Quercetin-3-O-β-D-glucuronide attenuates osteoarthritis by inhibiting cartilage extracellular matrix degradation and inflammation
Keywords
Extracellular matrix
Inflammation
Nrf2
Osteoarthritis
Quercetin-3-O-β-D-glucuronide
AbbreviationsQ3GA
quercetin-3-O-β-D-glucuronide
ROS
reactive oxygen species
Nrf2
nuclear factor erythroid 2-related factor 2
ADAMTS
a disintegrin and metalloproteinase with thrombospondin motifs
MMP
matrix metalloproteinase
DMEM
Dulbecco's modification of Eagle's medium Dulbecco
qRT-PCR
quantitative real-time polymerase chain reaction
Keap1
Kelch-like ECH associated protein 1
MNX
medial meniscal transection
micro-CT
micro-computed tomography
BV/TV
bone volume/total tissue volume
Tb.Sp
trabecular separation
OARSI
Osteoarthritis Research Society International
iNOS
inducible nitric oxide synthase
© 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.
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