Recent developments in targeting breast cancer stem cells (BCSCs): a descriptive review of therapeutic strategies and emerging therapies

Bray F, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394–424.

Article  PubMed  Google Scholar 

Organization, W.H. Preventing Cancer. 2020 [cited 2020 18-11-2020]; Available from: https://www.fda.gov/drugs/new-drugs-fda-cders-new-molecular-entities-and-new-therapeutic-biological-products/novel-drug-approvals-2019.

Zhou J, et al. Stem cells and cellular origins of breast cancer: updates in the rationale, controversies, and therapeutic implications. Front Oncol. 2019;9:820–820.

Article  PubMed  PubMed Central  Google Scholar 

Elbaiomy MA, et al. Clinical impact of breast cancer stem cells in metastatic breast cancer patients. J Oncol. 2020;2020:2561726.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bianchini G, et al. Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease. Nat Rev Clin Oncol. 2016;13(11):674–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Greaves M, Maley CC. Clonal evolution in cancer. Nature. 2012;481(7381):306–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tudoran OM, Balacescu O, Berindan-Neagoe I. Breast cancer stem-like cells: clinical implications and therapeutic strategies. Clujul Medical. 2016;89(2):193.

PubMed  PubMed Central  Google Scholar 

Dragu DL, et al. Therapies targeting cancer stem cells: current trends and future challenges. World J Stem Cells. 2015;7(9):1185.

Article  PubMed  PubMed Central  Google Scholar 

Al-Hajj M, et al. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A. 2003;100(7):3983–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shipitsin M, et al. Molecular definition of breast tumor heterogeneity. Cancer Cell. 2007;11(3):259–73.

Article  CAS  PubMed  Google Scholar 

Kai K, et al. Breast cancer stem cells. Breast Cancer. 2010;17(2):80–5.

Article  PubMed  Google Scholar 

Ma X, et al. Modulation of drug-resistant membrane and apoptosis proteins of breast cancer stem cells by targeting berberine liposomes. Biomaterials. 2013;34(18):4452–65.

Article  CAS  PubMed  Google Scholar 

Tam WL, et al. Protein kinase C α is a central signaling node and therapeutic target for breast cancer stem cells. Cancer Cell. 2013;24(3):347–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Singh JK, et al. Recent advances reveal IL-8 signaling as a potential key to targeting breast cancer stem cells. Breast Cancer Res. 2013;15(4):210.

Article  PubMed  PubMed Central  Google Scholar 

Gangopadhyay S, et al. Breast cancer stem cells: a novel therapeutic target. Clin Breast Cancer. 2013;13(1):7–15.

Article  CAS  PubMed  Google Scholar 

Glumac PM, LeBeau AM. The role of CD133 in cancer: a concise review. Clin Transl Med. 2018;7(1):18.

Article  PubMed  PubMed Central  Google Scholar 

Vikram R, et al. Tumorigenic and metastatic role of CD44(-/low)/CD24(-/low) cells in luminal breast cancer. Cancers. 2020;12(5):1239.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen K, Huang Y-H, Chen J-L. Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol Sin. 2013;34(6):732.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muntimadugu E, et al. CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel. Colloids Surf B Biointerfaces. 2016;143:532–46.

Article  CAS  PubMed  Google Scholar 

Daquan Chen GW, Song W, Zhang Q. Novel CD44 receptor targeting multifunctional “nano-eggs” based on double pH-sensitive nanoparticles for co-delivery of curcumin and paclitaxel to cancer cells and cancer stem cells. J Nanopart Res. 2015;17:10.

Google Scholar 

Najjar MK, Manore SG, Regua AT, Lo HW. Antibody-drug conjugates for the treatment of HER2-positive breast cancer. Genes (Basel). 2022;13:2065.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luksik AS, Yazigi E, Shah P, Jackson CM. CAR T cell therapy in glioblastoma: overcoming challenges related to antigen expression. Cancers (Basel). 2023;15:1414.

Article  CAS  PubMed  Google Scholar 

Yanze Sun XY, Wang X, et al. Bispecific antibodies in cancer therapy: Target selection and regulatory requirements. Acta Pharm Sin B. 2023;13:3583–97.

Article  PubMed  PubMed Central  Google Scholar 

Choi YH, Yu AM. ABC transporters in multidrug resistance and pharmacokinetics, and strategies for drug development. Curr Pharm Des. 2014;20(5):793–807.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yue-Li Sun AP, Kumar P, Chen Z-S. Role of ABC transporters in cancer chemotherapy. Chin J Cancer. 2012;31(2):51.

Article  PubMed  PubMed Central  Google Scholar 

Chuthapisith S, et al. Breast cancer chemoresistance: emerging importance of cancer stem cells. Surg Oncol. 2010;19(1):27–32.

Article  PubMed  Google Scholar 

Shivhare S, Das A. Cell density modulates chemoresistance in breast cancer cells through differential expression of ABC transporters. Mol Biol Rep. 2023;50(1):215–25.

Article  CAS  PubMed  Google Scholar 

Cui J, et al. Targeting ABCA12-controlled ceramide homeostasis inhibits breast cancer stem cell function and chemoresistance. Sci Adv. 2023;9(48):1891.

Article  Google Scholar 

Wu CP, Ohnuma S, Ambudkar SV. Discovering natural product modulators to overcome multidrug resistance in cancer chemotherapy. Curr Pharm Biotechnol. 2011;12(4):609–20.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ciocca DR, Calderwood SK. Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications. Cell Stress Chaperones. 2005;10(2):86–103.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mao L. NOTCH mutations: multiple faces in human malignancies. Cancer Prev Res (Philadelphia, Pa). 2015;8:259–61.

Article  CAS  Google Scholar 

Takebe N, Nguyen D, Yang SX. Targeting notch signaling pathway in cancer: clinical development advances and challenges. Pharmacol Ther. 2014;141(2):140–9.

Article  CAS  PubMed  Google Scholar 

Aithal MG, Rajeswari N. Role of Notch signalling pathway in cancer and its association with DNA methylation. J Genet. 2013;92(3):667–75.

Article  CAS  PubMed  Google Scholar 

Harrison H, et al. Regulation of breast cancer stem cell activity by signaling through the Notch4 receptor. Can Res. 2010;70(2):709–18.

Article  CAS  Google Scholar 

Hermawan A, et al. Bioinformatics and in vitro studies reveal the importance of p53, PPARG and notch signaling pathway in inhibition of breast cancer stem cells by hesperetin. Adv Pharm Bull. 2021;11(2):351.

CAS  PubMed  Google Scholar 

Cejuela M, Martin-Castillo B, Menendez JA, Pernas S. Metformin and breast cancer: Where are we now? Int J Mol Sci. 2022;23(5):2705.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rossini M, Martini F, Torreggiani E, Fortini F, Aquila G, Sega FV, Patergnani S, Pinton P, Maniscalco P, Cavallesco G, Rizzo P. Metformin induces apoptosis and inhibits notch1 in malignant pleural mesothelioma cells. Front Cell Dev Biol. 2021;8:534499.

Article  PubMed  PubMed Central  Google Scholar 

Chia YH, Ma CX. Hedgehog pathway inhibitors: potential applications in breast cancer. Curr Breast Cancer Rep. 2011;3:15–23.

Article  CAS  Google Scholar 

Tsao A-N, et al. Dinaciclib inhibits the stemness of two subtypes of human breast cancer cells by targeting the FoxM1 and Hedgehog signaling pathway. Oncol Rep. 2022;47(5):1–12.

Article  Google Scholar 

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