Kieffer, B. L. & Evans, C. J. Opioid receptors: from binding sites to visible molecules in vivo. Neuropharmacology 56, 205–212 (2009).

Article  CAS  PubMed  Google Scholar 

Corder, G., Castro, D. C., Bruchas, M. R. & Scherrer, G. Endogenous and exogenous opioids in pain. Annu. Rev. Neurosci. 41, 453–473 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hilger, D., Masureel, M. & Kobilka, B. K. Structure and dynamics of GPCR signaling complexes. Nat. Struct. Mol. Biol. 25, 4–12 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

von Zastrow, M. Proteomic approaches to investigate regulated trafficking and signaling of G protein-coupled receptors. Mol. Pharmacol. 99, 392–398 (2021).

Article  Google Scholar 

Degrandmaison, J., Rochon-Haché, S., Parent, J.-L. & Gendron, L. Knock-in mouse models to investigate the functions of opioid receptors in vivo. Front. Cell. Neurosci. 16, 807549 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rhee, H.-W. et al. Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging. Science 339, 1328–1331 (2013).

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Hung, V. et al. Proteomic mapping of the human mitochondrial intermembrane space in live cells via ratiometric APEX tagging. Mol. Cell 55, 332–341 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lobingier, B. T. et al. An approach to spatiotemporally resolve protein interaction networks in living cells. Cell 169, 350–360 (2017).

Paek, J. et al. Multidimensional tracking of GPCR signaling via peroxidase-catalyzed proximity labeling. Cell 169, 338–349 (2017).

Manglik, A. et al. Structure-based discovery of opioid analgesics with reduced side effects. Nature 537, 185–190 (2016).

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

McPherson, J. et al. μ-Opioid receptors: correlation of agonist efficacy for signalling with ability to activate internalization. Mol. Pharmacol. 78, 756–766 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lau, E. K. et al. Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection. Sci. Signal. 4, ra52 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Choi, M. et al. MSstats: an R package for statistical analysis of quantitative mass spectrometry-based proteomic experiments. Bioinformatics 30, 2524–2526 (2014).

Article  CAS  PubMed  Google Scholar 

Ehrlich, A. T. et al. Biased signaling of the mu opioid receptor revealed in native neurons. iScience 14, 47–57 (2019).

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Hegde, R. S., Roychoudhury, K. & Pandey, R. N. The multi-functional eyes absent proteins. Crit. Rev. Biochem. Mol. Biol. 55, 372–385 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fan, X. et al. The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins. J. Biol. Chem. 275, 32129–32134 (2000).

Article  CAS  PubMed  Google Scholar 

Embry, A. C., Glick, J. L., Linder, M. E. & Casey, P. J. Reciprocal signaling between the transcriptional co-factor Eya2 and specific members of the Gαi family. Mol. Pharmacol. 66, 1325–1331 (2004).

Article  CAS  PubMed  Google Scholar 

Schwenk, J. et al. Native GABAB receptors are heteromultimers with a family of auxiliary subunits. Nature 465, 231–235 (2010).

Article  ADS  CAS  PubMed  Google Scholar 

Turecek, R. et al. Auxiliary GABAB receptor subunits uncouple G protein βγ subunits from effector channels to induce desensitization. Neuron 82, 1032–1044 (2014).

Article  CAS  PubMed  Google Scholar 

Zheng, S., Abreu, N., Levitz, J. & Kruse, A. C. Structural basis for KCTD-mediated rapid desensitization of GABAB signalling. Nature 567, 127–131 (2019).

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

DeWire, S. M. et al. A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine. J. Pharmacol. Exp. Ther. 344, 708–717 (2013).

Article  CAS  PubMed  Google Scholar 

Kliewer, A. et al. Morphine‐induced respiratory depression is independent of ß‐arrestin2 signalling. Br. J. Pharmacol. 177, 2923–2931 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bachmutsky, I., Wei, X. P., Durand, A. & Yackle, K. ß-arrestin 2 germline knockout does not attenuate opioid respiratory depression. eLife 10, e62552 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cullen, P. J. & Steinberg, F. To degrade or not to degrade: mechanisms and significance of endocytic recycling. Nat. Rev. Mol. Cell Biol. 19, 679–696 (2018).

Article  CAS  PubMed  Google Scholar 

Yong, X., Mao, L., Seaman, M. N. J. & Jia, D. An evolving understanding of sorting signals for endosomal retrieval. iScience 25, 104254 (2022).

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Lauffer, B. E. L. et al. SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane. J. Cell Biol. 190, 565–574 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Temkin, P. et al. SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors. Nat. Cell Biol. 13, 715–721 (2011).

Article  PubMed  PubMed Central  Google Scholar 

McGarvey, J. C. et al. Actin-sorting nexin 27 (SNX27)-retromer complex mediates rapid parathyroid hormone receptor recycling. J. Biol. Chem. 291, 10986–11002 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chan, A. S. M. et al. Sorting nexin 27 couples PTHR trafficking to retromer for signal regulation in osteoblasts during bone growth. Mol. Biol. Cell 27, 1367–1382 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

McNally, K. E. et al. Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling. Nat. Cell Biol. 19, 1214–1225 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Healy, M. D. et al. Structure of the endosomal Commander complex linked to Ritscher–Schinzel syndrome. Cell 186, 2219–2237 (2023).

Muntean, B. S. et al. Members of the KCTD family are major regulators of cAMP signaling. Proc. Natl Acad. Sci. USA 119, e2119237119 (2022).

Article  CAS  PubMed  Google Scholar 

Civciristov, S. et al. Ligand-dependent spatiotemporal signaling profiles of the μ-opioid receptor are controlled by distinct protein-interaction networks. J. Biol. Chem. 294, 16198–16213 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cox, J. & Mann, M. MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat. Biotechnol. 26, 1367–1372 (2008).

Article  CAS  PubMed  Google Scholar 

Tsai, T.-H. et al. Selection of features with consistent profiles improves relative protein quantification in mass spectrometry experiments. Mol. Cell. Proteomics 19, 944–959 (2020).

Yu, G., Wang, L.-G., Han, Y. & He, Q.-Y. clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16, 284–287 (2012).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Korotkevich, G. et al. Fast gene set enrichment analysis. Preprint at bioRxiv https://doi.org/10.1101/060012 (2016).

MacLean, B. et al. Skyline: an open source document editor for creating and analyzing targeted proteomics experiments. Bioinformatics 26, 966–968 (2010).

Article  CAS  PubMed  PubMed Central  Google Scholar