Repurposing mebendazole against triple-negative breast cancer CNS metastasis

Brosnan EM, Anders CK (2018) Understanding patterns of brain metastasis in breast cancer and designing rational therapeutic strategies. Ann Transl Med 6:163. https://doi.org/10.21037/atm.2018.04.35

Article  CAS  PubMed  PubMed Central  Google Scholar 

Spini A, Donnini S, Pantziarka P, Crispino S, Ziche M (2020) Repurposing of drugs for triple negative breast cancer: an overview. Ecancermedicalscience 14:1071. https://doi.org/10.3332/ecancer.2020.1071

Article  PubMed  PubMed Central  Google Scholar 

Roy-O’Reilly MA, Lanman T, Ruiz A, Rogawski D, Stocksdale B, Nagpal S (2023) Diagnostic and Therapeutic Updates in Leptomeningeal Disease. Curr Oncol Rep 25:937–950. https://doi.org/10.1007/s11912-023-01432-2

Article  PubMed  PubMed Central  Google Scholar 

Wang N, Bertalan MS, Brastianos PK (2018) Leptomeningeal metastasis from systemic cancer: Review and update on management. Cancer 124:21–35. https://doi.org/10.1002/cncr.30911

Article  PubMed  Google Scholar 

Groves MD (2010) New strategies in the management of leptomeningeal metastases. Arch Neurol 67:305–312. https://doi.org/10.1001/archneurol.2010.18

Article  PubMed  Google Scholar 

Niwinska A, Rudnicka H, Murawska M (2013) Breast cancer leptomeningeal metastasis: propensity of breast cancer subtypes for leptomeninges and the analysis of factors influencing survival. Med Oncol 30:408. https://doi.org/10.1007/s12032-012-0408-4

Article  PubMed  PubMed Central  Google Scholar 

Nair NU, Das A, Rogkoti VM, Fokkelman M, Marcotte R, de Jong CG, Koedoot E, Lee JS, Meilijson I, Hannenhalli S, Neel BG, de Water BV, Le Devedec SE, Ruppin E (2019) Migration rather than proliferation transcriptomic signatures are strongly associated with breast cancer patient survival. Sci Rep 9:10989. https://doi.org/10.1038/s41598-019-47440-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bhambhvani HP, Rodrigues AJ, Umeh-Garcia MC, Hayden Gephart M (2020) Leptomeningeal Carcinomatosis: Molecular Landscape, Current Management, and Emerging Therapies. Neurosurg Clin N Am 31:613–625. https://doi.org/10.1016/j.nec.2020.06.010

Article  PubMed  PubMed Central  Google Scholar 

Pushpakom S, Iorio F, Eyers PA, Escott KJ, Hopper S, Wells A, Doig A, Guilliams T, Latimer J, McNamee C, Norris A, Sanseau P, Cavalla D, Pirmohamed M (2019) Drug repurposing: progress, challenges and recommendations. Nat Rev Drug Discov 18:41–58. https://doi.org/10.1038/nrd.2018.168

Article  CAS  PubMed  Google Scholar 

Son DS, Lee ES, Adunyah SE (2020) The Antitumor Potentials of Benzimidazole Anthelmintics as Repurposing Drugs. Immune Netw 20:e29. https://doi.org/10.4110/in.2020.20.e29

Article  PubMed  PubMed Central  Google Scholar 

Bai RY, Staedtke V, Aprhys CM, Gallia GL, Riggins GJ (2011) Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. Neuro Oncol 13:974–982. https://doi.org/10.1093/neuonc/nor077

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang Y, Liang J, Wu A, Chen Y, Zhao P, Lin T, Zhang M, Xu Q, Wang J, Huang Y (2017) Co-Delivery of Trichosanthin and Albendazole by Nano-Self-Assembly for Overcoming Tumor Multidrug-Resistance and Metastasis. ACS Appl Mater Interfaces 9:26648–26664. https://doi.org/10.1021/acsami.7b05292

Article  CAS  PubMed  Google Scholar 

Bai RY, Staedtke V, Wanjiku T, Rudek MA, Joshi A, Gallia GL, Riggins GJ (2015) Brain Penetration and Efficacy of Different Mebendazole Polymorphs in a Mouse Brain Tumor Model. Clin Cancer Res 21:3462–3470. https://doi.org/10.1158/1078-0432.CCR-14-2681

Article  CAS  PubMed  PubMed Central  Google Scholar 

Joe NS, Godet I, Milki N, Ain NUI, Oza HH, Riggins GJ, Gilkes DM (2022) Mebendazole prevents distant organ metastases in part by decreasing ITGbeta4 expression and cancer stemness. Breast Cancer Res 24:98. https://doi.org/10.1186/s13058-022-01591-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

White AC Jr, Coyle CM, Rajshekhar V, Singh G, Hauser WA, Mohanty A, Garcia HH, Nash TE (2018) Diagnosis and Treatment of Neurocysticercosis: 2017 Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH). Clin Infect Dis 66:e49–e75. https://doi.org/10.1093/cid/cix1084

Article  PubMed  PubMed Central  Google Scholar 

Butala C, Brook TM, Majekodunmi AO, Welburn SC (2021) Neurocysticercosis: Current Perspectives on Diagnosis and Management. Front Vet Sci 8:615703. https://doi.org/10.3389/fvets.2021.615703

Article  PubMed  PubMed Central  Google Scholar 

Francisca PA, Javier LF, Guadalupe PH, Fernanda GM, Nelly C, Helgi JC, Iliana GH, Susana RI (2020) Cysticidal activity of praziquantel-mebendazole combination: In vitro and in vivo studies. Acta Trop 202:105238. https://doi.org/10.1016/j.actatropica.2019.105238

Article  CAS  PubMed  Google Scholar 

Guerini AE, Triggiani L, Maddalo M, Bonu ML, Frassine F, Baiguini A, Alghisi A, Tomasini D, Borghetti P, Pasinetti N, Bresciani R, Magrini SM, Buglione M (2019) Mebendazole as a Candidate for Drug Repurposing in Oncology: An Extensive Review of Current Literature. Cancers (Basel) 11:1284. https://doi.org/10.3390/cancers11091284

Article  CAS  PubMed  Google Scholar 

Patil VM, Bhelekar A, Menon N, Bhattacharjee A, Simha V, Abhinav R, Abhyankar A, Sridhar E, Mahajan A, Puranik AD, Purandare N, Janu A, Ahuja A, Krishnatry R, Gupta T, Jalali R (2020) Reverse swing-M, phase 1 study of repurposing mebendazole in recurrent high-grade glioma. Cancer Med 9:4676–4685. https://doi.org/10.1002/cam4.3094

Article  CAS  PubMed  PubMed Central  Google Scholar 

Meco D, Attina G, Mastrangelo S, Navarra P, Ruggiero A (2023) Emerging Perspectives on the Antiparasitic Mebendazole as a Repurposed Drug for the Treatment of Brain Cancers. Int J Mol Sci 24:1334. https://doi.org/10.3390/ijms24021334

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kim LS, Huang S, Lu W, Lev DC, Price JE (2004) Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice. Clin Exp Metas 21:107–118. https://doi.org/10.1023/b:clin.0000024761.00373.55

Article  CAS  Google Scholar 

Alli E, Solow-Cordero D, Casey SC, Ford JM (2014) Therapeutic targeting of BRCA1-mutated breast cancers with agents that activate DNA repair. Can Res 74:6205–6215. https://doi.org/10.1158/0008-5472.CAN-14-1716

Article  CAS  Google Scholar 

Deng J, Chernikova SB, Wang Y, Rodriguez ML, Andersen SJ, Umeh-Garcia MC, Godfrey BO, Ahmadian SS, Fischer WN, Koller KJ, Jandeleit B, Ringold GM, Gephart MH (2021) A Novel Brain-Permeant Chemotherapeutic Agent for the Treatment of Brain Metastasis in Triple-Negative Breast Cancer. Mol Cancer Ther 20:2110–2116. https://doi.org/10.1158/1535-7163.MCT-21-0140

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kimura-Hayama ET, Higuera JA, Corona-Cedillo R, Chavez-Macias L, Perochena A, Quiroz-Rojas LY, Rodriguez-Carbajal J, Criales JL (2010) Neurocysticercosis: radiologic-pathologic correlation. Radiographics 30:1705–1719. https://doi.org/10.1148/rg.306105522

Article  PubMed  Google Scholar 

Kuster T, Zumkehr B, Hermann C, Theurillat R, Thormann W, Gottstein B, Hemphill A (2012) Voluntary ingestion of antiparasitic drugs emulsified in honey represents an alternative to gavage in mice. J Am Assoc Lab Anim Sci 51:219–223

CAS  PubMed  PubMed Central  Google Scholar 

De Witt M, Gamble A, Hanson D, Markowitz D, Powell C, Al Dimassi S, Atlas M, Boockvar J, Ruggieri R, Symons M (2017) Repurposing Mebendazole as a Replacement for Vincristine for the Treatment of Brain Tumors. Mol Med 23:50–56. https://doi.org/10.2119/molmed.2017.00011

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yang W, Soares J, Greninger P, Edelman EJ, Lightfoot H, Forbes S, Bindal N, Beare D, Smith JA, Thompson IR, Ramaswamy S, Futreal PA, Haber DA, Stratton MR, Benes C, McDermott U, Garnett MJ (2013) Genomics of Drug Sensitivity in Cancer (GDSC): a resource for therapeutic biomarker discovery in cancer cells. Nucleic Acids Res 41:D955-961. https://doi.org/10.1093/nar/gks1111

Article  CAS  PubMed  Google Scholar 

Lacey E (1990) Mode of action of benzimidazoles. Parasitol Today 6:112–115. https://doi.org/10.1016/0169-4758(90)90227-u

Article  CAS  PubMed  Google Scholar 

Lacey E (1988) The role of the cytoskeletal protein, tubulin, in the mode of action and mechanism of drug resistance to benzimidazoles. Int J Parasitol 18:885–936. https://doi.org/10.1016/0020-7519(88)90175-0

Article  CAS  PubMed  Google Scholar 

Dawson PJ, Gutteridge WE, Gull K (1984) A comparison of the interaction of anthelmintic benzimidazoles with tubulin isolated from mammalian tissue and the parasitic nematode Ascaridia galli. Biochem Pharmacol 33:1069–1074. https://doi.org/10.1016/0006-2952(84)90515-x

Article  CAS  PubMed  Google Scholar 

International Helminth Genomes C (2019) Comparative genomics of the major parasitic worms. Nat Genet 51:163–174. https://doi.org/10.1038/s41588-018-0262-1

Article  CAS  Google Scholar 

留言 (0)

沒有登入
gif