A new approach of nano-metformin as a protector against radiation-induced cardiac fibrosis and inflammation via CXCL1/TGF-Β pathway

Abbas HA, A SG, Mosallam FM, Gomaa SE (2022) Novel silver metformin nano-structure to impede virulence of Staphylococcus aureus. AMB Express 12: 1-13

Abeyrathna P, Su Y (2015) The critical role of Akt in cardiovascular function. Vascular Pharmacol 74:38–48

Article  CAS  Google Scholar 

Ajzashokouhi AH, Bostan HB, Jomezadeh V, Hayes AW, Karimi G (2020) A review on the cardioprotective mechanisms of metformin against doxorubicin. Human Exp Toxicology 39:237–248

Article  CAS  Google Scholar 

Aruna P, Gayathiri NM (2018) Cardioprotective activity of telmisartan, metformin and its combination against doxorubicin induced myocardial infarction in rat model. Res J Pharm Technol 11:5293–5296

Article  Google Scholar 

Azimzadeh O, Scherthan H, Sarioglu H, Barjaktarovic Z, Conrad M, Vogt A, Calzada-Wack J, Neff F, Aubele M, Buske C, Atkinson MJ, Tapio S (2011) Rapid proteomic remodeling of cardiac tissue caused by total body ionizing radiation. Proteomics 11:3299–3311

Article  CAS  PubMed  Google Scholar 

Bailey C (2017) Metformin: historical overview. Diabetologia 60:1566–1576

Article  CAS  PubMed  Google Scholar 

Boerma M, Sridharan V, Mao XW, Nelson GA, Cheema AK, Koturbash IS, S P, Tackett AJ, Hauer-Jensen M (2016) M. (2016). Effects of ionizing radiation on the heart. Mutation Research/Reviews in Mutation Research 770: 319-327

Cameron AR, Morrison VL, Levin D, Mohan M, Forteath C, Beall C, McNeilly AD, Balfour DJK, Savinko T, Wong AKF, Viollet B, Sakamoto K, Fagerholm SC, Foretz M, Lang CC, Rena G (2016) Anti-inflammatory effects of metformin irrespective of diabetes status. Circulation Res 119:652–665

Article  CAS  PubMed  Google Scholar 

Castellano G, Affuso F, Di Conza P, Fazio S (2009) The GH/IGF-1 axis and heart failure. Curr Cardio Rev 5:203–215

Article  CAS  Google Scholar 

Chinedu E, Arome D, Ameh FS (2013) A new method for determining acute toxicity in animal models. Toxic Int 20:224

Article  CAS  Google Scholar 

Czarkowska-Paczek B, Bartlomiejczyk I, Przybylski J (2006) The serum levels of growth factors: PDGF, TGF-beta and VEGF are increased after strenuous physical exercise. J Physio Pharmacol 57:189–197

CAS  Google Scholar 

Dehkordi AH, Abbaszadeh A, Mir S, Hasanvand A (2018) Metformin and its anti-inflammatory and anti-oxidative effects; new concepts. J Renal Injury Prevent 8:54–61

Article  Google Scholar 

Dobaczewski M, Gonzalez-Quesada C, Frangogiannis NG (2010) The extracellular matrix as a modulator of the inflammatory and reparative response following myocardial infarction. J Mole Cellular Cardio 48:504–511

Article  CAS  Google Scholar 

Driver C, Bamitale KD, Kazi A, Olla M, Nyane NA, Owira PM (2018) Cardioprotective effects of metformin. J Cardiovascular Pharm 72:121–127

Article  CAS  Google Scholar 

Efentakis P, Kremastiotis G, Varela A, Nikolaou PE, Papanagnou ED, Davos CH, ..., Terpos E (2019) Molecular mechanisms of carfilzomib-induced cardiotoxicity in mice and the emerging cardioprotective role of metformin. Blood, The Journal of the American Society of Hematology 133: 710-723

El Kiki SM, Omran MM, Mansour HH, Hasan HF (2020) Metformin and/or low dose radiation reduces cardiotoxicity and apoptosis induced by cyclophosphamide through SIRT-1/SOD and BAX/Bcl-2 pathways in rats. Molecular Bio Rep 47:511

Google Scholar 

El-Daly SM, El-Bana MA, Abd El-Rahman SS, Abdel-Latif Y, Medhat D (2023) Dynamic expression of H19 and MALAT1 and their correlation with tumor progression biomarkers in a multistage hepatocarcinogenesis model. Cell Biochem Funct: 1-13

Flecknell PA (1993) Anaesthesia of animals for biomedical research. BJA: British Journal of Anaesthesia 71: 885-894

Foray N, Bourguignon M, Hamada N (2016) Individual response to ionizing radiation. Mutation Res/Rev Mutation Res 770:369–386

Article  CAS  Google Scholar 

Garg P, Morris P, Fazlanie AL, Vijayan S, Dancso B, Dastidar AG, Plein S, Mueller C, Haaf P (2017) Cardiac biomarkers of acute coronary syndrome: from history to high-sensitivity cardiac troponin. Int Emergency Med 12:147–155

Article  Google Scholar 

Gujral D, Lloyd G, Bhattacharyya S (2016) Radiation-induced valvular heart disease. Heart 102:269–276

Article  CAS  PubMed  Google Scholar 

Helm JS, Rudel RA (2020) Adverse outcome pathways for ionizing radiation and breast cancer involve direct and indirect DNA damage, oxidative stress, inflammation, genomic instability, and interaction with hormonal regulation of the breast. Archives Toxicol 94:1511–1549

Article  CAS  Google Scholar 

Jiang W, Xiong Y, Li X, Yang Y (2021) Cardiac fibrosis: cellular effectors, molecular pathways, and exosomal roles. Front Cardiovas Med 8:715258

Article  CAS  Google Scholar 

Karam HM, Radwan RR (2019) Metformin modulates cardiac endothelial dysfunction, oxidative stress and inflammation in irradiated rats: a new perspective of an antidiabetic drug. Clin Exp Pharmacol Physio 46:1124–1132

Article  CAS  Google Scholar 

Koutroumpakis E, Palaskas NL, Lin SH, Abe JI, Liao Z, Banchs J, Deswal A, Yusuf SW (2020) Modern radiotherapy and risk of cardiotoxicity. Chemotherapy 65:65–76

Article  CAS  PubMed  Google Scholar 

Leask A (2015) Getting to the heart of the matter: new insights into cardiac fibrosis. Circulation Res 116:1269–1276

Article  CAS  PubMed  Google Scholar 

Ma R, Yi B, Riker AI, Xi Y (2020) Metformin and cancer immunity. Acta Pharmacologica Sinica 41:1403–1409

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Maggio FM, Minafra L, Forte GI, Cammarata FP, Lio D, Messa C, ..., Bravatà V (2015) Portrait of inflammatory response to ionizing radiation treatment. Journal of inflammation 12: 1-11

Mohammed I, Hollenberg MD, Ding H, Triggle CR (2021) A critical review of the evidence that metformin is a putative anti-aging drug that enhances healthspan and extends lifespan. Front Endocrinol 12:718942

Article  Google Scholar 

Nandini HS, Paudel YN, Krishna KL (2019) Envisioning the neuroprotective effect of metformin in experimental epilepsy: a portrait of molecular crosstalk. Life Sci 233:116686

Article  Google Scholar 

Paget G, Barnes J (1964) Toxicity tests Evaluation of drug activities. Pharmacom 1:135–165

Google Scholar 

Park HJ, Yun DH, Kim SK, Chung JH, Lee JS, Park HK, Chon J, Kim DH, Yoo SD, Kim HS (2013) Association of CXCL 1 promoter polymorphism with ischaemic stroke in Korean population. Int J Immunogen 40:306–310

Article  CAS  Google Scholar 

Paudel YN, Angelopoulou E, Piperi C, Shaikh MF, Othman I (2020) Emerging neuroprotective effect of metformin in Parkinson’s disease: a molecular crosstalk. Pharma Res 152:104593

Article  CAS  Google Scholar 

Pereira A, de Souza Lima ML, da Silva-Junior AA, Dos Santos Silva E, F dAJR, A MA, F AJS, S OA, L DSF, T dACEC, B GGC, C dM, C BGA, F dCLR, Arajo d (2021) In vitro-in vivo availability of metformin hydrochloride-PLGA nanoparticles in diabetic rats in a periodontal disease experimental model. Pharm Biol 59: 1576-1584

Pordel S, Sajedi Khanian M, Karimi MH, Nikoo H, Doroudchi M (2018) Plasma CXCL 1 levels and TRAF 3 IP 2 variants in patients with myocardial infarction. Journal of clinical laboratory analysis: e22402

Porsch H, Mehić M, Olofsson B, Heldin P, Heldin CH (2014) Platelet-derived growth factor β-receptor, transforming growth factor β type I receptor, and CD44 protein modulate each other’s signaling and stability. J Biolog Chem 289:19747–19757

Article  CAS  Google Scholar 

Ravanat JL, Douki T (2016) UV and ionizing radiations induced DNA damage, differences and similarities. Radia Phys Chem 128:92–102

Article  CAS  Google Scholar 

Skuli SJ, Alomari S, Gaitsch H, Bakayoko AI, Skuli N, Tyler BM (2022) Metformin and cancer, an ambiguanidous relationship. Pharmaceuticals 15(5):626

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spetz J, Moslehi J, Sarosiek K (2020) Radiation-induced cardiovascular toxicity: mechanisms, prevention and treatment. Curr Treat Options Cardiovasc Med 20:31

Article  Google Scholar 

Suvarna S, Layton C, Bancroft J (2013) Bancroft’s theory and practice of histological techniques. Oxford 33, Churchill Livingstone,

Tahir K, Pauley E, Dai X, Smith S, Sweeney C, Stouffer G (2019) Mechanisms of ST elevation myocardial infarction in patients hospitalized for noncardiac conditions. Am J Cardiol 123:1393–1398

Article  PubMed  Google Scholar 

Taunk N, Haffty B, Kostis J, Goyal S (2015) Radiation-induced heart disease: pathologic abnormalities and putative mechanisms. Front Oncol: 5

Torres W, Nava M, Galbán N, Gómez Y, Morillo V, Rojas M, Cano C, Chacín M, D’Marco L, Herazo Y, Velasco M, Bermúdez V, Rojas-Quintero J (2020) Anti-aging effect of metformin: a molecular and therapeutical perspective. Current Pharm Design 26:4496–4508

Article  CAS  Google Scholar 

Trojanowska M (2008) Role of PDGF in fibrotic diseases and systemic sclerosis. Rheumatol 47:v2–v4

Article  CAS  Google Scholar 

Tsuji G, Hashimoto-Hachiya A, Yen VH, Takemura M, Yumine A, Furue K, ..., Nakahara T (2020) Metformin inhibits IL-1β secretion via impairment of NLRP3 inflammasome in keratinocytes: implications for preventing the development of psoriasis. Cell Death Discovery 6: 11

Wang L, Zhang YL, Lin QY, Liu Y, Guan XM, Ma XL, Cao HJ, liu Y, Bai J, Xia YL, Du J, Li HH (2018) CXCL1–CXCR2 axis mediates angiotensin II-induced cardiac hypertrophy and remodelling through regulation of monocyte infiltration. Eur Heart J 39(20): 1818-1831

Wu CL, Yin R, Wang SN, Ying R (2021) A review of CXCL1 in cardiac fibrosis. Front Cardiovas Med 8:674498

Article  CAS  Google Scholar 

Zhang YL, Cao HJ, Han X, Teng F, Chen C, Yang J, ..., Li HH (2020) Chemokine receptor CXCR-2 initiates atrial fibrillation by triggering monocyte mobilization in mice. Hypertension 76: 381-392

Zhao T, Zhao W, Chen Y, Li VS, Meng W, Sun Y (2013) Platelet-derived growth factor-D promotes fibrogenesis of cardiac fibroblasts. Ame J Physio-Heart Circulatory Physio 304:H1719–H1726

Article  CAS  Google Scholar 

Zhao XY, Zhao LY, Zheng QS, Su JL, Guan H, Shang FJ, ..., Lu XL (2008) Chymase induces profibrotic response via transforming growth factor-β1/Smad activation in rat cardiac fibroblasts. Molecular and cellular biochemistry 310: 159-166

Zheng HC, Onderko L, Francis SA (2017) Cardiovascular risk in survivors of cancer. Current Cardio Rep 19:1–10

Article  Google Scholar 

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