The combination treatment of hypothermia and intranasal insulin ameliorates the structural and functional changes in a rat model of traumatic brain injury

Adzovic L, Domenici L (2014) Insulin induces phosphorylation of the AMPA receptor subunit GluR1, reversed by ZIP, and over-expression of Protein Kinase M zeta, reversed by amyloid beta. J Neurochem 131(5):582–587

Article  CAS  PubMed  Google Scholar 

Adzovic L, Lynn AE, D’Angelo HM, Crockett AM, Kaercher RM, Royer SE, Hopp SC, Wenk GL (2015) Insulin improves memory and reduces chronic neuroinflammation in the hippocampus of young but not aged brains. J neuro inflammation 12(1):1–10

CAS  Google Scholar 

Benedict C, Hallschmid M, Hatke A, Schultes B, Fehm HL, Born J, Kern W (2004) Intranasal insulin improves memory in humans. Psychoneuroendocrinology 29(10):1326–1334

Article  CAS  PubMed  Google Scholar 

Brabazon F, Wilson CM, Jaiswal S, Reed J, Frey WH 2nd, Byrnes KR (2017) Intranasal insulin treatment of an experimental model of moderate traumatic brain injury. J Cereb Blood Flow Metab 37(9):3203–3218

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Y, Zhao Y, Dai C-l, Liang Z, Run X, Iqbal K, Liu F, Gong C-X (2014) Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice. Exp Neurol 261:610–619

Article  CAS  PubMed  Google Scholar 

Clark RS, Kochanek PM, Marion DW, Schiding JK, White M, Palmer AM, DeKosky ST (1996) Mild posttraumatic hypothermia reduces mortality after severe controlled cortical impact in rats. J Cereb Blood Flow Metab 16(2):253–261

Article  CAS  PubMed  Google Scholar 

Clifton GL, Miller ER, Choi SC, Levin HS, McCauley S, Smith KR Jr, Muizelaar JP, Wagner FC Jr, Marion DW, Luerssen TG (2001) Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 344(8):556–563

Article  CAS  PubMed  Google Scholar 

Cornelius C, Crupi R, Calabrese V, Graziano A, Milone P, Pennisi G, Radak Z, Calabrese EJ, Cuzzocrea S (2013) Traumatic brain injury: oxidative stress and neuroprotection. Antioxid Redox Signal 19(8):836–853

Article  CAS  PubMed  Google Scholar 

Corrigan F, Mander KA, Leonard AV, Vink R (2016) Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation. J Neuroinflammation 13(1):1–12

Article  Google Scholar 

Dash S, Xiao C, Morgantini C, Koulajian K, Lewis GF (2015) Intranasal insulin suppresses endogenous glucose production in humans compared with placebo in the presence of similar venous insulin concentrations. Diabetes 64(3):766–774

Article  CAS  PubMed  Google Scholar 

DeKosky ST, Abrahamson EE, Taffe KM, Dixon CE, Kochanek PM, Ikonomovic MD (2004) Effects of post-injury hypothermia and nerve growth factor infusion on antioxidant enzyme activity in the rat: implications for clinical therapies. J Neurochem 90(4):998–1004

Article  CAS  PubMed  Google Scholar 

Dou J-T, Chen M, Dufour F, Alkon DL, Zhao W-Q (2005) Insulin receptor signaling in long-term memory consolidation following spatial learning. Learn Mem 12(6):646–655

Article  PubMed  PubMed Central  Google Scholar 

Erecinska M, Thoresen M, Silver IA (2003) Effects of hypothermia on energy metabolism in Mammalian central nervous system. J Cereb Blood Flow Metab 23(5):513–530

Article  CAS  PubMed  Google Scholar 

Fishwick KJ, Rylett RJ (2015) Insulin regulates the activity of the high-affinity choline transporter CHT. PLoS ONE 10(7):e0132934

Article  PubMed  PubMed Central  Google Scholar 

Glenn TC, Kelly DF, Boscardin WJ, McArthur DL, Vespa P, Oertel M, Hovda DA, Bergsneider M, Hillered L, Martin NA (2003) Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism. J Cereb Blood Flow Metab 23(10):1239–1250

Article  CAS  PubMed  Google Scholar 

Gundersen H, Bendtsen TF, Korbo L, Marcussen N, Møller A, Nielsen K, Nyengaard J, Pakkenberg B, Sørensen FB, Vesterby A (1988) Some new, simple and efficient stereological methods and their use in pathological research and diagnosis. APMIS 96(1–6):379–394

Article  CAS  PubMed  Google Scholar 

Han HS, Qiao Y, Karabiyikoglu M, Giffard RG, Yenari MA (2002) Influence of mild hypothermia on inducible nitric oxide synthase expression and reactive nitrogen production in experimental stroke and inflammation. J Neurosci 22(10):3921–3928

Article  CAS  PubMed  PubMed Central  Google Scholar 

Havrankova J, Roth J, BROWNSTEIN M, (1978) Insulin receptors are widely distributed in the central nervous system of the rat. Nature 272(5656):827–829

Article  ADS  CAS  PubMed  Google Scholar 

Hiebert JB, Shen Q, Thimmesch AR, Pierce JD (2015) Traumatic brain injury and mitochondrial dysfunction. Am J Med Sci 350(2):132–138

Article  PubMed  Google Scholar 

Jalloh I, Carpenter KL, Helmy A, Carpenter TA, Menon DK, Hutchinson PJ (2015) Glucose metabolism following human traumatic brain injury: methods of assessment and pathophysiological findings. Metab Brain Dis 30(3):615–632

Article  CAS  PubMed  Google Scholar 

Jia F, Mao Q, Liang Y-M, Jiang J-Y (2009) Effect of post-traumatic mild hypothermia on hippocampal cell death after traumatic brain injury in rats. J Neurotrauma 26(2):243–252

Article  PubMed  Google Scholar 

Karimi F, Anari H, Yousefi Nejad A, Karbalay-Doust S, Naseh M (2022) Post-weaning exposure to sunset yellow FCF induces behavioral impairment and structural changes in the adult rat medial prefrontal cortex: protective effects of coenzyme Q10. Int J Dev Neurosci 82(4):303–313

Article  CAS  PubMed  Google Scholar 

Kim J-H, Lee J-Y, Suk K (2011) Therapeutic hypothermia in brain injuries and related diseases. Recent Pat Inflammation Allergy Drug Discovery 5(2):155–164

Article  CAS  Google Scholar 

Kochanek PM, Clark RS, Ruppel RA, Adelson PD, Bell MJ, Whalen MJ, Robertson CL, Satchell MA, Seidberg NA, Marion DW (2000) Biochemical, cellular, and molecular mechanisms in the evolution of secondary damage after severe traumatic brain injury in infants and children: lessons learned from the bedside. Pediatr Crit Care Med 1(1):4–19

Article  PubMed  Google Scholar 

Kristiansen SLB, Nyengaard JR (2012) Digital stereology in neuropathology. APMIS 120(4):327–340

Article  PubMed  Google Scholar 

Len T, Neary J (2011) Cerebrovascular pathophysiology following mild traumatic brain injury. Clin Physiol Funct Imaging 31(2):85–93

CAS  PubMed  Google Scholar 

Lotocki G, de Rivero Vaccari JP, Perez ER, Sanchez-Molano J, Furones-Alonso O, Bramlett HM, Dietrich WD (2009) Alterations in blood-brain barrier permeability to large and small molecules and leukocyte accumulation after traumatic brain injury: effects of post-traumatic hypothermia. J Neurotrauma 26(7):1123–1134

Article  PubMed  PubMed Central  Google Scholar 

Ma M, Matthews BT, Lampe JW, Meaney DF, Shofer FS, Neumar RW (2009) Immediate short-duration hypothermia provides long-term protection in an in vivo model of traumatic axonal injury. Exp Neurol 215(1):119–127

Article  PubMed  Google Scholar 

Meftahi GH, Bayat M, Zarifkar AH, Akbari S, Haghigh AB, Naseh M, Nejad AY, Haghani M (2021) Treatment with edaravone improves the structure and functional changes in the hippocampus after chronic cerebral hypoperfusion in rat. Brain Res Bull 174:122–130

Article  CAS  PubMed  Google Scholar 

Mou Y, Wilgenburg BJ, Lee Y-j, Hallenbeck JM (2013) A method for hypothermia-induction and maintenance allows precise body and brain temperature control in mice. J Neurosci Methods 213(1):1–5

Article  PubMed  Google Scholar 

Naseh M, Bayat M, Akbari S, Vatanparast J, Shabani M, Haghighi AB, Haghani M (2022) Neuroprotective effects of sodium valproate on hippocampal cell and volume, and cognitive function in a rat model of focal cerebral ischemia. Physiol Behav 251:113806

Article  CAS  PubMed  Google Scholar 

Paxinos G, Watson C (2006) The rat brain in stereotaxic coordinates: hard cover. Elsevier

Google Scholar 

Reger MA, Watson G, Green PS, Baker LD, Cholerton B, Fishel MA, Plymate SR, Cherrier MM, Schellenberg GD, Frey Ii WH (2008) Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-β in memory-impaired older adults. J Alzheimers Dis 13(3):323–331

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rubinow MJ, Juraska JM (2009) Neuron and glia numbers in the basolateral nucleus of the amygdala from preweaning through old age in male and female rats: a stereological study. Journal of Comparative Neurology 512(6):717–725

Article  PubMed  Google Scholar 

Schulingkamp R, Pagano T, Hung D, Raffa R (2000) Insulin receptors and insulin action in the brain: review and clinical implications. Neurosci Biobehav Rev 24(8):855–872

Article  CAS  PubMed  Google Scholar 

Shaughness M, Acs D, Brabazon F, Hockenbury N, Byrnes KR (2020) Role of insulin in neurotrauma and neurodegeneration: a review. Front Neurosci 14:547175

Article  PubMed  PubMed Central  Google Scholar 

Skeberdis VA, Lan J-y, Zheng X, Zukin RS, Bennett MV (2001) Insulin promotes rapid delivery of n-methyl-d-aspartate receptors to the cell surface by exocytosis. Proc Natl Acad Sci 98(6):3561–3566

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