James KD, Cosway EJ, Parnell SM, White AJ, Jenkinson WE, Anderson G. Assembling the thymus medulla: Development and function of epithelial cell heterogeneity. Bioessays. 2024;46:e2300165.

Article  PubMed  Google Scholar 

Givony T, Leshkowitz D, Del Castillo D, Nevo S, Kadouri N, Dassa B, et al. Thymic mimetic cells function beyond self-tolerance. Nature. 2023;622:164–72.

Article  ADS  CAS  PubMed  Google Scholar 

Michelson DA, Hase K, Kaisho T, Benoist C, Mathis D. Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells. Cell. 2022;185:2542–58.e18.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tao W, Ye Z, Wei Y, Wang J, Yang W, Yu G, et al. Insm1 regulates mTEC development and immune tolerance. Cell Mol Immunol. 2023;20:1472–86.

Article  CAS  PubMed  Google Scholar 

Michelson DA, Zuo C, Verzi M, Benoist C, Mathis D. Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus. J Exp Med. 2023;220:e20230461.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, Turley SJ, et al. Projection of an immunological self shadow within the thymus by the aire protein. Science. 2002;298:1395–401.

Article  ADS  CAS  PubMed  Google Scholar 

Ragazzini R, Boeing S, Zanieri L, Green M, D’Agostino G, Bartolovic K, et al. Defining the identity and the niches of epithelial stem cells with highly pleiotropic multilineage potency in the human thymus. Dev Cell. 2023;58:2428–46.e9.

Article  CAS  PubMed  Google Scholar 

Kashima J, Hashimoto T, Yoshida A, Goto Y, Ushiku T, Ohe Y, et al. Insulinoma-associated-1 (INSM1) expression in thymic squamous cell carcinoma. Virchows Arch. 2022;481:893–901.

Article  CAS  PubMed  Google Scholar 

Cowan JE, Jenkinson WE, Anderson G. Thymus medulla fosters generation of natural Treg cells, invariant gammadelta T cells, and invariant NKT cells: what we learn from intrathymic migration. Eur J Immunol. 2015;45:652–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Farr AG, Rudensky A. Medullary thymic epithelium: a mosaic of epithelial “self”? J Exp Med. 1998;188:1–4.

Article  CAS  PubMed  PubMed Central  Google Scholar