The localization, origin, and impact of platelets in the tumor microenvironment are tumor type-dependent

Gasic GJ, Gasic TB, Stewart CC. Antimetastatic effects associated with platelet reduction. Proc Natl Acad Sci U S A. 1968;61:46.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Labelle M, Begum S, Hynes RO. Direct signaling between platelets and Cancer cells induces an epithelial-mesenchymal-like Transition and promotes metastasis. Cancer Cell. 2011;20:576–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Nieswandt B, Hafner M, Echtenacher B, Männel DN. Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Cancer Res. 1999;59:1295–300.

CAS  PubMed  Google Scholar 

Kim YJ, Borsig L, Varki NM, Varki A. P-selectin deficiency attenuates tumor growth and metastasis. Proc Natl Acad Sci U S A. 1998;95:9325–30.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Jain S, Zuka M, Liu J, Russell S, Dent J, Guerrero JA, et al. Platelet glycoprotein Ibα supports experimental lung metastasis. Proc Natl Acad Sci U S A. 2007;104:9024–8.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Jain S, Russell S, Ware J. Platelet glycoprotein VI facilitates experimental lung metastasis in syngenic mouse models. J Thromb Haemost. 2009;7:1713–7.

Article  CAS  PubMed  Google Scholar 

Mezouar S, Darbousset R, Dignat-George F, Panicot-Dubois L, Dubois C. Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo. Int J Cancer. 2015;136:462–75.

Article  CAS  PubMed  Google Scholar 

Stone RL, Nick AM, McNeish IA, Balkwill F, Han HD, Bottsford-Miller J, et al. Paraneoplastic thrombocytosis in Ovarian Cancer. N Engl J Med. 2012;366:610–8.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bottsford-Miller J, Choi HJ, Dalton HJ, Stone RL, Cho MS, Haemmerle M, et al. Differential platelet levels affect response to taxane-based therapy in ovarian cancer. Clin Cancer Res. 2015;21:602–10.

Article  CAS  PubMed  Google Scholar 

Plantureux L, Mege D, Crescence L, Carminita E, Robert S, Cointe S, et al. The interaction of platelets with colorectal cancer cells inhibits tumor growth but promotes metastasis. Cancer Res. 2020;80:291–303.

Article  CAS  PubMed  Google Scholar 

Volz J, Mammadova-Bach E, Gil-Pulido J, Nandigama R, Remer K, Sorokin L, et al. Inhibition of platelet GPVI induces intratumor hemorrhage and increases efficacy of chemotherapy in mice. Blood. 2019;133:2696–706.

Article  CAS  PubMed  Google Scholar 

Cho MS, Bottsford-Miller J, Vasquez HG, Stone R, Zand B, Kroll MH, et al. Platelets increase the proliferation of ovarian cancer cells. Blood. 2012;120:4869–72.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Michael Jv, Wurtzel JGT, Mao GF, Rao AK, Kolpakov MA, Sabri A, et al. Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth. Blood. 2017;130:567–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Egan K, Crowley D, Smyth P, O’Toole S, Spillane C, Martin C et al. Platelet adhesion and Degranulation Induce Pro-survival and Pro-angiogenic Signalling in Ovarian Cancer cells. PLoS ONE. 2011;6.

Ibele GM, Kay NE, Johnson GJ, Jacob HS. Human platelets exert cytotoxic effects on tumor cells. Blood. 1985;65:1252–5.

Article  CAS  PubMed  Google Scholar 

Kisucka J, Butterfield CE, Duda DG, Eichenberger SC, Saffaripour S, Ware J, et al. Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage. Proc Natl Acad Sci U S A. 2006;103:855–60.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Zhang Y, Cedervall J, Hamidi A, Herre M, Viitaniemi K, D’Amico G, et al. Platelet-specific PDGFB ablation impairs Tumor Vessel Integrity and promotes metastasis. Cancer Res. 2020;80:3345–58.

Article  CAS  PubMed  Google Scholar 

Ho-Tin-Noé B, Goerge T, Cifuni SM, Duerschmied D, Wagner DD. Platelet granule secretion continuously prevents intratumor hemorrhage. Cancer Res. 2008;68:6851–8.

Article  PubMed  PubMed Central  Google Scholar 

Ho-Tin-Noé B, Carbo C, Demers M, Cifuni SM, Goerge T, Wagner DD. Innate Immune cells induce hemorrhage in tumors during Thrombocytopenia. Am J Pathol. 2009;175:1699–708.

Article  PubMed  PubMed Central  Google Scholar 

Pavlović N, Kopsida M, Gerwins P, Heindryckx F. Activated platelets contribute to the progression of hepatocellular carcinoma by altering the tumor environment. Life Sci. 2021;277:119612.

Article  PubMed  Google Scholar 

Hinterleitner C, Strähle J, Malenke E, Hinterleitner M, Henning M, Seehawer M et al. Platelet PD-L1 reflects collective intratumoral PD-L1 expression and predicts immunotherapy response in non-small cell lung cancer. Nat Commun. 2021;12.

Gurney AL, Carver-Moore K, De Sauvage FJ, Moore MW. Thrombocytopenia in c-mpl-deficient mice. Science. 1994;265:1445–7.

Article  ADS  CAS  PubMed  Google Scholar 

Lockyer S, Okuyama K, Begum S, Le S, Sun B, Watanabe T, et al. GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism. Thromb Res. 2006;118:371–80.

Article  CAS  PubMed  Google Scholar 

Fidler IJ. Biological behavior of malignant melanoma cells correlated to their survival in vivo. Cancer Res. 1975;35:218–24.

CAS  PubMed  Google Scholar 

Stewart TJ, Abrams SI. Altered Immune function during long-term host-tumor interactions can be modulated to Retard Autochthonous neoplastic growth. J Immunol. 2007;179:2851–9.

Article  CAS  PubMed  Google Scholar 

Guy CT, Cardiff RD, Muller WJ. Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease. Mol Cell Biol. 1992;12:954–61.

CAS  PubMed  PubMed Central  Google Scholar 

Lin EY, Jones JG, Li P, Zhu L, Whitney KD, Muller WJ, et al. Progression to Malignancy in the Polyoma Middle T Oncoprotein mouse breast Cancer Model provides a Reliable Model for Human diseases. Am J Pathol. 2003;163:2113–26.

Article  PubMed  PubMed Central  Google Scholar 

Pfefferle AD, Herschkowitz JI, Usary J, Harrell JC, Spike BT, Adams JR, et al. Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts. Genome Biol. 2013;14:1–16.

Article  Google Scholar 

Attalla S, Taifour T, Bui T, Muller W. Insights from transgenic mouse models of PyMT-induced breast cancer: recapitulating human breast cancer progression in vivo. Oncogene. 2021;40:475–91.

Article  CAS  PubMed  Google Scholar 

Leunig M, Yuan F, Menger MD, Boucher Y, Goetz AE, Messmer K, et al. Angiogenesis, Microvascular Architecture, Microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. Cancer Res. 1992;52:6553–60.

CAS  PubMed  Google Scholar 

Lockyer S, Okuyama K, Begum S, Le S, Sun B, Watanabe T, et al. Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice. Blood. 2015;126:1017–26.

Article  Google Scholar 

Wendel M, Galani IE, Suri-Payer E, Cerwenka A. Natural killer cell accumulation in tumors is dependent on IFN-gamma and CXCR3 ligands. Cancer Res. 2008;68:8437–45.

Article  CAS  PubMed  Google Scholar 

Alexander WS, Roberts AW, Nicola NA, Li R, Metcalf D. Deficiencies in Progenitor cells of multiple hematopoietic lineages and defective megakaryocytopoiesis in mice lacking the Thrombopoietin receptor c-Mpl. Blood. 1996;87:2162–70.

Article  CAS  PubMed  Google Scholar 

Morowski M, Vögtle T, Kraft P, Kleinschnitz C, Stoll G, Nieswandt B. Only severe thrombocytopenia results in bleeding and defective thrombus formation in mice. Blood. 2013;121:4938–47.

Article  CAS  PubMed  Google Scholar 

Goerge T, Ho-Tin-Noe B, Carbo C, Benarafa C, Remold-O’Donnell E, Zhao BQ, et al. Inflammation induces hemorrhage in thrombocytopenia. Blood. 2008;111:4958–64.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Boulaftali Y, Hess PR, Getz TM, Cholka A, Stolla M, Mackman N, et al. Platelet ITAM signaling is critical for vascular integrity in inflammation. J Clin Invest. 2013;123:908–16.

CAS  PubMed  PubMed Central  Google Scholar 

Rayes J, Jadoui S, Lax S, Gros A, Wichaiyo S, Ollivier V, et al. The contribution of platelet glycoprotein receptors to inflammatory bleeding prevention is stimulus and organ dependent. Haematologica. 2018;103:e256–8.

Article  CAS 

留言 (0)

沒有登入
gif