Dai H, Alsalhe TA, Chalghaf N, Riccò M, Bragazzi NL, Wu J. The global burden of disease attributable to high body mass index in 195 countries and territories, 1990–2017: an analysis of the Global Burden of Disease Study. PLoS Med. 2020;17(7): e1003198.

Article  PubMed  PubMed Central  Google Scholar 

Ferrannini E, Haffner SM, Mitchell BD, Stern MP. Hyperinsulinaemia: the key feature of a cardiovascular and metabolic syndrome. Diabetologia. 1991;34(6):416–22.

Article  CAS  PubMed  Google Scholar 

Petersen MC, Shulman GI. Mechanisms of insulin action and insulin resistance. Physiol Rev. 2018;98(4):2133–223.

Article  CAS  PubMed  PubMed Central  Google Scholar 

van der Kolk BW, Vogelzangs N, Jocken JWE, Valsesia A, Hankemeier T, Astrup A, et al. Plasma lipid profiling of tissue-specific insulin resistance in human obesity. Int J Obes. 2019;43(5):989–98.

Article  Google Scholar 

Vogelzangs N, van der Kallen CJH, van Greevenbroek MMJ, van der Kolk BW, Jocken JWE, Goossens GH, et al. Metabolic profiling of tissue-specific insulin resistance in human obesity: results from the Diogenes study and the Maastricht Study. Int J Obes. 2020;44(6):1376–86.

Article  CAS  Google Scholar 

Leon-Acuña A, Alcala-Diaz JF, Delgado-Lista J, Torres-Peña JD, Lopez-Moreno J, Camargo A, et al. Hepatic insulin resistance both in prediabetic and diabetic patients determines postprandial lipoprotein metabolism: from the CORDIOPREV study. Cardiovasc Diabetol. 2016;15(1):68.

Article  PubMed  PubMed Central  Google Scholar 

Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women. JAMA. 2007;298(3):309–16.

Article  CAS  PubMed  Google Scholar 

Stalenhoef AF, de Graaf J. Association of fasting and nonfasting serum triglycerides with cardiovascular disease and the role of remnant-like lipoproteins and small dense LDL. Curr Opin Lipidol. 2008;19(4):355–61.

Article  CAS  PubMed  Google Scholar 

Nordestgaard BG, Benn M, Schnohr P, Tybjærg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298(3):299–308.

Article  CAS  PubMed  Google Scholar 

Gijbels A, Trouwborst I, Jardon KM, Hul GB, Siebelink E, Bowser SM, et al. The PERSonalized glucose optimization through nutritional intervention (PERSON) study: rationale, design and preliminary screening results. Front Nutr. 2021;8: 694568.

Article  PubMed  PubMed Central  Google Scholar 

Schaefer EJ, McNamara JR, Tayler T, Daly JA, Gleason JL, Seman LJ, et al. Comparisons of effects of statins (atorvastatin, fluvastatin, lovastatin, pravastatin, and simvastatin) on fasting and postprandial lipoproteins in patients with coronary heart disease versus control subjects. Am J Cardiol. 2004;93(1):31–9.

Article  CAS  PubMed  Google Scholar 

Hajer GR, Dallinga-Thie GM, Van Vark-van der Zee LC, Visseren FLJ. The effect of statin alone or in combination with ezetimibe on postprandial lipoprotein composition in obese metabolic syndrome patients. Atherosclerosis. 2009;202(1):216–24.

Article  CAS  PubMed  Google Scholar 

Lucassen DA, Brouwer-Brolsma EM, van de Wiel AM, Siebelink E, Feskens EJM. Iterative development of an innovative smartphone-based dietary assessment tool: Traqq. J Vis Exp. 2021(169).

Abdul-Ghani MA, Matsuda M, Balas B, DeFronzo RA. Muscle and liver insulin resistance indexes derived from the oral glucose tolerance test. Diabetes Care. 2007;30(1):89–94.

Article  CAS  PubMed  Google Scholar 

O’Donovan SD, Lenz M, Goossens GH, van der Kallen CJH, Eussen S, Stehouwer CDA, et al. Improved quantification of muscle insulin sensitivity using oral glucose tolerance test data: the MISI Calculator. Sci Rep. 2019;9(1):9388.

Article  ADS  PubMed  PubMed Central  Google Scholar 

Schram MT, Sep SJ, van der Kallen CJ, Dagnelie PC, Koster A, Schaper N, et al. The Maastricht Study: an extensive phenotyping study on determinants of type 2 diabetes, its complications and its comorbidities. Eur J Epidemiol. 2014;29(6):439–51.

Article  PubMed  Google Scholar 

Matsuda M, DeFronzo RA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care. 1999;22(9):1462–70.

Article  CAS  PubMed  Google Scholar 

Alberti KG, Zimmet PZ. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998;15(7):539–53.

Article  CAS  PubMed  Google Scholar 

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412–9.

Article  CAS  PubMed  Google Scholar 

Soininen P, Kangas AJ, Würtz P, Suna T, Ala-Korpela M. Quantitative serum nuclear magnetic resonance metabolomics in cardiovascular epidemiology and genetics. Circ Cardiovasc Genet. 2015;8(1):192–206.

Article  CAS  PubMed  Google Scholar 

Streppel MT, de Vries JH, Meijboom S, Beekman M, de Craen AJ, Slagboom PE, et al. Relative validity of the food frequency questionnaire used to assess dietary intake in the Leiden Longevity Study. Nutr J. 2013;12:75.

Article  PubMed  PubMed Central  Google Scholar 

Looman M, Feskens EJM, de Rijk M, Meijboom S, Biesbroek S, Temme EHM, et al. Development and evaluation of the Dutch Healthy Diet index 2015. Public Health Nutr. 2017;20(13):2289–99.

Article  PubMed  PubMed Central  Google Scholar 

Baecke JA, Burema J, Frijters JE. A short questionnaire for the measurement of habitual physical activity in epidemiological studies. Am J Clin Nutr. 1982;36(5):936–42.

Article  CAS  PubMed  Google Scholar 

Erdős B, Westerhuis JA, Adriaens ME, O’Donovan SD, Xie R, Singh-Povel CM, et al. Analysis of high-dimensional metabolomics data with complex temporal dynamics using RM-ASCA+. PLoS Comput Biol. 2023;19(6): e1011221.

Article  ADS  PubMed  PubMed Central  Google Scholar 

Madssen TS, Giskeødegård GF, Smilde AK, Westerhuis JA. Repeated measures ASCA+ for analysis of longitudinal intervention studies with multivariate outcome data. PLoS Comput Biol. 2021;17(11): e1009585.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc Ser B (Methodol). 1995;57(1):289–300.

MathSciNet  Google Scholar 

Gill JMR, Brown JC, Bedford D, Wright DM, Cooney J, Hughes DA, et al. Hepatic production of VLDL1 but not VLDL2 is related to insulin resistance in normoglycaemic middle-aged subjects. Atherosclerosis. 2004;176(1):49–56.

Article  CAS  PubMed  Google Scholar 

Pont F, Duvillard L, Florentin E, Gambert P, Vergès B. Early kinetic abnormalities of ApoB-containing lipoproteins in insulin-resistant women with abdominal obesity. Arterioscler Thromb Vasc Biol. 2002;22(10):1726–32.

Article  CAS  PubMed  Google Scholar 

Haas ME, Attie AD, Biddinger SB. The regulation of ApoB metabolism by insulin. Trends Endocrinol Metab. 2013;24(8):391–7.

Article  CAS  PubMed  Google Scholar 

Sparks JD, Sparks CE, Adeli K. Selective hepatic insulin resistance, VLDL overproduction, and hypertriglyceridemia. Arterioscler Thromb Vasc Biol. 2012;32(9):2104–12.

Article  CAS  PubMed  Google Scholar 

Vergès B. Pathophysiology of diabetic dyslipidaemia: where are we? Diabetologia. 2015;58(5):886–99.

Article  PubMed  PubMed Central  Google Scholar 

Adiels M, Westerbacka J, Soro-Paavonen A, Häkkinen AM, Vehkavaara S, Caslake MJ, et al. Acute suppression of VLDL1 secretion rate by insulin is associated with hepatic fat content and insulin resistance. Diabetologia. 2007;50(11):2356–65.

Article  CAS  PubMed  Google Scholar 

Brown MS, Goldstein JL. Selective versus total insulin resistance: a pathogenic paradox. Cell Metab. 2008;7(2):95–6.

Article  CAS  PubMed  Google Scholar 

Smith GI, Shankaran M, Yoshino M, Schweitzer GG, Chondronikola M, Beals JW, et al. Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease. J Clin Investig. 2020;130(3):1453–60.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tall AR. Plasma cholesteryl ester transfer protein. J Lipid Res. 1993;34(8):1255–74.

Article  CAS  PubMed  Google Scholar 

Guérin M, Goff WL, Lassel TS, Tol AV, Steiner G, Chapman MJ. Proatherogenic role of elevated CE transfer from HDL to VLDL1 and dense LDL in type 2 diabetes. Arterioscler Thromb Vasc Biol. 2001;21(2):282–8.

Article  PubMed