Systemic Inflammatory Regulators Associated with Osteoporosis: A Bidirectional Mendelian Randomization Study

Compston JE, McClung MR, Leslie WD (2019) Osteoporosis. Lancet 393:364–376. https://doi.org/10.1016/S0140-6736(18)32112-3

Article  CAS  PubMed  Google Scholar 

Zhang C, Feng J, Wang S et al (2020) Incidence of and trends in hip fracture among adults in urban China: a nationwide retrospective cohort study. PLoS Med 17:e1003180. https://doi.org/10.1371/journal.pmed.1003180

Article  PubMed  PubMed Central  Google Scholar 

Kanis JA (1994) Assessment of fracture risk and its application to screening for postmenopausal osteoporosis: synopsis of a WHO report. WHO Study Group. Osteoporos Int 4(6):368–381. https://doi.org/10.1007/BF01622200

Iantomasi T, Romagnoli C, Palmini G et al (2023) Oxidative stress and inflammation in osteoporosis: molecular mechanisms involved and the relationship with microRNAs. Int J Mol Sci. https://doi.org/10.3390/ijms24043772

Article  PubMed  PubMed Central  Google Scholar 

Xu J, Yu L, Liu F, Wan L, Deng Z (2023) The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review. Front Immunol 14:1222129. https://doi.org/10.3389/fimmu.2023.1222129

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhang J, Jiang J, Qin Y et al (2023) Systemic immune-inflammation index is associated with decreased bone mass density and osteoporosis in postmenopausal women but not in premenopausal women. Endocr Connect. https://doi.org/10.1530/EC-22-0461

Article  PubMed  PubMed Central  Google Scholar 

Fischer V, Haffner-Luntzer M (2022) Interaction between bone and immune cells: implications for postmenopausal osteoporosis. Semin Cell Dev Biol 123:14–21. https://doi.org/10.1016/j.semcdb.2021.05.014

Article  PubMed  Google Scholar 

Soh GT, Mohammad AH, Syed Isa SNL, Chin KY, Mohamed N (2023) Comparison of cytokine profile between postmenopausal women with and without osteoporosis—a case-control study. Endocr Metab Immune Disord Drug Targets 23:811–817. https://doi.org/10.2174/1871530323666221114111029

Article  CAS  PubMed  Google Scholar 

Ma X, Zhu X, He X, Yi X, Jin A (2021) The Wnt pathway regulator expression levels and their relationship to bone metabolism in thoracolumbar osteoporotic vertebral compression fracture patients. Am J Transl Res 13:4812–4818

CAS  PubMed  PubMed Central  Google Scholar 

Ebrahim S, Davey Smith G (2008) Mendelian randomization: can genetic epidemiology help redress the failures of observational epidemiology? Hum Genet 123:15–33. https://doi.org/10.1007/s00439-007-0448-6

Article  PubMed  Google Scholar 

Liu B, Lyu L, Zhou W et al (2023) Associations of the circulating levels of cytokines with risk of amyotrophic lateral sclerosis: a Mendelian randomization study. BMC Med 21:39. https://doi.org/10.1186/s12916-023-02736-7

Article  CAS  PubMed  PubMed Central  Google Scholar 

Shi Q, Wang Q, Wang Z, Lu J, Wang R (2023) Systemic inflammatory regulators and proliferative diabetic retinopathy: a bidirectional Mendelian randomization study. Front Immunol 14:1088778. https://doi.org/10.3389/fimmu.2023.1088778

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ahola-Olli AV, Wurtz P, Havulinna AS et al (2017) Genome-wide association study identifies 27 loci influencing concentrations of circulating cytokines and growth factors. Am J Hum Genet 100:40–50. https://doi.org/10.1016/j.ajhg.2016.11.007

Article  CAS  PubMed  Google Scholar 

Medina-Gomez C, Kemp JP, Trajanoska K et al (2018) Life-course genome-wide association study meta-analysis of total body BMD and assessment of age-specific effects. Am J Hum Genet 102:88–102. https://doi.org/10.1016/j.ajhg.2017.12.005

Article  CAS  PubMed  PubMed Central  Google Scholar 

Morris JA, Kemp JP, Youlten SE et al (2019) An atlas of genetic influences on osteoporosis in humans and mice. Nat Genet 51:258–266. https://doi.org/10.1038/s41588-018-0302-x

Article  CAS  PubMed  Google Scholar 

Bowden J, Del Greco MF, Minelli C et al (2016) Assessing the suitability of summary data for two-sample Mendelian randomization analyses using MR-Egger regression: the role of the I2 statistic. Int J Epidemiol 45:1961–1974. https://doi.org/10.1093/ije/dyw220

Article  PubMed  PubMed Central  Google Scholar 

Bowden J, Del Greco MF, Minelli C et al (2017) A framework for the investigation of pleiotropy in two-sample summary data Mendelian randomization. Stat Med 36:1783–1802. https://doi.org/10.1002/sim.7221

Article  PubMed  PubMed Central  Google Scholar 

Burgess S, Thompson SG (2017) Interpreting findings from Mendelian randomization using the MR-Egger method. Eur J Epidemiol 32:377–389. https://doi.org/10.1007/s10654-017-0255-x

Article  PubMed  PubMed Central  Google Scholar 

Verbanck M, Chen CY, Neale B, Do R (2018) Publisher correction: detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Nat Genet 50:1196. https://doi.org/10.1038/s41588-018-0164-2

Article  CAS  PubMed  Google Scholar 

Huang JV, Schooling CM (2017) Inflammation and bone mineral density: a Mendelian randomization study. Sci Rep 7:8666. https://doi.org/10.1038/s41598-017-09080-w

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kasher M, Williams FMK, Freidin MB et al (2022) Understanding the complex genetic architecture connecting rheumatoid arthritis, osteoporosis and inflammation: discovering causal pathways. Hum Mol Genet 31:2810–2819. https://doi.org/10.1093/hmg/ddac061

Article  CAS  PubMed  PubMed Central  Google Scholar 

Smith SL, Alexander S, Nair N et al (2023) Pre-treatment calprotectin (MRP8/14) provides no added value to testing CRP alone in terms of predicting response to TNF inhibitors in rheumatoid arthritis in a post hoc analysis. Ann Rheum Dis 82:611–620. https://doi.org/10.1136/ard-2022-222519

Article  CAS  PubMed  Google Scholar 

Wan H, Qian TY, Hu XJ, Huang CY, Yao WF (2018) Correlation of serum CCL3/MIP-1alpha levels with disease severity in postmenopausal osteoporotic females. Balkan Med J 35:320–325. https://doi.org/10.4274/balkanmedj.2017.1165

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fu R, Liu H, Zhao S et al (2014) Osteoblast inhibition by chemokine cytokine ligand3 in myeloma-induced bone disease. Cancer Cell Int 14:132. https://doi.org/10.1186/s12935-014-0132-6

Article  CAS  PubMed  PubMed Central  Google Scholar 

Yu D, Zhang S, Ma C et al (2023) CCL3 in the bone marrow microenvironment causes bone loss and bone marrow adiposity in aged mice. JCI Insight. https://doi.org/10.1172/jci.insight.159107

Article  PubMed  PubMed Central  Google Scholar 

Kawao N, Tamura Y, Horiuchi Y et al (2015) The tissue fibrinolytic system contributes to the induction of macrophage function and CCL3 during bone repair in mice. PLoS ONE 10:e0123982. https://doi.org/10.1371/journal.pone.0123982

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wiley SR, Schooley K, Smolak PJ et al (1995) Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3:673–682. https://doi.org/10.1016/1074-7613(95)90057-8

Article  CAS  PubMed  Google Scholar 

Faienza MF, D’Amato G, Chiarito M et al (2019) Mechanisms involved in childhood obesity-related bone fragility. Front Endocrinol (Lausanne) 10:269. https://doi.org/10.3389/fendo.2019.00269

Article  PubMed  Google Scholar 

Li J, Li X, Zhou S et al (2022) Tetrandrine inhibits RANKL-induced osteoclastogenesis by promoting the degradation of TRAIL. Mol Med 28:141. https://doi.org/10.1186/s10020-022-00568-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liao HJ, Tsai HF, Wu CS, Chyuan IT, Hsu PN (2019) TRAIL inhibits RANK signaling and suppresses osteoclast activation via inhibiting lipid raft assembly and TRAF6 recruitment. Cell Death Dis 10:77. https://doi.org/10.1038/s41419-019-1353-3

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zheng J, Wang X, Yu J, Zhan Z, Guo Z (2022) IL-6, TNF-alpha and IL-12p70 levels in patients with colorectal cancer and their predictive value in anti-vascular therapy. Front Oncol 12:997665. https://doi.org/10.3389/fonc.2022.997665

Article  CAS  PubMed  PubMed Central  Google Scholar 

Huan X, Zhao R, Song J et al (2022) Increased serum IL-2, IL-4, IL-5 and IL-12p70 levels in AChR subtype generalized myasthenia gravis. BMC Immunol 23:26. https://doi.org/10.1186/s12865-022-00501-8

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ilesanmi-Oyelere BL, Schollum L, Kuhn-Sherlock B et al (2019) Inflammatory markers and bone health in postmenopausal women: a cross-sectional overview. Immun Ageing 16:15. https://doi.org/10.1186/s12979-019-0155-x

Article 

留言 (0)

沒有登入
gif