Let-7a-3p overexpression increases chemosensitivity to carmustine and synergistically promotes autophagy and suppresses cell survival in U87MG glioblastoma cancer cells

Agraval H, Yadav UC (2019) MMP-2 and MMP-9 mediate cigarette smoke extract-induced epithelial-mesenchymal transition in airway epithelial cells via EGFR/Akt/GSK3β/β-catenin pathway: amelioration by fisetin. Chem Biol Interact 314:108846

Article  CAS  PubMed  Google Scholar 

Alexandri C, Van Den Steen G, Demeestere I (2022) Let-7a mimic transfection reduces chemotherapy-induced damage in a mouse ovarian transplantation model. Sci Rep 12:10863

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alifieris C, Trafalis DT (2015) Glioblastoma multiforme: pathogenesis and treatment. Pharmacol Ther 152:63–82

Article  CAS  PubMed  Google Scholar 

Bader AG, Brown D, Winkler M (2010) The promise of microRNA replacement therapy. Can Res 70:7027–7030

Article  CAS  Google Scholar 

Bastiancich C, Danhier P, Préat V, Danhier F (2016) Anticancer drug-loaded hydrogels as drug delivery systems for the local treatment of glioblastoma. J Control Release 243:29–42

Article  CAS  PubMed  Google Scholar 

Biamonte F, Santamaria G, Sacco A, Perrone FM, Di Cello A, Battaglia AM, Salatino A, Di Vito A, Aversa I, Venturella R (2019) MicroRNA let-7g acts as tumor suppressor and predictive biomarker for chemoresistance in human epithelial ovarian cancer. Sci Rep 9:1–12

Article  CAS  Google Scholar 

Blower PE, Chung J-H, Verducci JS, Lin S, Park J-K, Dai Z, Liu C-G, Schmittgen TD, Reinhold WC, Croce CM (2008) MicroRNAs modulate the chemosensitivity of tumor cells. Mol Cancer Ther 7:1–9

Article  CAS  PubMed  Google Scholar 

Cai K, Wan Y, Sun G, Shi L, Bao X, Wang Z (2012) Let-7a inhibits proliferation and induces apoptosis by targeting EZH2 in nasopharyngeal carcinoma cells. Oncol Rep 28:2101–2106

Article  CAS  PubMed  Google Scholar 

Chakraborty C, Sharma AR, Sharma G, Sarkar BK, Lee S-S (2018) The novel strategies for next-generation cancer treatment: miRNA combined with chemotherapeutic agents for the treatment of cancer. Oncotarget 9:10164

Article  PubMed  PubMed Central  Google Scholar 

Che F, Xie X, Wang L, Su Q, Jia F, Ye Y, Zang L, Wang J, Li H, Quan Y (2018) B7–H6 expression is induced by lipopolysaccharide and facilitates cancer invasion and metastasis in human gliomas. Int Immunopharmacol 59:318–327

Article  CAS  PubMed  Google Scholar 

Chen VCH, Hsieh YH, Chen LJ, Hsu TC, Tzang BS (2018) Escitalopram oxalate induces apoptosis in U-87 MG cells and autophagy in GBM 8401 cells. J Cell Mol Med 22:1167–1178

Article  CAS  PubMed  Google Scholar 

Chen C, Liang H, Qin R, Li X, Wang L, Du S, Chen Z, Meng X, Lv Z, Wang Q (2022) Doramectin inhibits glioblastoma cell survival via regulation of autophagy in vitro and in vivo. Int J Oncol 60:1–16

Article  CAS  PubMed  Google Scholar 

Chirshev E, Oberg KC, Ioffe YJ, Unternaehrer JJ (2019) Let-7 as biomarker, prognostic indicator, and therapy for precision medicine in cancer. Clin Transl Med 8:1–14

Article  Google Scholar 

Colella B, Faienza F, Di Bartolomeo S (2019) EMT regulation by autophagy: a new perspective in glioblastoma biology. Cancers 11:312

Article  CAS  PubMed  PubMed Central  Google Scholar 

Davis ME (2016) Glioblastoma: overview of disease and treatment. Clin J Oncol Nurs 20:S2

Article  PubMed  PubMed Central  Google Scholar 

Di Filippo LD, Duarte JL, Luiz MT, de Araújo JTC, Chorilli M (2021) Drug delivery nanosystems in glioblastoma multiforme treatment: current state of the art. Curr Neuropharmacol 19:787–812

Article  PubMed  PubMed Central  Google Scholar 

Di Leva G, Garofalo M, Croce CM (2014) MicroRNAs in cancer. Annu Rev Pathol 9:287–314

Article  PubMed  Google Scholar 

Dong Z, Lei Q, Yang R, Zhu S, Ke X-X, Yang L, Cui H, Yi L (2017) Inhibition of neurotensin receptor 1 induces intrinsic apoptosis via let-7a-3p/Bcl-w axis in glioblastoma. Br J Cancer 116:1572–1584

Article  CAS  PubMed  PubMed Central  Google Scholar 

Duan S, Li J, Tian J, Yin H, Zhai Q, Wu Y, Yao S, Zhang L (2019) Crosstalk between let-7a-5p and BCL-xL in the initiation of toxic autophagy in lung cancer. Mol Ther Oncol 15:69–78

Article  CAS  Google Scholar 

Eisenberg-Lerner A, Bialik S, Simon H-U, Kimchi A (2009) Life and death partners: apoptosis, autophagy and the cross-talk between them. Cell Death Differ 16:966–975

Article  CAS  PubMed  Google Scholar 

Elgendy M, Ciro M, Abdel-Aziz AK, Belmonte G, Dal Zuffo R, Mercurio C, Miracco C, Lanfrancone L, Foiani M, Minucci S (2014) Beclin 1 restrains tumorigenesis through Mcl-1 destabilization in an autophagy-independent reciprocal manner. Nat Commun 5:5637

Article  CAS  PubMed  Google Scholar 

Engeland K (2018) Cell cycle arrest through indirect transcriptional repression by p53: I have a DREAM. Cell Death Differ 25:114–132

Article  CAS  PubMed  Google Scholar 

Fan H, Jiang M, Li B, He Y, Huang C, Luo D, Xu H, Yang L, Zhou J (2018) MicroRNA-let-7a regulates cell autophagy by targeting Rictor in gastric cancer cell lines MGC-803 and SGC-7901. Oncol Rep 39:1207–1214

CAS  PubMed  Google Scholar 

Fisher JP, Adamson DC (2021) Current FDA-approved therapies for high-grade malignant gliomas. Biomedicines 9:324

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flum M, Dicks S, Teng Y-H, Schrempp M, Nyström A, Boerries M, Hecht A (2022) Canonical TGFβ signaling induces collective invasion in colorectal carcinogenesis through a Snail1-and Zeb1-independent partial EMT. Oncogene 41:1492–1506

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fulda S, Kögel D (2015) Cell death by autophagy: emerging molecular mechanisms and implications for cancer therapy. Oncogene 34:5105–5113

Article  CAS  PubMed  Google Scholar 

Giovannetti E, Erozenci A, Smit J, Danesi R, Peters GJ (2012) Molecular mechanisms underlying the role of microRNAs (miRNAs) in anticancer drug resistance and implications for clinical practice. Crit Rev Oncol Hematol 81:103–122

Article  PubMed  Google Scholar 

Gómez-Oliva R, Domínguez-García S, Carrascal L, Abalos-Martínez J, Pardillo-Díaz R, Verástegui C, Castro C, Nunez-Abades P, Geribaldi-Doldán N (2021) Evolution of experimental models in the study of glioblastoma: toward finding efficient treatments. Front Oncol 10:614295

Article  PubMed  PubMed Central  Google Scholar 

Guo X, Xue H, Guo X, Gao X, Xu S, Yan S, Han X, Li T, Shen J, Li G (2015) MiR224-3p inhibits hypoxia-induced autophagy by targeting autophagy-related genes in human glioblastoma cells. Oncotarget 6:41620

Article  PubMed  PubMed Central  Google Scholar 

Haar CP, Hebbar P, Wallace GC, Das A, Vandergrift WA, Smith JA, Giglio P, Patel SJ, Ray SK, Banik NL (2012) Drug resistance in glioblastoma: a mini review. Neurochem Res 37:1192–1200

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu X, Yan P, Feng J, Zhang F (2020) Expression of microRNA-210 and the prognosis in glioma patients: a meta-analysis. Biomark Med 14:795–805

Article  PubMed  Google Scholar 

Huang X, Qi Q, Hua X, Li X, Zhang W, Sun H, Li S, Wang X, Li B (2014) Beclin 1, an autophagy-related gene, augments apoptosis in U87 glioblastoma cells. Oncol Rep 31:1761–1767

Article  CAS  PubMed  Google Scholar 

Iwasaki T, Tanaka K, Kawano M, Itonaga I, Tsumura H (2015) Tumor-suppressive microRNA-let-7a inhibits cell proliferation via targeting of E2F2 in osteosarcoma cells. Int J Oncol 46:1543–1550

Article  CAS  PubMed  Google Scholar 

Kim KH, Lee M-S (2014) Autophagy—a key player in cellular and body metabolism. Nat Rev Endocrinol 10:322–337

Article  CAS  PubMed  Google Scholar 

Kolliopoulos C, Ali MM, Castillejo-Lopez C, Heldin C-H, Heldin P (2022) CD44 depletion in glioblastoma cells suppresses growth and stemness and induces senescence. Cancers 14:3747

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kong L, Ji H, Gan X, Cao S, Li Z, Jin Y (2022) Knockdown of CD44 inhibits proliferation, migration and invasion of osteosarcoma cells accompanied by downregulation of cathepsin S. J Orthop Surg Res 17:1–10

Article  CAS  Google Scholar 

Lee S-T, Chu K, Oh H-J, Im W-S, Lim J-Y, Kim S-K, Park C-K, Jung K-H, Lee SK, Kim M (2011) Let-7 microRNA inhibits the proliferation of human glioblastoma cells. J Neurooncol 102:19–24

Article  CAS  PubMed 

留言 (0)

沒有登入
gif