Comprehensive ocular and systemic pharmacokinetics of dexamethasone after subconjunctival and intravenous injections in rabbits

AbbreviationsCmax

peak drug concentration

HPLC

high-performance liquid chromatography

ka

absorption rate constant

LC-MS/MS

liquid chromatography-tandem mass spectrometry

LLOQ

lower limit of quantitation

NCA

non-compartmental analysis

OFV

objective function value

Q

intercompartmental clearance

QSPR

quantitative structure–property relationship

RSE

relative standard error

SAEM

stochastic approximation expectation maximisation algorithm

tmax

time to peak drug concentration

V1

apparent volume of the central compartment

V2

apparent volume of the peripheral compartment

Keywords

Subconjunctival pharmacokinetics

Dexamethasone

Ocular bioavailability

Intravenous pharmacokinetics

Population pharmacokinetic modelling

Non-compartmental analysis

Data availability

Data will be made available on request.

© 2024 The Authors. Published by Elsevier B.V.

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