Evaluation of efficacy and safety of glucosamine sulfate, chondroitin sulfate, and their combination regimen in the management of knee osteoarthritis: a systematic review and meta-analysis

Bourgeois P, Chales G, Dehais J, Delcambre B, Kuntz JL, Rozenberg S (1998) Efficacy and tolerability of chondroitin sulfate 1200 mg/day vs chondroitin sulfate 3 × 400 mg/day vs placebo. Osteoarthrit Cartilage 6(Suppl A):25–30. https://doi.org/10.1016/s1063-4584(98)80008-3

Article  Google Scholar 

Bucsi L, Poór G (1998) Efficacy and tolerability of oral chondroitin sulfate as a symptomatic slow-acting drug for osteoarthritis (SYSADOA) in the treatment of knee osteoarthritis. Osteoarthrit Cartilage 6(Suppl A):31–36. https://doi.org/10.1016/s1063-4584(98)80009-5

Article  Google Scholar 

Cui A, Li H, Wang D, Zhong J, Chen Y, Lu H (2020) Global, regional prevalence, incidence and risk factors of knee osteoarthritis in population-based studies. EClinicalMedicine 29–30:100587. https://doi.org/10.1016/j.eclinm.2020.100587

Article  PubMed  PubMed Central  Google Scholar 

Elgawish MH, Zakaria MA, Fahmy HS (2015) Effect of chondroitin sulfate on cartilage volume loss and subchondral bone marrow lesions in osteoarthritis knee. Egypt Rheumatol Rehabil 42:153–158. https://doi.org/10.4103/1110-161X.163948

Article  Google Scholar 

Fransen M, Agaliotis M, Nairn L, Votrubec M, Bridgett L, Su S, Jan S, March L, Edmonds J, Norton R, Woodward M, Day R, LEGS study collaborative group (2015) Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens. Ann Rheum Dis 74(5):851–858. https://doi.org/10.1136/annrheumdis-2013-203954

Article  CAS  PubMed  Google Scholar 

Giordano N, Fioravanti A, Papakostas P, Montella A, Giorgi G, Nuti R (2009) The efficacy and tolerability of glucosamine sulfate in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled trial. Curr Ther Res Clin Exp 70(3):185–196. https://doi.org/10.1016/j.curtheres.2009.05.004

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haq I, Murphy E, Dacre J (2003) Osteoarthritis. Postgrad Med J 79(933):377–383. https://doi.org/10.1136/pmj.79.933.377

Article  CAS  PubMed  PubMed Central  Google Scholar 

Herrero-Beaumont G, Ivorra JA, Del Carmen Trabado M, Blanco FJ, Benito P, Martín-Mola E, Paulino J, Marenco JL, Porto A, Laffon A, Araújo D, Figueroa M, Branco J (2007) Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis Rheum 56(2):555–567. https://doi.org/10.1002/art.22371

Article  CAS  PubMed  Google Scholar 

Hughes R, Carr A (2002) A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology (oxford) 41(3):279–284. https://doi.org/10.1093/rheumatology/41.3.279

Article  CAS  PubMed  Google Scholar 

Kahan A, Uebelhart D, De Vathaire F, Delmas PD, Reginster JY (2009) Long-term effects of chondroitins 4 and 6 sulfate on knee osteoarthritis: the study on osteoarthritis progression prevention, a two-year, randomized, double-blind, placebo-controlled trial. Arthritis Rheum 60(2):524–533. https://doi.org/10.1002/art.24255

Article  CAS  PubMed  Google Scholar 

Lee YH, Woo JH, Choi SJ, Ji JD, Song GG (2010) Effect of glucosamine or chondroitin sulfate on the osteoarthritis progression: a meta-analysis. Rheumatol Int 30(3):357–363. https://doi.org/10.1007/s00296-009-0969-5

Article  CAS  PubMed  Google Scholar 

Lubis AMT, Siagian C, Wonggokusuma E, Marsetyo AF, Setyohadi B (2017) Comparison of glucosamine-chondroitin sulfate with and without methylsulfonylmethane in grade I–II knee osteoarthritis: a double blind randomized controlled trial. Acta Med Indones 49(2):105–111

PubMed  Google Scholar 

Madhu K, Chanda K, Saji MJ (2013) Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. Inflammopharmacology 21(2):129–136. https://doi.org/10.1007/s10787-012-0163-3

Article  CAS  PubMed  Google Scholar 

Mazieres B, Combe B, Van Phan A, Tondut J, Grynfeltt M (2001) Chondroitin sulfate in osteoarthritis of the knee: a prospective, double blind, placebo controlled multicenter clinical study. J Rheumatol 28(1):173–181

CAS  PubMed  Google Scholar 

Mazières B, Hucher M, Zaïm M, Garnero P (2007) Effect of chondroitin sulphate in symptomatic knee osteoarthritis: a multicentre, randomised, double-blind, placebo-controlled study. Ann Rheum Dis 66(5):639–645. https://doi.org/10.1136/ard.2006.059899

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meng Z, Liu J, Zhou N (2023) Efficacy and safety of the combination of glucosamine and chondroitin for knee osteoarthritis: a systematic review and meta-analysis. Arch Orthop Trauma Surg 143(1):409–421. https://doi.org/10.1007/s00402-021-04326-9

Article  PubMed  Google Scholar 

Michel BA, Stucki G, Frey D, De Vathaire F, Vignon E, Bruehlmann P, Uebelhart D (2005) Chondroitins 4 and 6 sulfate in osteoarthritis of the knee: a randomized, controlled trial. Arthritis Rheum 52(3):779–786. https://doi.org/10.1002/art.20867

Article  CAS  PubMed  Google Scholar 

Möller I, Pérez M, Monfort J, Benito P, Cuevas J, Perna C, Doménech G, Herrero M, Montell E, Vergés J (2010) Effectiveness of chondroitin sulphate in patients with concomitant knee osteoarthritis and psoriasis: a randomized, double-blind, placebo-controlled study. Osteoarthrit Cartilage 18(Suppl 1):S32–S40. https://doi.org/10.1016/j.joca.2010.01.018

Article  Google Scholar 

NIAMS (2024) Osteoarthritis. https://www.niams.nih.gov/health-topics/osteoarthritis

Noack W, Fischer M, Förster KK, Rovati LC, Setnikar I (1994) Glucosamine sulfate in osteoarthritis of the knee. Osteoarthrit Cartilage 2(1):51–59. https://doi.org/10.1016/s1063-4584(05)80006-8

Article  CAS  Google Scholar 

Pal CP, Singh P, Chaturvedi S, Pruthi KK, Vij A (2016) Epidemiology of knee osteoarthritis in India and related factors. Indian J Orthop 50(5):518–522. https://doi.org/10.4103/0019-5413.189608

Article  PubMed  PubMed Central  Google Scholar 

Pavelká K, Gatterová J, Olejarová M, Machacek S, Giacovelli G, Rovati LC (2002) Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med 162(18):2113–2123. https://doi.org/10.1001/archinte.162.18.2113

Article  PubMed  Google Scholar 

Petersen SG, Beyer N, Hansen M, Holm L, Aagaard P, Mackey AL, Kjaer M (2011) Nonsteroidal anti-inflammatory drug or glucosamine reduced pain and improved muscle strength with resistance training in a randomized controlled trial of knee osteoarthritis patients. Arch Phys Med Rehabil 92(8):1185–1193. https://doi.org/10.1016/j.apmr.2011.03.009

Article  PubMed  Google Scholar 

Poolsup N, Suthisisang C, Channark P, Kittikulsuth W (2005) Glucosamine long-term treatment and the progression of knee osteoarthritis: systematic review of randomized controlled trials. Ann Pharmacother 39(6):1080–1087. https://doi.org/10.1345/aph.1E576

Article  CAS  PubMed  Google Scholar 

Railhac JJ, Zaim M, Saurel AS, Vial J, Fournie B (2012) Effect of 12 months treatment with chondroitin sulfate on cartilage volume in knee osteoarthritis patients: a randomized, double-blind, placebo-controlled pilot study using MRI. Clin Rheumatol 31(9):1347–1357. https://doi.org/10.1007/s10067-012-2022-4

Article  PubMed  Google Scholar 

Reginster JY, Deroisy R, Rovati LC, Lee RL, Lejeune E, Bruyere O, Giacovelli G, Henrotin Y, Dacre JE, Gossett C (2001) Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet (Lond, Engl) 357(9252):251–256. https://doi.org/10.1016/S0140-6736(00)03610-2

Article  CAS  Google Scholar 

Reginster JY, Dudler J, Blicharski T, Pavelka K (2017) Pharmaceutical-grade chondroitin sulfate is as effective as celecoxib and superior to placebo in symptomatic knee osteoarthritis: the ChONdroitin versus CElecoxib versus Placebo Trial (CONCEPT). Ann Rheum Dis 76(9):1537–1543. https://doi.org/10.1136/annrheumdis-2016-210860

Article  CAS  PubMed  Google Scholar 

Rindone JP, Hiller D, Collacott E, Nordhaugen N, Arriola G (2000) Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med 172(2):91–94. https://doi.org/10.1136/ewjm.172.2.91

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roman-Blas JA, Castañeda S, Sánchez-Pernaute O, Largo R, Herrero-Beaumont G, CS/GS Combined Therapy Study Group (2017) Combined treatment with chondroitin sulfate and glucosamine sulfate shows no superiority over placebo for reduction of joint pain and functional impairment in patients with knee osteoarthritis: a six-month multicenter, randomized, double-blind placebo-controlled clinical trial. Arthrit Rheumatol 69(1):77–85. https://doi.org/10.1002/art.39819

Article  CAS  Google Scholar 

Rondanelli M, Braschi V, Gasparri C, Nichetti M, Faliva MA, Peroni G, Naso M, Iannello G, Spadaccini D, Miraglia N, Putignano P, Alalwan TA, Perna S (2019) Effectiveness of non-animal chondroitin sulfate supplementation in the treatment of moderate knee osteoarthritis in a group of overweight subjects: a randomized, double-blind placebo-controlled pilot study. Nutrients 11(9):2027. https://doi.org/10.3390/nu11092027

Article  CAS  PubMed  PubMed Central  Google Scholar 

Uebelhart D, Thonar EJ, Delmas PD, Chantraine A, Vignon E (1998) Effects of oral chondroitin sulfate on the progression of knee osteoarthritis: a pilot study. Osteoarthrit Cartilage 6(Suppl A):39–46. https://doi.org/10.1016/s1063-4584(98)80011-3

Article  Google Scholar 

Uebelhart D, Malaise M, Marcolongo R, de Vathaire F, Piperno M, Mailleux E, Fioravanti A, Matoso L, Vignon E (2004) Intermittent treatment of knee osteoarthritis with oral chondroitin sulfate: a one-year, randomized, double-blind, multicenter study versus placebo. Osteoarthrit Cartilage 12(4):269–276. https://doi.org/10.1016/j.joca.2004.01.004

Article  Google Scholar 

Zhu X, Sang L, Wu D, Rong J, Jiang L (2018) Effectiveness and safety of glucosamine and chondroitin for the treatment of osteoarthritis: a meta-analysis of randomized controlled trials. J Orthop Surg Res 13(1):170. https://doi.org/10.1186/s13018-018-0871-5

Article  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif