Cuzick J, Adcock R, Kinney W, Castle PE, Robertson M, McDonald RM, Stoler MH, Du R, Wheeler CM, New Mexico HPV Pap Registry Steering Committee. Impact of HPV testing in opportunistic cervical screening: support for primary HPV screening in the United States. Int J Cancer. 2023;153(1):83–93. https://doi.org/10.1002/ijc.34519.

Article  CAS  PubMed  Google Scholar 

Sabanayagam R, Krishnamoorthy S, Gnanagurusamy J, Muruganatham B, Muthusami S. EGCG attenuate EGF triggered matrix abundance and migration in HPV positive and HPV negative cervical cancer cells. Med Oncol. 2023;40(9):261. https://doi.org/10.1007/s12032-023-02135-1.

Article  CAS  PubMed  Google Scholar 

Fullár A, Dudás J, Oláh L, Hollósi P, Papp Z, Sobel G, Karászi K, Paku S, Baghy K, Kovalszky I. Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression. BMC Cancer. 2015;15:256. https://doi.org/10.1186/s12885-015-1272-3.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Piao J, You K, Guo Y, Zhang Y, Li Z, Geng L. Substrate stiffness affects epithelial–mesenchymal transition of cervical cancer cells through miR-106b and its target protein DAB2. Int J Oncol. 2017;50(6):2033–42. https://doi.org/10.3892/ijo.2017.3978.

Article  CAS  PubMed  Google Scholar 

Kim JH, Moon MJ, Kim DY, Heo SH, Jeong YY. Hyaluronic acid-based nanomaterials for cancer therapy. Polymers (Basel). 2018;10(10):1133. https://doi.org/10.3390/polym10101133.

Article  CAS  PubMed  Google Scholar 

Noordhuis MG, Eijsink JJ, Ten Hoor KA, Roossink F, Hollema H, Arts HJ, Pras E, Maduro JH, Reyners AK, de Bock GH, Wisman GB, Schuuring E, van der Zee AG. Expression of epidermal growth factor receptor (EGFR) and activated EGFR predict poor response to (chemo)radiation and survival in cervical cancer. Clin Cancer Res. 2009;15(23):7389–97. https://doi.org/10.1158/1078-0432.CCR-09-1149.

Article  CAS  PubMed  Google Scholar 

Muthusami S, Sabanayagam R, Periyasamy L, Muruganantham B, Park WY. A review on the role of epidermal growth factor signaling in the development, progression and treatment of cervical cancer. Int J Biol Macromol. 2022;194:179–87. https://doi.org/10.1016/j.ijbiomac.2021.11.117.

Article  CAS  PubMed  Google Scholar 

Karamanos NK, Piperigkou Z, Passi A, Götte M, Rousselle P, Vlodavsky I. Extracellular matrix-based cancer targeting. Trends Mol Med. 2021;27(10):1000–13. https://doi.org/10.1016/j.molmed.2021.07.009.

Article  CAS  PubMed  Google Scholar 

Periyasamy L, Murugantham B, Muthusami S. Plumbagin binds to epidermal growth factor receptor and mitigate the effects of epidermal growth factor micro-environment in PANC-1 cells. Med Oncol. 2023;40(7):184. https://doi.org/10.1007/s12032-023-02048-z.

Article  CAS  PubMed  Google Scholar 

Spillmann D. Heparan sulfate: anchor for viral intruders? Biochimie. 2001;83(8):811–7. https://doi.org/10.1016/s0300-9084(01)01290-1.

Article  CAS  PubMed  Google Scholar 

De Pasquale V, Pavone LM. Heparan sulfate proteoglycans: the sweet side of development turns sour in mucopolysaccharidoses. Biochim Biophys Acta Mol Basis Dis. 2019;1865(11): 165539. https://doi.org/10.1016/j.bbadis.2019.165539.

Article  CAS  PubMed  Google Scholar 

Billings PC, Pacifici M. Interactions of signaling proteins, growth factors and other proteins with heparan sulfate: mechanisms and mysteries. Connect Tissue Res. 2015;56(4):272–80. https://doi.org/10.3109/03008207.2015.1045066.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kousar K, Naseer F, Abduh MS, Kakar S, Gul R, Anjum S, Ahmad T. Green synthesis of hyaluronic acid coated, thiolated chitosan nanoparticles for CD44 targeted delivery and sustained release of Cisplatin in cervical carcinoma. Front Pharmacol. 2023;13:1073004. https://doi.org/10.3389/fphar.2022.1073004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu S, Xu H, Wang W, Li S, Li H, Li T, Zhang W, Yu X, Liu L. The role of collagen in cancer: from bench to bedside. J Transl Med. 2019;17(1):309. https://doi.org/10.1186/s12967-019-2058-1.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Futyma K, Miotła P, Różyńska K, Zdunek M, Semczuk A, Rechberger T, Wojcierowski J. Expression of genes encoding extracellular matrix proteins: a macroarray study. Oncol Rep. 2014;32(6):2349–53. https://doi.org/10.3892/or.2014.3493.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sun Y, Ling J, Liu L. Collagen type X alpha 1 promotes proliferation, invasion and epithelial–mesenchymal transition of cervical cancer through activation of TGF-β/Smad signaling. Physiol Int. 2022. https://doi.org/10.1556/2060.2022.00006.

Article  PubMed  Google Scholar 

Thangavelu PU, Krenács T, Dray E, Duijf PH. In epithelial cancers, aberrant COL17A1 promoter methylation predicts its misexpression and increased invasion. Clin Epigenetics. 2016;8:120. https://doi.org/10.1186/s13148-016-0290-6.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Monaco S, Sparano V, Gioia M, Sbardella D, Di Pierro D, Marini S, Coletta M. Enzymatic processing of collagen IV by MMP-2 (gelatinase A) affects neutrophil migration and it is modulated by extracatalytic domains. Protein Sci. 2006;15(12):2805–15. https://doi.org/10.1110/ps.062430706.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wolf K, Alexander S, Schacht V, Coussens LM, von Andrian UH, van Rheenen J, Deryugina E, Friedl P. Collagen-based cell migration models in vitro and in vivo. Semin Cell Dev Biol. 2009;20(8):931–41. https://doi.org/10.1016/j.semcdb.2009.08.005.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sabanayagam R, Krishnamoorthy S, Mohan A, Muruganatham B, Muthusami S. A comparative analysis of phyto-components on EGFR binding, viability and migration in HPV positive ME180 and HPV negative C33A cervical cancer cells. Med Oncol. 2023;40(12):357.

Article  CAS  PubMed  Google Scholar 

Muthusami S, Prabakaran DS, Yu JR, Park WY. EGF-induced expression of Fused Toes Homolog (FTS) facilitates epithelial–mesenchymal transition and promotes cell migration in ME180 cervical cancer cells. Cancer Lett. 2014;351(2):252–9. https://doi.org/10.1016/j.canlet.2014.06.007.

Article  CAS  PubMed  Google Scholar 

López De Padilla CM, Coenen MJ, Tovar A, De la Vega RE, Evans CH, Müller SA. Picrosirius red staining: revisiting its application to the qualitative and quantitative assessment of collagen type I and Type III in Tendon. J Histochem Cytochem. 2021;69(10):633–43. https://doi.org/10.1369/00221554211046777.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Muthusami S, Senthilkumar K, Vignesh C, Ilangovan R, Stanley J, Selvamurugan N, Srinivasan N. Effects of Cissus quadrangularis on the proliferation, differentiation and matrix mineralization of human osteoblast like SaOS-2 cells. J Cell Biochem. 2011;112(4):1035–45. https://doi.org/10.1002/jcb.23016.

Article  CAS  PubMed  Google Scholar 

Periyasamy L, Murugantham B, Sundaraj R, Krishnamoorthi S, Muthusami S. Screening of MMP-2 inhibiting phytoconstituents for the development of newer pancreatic cancer treatment modalities. Protein Pept Lett. 2023;30(4):304–13.

Article  CAS  PubMed  Google Scholar 

Mohan A, Krishnamoorthy S, Sabanayagam R, Schwenk G, Feng E, Ji HF, Muthusami S. Pharmacophore based virtual screening for identification of effective inhibitors to combat HPV 16 E6 driven cervical cancer. Eur J Pharmacol. 2023;957:175961.

Article  CAS  PubMed  Google Scholar 

Cheng X, Yan H, Pang S, Ya M, Qiu F, Qin P, Zeng C, Lu Y. Liposomes as multifunctional nano-carriers for medicinal natural products. Front Chem. 2022;10: 963004. https://doi.org/10.3389/fchem.2022.963004.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Sidhu H, Capalash N. Plumbagin downregulates UHRF1, p-Akt, MMP-2 and suppresses survival, growth and migration of cervical cancer CaSki cells. Toxicol In Vitro. 2023;86: 105512. https://doi.org/10.1016/j.tiv.2022.105512.

Article  CAS  PubMed  Google Scholar 

Jaiswal A, Sabarwal A, Narayan Mishra JP, Singh RP. Plumbagin induces ROS-mediated apoptosis and cell cycle arrest and inhibits EMT in human cervical carcinoma cells. RSC Adv. 2018;8(56):32022–37. https://doi.org/10.1039/c8ra05339a.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Srinivas P, Gopinath G, Banerji A, Dinakar A, Srinivas G. Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells. Mol Carcinog. 2004;40(4):201–11. https://doi.org/10.1002/mc.20031.

Article  CAS  PubMed  Google Scholar 

Yamazaki S, Higuchi Y, Ishibashi M, Hashimoto H, Yasunaga M, Matsumura Y, Tsuchihara K, Tsuboi M, Goto K, Ochiai A, Ishii G. Collagen type I induces EGFR-TKI resistance in EGFR-mutated cancer cells by mTOR activation through Akt-independent pathway. Cancer Sci. 2018;109(6):2063–73. https://doi.org/10.1111/cas.13624.

Article  CAS  PubMed  PubMed Central  Google Scholar