Zeng F, Nijiati S, Liu Y, Yang Q, Liu X, Zhang Q, et al. Ferroptosis MRI for early detection of anticancer drug–induced acute cardiac/kidney injuries. Sci Adv. 2023;9. https://doi.org/10.1126/sciadv.add8539.

Zhang D, Xu Q, Wang N, Yang Y, Liu J, Yu G, et al. A complex micellar system co-delivering curcumin with doxorubicin against cardiotoxicity and tumor growth. Int J Nanomed. 2018;13:4549–61. https://doi.org/10.2147/ijn.S170067.

Article  Google Scholar 

Force T, Kolaja KL. Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes. Nat Rev Drug Discovery. 2011;10:111–26. https://doi.org/10.1038/nrd3252.

Article  CAS  PubMed  Google Scholar 

Chang H-M, Moudgil R, Scarabelli T, Okwuosa TM, Yeh ETH. Cardiovascular Complications of Cancer Therapy. J Am Coll Cardiol. 2017;70:2536–51. https://doi.org/10.1016/j.jacc.2017.09.1096.

Article  PubMed  PubMed Central  Google Scholar 

Ewer MS, Ewer SM. Cardiotoxicity of anticancer treatments. Nat Rev Cardiol. 2015;12:547–58. https://doi.org/10.1038/nrcardio.2015.65.

Article  CAS  PubMed  Google Scholar 

Galán-Arriola C, Lobo M, Vílchez-Tschischke JP, López GJ, de Molina-Iracheta A, Pérez-Martínez C, et al. Serial magnetic resonance imaging to identify early stages of anthracycline-induced cardiotoxicity. J Am Coll Cardiol. 2019;73:779–91. https://doi.org/10.1016/j.jacc.2018.11.046.

Article  PubMed  Google Scholar 

Zhan H, Aizawa K, Sun J, Tomida S, Otsu K, Conway SJ, et al. Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity. Cardiovasc Res. 2016;110:85–95. https://doi.org/10.1093/cvr/cvw032.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Govender J, Loos B, Marais E, Engelbrecht AM. Mitochondrial catastrophe during doxorubicin-induced cardiotoxicity: a review of the protective role of melatonin. J Pineal Res. 2014;57:367–80. https://doi.org/10.1111/jpi.12176.

Article  CAS  PubMed  Google Scholar 

Farhad H, Staziaki PV, Addison D, Coelho-Filho OR, Shah RV, Mitchell RN, et al. Characterization of the changes in cardiac structure and function in mice treated with anthracyclines using serial cardiac magnetic resonance imaging. Circ: Cardiovasc Imaging. 2016:9. https://doi.org/10.1161/circimaging.115.003584.

Sobczuk P, Czerwińska M, Kleibert M, Cudnoch-Jędrzejewska A. Anthracycline-induced cardiotoxicity and renin-angiotensin-aldosterone system—from molecular mechanisms to therapeutic applications. Heart Fail Rev. 2020;27:295–319. https://doi.org/10.1007/s10741-020-09977-1.

Article  CAS  PubMed Central  Google Scholar 

Hiona A, Lee AS, Nagendran J, Xie X, Connolly AJ, Robbins RC, et al. Pretreatment with angiotensin-converting enzyme inhibitor improves doxorubicin-induced cardiomyopathy via preservation of mitochondrial function. J Thorac Cardiovasc Surg. 2011;142:396-403.e3. https://doi.org/10.1016/j.jtcvs.2010.07.097.

Article  CAS  PubMed  Google Scholar 

Abd El-Aziz MA, Othman AI, Amer M, El-Missiry MA. Potential protective role of angiotensin-converting enzyme inhibitors captopril and enalapril against adriamycin-induced acute cardiac and hepatic toxicity in rats. J Appl Toxicol. 2001;21:469–73. https://doi.org/10.1002/jat.782.

Article  CAS  PubMed  Google Scholar 

Zhao S. Letter to the editor: is it time for imaging to level with pathology? Int J Cardiovasc Imaging. 2020;36:2249–50. https://doi.org/10.1007/s10554-020-01936-z.

Article  PubMed  Google Scholar 

Lu M, Zhu L, Prasad SK, Zhao S. Magnetic resonance imaging mimicking pathology detects myocardial fibrosis: a door to hope for improving the whole course management. Science Bulletin. 2023;68:864–7. https://doi.org/10.1016/j.scib.2023.04.014.

Article  ADS  PubMed  Google Scholar 

Shaikh AY, Shih JA. Chemotherapy-induced cardiotoxicity. Curr Heart Fail Rep. 2012;9:117–27. https://doi.org/10.1007/s11897-012-0083-y.

Article  CAS  PubMed  Google Scholar 

Meléndez GC, Jordan JH, D’Agostino RB, Lesnefsky EJ, Hundley WG. Accelerated left ventricular interstitial collagen deposition after receiving doxorubicin in hypertension. J Am Coll Cardiol. 2018;72:1555–7. https://doi.org/10.1016/j.jacc.2018.07.028.

Article  PubMed  PubMed Central  Google Scholar 

Ferreira de Souza T, Quinaglia A.C. Silva T, Osorio Costa F, Shah R, Neilan TG, Velloso L, et al. Anthracycline therapy is associated with cardiomyocyte atrophy and preclinical manifestations of heart disease. JACC Cardiovasc Imaging. 2018;11:1045–55. https://doi.org/10.1016/j.jcmg.2018.05.012.

Mayola MF, Thackeray JT. The potential of fibroblast activation protein-targeted imaging as a biomarker of cardiac remodeling and injury. Curr Cardiol Rep. 2023;25:515–23. https://doi.org/10.1007/s11886-023-01869-8.

Article  PubMed  PubMed Central  Google Scholar 

Ivey MJ, Tallquist MD. Defining the cardiac fibroblast. Circ J. 2016;80:2269–76. https://doi.org/10.1253/circj.CJ-16-1003.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kratochwil C, Flechsig P, Lindner T, Abderrahim L, Altmann A, Mier W, et al. 68Ga-FAPI PET/CT: tracer uptake in 28 different kinds of cancer. J Nucl Med. 2019;60:801–5. https://doi.org/10.2967/jnumed.119.227967.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen B-X, Xing H-Q, Gong J-N, Guo X-J, Xi X-Y, Yang Y-H, et al. Imaging of cardiac fibroblast activation in patients with chronic thromboembolic pulmonary hypertension. Eur J Nucl Med Mol Imaging. 2021;49:1211–22. https://doi.org/10.1007/s00259-021-05577-9.

Article  CAS  PubMed  Google Scholar 

Song W, Zhang X, He S, Gai Y, Qin C, Hu F, et al. (68)Ga-FAPI PET visualize heart failure: from mechanism to clinic. Eur J Nucl Med Mol Imaging. 2022. https://doi.org/10.1007/s00259-022-05994-4.

Article  PubMed  PubMed Central  Google Scholar 

Varasteh Z, Mohanta S, Robu S, Braeuer M, Li Y, Omidvari N, et al. Molecular imaging of fibroblast activity after myocardial infarction using a (68)Ga-labeled fibroblast activation protein inhibitor, FAPI-04. J Nucl Med. 2019;60:1743–9. https://doi.org/10.2967/jnumed.119.226993.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Totzeck M, Siebermair J, Rassaf T, Rischpler C. Cardiac fibroblast activation detected by positron emission tomography/computed tomography as a possible sign of cardiotoxicity. Eur Heart J. 2020;41:1060. https://doi.org/10.1093/eurheartj/ehz736.

Article  PubMed  Google Scholar 

Xie B, Li L, Lin M, Nanna M, Su Y, Hua C, et al. 99mTc-HFAPi imaging identifies early myocardial fibrosis in the hypertensive heart. J Hypertens. 2023. https://doi.org/10.1097/hjh.0000000000003517.

Article  PubMed  PubMed Central  Google Scholar 

Luo W, Zou X, Wang Y, Dong Z, Weng X, Pei Z, et al. Critical role of the cGAS-STING pathway in doxorubicin-induced cardiotoxicity. Circ Res. 2023:132. https://doi.org/10.1161/circresaha.122.321587.

Meng C, Fan L, Wang X, Wang Y, Li Y, Pang S, et al. Preparation and evaluation of animal models of cardiotoxicity in antineoplastic therapy. Oxid Med Cell Longev. 2022;2022:1–16. https://doi.org/10.1155/2022/3820591.

Article  CAS  Google Scholar 

Fan Y, Liang L, Tang X, Zhu J, Mu L, Wang M, et al. Changes in the gut microbiota structure and function in rats with doxorubicin-induced heart failure. Front Cell Infect Microbiol. 2023:13. https://doi.org/10.3389/fcimb.2023.1135428.

Xiao F, Jiang H, Li Z, Jiang X, Chen S, Niu Y, et al. Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice. Nat Commun. 2023:14. https://doi.org/10.1038/s41467-023-38141-0.

Leuschner F, Panizzi P, Chico-Calero I, Lee WW, Ueno T, Cortez-Retamozo V, et al. Angiotensin-converting enzyme inhibition prevents the release of monocytes from their splenic reservoir in mice with myocardial infarction. Circ Res. 2010;107:1364–73. https://doi.org/10.1161/circresaha.110.227454.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang G, Yang Q, Wu S, Xu X, Li X, Liang S, et al. Molecular imaging of fibroblast activity in pressure overload heart failure using [(68) Ga]Ga-FAPI-04 PET/CT. Eur J Nucl Med Mol Imaging. 2022. https://doi.org/10.1007/s00259-022-05984-6.

Article  PubMed  PubMed Central  Google Scholar 

Sun F, Wang C, Feng H, Yu F, Zhang X, Zhang P, et al. Visualization of activated fibroblasts in heart failure with preserved ejection fraction with [18F]AlF-NOTA-FAPI-04 PET/CT imaging. Mol Pharm. 2023;20:2634–41. https://doi.org/10.1021/acs.molpharmaceut.3c00075.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hu S, Gao Y, Gao R, Wang Y, Qu Y, Yang J, et al. The selective STING inhibitor H-151 preserves myocardial function and ameliorates cardiac fibrosis in murine myocardial infarction. Int Immunopharmacol. 2022;107: 108658. https://doi.org/10.1016/j.intimp.2022.108658.

Article  CAS  PubMed  Google Scholar 

Xu R, Ding Z, Li H, Shi J, Cheng L, Xu H, et al. Identification of early cardiac dysfunction and heterogeneity after pressure and volume overload in mice by high-frequency echocardiographic strain imaging. Front Cardiovasc Med. 2023:9. https://doi.org/10.3389/fcvm.2022.1071249.

Kourek C, Touloupaki M, Rempakos A, Loritis K, Tsougkos E, Paraskevaidis I, et al. Cardioprotective strategies from cardiotoxicity in cancer patients: a comprehensive review. J Cardiovasc Dev Dis. 2022:9. https://doi.org/10.3390/jcdd9080259.

Miller KD, Nogueira L, Devasia T, Mariotto AB, Yabroff KR, Jemal A, et al. Cancer treatment and survivorship statistics, 2022. CA: A Cancer J Clin. 2022:72:409–36. https://doi.org/10.3322/caac.21731.

Shan K. Anthracycline-induced cardiotoxicity. Ann Int Med. 1996:125. https://doi.org/10.7326/0003-4819-125-1-199607010-00008.

McGowan JV, Chung R, Maulik A, Piotrowska I, Walker JM, Yellon DM. Anthracycline chemotherapy and cardiotoxicity. Cardiovasc Drugs Ther. 2017;31:63–75. https://doi.org/10.1007/s10557-016-6711-0.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cardinale D, Colombo A, Lamantia G, Colombo N, Civelli M, De Giacomi G, et al. Anthracycline-induced cardiomyopathy. J Am Coll Cardiol. 2010;55:213–20. https://doi.org/10.1016/j.jacc.2009.03.095.

Article  CAS  PubMed  Google Scholar 

Tan TC, Scherrer-Crosbie M. Assessing the cardiac toxicity of chemotherapeutic agents: role of echocardiography. Current Cardiovascular Imaging Reports. 2012;5:403–9. https://doi.org/10.1007/s12410-012-9163-3.