Synergistic effects of mesenchymal stem cell-derived extracellular vesicles and dexamethasone on macrophage polarization under inflammatory conditions

Abdolmohammadi K, Mahmoudi T, Alimohammadi M, Tahmasebi S, Zavvar M, Hashemi SM (2022) Mesenchymal stem cell-based therapy as a new therapeutic approach for acute inflammatory diseases. Life Sci. https://doi.org/10.1007/s12016-021-08892-z

Article  PubMed  Google Scholar 

Armstrong J, Harbron C, Lea S, Booth G, Cadden P, Wreggett K, Singh D (2011) Synergistic effects of p38 mitogen-activated protein kinase inhibition with a corticosteroid in alveolar macrophages from patients with chronic obstructive pulmonary disease. J Pharmacol Exp Ther 338(3):732–740

Article  CAS  PubMed  Google Scholar 

Cao L, Xu H, Wang G, Liu M, Tian D, Yuan Z (2019) Extracellular vesicles derived from bone marrow mesenchymal stem cells attenuate dextran sodium sulfate-induced ulcerative colitis by promoting M2 macrophage polarization. Int Immunopharmacol 72:264–274

Article  CAS  PubMed  Google Scholar 

Chamberlain CS, Clements AE, Kink JA, Choi U, Baer GS, Halanski MA, Hematti P, Vanderby R (2019) Extracellular vesicle-educated macrophages promote early achilles tendon healing. Stem Cells 37(5):652–662

Article  CAS  PubMed  Google Scholar 

Chang C-L, Chen C-H, Chiang JY, Sun C-K, Chen Y-L, Chen K-H, Sung P-H, Huang T-H, Li Y-C, Chen H-H (2019) Synergistic effect of combined melatonin and adipose-derived mesenchymal stem cell (ADMSC)-derived exosomes on amelioration of dextran sulfate sodium (DSS)-induced acute colitis. Am J Trans Res 11(5):2706

CAS  Google Scholar 

Chawla A, Nguyen KD, Goh YS (2011) Macrophage-mediated inflammation in metabolic disease. Nat Rev Immunol 11(11):738–749

Article  CAS  PubMed  PubMed Central  Google Scholar 

Engelen SE, Robinson AJ, Zurke Y-X, Monaco C (2022) Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed? Nat Rev Cardiol 19(8):522–542

Article  CAS  PubMed  PubMed Central  Google Scholar 

Eshghi F, Tahmasebi S, Alimohammadi M, Soudi S, Khaligh SG, Khosrojerdi A, Heidari N, Hashemi SM (2022) Study of immunomodulatory effects of mesenchymal stem cell-derived exosomes in a mouse model of LPS induced systemic inflammation. Life Sci 310:120938

Article  CAS  PubMed  Google Scholar 

Fan L, Liu C, Chen X, Zheng L, Zou Y, Wen H, Guan P, Lu F, Luo Y, Tan G (2022) Exosomes-loaded electroconductive hydrogel synergistically promotes tissue repair after spinal cord injury via immunoregulation and enhancement of myelinated axon growth. Adv Sci 9(13):2105586

Article  CAS  Google Scholar 

Feng Q, Xu M, Yu Y, Hou Y, Mi X, Sun Y, Ma S, Zuo X, Shao L, Hou M (2017) High-dose dexamethasone or all-trans-retinoic acid restores the balance of macrophages towards M2 in immune thrombocytopenia. J Thromb Haemost 15(9):1845–1858

Article  CAS  PubMed  Google Scholar 

Fujiwara N, Kobayashi K (2005) Macrophages in inflammation. Curr Drug Targets-Inflamm Allergy 4(3):281–286

Article  CAS  PubMed  Google Scholar 

Fullerton JN, Gilroy DW (2016) Resolution of inflammation: a new therapeutic frontier. Nat Rev Drug Discov 15(8):551–567

Article  CAS  PubMed  Google Scholar 

Gong Z, Zhan D, Nie M, Li X, Gao C, Liu X, Xiang T, Yuan J, Jiang W, Huang J (2021) Dexamethasone enhances the efficacy of atorvastatin in inhibiting excessively inflammation-induced abnormal angiogenesis by regulating macrophages. J Neuroinflammation 18(1):1–16

Article  Google Scholar 

Gwyer Findlay E, Hussell T (2012) Macrophage-mediated inflammation and disease: a focus on the lung. Med Inflamm. https://doi.org/10.1155/2012/140937

Article  Google Scholar 

Han GH, Kim SJ, Ko WK, Lee D, Han IB, Sheen SH, Hong JB, Sohn S (2021) Transplantation of tauroursodeoxycholic acid–inducing M2-phenotype macrophages promotes an anti-neuroinflammatory effect and functional recovery after spinal cord injury in rats. Cell Prolif 54(6):e13050

Article  CAS  PubMed  PubMed Central  Google Scholar 

Harrell CR, Jovicic N, Djonov V, Arsenijevic N, Volarevic V (2019) Mesenchymal stem cell-derived exosomes and other extracellular vesicles as new remedies in the therapy of inflammatory diseases. Cells 8(12):1605

Article  CAS  PubMed  PubMed Central  Google Scholar 

Heidari N, Abbasi-Kenarsari H, Namaki S, Baghaei K, Zali MR, Mirsanei Z, Hashemi SM (2022) Regulation of the Th17/Treg balance by human umbilical cord mesenchymal stem cell-derived exosomes protects against acute experimental colitis. Exp Cell Res 419(1):113296

Article  CAS  PubMed  Google Scholar 

Heo JS, Lim J-Y, Yoon DW, Pyo S, Kim J (2020) Exosome and melatonin additively attenuates inflammation by transferring miR-34a, miR-124, and miR-135b. BioMed Res Int. https://doi.org/10.1155/2020/1621394

Article  PubMed  PubMed Central  Google Scholar 

Hu G, Drescher KM, Chen X-M (2012) Exosomal miRNAs: biological properties and therapeutic potential. Front Genet 3:56

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jeong H, Yoon H, Lee Y, Kim JT, Yang M, Kim G, Jung B, Park SH, Lee C-E (2022) SOCS3 attenuates dexamethasone-induced M2 polarization by down-regulation of GILZ via ROS-and p38 MAPK-dependent pathways. Immune Netw. https://doi.org/10.4110/in.2022.22.e33

Article  PubMed  PubMed Central  Google Scholar 

Jiang K, Weaver JD, Li Y, Chen X, Liang J, Stabler CL (2017) Local release of dexamethasone from macroporous scaffolds accelerates islet transplant engraftment by promotion of anti-inflammatory M2 macrophages. Biomaterials 114:71–81

Article  CAS  PubMed  Google Scholar 

Joo HS, Suh JH, Lee HJ, Bang ES, Lee JM (2020) Current knowledge and future perspectives on mesenchymal stem cell-derived exosomes as a new therapeutic agent. Int J Mol Sci 21(3):727

Article  CAS  PubMed  PubMed Central  Google Scholar 

Khosravi M, MoriBazofti H, Mohammadian B, Rashno M (2023) The effects of the differentiated macrophages by dexamethasone on the immune responses. Int Immunopharmacol 124:110826

Article  CAS  PubMed  Google Scholar 

Khosrojerdi A, Soudi S, Hosseini AZ, Eshghi F, Shafiee A, Hashemi SM (2021) Immunomodulatory and therapeutic effects of mesenchymal stem cells on organ dysfunction in sepsis. Shock 55(4):423–440

Article  CAS  PubMed  Google Scholar 

Liang Z-Y, Xu X-J, Rao J, Yang Z-L, Wang C-H, Chen C-M (2022) Mesenchymal stem cell-derived exosomal miRNAs promote M2 macrophages polarization: therapeutic opportunities for spinal cord injury. Front Mol Neurosci 15:926928

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu Y-C, Zou X-B, Chai Y-F, Yao Y-M (2014) Macrophage polarization in inflammatory diseases. Int J Biol Sci 10(5):520

Article  PubMed  PubMed Central  Google Scholar 

Luo J, Ding X, Song W, Bai J-Y, Liu J, Li Z, Meng F-H, Chen F-H, Zhang Y-M (2019) Inducing macrophages M2 polarization by dexamethasone laden mesoporous silica nanoparticles from titanium implant surface for enhanced osteogenesis. Acta Metall Sin 32:1253–1260

Article  CAS  Google Scholar 

Mao F, Wu Y, Tang X, Kang J, Zhang B, Yan Y, Qian H, Zhang X, Xu W (2017) Exosomes derived from human umbilical cord mesenchymal stem cells relieve inflammatory bowel disease in mice. BioMed Res Int. https://doi.org/10.1155/2017/5356760

Article  PubMed  PubMed Central  Google Scholar 

Meizlish ML, Franklin RA, Zhou X, Medzhitov R (2021) Tissue homeostasis and inflammation. Annu Rev Immunol 39:557–581

Article  CAS  PubMed  Google Scholar 

Mirsanei Z, Heidari N, Hazrati A, Asemani Y, Niknam B, Yousefi Z, Jafari R (2023) Oleuropein reduces LPS-induced inflammation via stimulating M2 macrophage polarization. Biomed Pharmacother 163:114857

Article  CAS  PubMed  Google Scholar 

Moss SF, Blaser MJ (2005) Mechanisms of disease: inflammation and the origins of cancer. Nat Clin Pract Oncol 2(2):90–97

Article  CAS  PubMed  Google Scholar 

Murray PJ (2017) Macrophage polarization. Annu Rev Physiol 79:541–566

Article  CAS  PubMed  Google Scholar 

Niknam B, Baghaei K, Hashemi SM, Hatami B, Zali MR, Amani D (2023) Human Wharton’s jelly mesenchymal stem cells derived-exosomes enriched by miR-124 promote an anti-fibrotic response in an experimental model of liver fibrosis. Int Immunopharmacol 119:110294

Article  CAS  PubMed  Google Scholar 

Oishi Y, Manabe I (2018) Macrophages in inflammation, repair and regeneration. Int Immunol 30(11):511–528

Article  CAS  PubMed  Google Scholar 

Podaru M-N, Fields L, Kainuma S, Ichihara Y, Hussain M, Ito T, Kobayashi K, Mathur A, D’Acquisto F, Lewis-McDougall F (2019) Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy. Basic Res Cardiol 114:1–18

Article  CAS  Google Scholar 

Prasher P, Zacconi FC, Withey J, Rathbone M, Dua K (2023) Recent developments in anti-inflammatory therapy. Elsevier, Amsterdam

Google Scholar 

留言 (0)

沒有登入
gif