Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, et al. CBTRUS Statistical Report: primary brain and other Central Nervous System tumors diagnosed in the United States in 2016–2020. Neuro Oncol. 2023;25(Supplement4):iv1–99.

Article  PubMed  Google Scholar 

Brennan CW, Verhaak RG, McKenna A, Campos B, Noushmehr H, Salama SR, et al. The somatic genomic landscape of glioblastoma. Cell. 2013;155(2):462–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Theeler BJ, Yung WK, Fuller GN, De Groot JF. Moving toward molecular classification of diffuse gliomas in adults. Neurology. 2012;79(18):1917–26.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li H, Li J, Chen L, Qi S, Yu S, Weng Z, et al. HERC3-Mediated SMAD7 ubiquitination degradation promotes Autophagy-Induced EMT and Chemoresistance in Glioblastoma. Clin Cancer Res. 2019;25(12):3602–16.

Article  CAS  PubMed  Google Scholar 

Juratli TA, Qin N, Cahill DP, Filbin MG. Molecular pathogenesis and therapeutic implications in pediatric high-grade gliomas. Pharmacol Ther. 2018;182:70–9.

Article  CAS  PubMed  Google Scholar 

Brandner S, von Deimling A. Diagnostic, prognostic and predictive relevance of molecular markers in gliomas. Neuropathol Appl Neurobiol. 2015;41(6):694–720.

Article  CAS  PubMed  Google Scholar 

Fang R, Chen X, Zhang S, Shi H, Ye Y, Shi H, et al. EGFR/SRC/ERK-stabilized YTHDF2 promotes cholesterol dysregulation and invasive growth of glioblastoma. Nat Commun. 2021;12(1):177.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liu J, Gao L, Zhan N, Xu P, Yang J, Yuan F, et al. Hypoxia induced ferritin light chain (FTL) promoted epithelia mesenchymal transition and chemoresistance of glioma. J Exp Clin Cancer Res. 2020;39(1):137.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Xu A, Wang X, Luo J, Zhou M, Yi R, Huang T, et al. Overexpressed P75CUX1 promotes EMT in glioma infiltration by activating beta-catenin. Cell Death Dis. 2021;12(2):157.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang J, Chen Y, Wang Q, Xu H, Wu C, Jiang Q, et al. MEOX2-mediated regulation of cathepsin S promotes cell proliferation and motility in glioma. Cell Death Dis. 2022;13(4):360.

Article  PubMed  PubMed Central  Google Scholar 

Guccione E, Richard S. The regulation, functions and clinical relevance of arginine methylation. Nat Rev Mol Cell Biol. 2019;20(10):642–57.

Article  CAS  PubMed  Google Scholar 

Poulard C, Corbo L, Le Romancer M. Protein arginine methylation/demethylation and cancer. Oncotarget. 2016;7(41):67532–50.

Article  PubMed  PubMed Central  Google Scholar 

Peng C, Wong CC. The story of protein arginine methylation: characterization, regulation, and function. Expert Rev Proteom. 2017;14(2):157–70.

Article  CAS  Google Scholar 

Feng J, Dang Y, Zhang W, Zhao X, Zhang C, Hou Z, et al. PTEN arginine methylation by PRMT6 suppresses PI3K-AKT signaling and modulates pre-mRNA splicing. Proc Natl Acad Sci U S A. 2019;116(14):6868–77.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bedford MT, Clarke SG. Protein arginine methylation in mammals: who, what, and why. Mol Cell. 2009;33(1):1–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Blanc RS, Richard S. Arginine methylation: the coming of Age. Mol Cell. 2017;65(1):8–24.

Article  CAS  PubMed  Google Scholar 

Hyllus D, Stein C, Schnabel K, Schiltz E, Imhof A, Dou Y, et al. PRMT6-mediated methylation of R2 in histone H3 antagonizes H3 K4 trimethylation. Genes Dev. 2007;21(24):3369–80.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Waldmann T, Izzo A, Kamieniarz K, Richter F, Vogler C, Sarg B, et al. Methylation of H2AR29 is a novel repressive PRMT6 target. Epigenetics Chromatin. 2011;4:11.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Casadio F, Lu X, Pollock SB, LeRoy G, Garcia BA, Muir TW, et al. H3R42me2a is a histone modification with positive transcriptional effects. Proc Natl Acad Sci U S A. 2013;110(37):14894–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chan LH, Zhou L, Ng KY, Wong TL, Lee TK, Sharma R, et al. PRMT6 regulates RAS/RAF binding and MEK/ERK-Mediated Cancer Stemness activities in Hepatocellular Carcinoma through CRAF methylation. Cell Rep. 2018;25(3):690–701. e8.

Article  CAS  PubMed  Google Scholar 

Guccione E, Bassi C, Casadio F, Martinato F, Cesaroni M, Schuchlautz H, et al. Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive. Nature. 2007;449(7164):933–7.

Article  CAS  PubMed  Google Scholar 

Kirmizis A, Santos-Rosa H, Penkett CJ, Singer MA, Vermeulen M, Mann M, et al. Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation. Nature. 2007;449(7164):928–32.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bouchard C, Sahu P, Meixner M, Notzold RR, Rust MB, Kremmer E, et al. Genomic location of PRMT6-Dependent H3R2 methylation is linked to the Transcriptional Outcome of Associated genes. Cell Rep. 2018;24(12):3339–52.

Article  CAS  PubMed  Google Scholar 

Schneider L, Herkt S, Wang L, Feld C, Wesely J, Kuvardina ON, et al. PRMT6 activates cyclin D1 expression in conjunction with the transcription factor LEF1. Oncogenesis. 2021;10(5):42.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Di Lorenzo A, Yang Y, Macaluso M, Bedford MT. A gain-of-function mouse model identifies PRMT6 as a NF-kappaB coactivator. Nucleic Acids Res. 2014;42(13):8297–309.

Article  PubMed  PubMed Central  Google Scholar 

Harrison MJ, Tang YH, Dowhan DH. Protein arginine methyltransferase 6 regulates multiple aspects of gene expression. Nucleic Acids Res. 2010;38(7):2201–16.

Article  CAS  PubMed  PubMed Central  Google Scholar 

El-Andaloussi N, Valovka T, Toueille M, Hassa PO, Gehrig P, Covic M, et al. Methylation of DNA polymerase beta by protein arginine methyltransferase 1 regulates its binding to proliferating cell nuclear antigen. FASEB J. 2007;21(1):26–34.

Article  CAS  PubMed  Google Scholar 

Wong TL, Ng KY, Tan KV, Chan LH, Zhou L, Che N, et al. CRAF methylation by PRMT6 regulates aerobic glycolysis-driven Hepatocarcinogenesis via ERK-Dependent PKM2 Nuclear relocalization and activation. Hepatology. 2020;71(4):1279–96.

Article  CAS  PubMed  Google Scholar 

Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, et al. The Arginine methyltransferase PRMT6 regulates DNA methylation and contributes to global DNA hypomethylation in Cancer. Cell Rep. 2017;21(12):3390–7.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Almeida-Rios D, Graca I, Vieira FQ, Ramalho-Carvalho J, Pereira-Silva E, Martins AT, et al. Histone methyltransferase PRMT6 plays an oncogenic role of in prostate cancer. Oncotarget. 2016;7(33):53018–28.

Article  PubMed  PubMed Central  Google Scholar 

Yoshimatsu M, Toyokawa G, Hayami S, Unoki M, Tsunoda T, Field HI, et al. Dysregulation of PRMT1 and PRMT6, type I arginine methyltransferases, is involved in various types of human cancers. Int J Cancer. 2011;128(3):562–73.

Article  CAS  PubMed  Google Scholar 

Huang T, Yang Y, Song X, Wan X, Wu B, Sastry N, et al. PRMT6 methylation of RCC1 regulates mitosis, tumorigenicity, and radiation response of glioblastoma stem cells. Mol Cell. 2021;81(6):1276–e919.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen Z, Gan J, Wei Z, Zhang M, Du Y, Xu C, et al. The emerging role of PRMT6 in Cancer. Front Oncol. 2022;12:841381.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Limm K, Ott C, Wallner S, Mueller DW, Oefner P, Hellerbrand C, et al. Deregulation of protein methylation in melanoma. Eur J Cancer. 2013;49(6):1305–13.

Article  CAS  PubMed  Google Scholar