TCF1–LEF1 co-expression identifies a multipotent progenitor cell (TH2-MPP) across human allergic diseases

Paley, M. A. et al. Progenitor and terminal subsets of CD8+ T cells cooperate to contain chronic viral infection. Science 338, 1220–1225 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Im, S. J. et al. Defining CD8+ T cells that provide the proliferative burst after PD-1 therapy. Nature 537, 417–421 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Utzschneider, D. T. et al. T cell factor 1-expressing memory-like CD8+ T cells sustain the immune response to chronic viral infections. Immunity 45, 415–427 (2016).

Article  CAS  PubMed  Google Scholar 

Wu, T. et al. The TCF1–Bcl6 axis counteracts type I interferon to repress exhaustion and maintain T cell stemness. Sci. Immunol. 1, eaai8593 (2016).

Article  PubMed  PubMed Central  Google Scholar 

Sade-Feldman, M. et al. Defining T cell states associated with response to checkpoint immunotherapy in melanoma. Cell 175, 998–1013 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Philip, M. & Schietinger, A. CD8+ T cell differentiation and dysfunction in cancer. Nat. Rev. Immunol. 22, 209–223 (2022).

Article  CAS  PubMed  Google Scholar 

Walker, J. A. & McKenzie, A. N. J. TH2 cell development and function. Nat. Rev. Immunol. 18, 121–133 (2018).

Article  CAS  PubMed  Google Scholar 

Nakayama, T. et al. TH2 cells in health and disease. Annu. Rev. Immunol. 35, 53–84 (2016).

Article  PubMed  Google Scholar 

Gause, W. C., Rothlin, C. & Loke, P. Heterogeneity in the initiation, development and function of type 2 immunity. Nat. Rev. Immunol. 20, 603–614 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nelson, R. W. et al. T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity. Immunity 42, 95–107 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bangert, C. et al. Persistence of mature dendritic cells, TH2A, and Tc2 cells characterize clinically resolved atopic dermatitis under IL-4Rα blockade. Sci. Immunol. 6, eabe2749 (2021).

Article  CAS  PubMed  Google Scholar 

Smillie, C. S. et al. Intra- and inter-cellular rewiring of the human colon during ulcerative colitis. Cell 178, 714–730 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ma, J. et al. Single-cell analysis pinpoints distinct populations of cytotoxic CD4+ T cells and an IL-10+CD109+ TH2 cell population in nasal polyps. Sci. Immunol. 6, eabg6356 (2021).

Article  CAS  PubMed  Google Scholar 

Liu, X. et al. Single-cell RNA sequencing of subcutaneous adipose tissues identifies therapeutic targets for cancer-associated lymphedema. Cell Discov. 8, 58 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wen, T. et al. Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis. J. Clin. Invest. 129, 2014–2028 (2019).

Article  PubMed  PubMed Central  Google Scholar 

Morgan, D. M. et al. Clonally expanded, GPR15-expressing pathogenic effector TH2 cells are associated with eosinophilic esophagitis. Sci. Immunol. 6, eabi5586 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Korsunsky, I. et al. Fast, sensitive and accurate integration of single-cell data with Harmony. Nat. Methods 16, 1289–1296 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Alladina, J. et al. A human model of asthma exacerbation reveals transcriptional programs and cell circuits specific to allergic asthma. Sci. Immunol. 8, eabq6352 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Siddiqui, S. et al. Epithelial miR-141 regulates IL-13-induced airway mucus production. JCI Insight 6, e139019 (2021).

Article  PubMed  PubMed Central  Google Scholar 

Okano, M. et al. Interleukin-33-activated neuropeptide CGRP-producing memory TH2 cells cooperate with somatosensory neurons to induce conjunctival itch. Immunity 55, 2352–2368 (2022).

Article  CAS  PubMed  Google Scholar 

Liu, Y. et al. Classification of human chronic inflammatory skin disease based on single-cell immune profiling. Sci. Immunol. 7, eabl9165 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mitson-Salazar, A. et al. Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function. J. Allergy Clin. Immunol. 137, 907–918 (2016).

Article  CAS  PubMed  Google Scholar 

Wambre, E. et al. A phenotypically and functionally distinct human TH2 cell subpopulation is associated with allergic disorders. Sci. Transl. Med. 9, eaam9171 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Faustino, L. D. et al. Interleukin-33 activates regulatory T cells to suppress innate γδ T cell responses in the lung. Nat. Immunol. 21, 1371–1383 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morimoto, Y. et al. Amphiregulin-producing pathogenic memory T helper 2 cells instruct eosinophils to secrete osteopontin and facilitate airway fibrosis. Immunity 49, 134–150 (2018). .

Zhao, X., Shan, Q. & Xue, H.-H. TCF1 in T cell immunity: a broadened frontier. Nat. Rev. Immunol. 22, 147–157 (2022).

Article  CAS  PubMed  Google Scholar 

Kumar, B. V. et al. Human tissue-resident memory T cells are defined by core transcriptional and functional signatures in lymphoid and mucosal sites. Cell Rep. 20, 2921–2934 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Skon, C. N. et al. Transcriptional downregulation of S1pr1 is required for the establishment of resident memory CD8+ T cells. Nat. Immunol. 14, 1285–1293 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hombrink, P. et al. Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells. Nat. Immunol. 17, 1467–1478 (2016).

Article  CAS  PubMed  Google Scholar 

Schnell, A. et al. Stem-like intestinal TH17 cells give rise to pathogenic effector T cells during autoimmunity. Cell 184, 6281–6298 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Karmaus, P. W. F. et al. Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity. Nature 565, 101–105 (2019).

Article  CAS  PubMed  Google Scholar 

Gearty, S. V. et al. An autoimmune stem-like CD8 T cell population drives type 1 diabetes. Nature 602, 156–161 (2022).

Article  CAS  PubMed  Google Scholar 

Wang, W. et al. Single-cell profiling identifies mechanisms of inflammatory heterogeneity in chronic rhinosinusitis. Nat. Immunol. 23, 1484–1494 (2022).

Article  CAS  PubMed  Google Scholar 

Utzschneider, D. T. et al. Active maintenance of T cell memory in acute and chronic viral infection depends on continuous expression of FOXO1. Cell Rep. 22, 3454–3467 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Delpoux, A. et al. Continuous activity of Foxo1 is required to prevent anergy and maintain the memory state of CD8+ T cells. J. Exp. Med. 215, 575–594 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Staron, M. M. et al. The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8+ T cells during chronic infection. Immunity 41, 802–814 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tibbitt, C. A. et al. Single-cell RNA sequencing of the T helper cell response to house dust mites defines a distinct gene expression signature in airway TH2 cells. Immunity 51, 1

留言 (0)

沒有登入
gif