Levy SE, Mandell DS, Schultz RT. Autism Lancet. 2009;374(9701):1627–38.

Article  PubMed  Google Scholar 

de la Torre-Ubieta L, Won H, Stein JL, Geschwind DH. Advancing the understanding of autism disease mechanisms through genetics. Nat Med. 2016;22(4):345–61.

Article  PubMed  PubMed Central  Google Scholar 

Mei Y, Monteiro P, Zhou Y, Kim JA, Gao X, Fu Z, et al. Adult restoration of Shank3 expression rescues selective autistic-like phenotypes. Nature. 2016;530(7591):481–4.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Monteiro P, Feng G. SHANK proteins: roles at the synapse and in autism spectrum disorder. Nat Rev Neurosci. 2017;18(3):147–57.

Article  CAS  PubMed  Google Scholar 

Shcheglovitov A, Shcheglovitova O, Yazawa M, Portmann T, Shu R, Sebastiano V, et al. SHANK3 and IGF1 restore synaptic deficits in neurons from 22q13 deletion syndrome patients. Nature. 2013;503(7475):267–71.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bozdagi O, Sakurai T, Papapetrou D, Wang X, Dickstein DL, Takahashi N, et al. Haploinsufficiency of the autism-associated Shank3 gene leads to deficits in synaptic function, social interaction, and social communication. Mol Autism. 2010;1(1):15.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jacot-Descombes S, Keshav NU, Dickstein DL, Wicinski B, Janssen WGM, Hiester LL, et al. Altered synaptic ultrastructure in the prefrontal cortex of Shank3-deficient rats. Mol Autism. 2020;11(1):89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Peca J, Feliciano C, Ting JT, Wang W, Wells MF, Venkatraman TN, et al. Shank3 mutant mice display autistic-like behaviours and striatal dysfunction. Nature. 2011;472(7344):437–42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hayakawa M, Hayakawa H, Petrova T, Ritprajak P, Sutavani RV, Jimenez-Andrade GY, et al. Loss of functionally redundant p38 isoforms in T Cells Enhances Regulatory T Cell Induction. J Biol Chem. 2017;292(5):1762–72.

Article  CAS  PubMed  Google Scholar 

Han K, Holder JL Jr., Schaaf CP, Lu H, Chen H, Kang H, et al. SHANK3 overexpression causes manic-like behaviour with unique pharmacogenetic properties. Nature. 2013;503(7474):72–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang L, Xu Y, Sun S, Liang C, Li W, Li H, et al. Integrative analysis of gammadeltaT cells and dietary factors reveals predictive values for autism spectrum disorder in children. Brain Behav Immun. 2023;111:76–89.

Article  CAS  PubMed  Google Scholar 

Schwartz MW, Woods SC, Porte D Jr., Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature. 2000;404(6778):661–71.

Article  CAS  PubMed  Google Scholar 

Vohra MS, Benchoula K, Serpell CJ, Hwa WE. AgRP/NPY and POMC neurons in the arcuate nucleus and their potential role in treatment of obesity. Eur J Pharmacol. 2022;915:174611.

Article  CAS  PubMed  Google Scholar 

Dietrich MO, Zimmer MR, Bober J, Horvath TL. Hypothalamic agrp neurons drive stereotypic behaviors beyond feeding. Cell. 2015;160(6):1222–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mul JD, van Boxtel R, Bergen DJ, Brans MA, Brakkee JH, Toonen PW, et al. Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat. Obes (Silver Spring). 2012;20(3):612–21.

Article  CAS  Google Scholar 

Stutz B, Waterson MJ, Sestan-Pesa M, Dietrich MO, Skarica M, Sestan N, et al. AgRP neurons control structure and function of the medial prefrontal cortex. Mol Psychiatry. 2022;27(10):3951–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang F, Zhu J, Zhu H, Zhang Q, Lin Z, Hu H. Bidirectional control of social hierarchy by synaptic efficacy in medial prefrontal cortex. Science. 2011;334(6056):693–7.

Article  CAS  PubMed  Google Scholar 

Veenstra-VanderWeele J, Muller CL, Iwamoto H, Sauer JE, Owens WA, Shah CR, et al. Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior. Proc Natl Acad Sci U S A. 2012;109(14):5469–74.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Robson MJ, Quinlan MA, Margolis KG, Gajewski-Kurdziel PA, Veenstra-VanderWeele J, Gershon MD, et al. p38alpha MAPK signaling drives pharmacologically reversible brain and gastrointestinal phenotypes in the SERT Ala56 mouse. Proc Natl Acad Sci U S A. 2018;115(43):E10245–54.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 2006;51(2):239–49.

Article  CAS  PubMed  Google Scholar 

Quinlan MA, Robson MJ, Ye R, Rose KL, Schey KL, Blakely RD. Ex vivo quantitative proteomic analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 coding variant. Front Mol Neurosci. 2020;13:89.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Coulthard LR, White DE, Jones DL, McDermott MF, Burchill SA. p38(MAPK): stress responses from molecular mechanisms to therapeutics. Trends Mol Med. 2009;15(8):369–79.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vargas DL, Nascimbene C, Krishnan C, Zimmerman AW, Pardo CA. Neuroglial activation and neuroinflammation in the brain of patients with autism. Ann Neurol. 2005;57(1):67–81.

Article  CAS  PubMed  Google Scholar 

Reed MD, Yim YS, Wimmer RD, Kim H, Ryu C, Welch GM, et al. IL-17a promotes sociability in mouse models of neurodevelopmental disorders. Nature. 2020;577(7789):249–53.

Article  CAS  PubMed  Google Scholar 

Choi GB, Yim YS, Wong H, Kim S, Kim H, Kim SV, et al. The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring. Science. 2016;351(6276):933–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He Z, Zhu HH, Bauler TJ, Wang J, Ciaraldi T, Alderson N, et al. Nonreceptor tyrosine phosphatase Shp2 promotes adipogenesis through inhibition of p38 MAP kinase. Proc Natl Acad Sci U S A. 2013;110(1):E79–88.

Article  CAS  PubMed  Google Scholar 

Hornberg H, Perez-Garci E, Schreiner D, Hatstatt-Burkle L, Magara F, Baudouin S, et al. Rescue of oxytocin response and social behaviour in a mouse model of autism. Nature. 2020;584(7820):252–6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Richards C, Jones C, Groves L, Moss J, Oliver C. Prevalence of autism spectrum disorder phenomenology in genetic disorders: a systematic review and meta-analysis. Lancet Psychiatry. 2015;2(10):909–16.

Article  PubMed  Google Scholar 

Han J, Wu J, Silke J. An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling. F1000Res. 2020;9.

Hwang S, Wang X, Rodrigues RM, Ma J, He Y, Seo W, et al. Protective and detrimental roles of p38alpha mitogen-activated protein kinase in different stages of nonalcoholic fatty liver disease. Hepatology. 2020;72(3):873–91.

Article  CAS  PubMed  Google Scholar 

Wang J, Wu S, Zhan H, Bi W, Xu Y, Liang Y, et al. p38alpha in the preoptic area inhibits brown adipose tissue thermogenesis. Obes (Silver Spring). 2022;30(11):2242–55.

Article  CAS  Google Scholar 

Hui L, Bakiri L, Mairhorfer A, Schweifer N, Haslinger C, Kenner L, et al. p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat Genet. 2007;39(6):741–9.

Article  CAS  PubMed  Google Scholar 

Leneuve P, Zaoui R, Monget P, Le Bouc Y, Holzenberger M. Genotyping of cre-lox mice and detection of tissue-specific recombination by multiplex PCR. Biotechniques. 2001;31(5):1156–60.

Article  CAS  PubMed  Google Scholar 

Steele AD, Jackson WS, King OD, Lindquist S. The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington’s and prion diseases. Proc Natl Acad Sci U S A. 2007;104(6):1983–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu S, Wang J, Xu Y, Zhang Z, Jin X, Liang Y, et al. Energy deficiency promotes rhythmic foraging behavior by activating neurons in paraventricular hypothalamic nucleus. Front Nutr. 2023;10:1278906.

Article  PubMed  PubMed Central