Probiotic-derived silver nanoparticles target mTOR/MMP-9/BCL-2/dependent AMPK activation for hepatic cancer treatment

Shedid M, Abdelmonem M, Boraik A, Elmetwalli A, Esmael A. Role of plasma miRNA-501 expression profile as a marker of hepatocellular carcinoma (HCC) progression with hepatitis C virus infection. Am J Clin Pathol. 2019;152:S134.

Article  Google Scholar 

Elmetwalli A, Hashish SM, Hassan MG, El-Magd MA, El-Naggar SA, Tolba AM, et al. Modulation of the oxidative damage, inflammation, and apoptosis-related genes by dicinnamoyl-L-tartaric acid in liver cancer. Naunyn Schmiedebergs Arch Pharmacol. 2023. https://doi.org/10.1007/s00210-023-02511-8.

Article  PubMed  PubMed Central  Google Scholar 

El-Alosey AR, Eldiasty JG, Abushalfeh IYH, Almasaude AA, Mosallam SAER, Elmetwalli A. Perceptions of medicinal herbal products during the COVID-19 pandemic period among Saudi patients: a cross-sectional study. Naunyn Schmiedebergs Arch Pharmacol. 2023. https://doi.org/10.1007/s00210-023-02511-8.

Article  PubMed  Google Scholar 

Elmetwalli A, Nageh A, Youssef AI, Youssef M, Ahmed MAER, Noreldin AE, et al. Ammonia scavenger and glutamine synthetase inhibitors cocktail in targeting mTOR/β-catenin and MMP-14 for nitrogen homeostasis and liver cancer. Med Oncol. 2023;41:38.

Article  PubMed  Google Scholar 

Elmetwalli A, Kamosh NH, El Safty R, Youssef AI, Salama MM, Abd El-Razek KM, et al. Novel phloretin-based combinations targeting glucose metabolism in hepatocellular carcinoma through GLUT2/PEPCK axis of action: in silico molecular modelling and in vivo studies. Med Oncol. 2023;41:12.

Article  PubMed  Google Scholar 

Sahu T, Ratre YK, Chauhan S, Bhaskar L, Nair MP, Verma HK. Nanotechnology based drug delivery system: current strategies and emerging therapeutic potential for medical science. J Drug Deliv Sci Technol. 2021;63:102487.

Article  CAS  Google Scholar 

Mohammed ABA, Hegazy AE, Salah A. Novelty of synergistic and cytotoxicity activities of silver nanoparticles produced by Lactobacillus acidophilus. Appl Nanosci. 2023;13:633–40.

Article  CAS  Google Scholar 

Kaabipour S, Hemmati S. A review on the green and sustainable synthesis of silver nanoparticles and one-dimensional silver nanostructures. Beilstein J Nanotechnol. 2021;12:102–36.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moond M, Singh S, Sangwan S, Devi R, Beniwal R. Green synthesis and applications of silver nanoparticles: a systematic review. AATCC J Res. 2022;9:272–85.

Article  CAS  Google Scholar 

Khan MR, Urmi MA, Kamaraj C, Malafaia G, Ragavendran C, Rahman MM. Green synthesis of silver nanoparticles with its bioactivity, toxicity and environmental applications: a comprehensive literature review. Environ Nanotechnol Monit Manag. 2023. https://doi.org/10.1016/j.enmm.2023.100872.

Article  Google Scholar 

El-Deeb NM, Yassin AM, Al-Madboly LA, El-Hawiet A. A novel purified Lactobacillus acidophilus 20079 exopolysaccharide, LA-EPS-20079, molecularly regulates both apoptotic and NF-κB inflammatory pathways in human colon cancer. Microb Cell Fact. 2018;17:1–15.

Article  Google Scholar 

Mohd Yusof H, Abdul Rahman N, Mohamad R, Zaidan UH. Microbial mediated synthesis of silver nanoparticles by Lactobacillus Plantarum TA4 and its antibacterial and antioxidant activity. Appl Sci. 2020;10:6973.

Article  Google Scholar 

Kumar KK, Mahalakshmi S, Harikrishna N, Reddy G. Production, characterization and antimicrobial activity of silver nanoparticles produced by Lactobacillus amylophilus GV6. Eur J Pharm Med Res. 2016;3:236242.

Google Scholar 

Elmetwalli A, Hassan J, Alaa H, Hassan MG, Ali M, Eltayeb MF, et al. Nanoparticle zinc oxide obviates oxidative stress of liver cells in induced-diabetes mellitus model. Med J Viral Hepat. 2022;7:8–12.

Article  Google Scholar 

Barabadi H, Jounaki K, Pishgahzadeh E, Morad H, Sadeghian-Abadi S, Vahidi H, et al. Antiviral potential of green-synthesized silver nanoparticles. In: Hussain CM, editor., et al., Handbook of microbial nanotechnology. Elsevier: Amsterdam; 2022. p. 285–310.

Chapter  Google Scholar 

Talank N, Morad H, Barabadi H, Mojab F, Amidi S, Kobarfard F, et al. Bioengineering of green-synthesized silver nanoparticles: in vitro physicochemical, antibacterial, biofilm inhibitory, anticoagulant, and antioxidant performance. Talanta. 2022;243:123374.

Article  CAS  PubMed  Google Scholar 

Barabadi H, Mobaraki K, Ashouri F, Noqani H, Jounaki K, Mostafavi E. Nanobiotechnological approaches in antinociceptive therapy: animal-based evidence for analgesic nanotherapeutics of bioengineered silver and gold nanomaterials. Adv Colloid Interface Sci. 2023. https://doi.org/10.1016/j.cis.2023.102917.

Article  PubMed  Google Scholar 

Barabadi H, Noqani H, Ashouri F, Prasad A, Jounaki K, Mobaraki K, et al. Nanobiotechnological approaches in anticoagulant therapy: the role of bioengineered silver and gold nanomaterials. Talanta. 2023;256:124279.

Article  CAS  PubMed  Google Scholar 

Ong C, Lim JZZ, Ng CT, Li JJ, Yung LY, Bay BH. Silver nanoparticles in cancer: therapeutic efficacy and toxicity. Curr Med Chem. 2013;20:772–81.

CAS  PubMed  Google Scholar 

Kumar B, Smita K, Seqqat R, Benalcazar K, Grijalva M, Cumbal L. In vitro evaluation of silver nanoparticles cytotoxicity on Hepatic cancer (Hep-G2) cell line and their antioxidant activity: green approach for fabrication and application. J Photochem Photobiol B Biol. 2016;159:8–13.

Article  CAS  Google Scholar 

Piao MJ, Kang KA, Lee IK, Kim HS, Kim S, Choi JY, et al. Silver nanoparticles induce oxidative cell damage in human liver cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis. Toxicol Lett. 2011;201:92–100.

Article  CAS  PubMed  Google Scholar 

Li J, Chang X, Shang M, Niu S, Zhang W, Li Y, et al. The crosstalk between DRP1-dependent mitochondrial fission and oxidative stress triggers hepatocyte apoptosis induced by silver nanoparticles. Nanoscale. 2021;13:12356–69.

Article  CAS  PubMed  Google Scholar 

Dasgupta N, Ranjan S, Mishra D, Ramalingam C. Thermal co-reduction engineered silver nanoparticles induce oxidative cell damage in human colon cancer cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis. Chem Biol Interact. 2018;295:109–18.

Article  CAS  PubMed  Google Scholar 

Kowalski S, Karska J, Łapińska Z, Hetnał B, Saczko J, Kulbacka J. An overview of programmed cell death: apoptosis and pyroptosis—Mechanisms, differences, and significance in organism physiology and pathophysiology. J Cell Biochem. 2023. https://doi.org/10.1002/jcb.30413.

Article  PubMed  Google Scholar 

El-Sewedy T, Salama AF, Mohamed AE, Elbaioumy NM, El-Far AH, Albalawi AN, et al. Hepatocellular carcinoma cells: activity of amygdalin and sorafenib in targeting AMPK/mTOR and BCL-2 for anti-angiogenesis and apoptosis cell death. BMC Complement Med Ther. 2023;23:1–17.

Article  Google Scholar 

El-Shehawy AA, Elmetwalli A, El-Far AH, Mosallam SAER, Salama AF, Babalghith AO, et al. Thymoquinone, piperine, and sorafenib combinations attenuate liver and breast cancers progression: epigenetic and molecular docking approaches. BMC Complement Med Ther. 2023;23:1–21.

Article  Google Scholar 

Oliaei R, Keshtmand Z, Shabani R. The effect of Lactobacillus casei and Bacillus coagulans probiotics on liver damage induced by silver nanoparticles and expression of bax, BCL-2 and caspase 3 genes in male rats. Eur J Transl Myol. 2023. https://doi.org/10.4081/ejtm.2022.10673.

Article  Google Scholar 

Wani AK, Akhtar N, Mir TG, Singh R, Jha PK, Mallik SK, et al. Targeting apoptotic pathway of cancer cells with phytochemicals and plant-based nanomaterials. Biomolecules. 2023;13:194.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kah G, Chandran R, Abrahamse H. Biogenic silver nanoparticles for targeted cancer therapy and enhancing photodynamic therapy. Cells. 2023;12:2012.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roach PJ. AMPK→ uLK1→ autophagy. Mol Cell Biol. 2023.

Tang B, Luo Z, Zhang R, Zhang D, Nie G, Li M, et al. An update on the molecular mechanism and pharmacological interventions for Ischemia-reperfusion injury by regulating AMPK/mTOR signaling pathway in autophagy. Cell Signal. 2023;107:110665.

Article  CAS  PubMed  Google Scholar 

Ballesteros-Álvarez J, Andersen JK. mTORC2: the other mTOR in autophagy regulation. Aging Cell. 2021;20:e13431.

Article  PubMed  PubMed Central  Google Scholar 

Saikia R, Joseph J. AMPK: a key regulator of energy stress and calcium-induced autophagy. J Mol Med. 2021;99:1539–51.

Article  CAS  PubMed  Google Scholar 

Mondal S, Adhikari N, Banerjee S, Amin SA, Jha T. Matrix metalloproteinase-9 (MMP-9) and its inhibitors in cancer: a minireview. Eur J Med Chem. 2020;194:112260.

Article  CAS  PubMed  Google Scholar 

Sarkar A, Paul A, Banerjee T, Maji A, Saha S, Bishayee A, et al. Therapeutic advancements in targeting BCL-2 family proteins by epigenetic regulators, natural, and synthetic agents in cancer. Eur J Pharmacol. 2023;944:175588.

Article  CAS  PubMed  Google Scholar 

Heidari-Kalvani N, Alizadeh-Fanalou S, Yarahmadi S, Fallah S, Alipourfard I, Farahmandian N, et al. Investigation of the effects of catharanthine and Q10 on Nrf2 and its association with MMP-9, MRP1, and Bcl-2 and apoptosis in a model of hepatocellular carcinoma. Naunyn Schmiedebergs Arch Pharmacol. 2023. https://doi.org/10.1007/s00210-023-02767-0.

Article  PubMed  Google Scholar 

Hou J, Zhao L, Tang H, He X, Ye G, Shi F, et al. Silver nanoparticles induced oxidative stress and mitochondrial injuries mediated autophagy in HC11 cells through Akt/AMPK/mTOR pathway. Biol Trace Elem Res. 2021;199:1062–73.

Article  CAS  PubMed  Google Scholar 

Li L, Li L, Zhou X, Yu Y, Li Z, Zuo D, et al. Silver nanoparticles induce protective autophagy via Ca2+/CaMKKβ/AMPK/mTOR pathway in SH-SY5Y cells and rat brains. Nanotoxicology. 2019;13:369–91.

Article  CAS  PubMed  Google Scholar 

Chang X, Wang X, Li J, Shang M, Niu S, Zhang W, et al. Silver nanoparticles induced cytotoxicity in HT22 cells through autophagy and apoptosis via PI3K/AKT/mTOR signaling pathway. Ecotoxicol Environ Saf. 2021;208:111696.

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