Enhanced articular cartilage regeneration using costal chondrocyte-derived scaffold-free tissue engineered constructs with ascorbic acid treatment
Keywords
Articular cartilage regeneration
Cartilage tissue engineering
Costal chondrocytes
Osteochondral defect
Scaffold-free tissue engineering
AbbreviationsTEC
scaffold-free tissue-engineered construct
MSC
mesenchymal stem/stromal cell
Asc-2P
ascorbate 2-phosphate
DMEM
Dulbecco's modified Eagle's medium
EDTA
ethylenediamine tetraacetic acid
RT-qPCR
Real-time polymerase chain reaction
GAPDH
glyceraldehyde 3-phosphate dehydrogenase
DMMB
dimethyl methylene blue
PBS
phosphate-buffered saline
ICRS
International Cartilage Repair Society
ICRS-VHAS
ICRS Visual Histological Assessment Scale
ANOVA
One-way analysis of variance
DEGs
differentially expressed genes
KEGG
Kyoto Encyclopedia of Genes and Genomes
GSEA
gene set enrichment analysis
© 2024 The Authors. Published by Elsevier B.V. on behalf of Chinese Speaking Orthopaedic Society.
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