Dihydroartemisinin, a potential PTGS1 inhibitor, potentiated cisplatin-induced cell death in non-small cell lung cancer through activating ROS-mediated multiple signaling pathways
Keywords
Dihydroartemisinin (DHA)
Cisplatin
Endoplasmic reticulum (ER) stress
Reactive oxygen species (ROS)
Prostaglandin G/H synthase 1 (PTGS1)
Mitogen-activated protein kinases (MAPK)
AbbreviationsALT
Alanine aminotransferase
AST
Aspartate aminotransferase
ATF4
Transcription factor 4
DCFH-DA
2′, 7′-dichlorodihydrofluorescin diacetate
eIF2α
Eukaryotic initiation factor 2α
JNK
C-Jun-amino-terminal kinase
LAC
Local average onnectivity-based method
MTT
3-(4, 5-dimethyl thiazol-2-yl)-2, 5-diphenyl tetrazolium bromide
NSCLC
Non-small cell lung cancer
PBS
Phosphate-buffered saline
PTGS1
Prostaglandin G/H synthase 1
PTGS2
Prostaglandin-endoperoxide synthase 2
ROS
Reactive oxygen species
© 2024 The Authors. Published by Elsevier Inc. CCBYLICENSE
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