Albornoz EA, Amarilla AA, Modhiran N, Parker S, LI XX, Wijesundara DK, Aguado J, Zamora AP, Mcmillan CLD, Liang B, Peng NYG, Saima SNGJDJ, Fung FT, Lee JN, Paramitha JD, Parry D, Avumegah R, Isaacs MS, Miranda-Chacon ALOMW, Bradshaw Z, Salinas-Rebolledo D, Rajapakse C, Wolvetang NW, Munro EJ, Rojas-Fernandez TP, Young A, Stacey PR, Khromykh KJ, Chappell AA, Watterson KJ, D., Woodruff TM (2022) SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Mol Psychiatry

Dominic A, Le NT, Takahashi M (2022) Loop between NLRP3 inflammasome and reactive oxygen species. Antioxid Redox Signal 36:784–796

Article  CAS  PubMed  Google Scholar 

Dunn PJ, Harvey NR, Maksemous N, Smith RA, Sutherland HG, Haupt LM, Griffiths LR (2022) Investigation of mitochondrial related variants in a cerebral small Vessel Disease Cohort. Mol Neurobiol 59:5366–5378

Article  CAS  PubMed  PubMed Central  Google Scholar 

Edison P (2021) Microglial activation and blood-brain barrier leakage: chicken and egg? Brain 144:1284–1285

Article  PubMed  PubMed Central  Google Scholar 

Gao F, Jing Y, Zang P, Hu X, Gu C, Wu R, Chai B, Zhang Y (2019) Vascular cognitive impairment caused by Cerebral Small Vessel Disease is Associated with the TLR4 in the Hippocampus. J Alzheimers Dis 70:563–572

Article  PubMed  Google Scholar 

Gao Y, Li D, Lin J, Thomas AM, Miao J, Chen D, Li S, Chu C (2022) Cerebral small vessel disease: pathological mechanisms and potential therapeutic targets. Front Aging Neurosci 14:961661

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gordon R, Albornoz EA, Christie DC, Langley MR, Kumar V, Mantovani S, Robertson AAB, Butler MS, Rowe DB, O’neill LA, Kanthasamy AG, Schroder K, Cooper MA, Woodruff TM (2018) Inflammasome inhibition prevents alpha-synuclein pathology and dopaminergic neurodegeneration in mice. Sci Transl Med, 10

Gorelick PB, Scuteri A, Black SE, Decarli C, Greenberg SM, Ladecola C, Launer LJ, Laurent S, Lopez OL, Nyenhuis D, Petersen RC, Schneider JA, Tzourio C, Arnett DK, Bennett DA, Chui HC, Higashida RT, Lindquist R, Nilsson PM, Roman GC, Sellke FW, Seshadri S, American Heart Association Stroke Council, C. O. E., Prevention, C. O. C. N. C. O. C. R., Intervention, Council on Cardiovascular, S., Anesthesia (2011) Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association/american stroke association. Stroke, 42, 2672 – 713

Hainsworth AH, Markus HS (2008) Do in vivo experimental models reflect human cerebral small vessel disease? A systematic review. J Cereb Blood Flow Metab 28:1877–1891

Article  PubMed  Google Scholar 

Hannawi Y, Caceres E, Ewees MG, Powell KA, Bratasz A, Schwab JM, Rink CL, Zweier JL (2021) Characterizing the neuroimaging and histopathological correlates of Cerebral Small Vessel Disease in spontaneously hypertensive stroke-prone rats. Front Neurol 12:740298

Article  PubMed  PubMed Central  Google Scholar 

He X, Yang W, Zeng Z, Wei Y, Gao J, Zhang B, Li L, Liu L, Wan Y, Zeng Q, GONG Z, Liu L, Zhang H, Li Y, Yang S, Hu T, Wu L, Masliah E, Huang S, Cao H (2020) NLRP3-dependent pyroptosis is required for HIV-1 gp120-induced neuropathology. Cell Mol Immunol 17:283–299

Article  CAS  PubMed  Google Scholar 

Heneka MT, Kummer MP, Stutz A, Delekate A, Schwartz S, Vieira-Saecker A, Griep A, Axt D, Remus A, Tzeng TC, Gelpi E, Halle A, Korte M, Latz E, Golenbock DT (2013) NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice. Nature 493:674–678

Article  CAS  PubMed  Google Scholar 

Heneka MT, Mcmanus RM, Latz E (2018) Inflammasome signalling in brain function and neurodegenerative disease. Nat Rev Neurosci 19:610–621

Article  CAS  PubMed  Google Scholar 

Henning EC, Warach S, Spatz M (2010) Hypertension-induced vascular remodeling contributes to reduced cerebral perfusion and the development of spontaneous stroke in aged SHRSP rats. J Cereb Blood Flow Metab 30:827–836

Article  PubMed  Google Scholar 

Horie R, Yamori Y, Handa H (1978) An essential difference between stroke-prone SHR (SHRSP) and stroke-resistant SHR (SHRSR). Quantitative evidence obtained by Yamori’s preparation II. Jpn Heart J 19:630–632

Article  CAS  PubMed  Google Scholar 

Hu X, Yan J, Huang L, Araujo C, Peng J, Gao L, Liu S, Tang J, Zuo G, Zhang JH (2021) INT-777 attenuates NLRP3-ASC inflammasome-mediated neuroinflammation via TGR5/cAMP/PKA signaling pathway after subarachnoid hemorrhage in rats. Brain Behav Immun 91:587–600

Article  CAS  PubMed  Google Scholar 

Jalal FY, Yang Y, Thompson JF, Roitbak T, Rosenberg GA (2015) Hypoxia-induced neuroinflammatory white-matter injury reduced by minocycline in SHR/SP. J Cereb Blood Flow Metab 35:1145–1153

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaiser D, Weise G, Moller K, Scheibe J, Posel C, Baasch S, Gawlitza M, Lobsien D, Diederich K, Minnerup J, Kranz A, Boltze J, Wagner DC (2014) Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease. Acta Neuropathol Commun 2:169

Article  PubMed  PubMed Central  Google Scholar 

Kapasi A, Decarli C, Schneider JA (2017) Impact of multiple pathologies on the threshold for clinically overt dementia. Acta Neuropathol 134:171–186

Article  PubMed  PubMed Central  Google Scholar 

Kerkhofs D, Van Hagen BT, Milanova IV, Schell KJ, Van Essen H, Wijnands E, Goossens P, Blankesteijn WM, Unger T, Prickaerts J, Biessen EA, Van Oostenbrugge RJ, Foulquier S (2020) Pharmacological depletion of microglia and perivascular macrophages prevents vascular cognitive impairment in Ang II-induced hypertension. Theranostics 10:9512–9527

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu T, Zhang L, Joo D, Sun SC (2017) NF-kappaB signaling in inflammation. Signal Transduct Target Ther 2:17023

Article  PubMed  PubMed Central  Google Scholar 

Liu N, Xue Y, Tang J, Zhang M, Ren X, Fu J (2021) The dynamic change of phenotypic markers of smooth muscle cells in an animal model of cerebral small vessel disease. Microvasc Res 133:104061

Article  CAS  PubMed  Google Scholar 

Low A, Mak E, Rowe JB, Markus HS, O’brien JT (2019) Inflammation and cerebral small vessel disease: a systematic review. Ageing Res Rev 53:100916

Article  CAS  PubMed  Google Scholar 

Mangan MSJ, Olhava EJ, Roush WR, Seidel HM, Glick GD, Latz E (2018) Targeting the NLRP3 inflammasome in inflammatory diseases. Nat Rev Drug Discov 17:688

Article  CAS  PubMed  Google Scholar 

Mullard A (2019) NLRP3 inhibitors stoke anti-inflammatory ambitions. Nat Rev Drug Discov 18:405–407

Article  CAS  PubMed  Google Scholar 

Nabika T, Ohara H, Kato N, Isomura M (2012) The stroke-prone spontaneously hypertensive rat: still a useful model for post-GWAS genetic studies? Hypertens Res 35:477–484

Article  CAS  PubMed  Google Scholar 

Naeem A, Prakash R, Kumari N, Ali Khan M, Quaiyoom Khan A, Uddin S, Verma S, Robertson AB, Boltze A, J., Shadab Raza S (2024) MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer’s disease. Brain Behav Immun 116:70–84

Article  CAS  PubMed  Google Scholar 

Okamoto K, Aoki K (1963) Development of a strain of spontaneously hypertensive rats. Jpn Circ J 27:282–293

Article  CAS  PubMed  Google Scholar 

Quick S, Moss J, Rajani RM, Williams A (2021) A vessel for change: endothelial dysfunction in Cerebral Small Vessel Disease. Trends Neurosci 44:289–305

Article  CAS  PubMed  Google Scholar 

Rajani RM, Quick S, Ruigrok SR, Graham D, Harris SE, Verhaaren BFJ, FORNAGE M, Dominiczak Seshadrisatanurss, Wardlaw Afsmithc, J. M., Williams A (2018) Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Sci Transl Med, 10

Sharma B, Satija G, Madan A, Garg M, Alam MM, Shaquiquzzaman M, Khanna S, Tiwari P, Parvez S, Iqubal A, Haque SE, Khan MA (2023) Role of NLRP3 inflammasome and its inhibitors as emerging therapeutic drug candidate for Alzheimer’s Disease: a review of mechanism of activation, regulation, and inhibition. Inflammation 46:56–87

Article  CAS  PubMed  Google Scholar 

Shaul PW (2002) Regulation of endothelial nitric oxide synthase: location, location, location. Annu Rev Physiol 64:749–774

Article  CAS  PubMed  Google Scholar 

Swanson KV, Deng M, Ting JP (2019) The NLRP3 inflammasome: molecular activation and regulation to therapeutics. Nat Rev Immunol 19:477–489

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vorhees CV, Williams MT (2006) Morris water maze: procedures for assessing spatial and related forms of learning and memory. Nat Protoc 1:848–858

Article  PubMed  PubMed Central  Google Scholar 

Wang J, Cheng Q, Zhang Y, Hong C, Liu J, Liu X, Chang J (2023) PARP16-Mediated stabilization of amyloid precursor protein mRNA exacerbates Alzheimer’s Disease Pathogenesis. Aging Dis 14:1458–1471

PubMed  PubMed Central  Google Scholar 

Wardlaw JM, Smith C, Dichgans M (2013a) Mechanisms of sporadic cerebral small vessel disease: insights from neuroimaging. Lancet Neurol 12:483–497

Article  PubMed  Google Scholar 

Wardlaw JM, Smith C, Dichgans M (2019) Small vessel disease: mechanisms and clinical implications. Lancet Neurol 18:684–696

Article  PubMed  Google Scholar 

Wardlaw JM, Smith EE, Biessels GJ, Cordonnier C, Fazekas F, Frayne R, Lindley RI, O’brien JT, Barkhof F, Benavente OR, Black SE, Brayne C, Breteler M, Chabriat H, Decarli C, De Leeuw FE, Doubal F, Duering M, Fox NC, Greenberg S, Hachinski V, Kilimann I, Mok V, Oostenbrugge R, Pantoni L, Speck O, Stephan BC, Teipel S, Viswanathan A, Werring D, Chen C, Smith C, Van BUCHEM, Norrving M, Gorelick B, Dichgans PB, M., Neuroimaging ST F. R. V. C. O. 2013b. Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration. Lancet Neurol, 12, 822–838

Xu J, Nunez G (2023) The NLRP3 inflammasome: activation and regulation. Trends Biochem Sci 48:331–344

Article  CAS  PubMed  Google Scholar 

Yu E, Mercer J, Bennett M (2012) Mitochondria in vascular disease. Cardiovasc Res 95:173–182