Bian Y, Yin G, Wang G, Liu T, Liang L, Yang X, Zhang W, Tang D (2022) Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells. Cell Biol Toxicol. https://doi.org/10.1007/s10565-021-09681-2
Cai F, Chen M, Zha D, Zhang P, Zhang X, Cao N, Wang J, He Y, Fan X, Zhang W, Fu Z, Lai Y, Hua ZC, Zhuang H (2017) Curcumol potentiates celecoxib-induced growth inhibition and apoptosis in human non-small cell lung cancer. Oncotarget 8:115526–115545. https://doi.org/10.18632/oncotarget.23308
Cao ZY, Chen JQ, Lv T, Shi ZJ, Feng QY, Fang G (2021) Regulatory mechanism of zedoary turmeric oil on VEGFA, STAT3 and mTOR in ovarian cancer. Chin J Exp Tradit Med Formulae 27:70–80. https://doi.org/10.13422/j.cnki.syfjx.20211491
Chen X, Zong C, Gao Y, Cai R, Fang L, Lu J, Liu F, Qi Y (2014a) Curcumol exhibits anti-inflammatory properties by interfering with the JNK-mediated AP-1 pathway in lipopolysaccharide-activated RAW264.7 cells. Eur J Pharmacol 723:339–345. https://doi.org/10.1016/j.ejphar.2013.11.007
Article CAS PubMed Google Scholar
Chen G, Wang Y, Li M, Xu T, Wang X, Hong B, Niu Y (2014b) Curcumol induces HSC-T6 cell death through suppression of Bcl-2: involvement of PI3K and NF-κB pathways. Eur J Pharm Sci 65:21–28. https://doi.org/10.1016/j.ejps.2014.09.001
Article CAS PubMed Google Scholar
Chen Y, Zhu Z, Chen J, Zheng Y, Limsila B, Lu M, Gao T, Yang Q, Fu C, Liao W (2021) Terpenoids from Curcumae Rhizoma: their anticancer effects and clinical uses on combination and versus drug therapies. Biomed Pharmacother 138:111350. https://doi.org/10.1016/j.biopha.2021.111350
Article CAS PubMed Google Scholar
Chen B, Liu YS, Tian W, Ye TT, Yang R, Wang SJ (2023) Preparation of curcumol flexible liposomes for nebulized inhalation and in vitro and in vivo evaluation. Cent South Pharm 21:1130–1137. https://doi.org/10.7539/j.issn.1672-2981.2023.05.003
Chen L, Lu XY, Huang LJ, Jian JY, Jin J, Gu W, Yuan CM, Hao XJ (2020) Structural modification and inhibition of melanin content of curcumol. Nat Prod Res Dev 32:317–322. https://doi.org/10.16333/j.1001-6880.20.2.016
Dai LH, Sun Y, Chen XY (2019) Effects of curcumol on proliferation, migration, invasion and apoptosis of human ovarian cancer SKOV3 cells. J Wenzhou Med Univ 49:740–743. https://doi.org/10.3969/j.issn.2095-9400.2019.10.007
Dai S, Wang C, Zhao X, Ma C, Fu K, Liu Y, Peng C, Li Y (2023) Cucurbitacin B: a review of its pharmacology, toxicity, and pharmacokinetics. Pharmacol Res 187:106587. https://doi.org/10.1016/j.phrs.2022.106587
Article CAS PubMed Google Scholar
Ding J, Wang JJ, Huang C, Wang L, Deng S, Xu TL, Ge WH, Li WG, Li F (2014) Curcumol from Rhizoma Curcumae suppresses epileptic seizure by facilitation of GABA(A) receptors. Neuropharmacology 81:244–255. https://doi.org/10.1016/j.neuropharm.2014.02.009
Article CAS PubMed Google Scholar
Fang S, Wang L, Luo C, Yi H, Wang X, Ning B (2022) Curcumol inhibits the growth of xenograft-tumors in mice and the biological activities of pancreatic cancer cells by regulating the miR-21-5p/SMAD7 axis. Cell Cycle 21:1249–1266. https://doi.org/10.1080/15384101.2022.2046983
Article CAS PubMed PubMed Central Google Scholar
Gan Y, Zhou L, Wang R, Zhang Y, Li X, Han S, Rong P, Wang W, Li W (2023) Curcumol reduces aerobic glycolysis and overcomes chemoresistance by inducing Cdh1-mediated Skp2 ubiquitination. Am J Chin Med 53:1–18. https://doi.org/10.1142/S0192415X23500349
Gao L, Yang X, Li Y, Wang Z, Wang S, Tan S, Chen A, Cao P, Shao J, Zhang Z, Zhang F, Zheng S (2021a) Curcumol inhibits KLF5-dependent angiogenesis by blocking the ROS/ERK signaling in liver sinusoidal endothelial cells. Life Sci 264:118696. https://doi.org/10.1016/j.lfs.2020.118696
Article CAS PubMed Google Scholar
Gao L, Yang X, Liang B, Jia Y, Tan S, Chen A, Cao P, Zhang Z, Zheng S, Sun L, Zhang F, Shao J (2021b) Autophagy-induced p62 accumulation is required for curcumol to regulate KLF5-mediated angiogenesis in liver sinusoidal endothelial cells. Toxicology 452:152707. https://doi.org/10.1016/j.tox.2021.152707
Article CAS PubMed Google Scholar
Gao FT, Jin J, Jian JY, Chen L, Gu W, Yuan CM, Hao XJ, Huang LJ (2023) Synthesis and antifungal activity of curcumol derivatives. Chem Biodivers. https://doi.org/10.1002/cbdv.202300442
Gu W, Li JC, Ji D, Li L, Zhang J, Pan ZH, Yang JJ, Lu TL, Mao CQ (2018) Pharmacokinetic comparisons of typical constituents in Curcumae Rhizoma and vinegar-processed Curcumae Rhizoma after oral administration to rats. Evid Based Complement Alternat Med 2018:6809497. https://doi.org/10.1155/2018/6809497
Article PubMed PubMed Central Google Scholar
Guan X, Yu D, HuangFu M, Huang Z, Dou T, Liu Y, Zhou L, Li X, Wang L, Liu H, Wang J, Chen X (2021) Curcumol inhibits EBV-positive Nasopharyngeal carcinoma migration and invasion by targeting nucleolin. Biochem Pharmacol 192:114742. https://doi.org/10.1016/j.bcp.2021.114742
Article CAS PubMed Google Scholar
Guo P, Wang YW, Weng BX, Li XK, Yang SL, Ye FQ (2014) Synthesis, anti-tumor activity, and structure-activity relationships of curcumol derivatives. J Asian Nat Prod Res 16:53–58. https://doi.org/10.1080/10286020.2013.857660
Article CAS PubMed Google Scholar
Guo F, Li LL, Zang LQ (2018) Study of mechanism of curcumol on mediating anti breast cancer via down-regulation the expression of Bcl-2 protein. Chin J Clin Pharmacol 34:1175–1178. https://doi.org/10.13699/j.cnki.1001-6821.2018.10.012
Hashem S, Nisar S, Sageena G, Macha MA, Yadav SK, Krishnankutty R, Uddin S, Haris M, Bhat AA (2021) Therapeutic effects of curcumol in several diseases; an overview. Nutr Cancer 73:181–195. https://doi.org/10.1080/01635581.2020.1749676
Article CAS PubMed Google Scholar
He S, Fu Y, Yan B, Tan H, Li H, Li J, Huang D, Huang Z, Lai J, Feng H, Sun Z, Lan Z (2021) Curcumol alleviates the inflammation of nucleus pulposus cells via the PI3K/Akt/NF-κB signaling pathway and delays intervertebral disk degeneration. World Neurosurg 155:402–411. https://doi.org/10.1016/j.wneu.2021.08.079
Hu Y, Xu R, Ma J, Yan Z, Ma J (2022) Curcumol enhances cisplatin sensitivity of gastric cancer: involvement of microRNA-7 and the nuclear factor-kappa B/snail family transcriptional repressor 1 axis. Bioengineered 13:11668–11683. https://doi.org/10.1080/21655979.2022.2070975
Article CAS PubMed Google Scholar
Huang L, Li A, Liao G, Yang F, Yang J, Chen X, Jiang X (2017) Curcumol triggers apoptosis of p53 mutant triple-negative human breast cancer MDA-MB 231 cells via activation of p73 and PUMA. Oncol Lett 14:1080–1088. https://doi.org/10.3892/ol.2017.6273
Article CAS PubMed PubMed Central Google Scholar
Huang X, Qian J, Li L, Zhang X, Wei G, Lv J, Qin F, Yu J, Xiao Y, Gong Z, Huo J (2020) Curcumol improves cisplatin sensitivity of human gastric cancer cells through inhibiting PI3K/AKT pathway. Drug Dev Res 81:1019–1025. https://doi.org/10.1002/ddr.21719
Article CAS PubMed Google Scholar
Huang KY, Lv XY, Zhou XQ, Dong Y, Shi MY, Tian N (2021) Study on the down-regulation of FoxD2-AS1 by Curcumol in the treatment of Glioma with temozolomide chemotherapy resistance. J Zhejiang Univ Tradit Chin Med 45:391–397. https://doi.org/10.16466/j.issn1005-5509.2021.04.014
Jia Y, Wang F, Guo Q, Li M, Wang L, Zhang Z, Jiang S, Jin H, Chen A, Tan S, Zhang F, Shao J, Zheng S (2018) Curcumol induces RIPK1/RIPK3 complex- dependent necroptosis via JNK1/2-ROS signaling in hepatic stellate cells. Redox Biol 19:375–387. https://doi.org/10.1016/j.redox.2018.09.007
Article CAS PubMed PubMed Central Google Scholar
Jia Y, Gao L, Yang X, Zhang F, Chen A, Wang S, Shao J, Tan S, Zheng S (2020) Blockade of periostin-dependent migration and adhesion by curcumol via inhibition of nuclear factor kappa B signaling in hepatic stellate cells. Toxicology 440:152475. https://doi.org/10.1016/j.tox.2020.152475
Article CAS PubMed Google Scholar
Jia S, Guo P, Lu J, Huang X, Deng L, Jin Y, Zhao L, Fan X (2021) Curcumol ameliorates lung inflammation and airway remodeling via inhibiting the abnormal activation of the Wnt/β-catenin pathway in chronic asthmatic mice. Drug Des Devel Ther 15:2641–2651. https://doi.org/10.2147/DDDT.S292642
Article PubMed PubMed Central Google Scholar
Jiang N, Guo J, Liu C, Zhou J (2022) Curcumol inhibits proliferation and promotes apoptosis of human osteosarcoma cell lines. Basic Res Clin Med 42:1200–1205
Lai C, Luo B, Shen J, Shao J (2022) Biomedical engineered nanomaterials to alleviate tumor hypoxia for enhanced photodynamic therapy. Pharmacol Res 186:106551. https://doi.org/10.1016/j.phrs.2022.106551
Article CAS PubMed Google Scholar
Li J, Mao C, Li L, Ji D, Yin F, Lang Y, Lu T, Xiao Y, Li L (2014) Pharmacokinetics and liver distribution study of unbound curdione and curcumol in rats by microdialysis coupled with rapid resolution liquid chromatography (RRLC) and tandem mass spectrometry. J Pharm Biomed Anal 95:146–150. https://doi.org/10.1016/j.jpba.2014.02.025
Article CAS PubMed Google Scholar
Li W, Hong B, Li Z, Li Q, Bi K (2018a) GC-MS method for determination and pharmacokinetic study of seven volatile constituents in rat plasma after oral administration of the essential oil of Rhizoma Curcumae. J Pharm Biomed Anal 149:577–585. https://doi.org/10.1016/j.jpba.2017.11.058
Article CAS PubMed Google Scholar
Li X, Liu H, Wang J, Qin J, Bai Z, Chi B, Yan W, Chen X (2018b) Curcumol induces cell cycle arrest and apoptosis by inhibiting IGF-1R/PI3K/Akt signaling pathway in human nasopharyngeal carcinoma CNE-2 cells. Phytother Res 32:2214–2225. https://doi.org/10.1002/ptr.6158
Article CAS PubMed Google Scholar
Li WJ, Lian YW, Guan QS, Li N, Liang WJ, Liu WX, Huang YB, Cheng Y, Luo H (2018c) Liver-targeted delivery of liposome-encapsulated curcumol using galactosylated- stearate. Exp Ther Med 16:925–930. https://doi.org/10.3892/etm.2018.6210
Article CAS PubMed PubMed Central Google Scholar
Li YQ, Li GZ, Dong Y, Ma X, Dong HJ, Wu QQ, Zhao WJ (2019b) Orobanone analogues from acid-promoted aromatization rearrangement of curcumol inhibit hypoxia-inducible factor-1 (HIF-1) in cell-based reporter assays. Bioorg Chem 85:357–363. https://doi.org/10.1016/j.bioorg.2019.01.013
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