Vascular leak in sepsis: physiological basis and potential therapeutic advances

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al. The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 2016;315(8):801–10.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Organization WH. Global report on the epidemiology and burden of sepsis: current evidence, identifying gaps and future directions. 2020.

Bateman RM, Sharpe MD, Jagger JE, Ellis CG. Sepsis impairs microvascular autoregulation and delays capillary response within hypoxic capillaries. Crit Care. 2015;19(1):1–14.

Article  Google Scholar 

Colbert JF, Schmidt EP. Endothelial and microcirculatory function and dysfunction in sepsis. Clin Chest Med. 2016;37(2):263–75.

Article  PubMed  PubMed Central  Google Scholar 

Joffre J, Hellman J, Ince C, Ait-Oufella H. Endothelial responses in sepsis. Am J Respir Crit Care Med. 2020;202(3):361–70.

Article  CAS  PubMed  Google Scholar 

Ince C, Mayeux PR, Nguyen T, Gomez H, Kellum JA, Ospina-Tascón GA, et al. The endothelium in sepsis. Shock. 2016;45(3):259.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fernández-Sarmiento J, Schlapbach LJ, Acevedo L, Santana CR, Acosta Y, Diana A, Monsalve MC, Carcillo JA. Endothelial damage in sepsis: the importance of systems biology. Front Pediatr. 2022;9(10):828968.

Article  Google Scholar 

Krüger-Genge A, Blocki A, Franke RP, Jung F. Vascular endothelial cell biology: an update. Int J Mol Sci. 2019;20(18):4411.

Article  PubMed  PubMed Central  Google Scholar 

Rajala R. How big is the endothelium? Comment on “spatial and temporal dynamics of the endothelium.” J Thromb Haemost. 2021;19(10):2634–5.

Article  PubMed  Google Scholar 

Aird WC. Spatial and temporal dynamics of the endothelium. J Thromb Haemost. 2005;3(7):1392–406.

Article  CAS  PubMed  Google Scholar 

Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288(5789):373–6.

Article  CAS  PubMed  Google Scholar 

Corson MA, James NL, Latta SE, Nerem RM, Berk BC, Harrison DG. Phosphorylation of endothelial nitric oxide synthase in response to fluid shear stress. Circ Res. 1996;79(5):984–91.

Article  CAS  PubMed  Google Scholar 

Govers R, Rabelink TJ. Cellular regulation of endothelial nitric oxide synthase. Am J Physiol Renal Physiol. 2001;280(2):F193-206.

Article  CAS  PubMed  Google Scholar 

López A, Lorente JA, Steingrub J, Bakker J, McLuckie A, Willatts S, et al. Multiple-center, randomized, placebo-controlled, double-blind study of the nitric oxide synthase inhibitor 546C88: effect on survival in patients with septic shock. Crit Care Med. 2004;32(1):21–30.

Article  PubMed  Google Scholar 

Vincent JL, Privalle CT, Singer M, Lorente JA, Boehm E, Meier-Hellmann A, et al. Multicenter, randomized, placebo-controlled phase III study of pyridoxalated hemoglobin polyoxyethylene in distributive shock (PHOENIX). Crit Care Med. 2015;43(1):57–64.

Article  CAS  PubMed  Google Scholar 

Boerma EC, Koopmans M, Konijn A, Kaiferova K, Bakker AJ, van Roon EN, et al. Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. Crit Care Med. 2010;38(1):93–100.

Article  CAS  PubMed  Google Scholar 

Trzeciak S, Glaspey LJ, Dellinger RP, Durflinger P, Anderson K, Dezfulian C, et al. Randomized controlled trial of inhaled nitric oxide for the treatment of microcirculatory dysfunction in patients with sepsis. Crit Care Med. 2014;42(12):2482–92.

Article  CAS  PubMed  Google Scholar 

Moncada S, Higgs EA, Vane JR. Human arterial and venous tissues generate prostacyclin (prostaglandin x), a potent inhibitor of platelet aggregation. The Lancet. 1977;309(8001):18–21.

Article  Google Scholar 

Kinlay S, Behrendt D, Wainstein M, Beltrame J, Fang JC, Creager MA, et al. Role of endothelin-1 in the active constriction of human atherosclerotic coronary arteries. Circulation. 2001;104(10):1114–8.

Article  CAS  PubMed  Google Scholar 

Saye JA, Singer HA, Peach MJ. Role of endothelium in conversion of angiotensin I to angiotensin II in rabbit aorta. Hypertension. 1984;6(2_pt_1):216–21.

Article  CAS  PubMed  Google Scholar 

Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis. Physiol Rev. 2004;84(3):869–901.

Article  CAS  PubMed  Google Scholar 

Kooij G, Van Horssen J, De Vries E. Tight junctions of the blood–brain barrier. Blood–Brain Barr Microenviron Basic Physiol Neurol Dis. 2005;38(6):47–69.

Google Scholar 

Risau W, Rubanyi GM. Structural, biochemical and functional differentiation of the vascular endothelium. Morphogenesis Endothel. 2000. https://doi.org/10.1201/9781482284119-2/structural-biochemical-functional-differentiation-vascular-endothelium-maya-simionescu.

Article  Google Scholar 

Hartsock A, Nelson WJ. Adherens and tight junctions: structure, function and connections to the actin cytoskeleton. Biochim Biophys Acta BBA Biomembr. 2008;1778(3):660–9.

Article  CAS  Google Scholar 

Carden D, Xiao F, Moak C, Willis BH, Robinson-Jackson S, Alexander S. Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol. 1998;275(2):385–92.

Google Scholar 

Schulz B, Pruessmeyer J, Maretzky T, Ludwig A, Blobel CP, Saftig P, et al. ADAM10 regulates endothelial permeability and T-cell transmigration by proteolysis of vascular endothelial cadherin. Circ Res. 2008;102(10):1192–201.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hahmeyer ML, Da S, Da Silva-Santos JE. Rho-proteins and downstream pathways as potential targets in sepsis and septic shock: what have we learned from basic research. Cells. 2021;10(8):1844.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, et al. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem. 2007;282(33):23910–8.

Article  CAS  PubMed  Google Scholar 

Xing J, Wang Q, Coughlan K, Viollet B, Moriasi C, Zou MH. Inhibition of AMP-activated protein kinase accentuates lipopolysaccharide-induced lung endothelial barrier dysfunction and lung injury in vivo. Am J Pathol. 2013;182(3):1021–30.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haidari M, Zhang W, Chen Z, Ganjehei L, Mortazavi A, Warier N, et al. Atorvastatin preserves the integrity of endothelial adherens junctions by inhibiting vascular endothelial cadherin tyrosine phosphorylation. Exp Cell Res. 2012;318(14):1673–84.

Article  CAS  PubMed  Google Scholar 

Anderson JM, Van Itallie CM. Physiology and function of the tight junction. Cold Spring Harb Perspect Biol. 2009;1(2):a002584.

Article  PubMed  PubMed Central  Google Scholar 

Zihni C, Mills C, Matter K, Balda MS. Tight junctions: from simple barriers to multifunctional molecular gates. Nat Rev Mol Cell Biol. 2016;17(9):564–80.

Article  CAS  PubMed  Google Scholar 

Matter K, Balda MS. Signalling to and from tight junctions. Nat Rev Mol Cell Biol. 2003;4(3):225–36.

Article  CAS  PubMed  Google Scholar 

Tornavaca O, Chia M, Dufton N, Almagro LO, Conway DE, Randi AM, et al. ZO-1 controls endothelial adherens junctions, cell–cell tension, angiogenesis, and barrier formation. J Cell Biol. 2015;208(6):821.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hautefort A, Pfenniger A, Kwak BR. Endothelial connexins in vascular function. Vasc Biol. 2019;1(1):H117.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clark PR, Kim RK, Pober JS, Kluger MS. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-κB-dependent phases. PLoS ONE. 2015;10(3):e0120075.

Article  PubMed  PubMed Central  Google Scholar 

Arnalich F, Garcia-Palomero E, López J, Jiménez M, Madero R, Renart J, et al. Predictive value of nuclear factor kappaB activity and plasma cytokine levels in patients with sepsis. Infect Immun. 2000;68(4):1942–5.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chousterman BG, Swirski FK, Weber GF. Cytokine storm and sepsis disease pathogenesis. Semin Immunopathol. 2017;39(5):517–28.

Article  CAS  PubMed 

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