The Global Health Observatory. Global health estimates 2020: deaths by cause, age, sex, by country and by region. 2000-2019 (WHO, 2020).

Bray, F. et al. The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer 127, 3029–3030 (2021).

Article  PubMed  Google Scholar 

Meijers, R. A. & de Boer, R. A. Common risk factors for heart failure and cancer. Cardiovasc. Res. 115, 844–853 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

de Boer, R. A. et al. Cancer and heart disease: associations and relations. Eur. J. Heart Fail. 21, 1515–1525 (2019).

Article  PubMed  Google Scholar 

Koene, R. J. et al. Shared risk factors in cardiovascular disease and cancer. Circulation 133, 1104–1114 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Stoltzfus, K. C. et al. Fatal heart disease among cancer patients. Nat. Commun. 11, 2020 (2011).

Google Scholar 

Battisti, N. M. L. et al. Prevalence of cardiovascular disease in patients with potentially curable malignancies: a national registry dataset analysis. JACC CardioOncol. 4, 238–253 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Florido, R. et al. Cardiovascular disease risk among cancer survivors: the Atherosclerosis Risk in Communities (ARIC) study. J. Am. Coll. Cardiol. 80, 22–32 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Paterson, D. I. et al. Incident cardiovascular disease among adults with cancer. JACC CardioOncol. 4, 85–94 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Zhang, X. et al. Ten-year cardiovascular risk among cancer survivors: the National Health and Nutrition Examination Survey. PLoS ONE 16, e0247919 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aboumsallem, J. P., Moslehi, J. & de Boer, R. A. Reverse cardio-oncology: cancer development in patients with cardiovascular disease. J. Am. Heart Assoc. 9, e013754 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Bell, C. F. et al. Risk of cancer after diagnosis of cardiovascular disease. JACC CardioOncol. 5, 431–440 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Chianca, M. et al. Bidirectional relationship between cancer and heart failure: insights on circulating biomarkers. Front. Cardiovasc. Med. 9, 936654 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayek, S. S. et al. Preparing the cardiovascular workforce to care for oncology patients: JACC review topic of the week. J. Am. Coll. Cardiol. 73, 2226–2235 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Herrmann, J. Adverse cardiac effects of cancer therapies: cardiotoxicity and arrhythmia. Nat. Rev. Cardiol. 17, 474–502 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herrmann, J. Vascular toxic effects of cancer therapies. Nat. Rev. Cardiol. 17, 503–522 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Omland, T., Heck, S. L. & Gulati, G. The role of cardioprotection in cancer therapy cardiotoxicity. JACC CardioOncol. 4, 19–37 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Tan, S. et al. Immune checkpoint inhibitor therapy in oncology. JACC CardioOncol. 4, 579–597 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Quartermaine, C. et al. Cardiovascular toxicities of BTK inhibitors in chronic lymphocytic leukemia. JACC CardioOncol. 5, 570–590 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Glen, C. et al. Mechanistic and clinical overview cardiovascular toxicity of BRAF and MEK inhibitors: JACC: CardioOncology state-of-the-art review. JACC CardioOncol. 4, 1–18 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Parashar, S. et al. Cancer treatment-related cardiovascular toxicity in gynecologic malignancies. JACC CardioOncol. 5, 159–173 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Welty, N. E. & Gill, S. I. Cancer immunotherapy beyond checkpoint blockade. JACC CardioOncol. 4, 563–578 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Georgiopoulos, G. et al. Cardiovascular toxicity of proteasome inhibitors: underlying mechanisms and management strategies: JACC: CardioOncology state-of-the-art review. JACC CardioOncol. 5, 1–21 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Bergom, C. et al. Past, present, and future of radiation-induced cardiotoxicity: refinements in targeting, surveillance, and risk stratification. JACC CardioOncol. 3, 343–359 (2021).

Article  PubMed  PubMed Central  Google Scholar 

de Boer, R. A. et al. Common mechanistic pathways in cancer and heart failure. A scientific roadmap on behalf of the Translational Research Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur. J. Heart Fail. 22, 2272–2289 (2020).

Article  PubMed  Google Scholar 

Karlstaedt, A., Moslehi, J. & de Boer, R. A. Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer. Nat. Rev. Cardiol. 19, 414–425 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Leiva, O. et al. Common pathophysiology in cancer, atrial fibrillation, atherosclerosis, and thrombosis: JACC: CardioOncology state-of-the-art review. JACC CardioOncol. 3, 619–634 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Fuchs, F. D. & Whelton, P. K. High blood pressure and cardiovascular disease. Hypertension 75, 285–292 (2020).

Article  CAS  PubMed  Google Scholar 

Cohen, J. B. et al. Hypertension in cancer patients and survivors. JACC CardioOncol. 1, 238–251 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Lewington, S. et al. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet 360, 1903–1913 (2002).

Article  PubMed  Google Scholar 

Rahimi, K. et al. Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis. Lancet 397, 1625–1636 (2021).

Article  Google Scholar 

Ettehad, D. et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet 387, 957–967 (2016).

Article  PubMed  Google Scholar 

Seretis, A. et al. Association between blood pressure and risk of cancer development: a systematic review and meta-analysis of observational studies. Sci. Rep. 9, 8565 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Harding, J. L. et al. Hypertension, antihypertensive treatment and cancer incidence and mortality: a pooled collaborative analysis of 12 Australian and New Zealand cohorts. J. Hypertens. 34, 149–155 (2016).

Article  CAS  PubMed  Google Scholar 

Han, H. et al. Hypertension and breast cancer risk: a systematic review and meta-analysis. Sci. Rep. 7, 44877 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nelson, R. H. Hyperlipidemia as a risk factor for cardiovascular disease. Prim. Care 40, 195–211 (2013).

Article  PubMed  Google Scholar 

Borén, J. et al. Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. Eur. Heart J. 41, 2313–2330 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Lewington, S. et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a meta-analysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet 370, 1829–1839 (2007).

Article  PubMed  Google Scholar 

Navarese, E. P. et al. Association between baseline LDL-C level and total and cardiovascular mortality after LDL-C lowering: a systematic review and meta-analysis. JAMA 319, 1566–1579 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar