WHO Classification of Tumours Editorial Board. WHO Classification of Endocrine and Neuroendocrine Tumours (WHO, 2022).

WHO Classification of Tumours Editorial Board. WHO Classification of Digestive Tumours (WHO, 2019).

Rindi, G. et al. Overview of the 2022 WHO Classification of Neuroendocrine Neoplasms. Endocr. Pathol. 33, 115–154 (2022).

Article  CAS  PubMed  Google Scholar 

Raj, N. et al. Real-time genomic characterization of metastatic pancreatic neuroendocrine tumors has prognostic implications and identifies potential germline actionability. JCO Precis. Oncol. 2018, PO.17.00267 (2018).

PubMed  Google Scholar 

Rindi, G., Luinetti, O., Cornaggia, M., Capella, C. & Solcia, E. Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study. Gastroenterology 104, 994–1006 (1993).

Article  CAS  PubMed  Google Scholar 

Rindi, G. et al. Gastric carcinoids and neuroendocrine carcinomas: pathogenesis, pathology, and behavior. World J. Surg. 20, 168–172 (1996).

Article  CAS  PubMed  Google Scholar 

Rindi, G. et al. ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: prognostic evaluation by pathological analysis. Gastroenterology 116, 532–542 (1999).

Article  CAS  PubMed  Google Scholar 

Vanoli, A. et al. Prognostic evaluations tailored to specific gastric neuroendocrine neoplasms: analysis of 200 cases with extended follow-up. Neuroendocrinology 107, 114–126 (2018).

Article  CAS  PubMed  Google Scholar 

Dasari, A. et al. Trends in the incidence, prevalence, and survival outcomes in patients with neuroendocrine tumors in the United States. JAMA Oncol. 3, 1335–1342 (2017). This is the largest population-based study report to date to highlight epidemiology of neuroendocrine tumours, including those of the stomach.

Article  PubMed  PubMed Central  Google Scholar 

Rustgi, S. D. et al. Epidemiology of gastric malignancies 2000–2018 according to histology: a population-based analysis of incidence and temporal trends. Clin. Gastroenterol. Hepatol. 21, 3285–3295.e8 (2023).

Article  CAS  PubMed  Google Scholar 

IARC. Cancer Today stomach cancer data. WHO https://gco.iarc.fr/today/en/dataviz/tables?mode=population&cancers=7 (2022).

Ellis, L., Shale, M. J. & Coleman, M. P. Carcinoid tumors of the gastrointestinal tract: trends in incidence in England since 1971. Am. J. Gastroenterol. 105, 2563–2569 (2010).

Article  PubMed  Google Scholar 

Carmack, S. W., Genta, R. M., Schuler, C. M. & Saboorian, M. H. The current spectrum of gastric polyps: a 1-year national study of over 120,000 patients. Am. J. Gastroenterol. 104, 1524–1532 (2009).

Article  PubMed  Google Scholar 

Vannella, L. et al. Development of type I gastric carcinoid in patients with chronic atrophic gastritis. Aliment. Pharmacol. Ther. 33, 1361–1369 (2011).

Article  CAS  PubMed  Google Scholar 

Shah, S. C., Piazuelo, M. B., Kuipers, E. J. & Li, D. AGA clinical practice update on the diagnosis and management of atrophic gastritis: expert review. Gastroenterology 161, 1325–1332.e7 (2021).

Article  CAS  PubMed  Google Scholar 

Garcia-Carbonero, R. et al. Incidence, patterns of care and prognostic factors for outcome of gastroenteropancreatic neuroendocrine tumors (GEP-NETs): results from the National Cancer Registry of Spain (RGETNE). Ann. Oncol. 21, 1794–1803 (2010).

Article  CAS  PubMed  Google Scholar 

Genus, T. S. E. et al. Impact of neuroendocrine morphology on cancer outcomes and stage at diagnosis: a UK nationwide cohort study 2013–2015. Br. J. Cancer 121, 966–972 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Palepu, J. et al. Trends in diagnosis of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in India: a report of multicenter data from a web-based registry. Indian. J. Gastroenterol. 36, 445–451 (2017).

Article  PubMed  Google Scholar 

Fan, J.-H. et al. A nation-wide retrospective epidemiological study of gastroenteropancreatic neuroendocrine neoplasms in china. Oncotarget 8, 71699–71708 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Tsai, H.-J. et al. The epidemiology of neuroendocrine tumors in Taiwan: a nation-wide cancer registry-based study. PLoS ONE 8, e62487 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Masui, T., Ito, T., Komoto, I. & Uemoto, S. Recent epidemiology of patients with gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NEN) in Japan: a population-based study. BMC Cancer 20, 1104 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Eom, B. W., Jung, K.-W., Won, Y.-J., Yang, H. & Kim, Y.-W. Trends in gastric cancer incidence according to the clinicopathological characteristics in Korea, 1999–2014. Cancer Res. Treat. 50, 1343–1350 (2018).

Article  PubMed  PubMed Central  Google Scholar 

Lahner, E. et al. Gastric cancer in patients with type I gastric carcinoids. Gastric Cancer 18, 564–570 (2015).

Article  PubMed  Google Scholar 

Lenti, M. V. et al. Autoimmune gastritis. Nat. Rev. Dis. Prim. 6, 56 (2020).

Article  PubMed  Google Scholar 

Vannella, L., Lahner, E., Osborn, J. & Annibale, B. Systematic review: gastric cancer incidence in pernicious anaemia. Aliment. Pharmacol. Ther. 37, 375–382 (2013).

Article  CAS  PubMed  Google Scholar 

Miceli, E. et al. Long-term natural history of autoimmune gastritis: results from a prospective, monocentric series. Am. J. Gastroenterol. https://doi.org/10.14309/ajg.0000000000002619 (2023).

Panzuto, F. et al. European Neuroendocrine Tumor Society (ENETS) 2023 guidance paper for gastroduodenal neuroendocrine tumours (NETs) G1–G3. J. Neuroendocrinol. 35, e13306 (2023). This paper discusses the guidelines of the European Neuroendocrine Tumor Society (ENETS) regarding the clinical management of gastric neuroendocrine tumours.

Article  CAS  PubMed  Google Scholar 

Yao, J. C. et al. One hundred years after ‘carcinoid’: epidemiology of and prognostic factors for neuroendocrine tumors in 35,825 cases in the United States. J. Clin. Oncol. 26, 3063–3072 (2008).

Article  PubMed  Google Scholar 

Panzuto, F. et al. Tumour type and size are prognostic factors in gastric neuroendocrine neoplasia: a multicentre retrospective study. Dig. Liver Dis. 51, 1456–1460 (2019). This is a large multicentre retrospective study to evaluate prognostic factors in gastric neuroendocrine tumours.

Article  PubMed  Google Scholar 

Felder, S. et al. Gastric neuroendocrine neoplasias: manifestations and comparative outcomes. Endocr. Relat. Cancer 26, 751–763 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Exarchou, K., Howes, N. & Pritchard, D. M. Systematic review: management of localised low‐grade upper gastrointestinal neuroendocrine tumours. Aliment. Pharmacol. Ther. 51, 1247–1267 (2020).

Article  PubMed  Google Scholar 

Laffi, A. et al. Gastric neuroendocrine tumors (g-NETs): a systematic review of the management and outcomes of type 3 g-NETs. Cancers 15, 2202 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Min, B.-H. et al. Clinicopathological features and outcome of type 3 gastric neuroendocrine tumours. Br. J. Surg. 105, 1480–1486 (2018).

Article  PubMed  Google Scholar 

Engevik, A. C., Kaji, I. & Goldenring, J. R. The physiology of the gastric parietal cell. Physiol. Rev. 100, 573–602 (2020). This is a paper on the state-of-the-art knowledge about gastric physiology, which is fundamental to understand pathogenesis and management of type I and type II gNETs.

Article  CAS  PubMed  Google Scholar 

Jensen, R. T. & Ito, T. in Endotext (eds Feingold, K. et al.) (Endotext, 2023).

Amedei, A. et al. Molecular mimicry between Helicobacter pylori antigens and H+,K+-adenosine triphosphatase in human gastric autoimmunity. J. Exp. Med. 198, 1147–1156 (2003).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lundell, L., Vieth, M., Gibson, F., Nagy, P. & Kahrilas, P. J. Systematic review: the effects of long‐term proton pump inhibitor use on serum gastrin levels and gastric histology. Aliment. Pharmacol. Ther. 42, 649–663 (2015).

Article  CAS  PubMed  Google Scholar 

Vanoli, A., Parente, P., Fassan, M., Mastracci, L. & Grillo, F. Gut inflammation and tumorigenesis: every site has a different tale to tell. Intern. Emerg. Med. 18, 2169–2179 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Arnold, R. et al. Antral gastrin-producing G-cells and somatostatin-producing D-cells in different states of gastric acid secretion. Gut 23, 285–291 (1982).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Annibale, B. et al. Antral gastrin cell hyperfunction and Helicobacter pylori infection. Aliment. Pharmacol. Ther. 10, 607–615 (1996).

Article  CAS  PubMed  Google Scholar 

Rindi, G. et al. Helicobacter pylori infection in children with antral gastrin cell hyperfunction. J. Pediatr. Gastroenterol. Nutr. 18, 152–158 (1994).

CAS  PubMed  Google Scholar 

Pashankar, D. S., Israel, D. M., Jevon, G. P. & Buchan, A. M. J. Effect of long-term omeprazole treatment on antral G and D cells in children. J. Pediatr. Gastroenterol. Nutr. 33, 537–542 (2001).

CAS