Demaria, O. et al. Harnessing innate immunity in cancer therapy. Nature 574, 45–56 (2019).

Article  CAS  PubMed  Google Scholar 

Gajewski, T. F., Schreiber, H. & Fu, Y. X. Innate and adaptive immune cells in the tumor microenvironment. Nat. Immunol. 14, 1014–1022 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ganz, T. & Nemeth, E. Iron homeostasis in host defence and inflammation. Nat. Rev. Immunol. 15, 500–510 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Belkaid, Y. & Hand, T. W. Role of the microbiota in immunity and inflammation. Cell 157, 121–141 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vetizou, M. et al. Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota. Science 350, 1079–1084 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sivan, A. et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 350, 1084–1089 (2015).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Giunta, E. F. et al. Baseline IFN-γ and IL-10 expression in PBMCs could predict response to PD-1 checkpoint inhibitors in advanced melanoma patients. Sci. Rep. 10, 17626 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yatsunenko, T. et al. Human gut microbiome viewed across age and geography. Nature 486, 222–227 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li, K. et al. CD8(+) T cell immunity blocks the metastasis of carcinogen-exposed breast cancer. Sci. Adv. 7, eabd8936 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Watowich, M. B., Gilbert, M. R. & Larion, M. T cell exhaustion in malignant gliomas. Trends Cancer 9, 270–292 (2023).

Article  PubMed  PubMed Central  Google Scholar 

Douglas, G. M. et al. PICRUSt2 for prediction of metagenome functions. Nat. Biotechnol. 38, 685–688 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Remus, D. M. et al. Impact of 4 Lactobacillus plantarum capsular polysaccharide clusters on surface glycan composition and host cell signaling. Micro. Cell Fact. 11, 149 (2012).

Article  CAS  Google Scholar 

Garcia-Vello, P. et al. Structural features and immunological perception of the cell surface glycans of Lactobacillus plantarum: a novel rhamnose-rich polysaccharide and teichoic acids. Carbohydr. Polym. 233, 115857 (2020).

Article  CAS  PubMed  Google Scholar 

Tietze, J. K. et al. The proportion of circulating CD45RO(+)CD8(+) memory T cells is correlated with clinical response in melanoma patients treated with ipilimumab. Eur. J. Cancer 75, 268–279 (2017).

Article  CAS  PubMed  Google Scholar 

Zhao, X., Shan, Q. & Xue, H. H. TCF1 in T cell immunity: a broadened frontier. Nat. Rev. Immunol. https://doi.org/10.1038/s41577-021-00563-6 (2021).

Article  PubMed  Google Scholar 

Roh, W. et al. Integrated molecular analysis of tumor biopsies on sequential CTLA-4 and PD-1 blockade reveals markers of response and resistance. Sci. Transl. Med. 9, eaah3560 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Rudqvist, N. P. et al. Radiotherapy and CTLA-4 blockade shape the TCR repertoire of tumor-infiltrating T cells. Cancer Immunol. Res. 6, 139–150 (2018).

Article  CAS  PubMed  Google Scholar 

Huang, C. P., Liu, L. X. & Shyr, C. R. Tumor-associated macrophages facilitate bladder cancer progression by increasing cell growth, migration, invasion and cytokine expression. Anticancer Res. 40, 2715–2724 (2020).

Article  CAS  PubMed  Google Scholar 

Yost, K. E. et al. Clonal replacement of tumor-specific T cells following PD-1 blockade. Nat. Med. 25, 1251–1259 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muntjewerff, E. M., Meesters, L. D. & van den Bogaart, G. Antigen cross-presentation by macrophages. Front. Immunol. 11, 1276 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bain, C. C. et al. Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice. Nat. Immunol. 15, 929–937 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tamoutounour, S. et al. CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis. Eur. J. Immunol. 42, 3150–3166 (2012).

Article  CAS  PubMed  Google Scholar 

Weber, B., Saurer, L., Schenk, M., Dickgreber, N. & Mueller, C. CX3CR1 defines functionally distinct intestinal mononuclear phagocyte subsets which maintain their respective functions during homeostatic and inflammatory conditions. Eur. J. Immunol. 41, 773–779 (2011).

Article  CAS  PubMed  Google Scholar 

Buscher, K. et al. Natural variation of macrophage activation as disease-relevant phenotype predictive of inflammation and cancer survival. Nat. Commun. 8, 16041 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muckenthaler, M. U., Rivella, S., Hentze, M. W. & Galy, B. A red carpet for iron metabolism. Cell 168, 344–361 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kroner, A. et al. TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord. Neuron 83, 1098–1116 (2014).

Article  CAS  PubMed  Google Scholar 

Pereira, M. et al. Acute iron deprivation reprograms human macrophage metabolism and reduces inflammation in vivo. Cell Rep. 28, 498–511 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tannahill, G. M. et al. Succinate is an inflammatory signal that induces IL-1β through HIF-1α. Nature 496, 238–242 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peyssonnaux, C. et al. HIF-1α expression regulates the bactericidal capacity of phagocytes. J. Clin. Invest. 115, 1806–1815 (2005).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Winn, N. C., Volk, K. M. & Hasty, A. H. Regulation of tissue iron homeostasis: the macrophage ‘ferrostat’. JCI Insight 5, e132964 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Abreu, R., Quinn, F. & Giri, P. K. Role of the hepcidin-ferroportin axis in pathogen-mediated intracellular iron sequestration in human phagocytic cells. Blood Adv. 2, 1089–1100 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ganz, T. Iron in innate immunity: starve the invaders. Curr. Opin. Immunol. 21, 63–67 (2009).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cassat, J. E. & Skaar, E. P. Iron in infection and immunity. Cell Host Microbe 13, 509–519 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gozzelino, R., Jeney, V. & Soares, M. P. Mechanisms of cell protection by heme oxygenase-1. Annu. Rev. Pharmacol. Toxicol. 50, 323–354 (2010).

Article  CAS  PubMed  Google Scholar 

Chi, Y. et al. Cancer cells deploy lipocalin-2 to collect limiting iron in leptomeningeal metastasis. Science 369, 276–282 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mertens, C. et al. Intracellular iron chelation modulates the macrophage iron phenotype with consequences on tumor progression. PLoS ONE 11, e0166164 (2016).