International Diabetes Federation (2021) IDF diabetes atlas 2021. https://diabetesatlas.org/atlas/tenth-edition/. Updated 05 April 2021. Accessed 05 Nov 2021

Ott C, Jacobs K, Haucke E, Navarrete Santos A, Grune T, Simm A (2014) Role of advanced glycation end products in cellular signaling. Redox Biol 2:411–429

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raghavan S, Vassy JL, Ho YL, Song RJ, Gagnon DR, Cho K, Wilson PWF, Phillips LS (2019) Diabetes mellitus-related all-cause and cardiovascular mortality in a national cohort of adults. J Am Heart Assoc 8:e011295

Article  PubMed  PubMed Central  Google Scholar 

Newman JD, Schwartzbard AZ, Weintraub HS, Goldberg IJ, Berger JS (2017) Primary prevention of cardiovascular disease in diabetes mellitus. J Am Coll Cardiol 70:883–893

Article  PubMed  PubMed Central  Google Scholar 

Matsumoto T, Taguchi K, Kobayashi T (2021) Relationships between advanced glycation end products (AGEs), vasoactive substances, and vascular function. J Smooth Muscle Res 57:94–107

Article  PubMed  Google Scholar 

Tousoulis D, Papageorgiou N, Androulakis E, Siasos G, Latsios G, Tentolouris K, Stefanadis C (2013) Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches. J Am Coll Cardiol 62:667–676

Article  CAS  PubMed  Google Scholar 

Meza CA, La Favor JD, Kim DH, Hickner RC (2019) Endothelial dysfunction: is there a hyperglycemia-induced imbalance of NOX and NOS? Int J Mol Sci 20(15):3775

Article  CAS  PubMed  PubMed Central  Google Scholar 

Montero D, Walther G, Perez-Martin A, Vicente-Salar N, Roche E, Vinet A (2013) Vascular smooth muscle function in type 2 diabetes mellitus: a systematic review and meta-analysis. Diabetologia 56:2122–2133

Article  CAS  PubMed  Google Scholar 

Nieves-Cintron M, Syed AU, Buonarati OR, Rigor RR, Nystoriak MA, Ghosh D, Sasse KC, Ward SM, Santana LF, Hell JW et al (2017) Impaired BKCa channel function in native vascular smooth muscle from humans with type 2 diabetes. Sci Rep 7:14058

Article  PubMed  PubMed Central  Google Scholar 

Nieves-Cintron M, Syed AU, Nystoriak MA, Navedo MF (2018) Regulation of voltage-gated potassium channels in vascular smooth muscle during hypertension and metabolic disorders. Microcirculation 25:10

Article  PubMed Central  Google Scholar 

Fleischmann BK, Murray RK, Kotlikoff MI (1994) Voltage window for sustained elevation of cytosolic calcium in smooth muscle cells. Proc Natl Acad Sci USA 91:11914–11918

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nystoriak MA, Nieves-Cintron M, Patriarchi T, Buonarati OR, Prada MP, Morotti S, Grandi E, Fernandes JD, Forbush K, Hofmann F et al (2017) Ser 1928 phosphorylation by PKA stimulates the L-type Ca2+ channel CaV1.2 and vasoconstriction during acute hyperglycemia and diabetes. Sci Signal 10:eaaf9647

Article  PubMed  PubMed Central  Google Scholar 

Syed AU, Reddy GR, Ghosh D, Prada MP, Nystoriak MA, Morotti S, Grandi E, Sirish P, Chiamvimonvat N, Hell JW et al (2019) Adenylyl cyclase 5-generated cAMP controls cerebral vascular reactivity during diabetic hyperglycemia. J Clin Invest 129:3140–3152

Article  PubMed  PubMed Central  Google Scholar 

Martin-Aragon Baudel M, Flores-Tamez VA, Hong J, Reddy GR, Maillard P, Burns AE, Man KNM, Sasse KC, Ward SM, Catterall WA et al (2022) Spatiotemporal control of vascular CaV1.2 by alpha1C S1928 phosphorylation. Circ Res 131:1018–1033

Article  CAS  PubMed  PubMed Central  Google Scholar 

Aschner PJ, Ruiz AJ (2012) Metabolic memory for vascular disease in diabetes. Diabetes Technol Ther 14(Suppl 1):S68–S74

Article  CAS  PubMed  Google Scholar 

Yao Y, Song Q, Hu C, Da X, Yu Y, He Z, Xu C, Chen Q, Wang QK (2022) Endothelial cell metabolic memory causes cardiovascular dysfunction in diabetes. Cardiovasc Res 118:196–211

Article  CAS  PubMed  Google Scholar 

Maranta F, Cianfanelli L, Cianflone D (2021) Glycaemic control and vascular complications in diabetes mellitus type 2. Adv Exp Med Biol 1307:129–152

Article  CAS  PubMed  Google Scholar 

Bebu I, Braffett BH, de Boer IH, Aiello LP, Bantle JP, Lorenzi GM, Herman WH, Gubitosi-Klug RA, Perkins BA, Lachin JM et al (2023) Relationships between the cumulative incidences of long-term complications in type 1 diabetes: the DCCT/EDIC study. Diabetes Care 46:361–368

Article  CAS  PubMed  Google Scholar 

Marasco LE, Kornblihtt AR (2023) The physiology of alternative splicing. Nat Rev Mol Cell Biol 24:242–254

Article  CAS  PubMed  Google Scholar 

Rogalska ME, Vivori C, Valcarcel J (2023) Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects. Nat Rev Genet 24:251–269

Article  CAS  PubMed  Google Scholar 

Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ (2008) Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 40:1413–1415

Article  CAS  PubMed  Google Scholar 

Wang ET, Sandberg R, Luo S, Khrebtukova I, Zhang L, Mayr C, Kingsmore SF, Schroth GP, Burge CB (2008) Alternative isoform regulation in human tissue transcriptomes. Nature 456:470–476

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang ZZ, Liang MC, Lu S, Yu D, Yu CY, Yue DT, Soong TW (2004) Transcript scanning reveals novel and extensive splice variations in human L-type voltage-gated calcium channel, Cav1.2 alpha1 subunit. J Biol Chem 279:44335–44343

Article  CAS  PubMed  Google Scholar 

Lei J, Liu X, Song M, Zhou Y, Fan J, Shen X, Xu X, Kapoor I, Zhu G, Wang J (2020) Aberrant exon 8/8a splicing by downregulated PTBP (polypyrimidine tract-binding protein) 1 increases CaV1.2 dihydropyridine resistance to attenuate vasodilation. Arterioscler Thromb Vasc Biol 40:2440–2453

Article  CAS  PubMed  Google Scholar 

Wang J, Thio SS, Yang SS, Yu D, Yu CY, Wong YP, Liao P, Li S, Soong TW (2011) Splice variant specific modulation of CaV1.2 calcium channel by galectin-1 regulates arterial constriction. Circ Res 109:1250–1258

Article  CAS  PubMed  Google Scholar 

Fan J, Fan W, Lei J, Zhou Y, Xu H, Kapoor I, Zhu G, Wang J (2019) Galectin-1 attenuates cardiomyocyte hypertrophy through splice-variant specific modulation of CaV1.2 calcium channel. Biochim Biophys Acta Mol Basis Dis 1865:218–229

Article  CAS  PubMed  Google Scholar 

Li G, Wang J, Liao P, Bartels P, Zhang H, Yu D, Liang MC, Poh KK, Yu CY, Jiang F et al (2017) Exclusion of alternative exon 33 of CaV1.2 calcium channels in heart is proarrhythmogenic. Proc Natl Acad Sci USA 114:E4288–E4295

CAS  PubMed  PubMed Central  Google Scholar 

Zhou Y, Fan J, Zhu H, Ji L, Fan W, Kapoor I, Wang Y, Wang Y, Zhu G, Wang J (2017) Aberrant splicing induced by dysregulated Rbfox2 produces enhanced function of CaV1.2 calcium channel and vascular myogenic tone in hypertension. Hypertension 70:1183–1192

Article  CAS  PubMed  Google Scholar 

Hu Z, Liang MC, Soong TW (2017) Alternative splicing of L-type CaV12 calcium channels: implications in cardiovascular diseases. Genes 8(12):344

Article  PubMed  PubMed Central  Google Scholar 

Zhang C, Zhang Z, Castle J, Sun S, Johnson J, Krainer AR, Zhang MQ (2008) Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. Genes Dev 22:2550–2563

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim KK, Adelstein RS, Kawamoto S (2009) Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors. J Biol Chem 284:31052–31061

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang ZZ, Zheng S, Nikolic J, Black DL (2009) Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins. Mol Cell Biol 29:4757–4765

Article  CAS  PubMed  PubMed Central  Google Scholar 

Song M, Hou W, Mustafa AU, Li P, Lei J, Zhou Y, Ji L, Sun Y, Zhou H, Xu Y, Wang J (2022) Diminished Rbfox1 increases vascular constriction by dynamically regulating alternative splicing of CaV1.2 calcium channel in hypertension. Clin Sci 136:803–817

Article  CAS  Google Scholar 

Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P (2005) Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: a model for type 2 diabetes and pharmacological screening. Pharmacol Res 52:313–320

Article  CAS  PubMed  Google Scholar 

Oldfield MD, Bach LA, Forbes JM, Nikolic-Paterson D, McRobert A, Thallas V, Atkins RC, Osicka T, Jerums G, Cooper ME (2001) Advanced glycation end products cause epithelial-myofibroblast transdifferentiation via the receptor for advanced glycation end products (RAGE). J Clin Invest 108:1853–1863

Article  CAS  PubMed  PubMed Central