Available online 2 April 2024

Using nationwide Danish health register data, associations between fluoroquinolone use and elevated hazard rates of Achilles tendon rupture were found.

Associations were most pronounced with increasing dosage and within 30 days following fluoroquinolone use.

Despite recent findings calling the previously suggested associations between fluoroquinolones and aortic and valvular diseases into question, advised caution in relation to tendinopathies still seems relevant.

© 2024 Published by Elsevier B.V. on behalf of Shanghai University of Sport.