Establishment of microneurovascular units in alginate hydrogel microspheres to reveal the anti-hypoxic effect of salidroside

Journal of Pharmaceutical Analysis

Available online 20 March 2024, 100967

Journal of Pharmaceutical AnalysisAuthor links open overlay panel, , , , , , , Editor highlights•

Microfluidic co-culture of BV2 microglia and HT22 neurons in a 3D scaffold are for AHM.

Microtissues resembling mNVU exhibit responsiveness to hypoxia.

We evaluated Sal's anti-hypoxic mechanisms and influence on the TCA cycle.

A cell replacement method, suitable for various models, especially beneficial for drug screening.

© 2024 The Author(s). Published by Elsevier B.V. on behalf of Xi’an Jiaotong University.

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