Estrogen-receptor status determines differential regulation of α1- and α2-adrenoceptor-mediated cell survival, angiogenesis, and intracellular signaling responses in breast cancer cell lines

Meites J. Relation of the neuroendocrine system to the development and growth of experimental mammary tumors. J Neural Transm. 1980;48:25–42.

Article  CAS  PubMed  Google Scholar 

ThyagaRajan S, Felten DL. Modulation of neuroendocrine–immune signaling by L-deprenyl and L-desmethyldeprenyl in aging and mammary cancer. Mech Ageing Dev. 2002;123:1065–79.

Article  CAS  PubMed  Google Scholar 

Danese A, McEwen BS. Adverse childhood experiences, allostasis, allostatic load, and age-related disease. Physiol Behav. 2012;106:29–39.

Article  CAS  PubMed  Google Scholar 

ThyagaRajan S, Madden KS, Teruya B, Stevens SY, Felten DL, Bellinger DL. Age-associated alterations in sympathetic noradrenergic innervation of primary and secondary lymphoid organs in female Fischer 344 rats. J Neuroimmunol. 2011;233:54–64.

Article  CAS  PubMed  Google Scholar 

ThyagaRajan S, Tran L, Molinaro CA, Gridley DS, Felten DL, Bellinger DL. Prevention of mammary tumor development through neuroimmunomodulation in the spleen and lymph nodes of old female sprague-dawley rats by L-deprenyl. NeuroImmunoModulation. 2013;20:141–51.

Article  CAS  PubMed  Google Scholar 

Roets E, Vandeputte-Van Messom G, Peeters G. Relationship between milkability and adrenoceptor concentrations in teat tissue in primiparous cows. J Dairy Sci. 1986;69:3120–30.

Article  CAS  PubMed  Google Scholar 

Hammon HM, Bruckmaier RM, Honegger UE, Blum JW. Distribution and density of alpha- and beta-adrenergic receptor binding sites in the bovine mammary gland. J Dairy Res. 1994;61:47–57.

Article  PubMed  Google Scholar 

Inderwies T, Pfaffl MW, Meyer HHD, Blum JW, Bruckmaier RM. Detection and quantification of mRNA expression of alpha- and beta-adrenergic receptor subtypes in the mammary gland of dairy cows. Domest Anim Endocrinol. 2003;24:123–35.

Article  CAS  PubMed  Google Scholar 

Vázquez SM, Pignataro O, Luthy IA. Alpha2-adrenergic effect on human breast cancer MCF-7 cells. Breast Cancer Res Treat. 1999;55:41–9.

Article  PubMed  Google Scholar 

Vázquez SM, Mladovan AG, Pérez C, Bruzzone A, Baldi A, Lüthy IA. Human breast cell lines exhibit functional alpha2-adrenoceptors. Cancer Chemother Pharmacol. 2006;58:50–61.

Article  PubMed  Google Scholar 

Bruzzone A, Piñero CP, Castillo LF, Sarappa MG, Rojas P, Lanari C, et al. Alpha2-adrenoceptor action on cell proliferation and mammary tumour growth in mice. Br J Pharmacol. 2008;155:494–504.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Obeid EI, Conzen SD. The role of adrenergic signaling in breast cancer biology. Cancer Biomark. 2013;13:161–9.

Article  PubMed  Google Scholar 

Priyanka HP, Singh RV, Pratap UP, ThyagaRajan S. Estrogen modulates β2-adrenoceptor-induced cell-mediated and inflammatory immune responses through ER-α involving distinct intracellular signaling pathways, antioxidant enzymes, and nitric oxide. Cell Immunol. 2014;292:1–8.

Article  CAS  PubMed  Google Scholar 

Chiesa IJ, Castillo LF, Lüthy IA. Contribution of alpha2-adrenoceptors to the mitogenic effect of catecholestrogen in human breast cancer MCF-7 cells. J Steroid Biochem Mol Biol. 2008;110:170–5.

Article  CAS  PubMed  Google Scholar 

Powe DG, Voss MJ, Habashy HO, Zänker KS, Green AR, Ellis IO, et al. Alpha- and beta-adrenergic receptor (AR) protein expression is associated with poor clinical outcome in breast cancer: an immunohistochemical study. Breast Cancer Res Treat. 2011;130:457–63.

Article  CAS  PubMed  Google Scholar 

Weil J, Benndorf R, Fredersdorf S, Griese DP, Eschenhagen T. Norepinephrine upregulates vascular endothelial growth factor in rat cardiac myocytes by a paracrine mechanism. Angiogenesis. 2003;6:303–9.

Article  CAS  PubMed  Google Scholar 

Maynadier M, Nirdé P, Ramirez J-M, Cathiard AM, Platet N, Chambon M, et al. Role of estrogens and their receptors in adhesion and invasiveness of breast cancer cells. Adv Exp Med Biol. 2008;617:485–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Razandi M, Pedram A, Levin ER. Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. Mol Endocrinol. 2000;14:1434–47.

Article  CAS  PubMed  Google Scholar 

P Priyanka H, S Nair R, 2020 Inspire Laboratory, Institute of Advanced Research in Health Sciences, Tamil Nadu Government Multi Super Speciality Hospital, Omandurar Government Estate, Chennai-600002. Neuroimmunomodulation by estrogen in health and disease. AIMS Neuroscience. 7: 401–17.

Armaiz-Pena GN, Cole SW, Lutgendorf SK, Sood AK. Neuroendocrine influences on cancer progression. Brain Behav Immun. 2013;30:S19-25.

Article  CAS  PubMed  Google Scholar 

Thaker PH, Han LY, Kamat AA, Arevalo JM, Takahashi R, Lu C, et al. Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma. Nat Med. 2006;12:939–44.

Article  CAS  PubMed  Google Scholar 

Priyanka HP, ThyagaRajan S. Selective modulation of lymphoproliferation and cytokine production via intracellular signaling targets by α1- and α2-adrenoceptors and estrogen in splenocytes. Int Immunopharmacol. 2013;17:774–84.

Article  CAS  PubMed  Google Scholar 

ThyagaRajan S, Hima L, Pratap UP, Priyanka HP, Vasantharekha R. Estrogen-induced neuroimmunomodulation as facilitator of and barrier to reproductive aging in brain and lymphoid organs. J Chem Neuroanat. 2019;95:6–12.

Article  CAS  PubMed  Google Scholar 

Young WF. Adrenal Medulla, Catecholamines, and Pheochromocytoma. Goldman’s Cecil Medicine [Internet]. Elsevier Inc.; 2011 [cited 2024 Jan 31]. p. 1470–5. Available from: http://www.scopus.com/inward/record.url?scp=84904370580&partnerID=8YFLogxK.

Dayanir V, Meyer RD, Lashkari K, Rahimi N. Identification of tyrosine residues in vascular endothelial growth factor receptor-2/FLK-1 involved in activation of phosphatidylinositol 3-kinase and cell proliferation. J Biol Chem. 2001;276:17686–92.

Article  CAS  PubMed  Google Scholar 

Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature. 1999;399:601–5.

Article  CAS  PubMed  Google Scholar 

Fulton D, Gratton J-P, McCabe TJ, Fontana J, Fujio Y, Walsh K, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature. 1999;399:597–601.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mayo LD, Kessler KM, Pincheira R, Warren RS, Donner DB. Vascular endothelial cell growth factor activates CRE-binding protein by signaling through the KDR receptor tyrosine kinase. J Biol Chem. 2001;276:25184–9.

Article  CAS  PubMed  Google Scholar 

X S, W W, Rd M, D B. Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases. Molecular and cellular biology [Internet]. 2002 [cited 2024 Jan 18];22. Available from: https://pubmed.ncbi.nlm.nih.gov/12391145/.

Takahashi T, Ueno H, Shibuya M. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene. 1999;18:2221–30.

Article  CAS  PubMed  Google Scholar 

Fournier E, Blaikie P, Rosnet O, Margolis B, Birnbaum D, Borg JP. Role of tyrosine residues and protein interaction domains of SHC adaptor in VEGF receptor 3 signaling. Oncogene. 1999;18:507–14.

Article  CAS  PubMed  Google Scholar 

Koduri S, Goldhar AS, Vonderhaar BK. Activation of vascular endothelial growth factor (VEGF) by the ER-alpha variant, ERDelta3. Breast Cancer Res Treat. 2006;95:37–43.

Article  CAS  PubMed  Google Scholar 

Ciccarelli M, Santulli G, Campanile A, Galasso G, Cervèro P, Altobelli GG, et al. Endothelial α1-adrenoceptors regulate neo-angiogenesis. Br J Pharmacol. 2008;153:936–46.

Article  CAS  PubMed  Google Scholar 

Lüthy IA, Bruzzone A, Piñero CP, Castillo LF, Chiesa IJ, Vázquez SM, et al. Adrenoceptors: non conventional target for breast cancer? Curr Med Chem. 2009;16:1850–62.

Article  PubMed  Google Scholar 

Szpunar MJ, Burke KA, Dawes RP, Brown EB, Madden KS. The antidepressant desipramine and α2-adrenergic receptor activation promote breast tumor progression in association with altered collagen structure. Cancer Prev Res (Phila). 2013;6:1262–72.

Article  CAS  PubMed  Google Scholar 

Watanabe K, Zhang X-Y, Kitagawa K, Yunoki T, Hayashi A. The effect of clonidine on VEGF expression in human retinal pigment epithelial cells (ARPE-19). Graefes Arch Clin Exp Ophthalmol. 2009;247:207–13.

Article  CAS  PubMed  Google Scholar 

Pérez Piñero C, Bruzzone A, Sarappa MG, Castillo LF, Lüthy IA. Involvement of α2- and β2-adrenoceptors on breast cancer cell proliferation and tumour growth regulation. Br J Pharmacol. 2012;166:721–36.

Article  PubMed  PubMed Central  Google Scholar 

Shen S-G, Zhang D, Hu H-T, Li J-H, Wang Z, Ma Q-Y. Effects of alpha-adrenoreceptor antagonists on apoptosis and proliferation of pancreatic cancer cells in vitro. World J Gastroenterol. 2008;14:2358–63.

Article  CAS 

留言 (0)

沒有登入
gif