono A, Suryodanindro A, Yanuar M, Gonzaga T, Parabang Z, Hariyono P, Febriansah R, Hermawansyah A, Setyani W, Wahab H (2021) Bioguided Fractionation of Local Plants against Matrix Metalloproteinase9 and Its Cytotoxicity against Breast Cancer Cell Models: In Silico and In Vitro Study (Part II). Molecules (Basel, Switzerland), 26

He X, Yao Q, Fan D, You Y, Lian W, Zhou Z, Duan L (2022) Combination of levofloxacin and cisplatin enhances anticancer efficacy via co-regulation of eight cancer-associated genes. Discover Oncol 13:76

Article  CAS  Google Scholar 

Hooper DC (2000) New uses for new and old quinolones and the challenge of resistance. Clin Infect Diseases: Official Publication Infect Dis Soc Am 30:243–254

Article  CAS  Google Scholar 

Ibrahim AIM, Abul-Futouh H, Bourghli LMS, Abu-Sini M, Sunoqrot S, Ikhmais B, Jha V, Sarayrah Q, Abulebdah DH, Ismail WH (2022) Design and synthesis of Thionated Levofloxacin: insights into a New Generation of quinolones with potential therapeutic and Analytical Applications. Curr Issues Mol Biol 44:4626–4638

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ikhmais BA, Hammad AM, Abusara OH, Hamadneh L, Abumansour H, Abdallah QM, Ibrahim AIM, Elsalem L, Awad M, Alshehada R (2023) Investigating Carvedilol’s repurposing for the treatment of Non-small Cell Lung Cancer via Aldehyde dehydrogenase activity modulation in the Presence of β-Adrenergic agonists. Curr Issues Mol Biol 45:7996–8012

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ismail WH, Abusara OH, Ikhmais B, Abul-Futouh H, Sunoqrot S, Ibrahim AIM (2023) Design, synthesis, and Biological Activity of Coniferyl Aldehyde Derivatives as potential anticancer and antioxidant agents. Jordan J Pharm Sci 16:368–380

Article  Google Scholar 

Jawad B, Poudel L, Podgornik R, Steinmetz NF, Ching WY (2019) Molecular mechanism and binding free energy of doxorubicin intercalation in DNA. Phys Chem Chem Phys 21:3877–3893

Article  CAS  PubMed  Google Scholar 

Jiang Y, Li H, Wang Y, Tian T, He Y, Jin Y, Han C, Jin X, Zhang F, Morii E (2017) ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line. Oncol Lett 14:6955–6961

PubMed  PubMed Central  Google Scholar 

Kahlert C, Gaitzsch E, Steinert G, Mogler C, Herpel E, Hoffmeister M, Jansen L, Benner A, Brenner H, Chang-Claude J, Rahbari N, Schmidt T, Klupp F, Grabe N, Lahrmann B, Koch M, Halama N, Büchler M, Weitz J (2012) Expression analysis of aldehyde dehydrogenase 1A1 (ALDH1A1) in colon and rectal cancer in association with prognosis and response to chemotherapy. Ann Surg Oncol 19:4193–4201

Article  PubMed  Google Scholar 

Khan AM, Rampal S, Sood NK (2017) Effect of repeated oral administration of levofloxacin, enrofloxacin, and meloxicam on antioxidant parameters and lipid peroxidation in rabbits. Hum Exp Toxicol 36:42–50

Article  CAS  PubMed  Google Scholar 

Kim IG, Kim SY, Choi SI, Lee JH, Kim KC, Cho EW (2014) Fibulin-3-mediated inhibition of epithelial-to-mesenchymal transition and self-renewal of ALDH + lung cancer stem cells through IGF1R signaling. Oncogene 33:3908–3917

Article  CAS  PubMed  Google Scholar 

Kloskowski T, Szeliski K, Fekner Z, Rasmus M, Dąbrowski P, Wolska A, Siedlecka N, Adamowicz J, Drewa T, Pokrywczyńska M (2021) Ciprofloxacin and levofloxacin as potential drugs in Genitourinary Cancer Treatment-The Effect of dose-response on 2D and 3D cell cultures. Int J Mol Sci, 22

Koch A, Tamez P, Pezzuto J, Soejarto D (2005) Evaluation of plants used for antimalarial treatment by the Maasai of Kenya. J Ethnopharmacol 101:95–99

Article  CAS  PubMed  Google Scholar 

Legnani L, Toma L, Caramella P, Chiacchio MA, Giofrè S, Delso I, Tejero T, Merino P (2016) Computational mechanistic study of Thionation of Carbonyl compounds with Lawesson’s reagent. J Org Chem 81:7733–7740

Article  CAS  PubMed  Google Scholar 

Liu L, Huang X, Shi F, Song J, Guo C, Yang J, Liang T, Bai X (2022) Combination therapy for pancreatic cancer: anti-PD-(L)1-based strategy. J Experimental Clin cancer Research: CR 41:56

Article  CAS  PubMed Central  Google Scholar 

Marcato P, Dean CA, Pan D, Araslanova R, Gillis M, Joshi M, Helyer L, Pan L, Leidal A, Gujar S, Giacomantonio CA, Lee PW (2011) Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis. Stem Cells 29:32–45

Article  CAS  PubMed  Google Scholar 

McGregor JC, Allen GP, Bearden DT (2008) Levofloxacin in the treatment of complicated urinary tract infections and acute pyelonephritis. Ther Clin Risk Manag 4:843–853

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moiseeva AA (2019) Anthracycline derivatives and their anticancer activity. J Nesmeyanov Inst Organoelement Compd Russian Acad Sci 2:9–18

CAS  Google Scholar 

Mondal ER, Das SK, Mukherjee P (2004) Comparative evaluation of antiproliferative activity and induction of apoptosis by some fluoroquinolones with a human non-small cell lung cancer cell line in culture. Asian Pac J cancer Prevention: APJCP 5:196–204

CAS  Google Scholar 

Moreb JS, Baker HV, Chang LJ, Amaya M, Lopez MC, Ostmark B, Chou W (2008) ALDH isozymes downregulation affects cell growth, cell motility and gene expression in lung cancer cells. Mol Cancer 7:87

Article  PubMed  PubMed Central  Google Scholar 

Muzio G, Maggiora M, Paiuzzi E, Oraldi M, Canuto RA (2012) Aldehyde dehydrogenases and cell proliferation. Free Radic Biol Med 52:735–746

Article  CAS  PubMed  Google Scholar 

Nickel JC, Downey J, Clark J, Casey RW, Pommerville PJ, Barkin J, Steinhoff G, Brock G, Patrick AB, Flax S, Goldfarb B, Palmer BW, Zadra J (2003) Levofloxacin for chronic prostatitis/chronic pelvic pain syndrome in men: a randomized placebo-controlled multicenter trial. Urology 62:614–617

Article  PubMed  Google Scholar 

Noguchi N, Saito Y, Niki E (2023) Actions of Thiols, Persulfides, and Polysulfides as Free Radical Scavenging antioxidants. Antioxid Redox Signal 39:728–743

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