1

F

72

Dysphagia, right otalgia, weight loss (>6kg in 3 months)

HT, DB2, CD, RTU

Current ATC

Trismus, normal tongue mobility,

Exophytic lesion of the lateral oropharyngeal wall (right)

Right neck node

MRI, PET–CT, endoscopy

Biopsies: SCC

cT4aN2bM0

OSCC

Primary: radiotherapy

Alternative: surgery, free flap, postoperative RT

2

M

45

Dysphonia (2 months)

Radiotherapy for cT1N0 of the glottic region (4y), Past TC

Anterior commissure lesion, decreased movement of vocal folds

Neck CT, PET–CT

Endoscopy, biopsy: LSCC

cT3N0M0

LSCC

Thyroid cartilage invasion

Primary: CHEP only

Alternative: CTh/immunotherapy

3

M

75

Dysphonia, neck pain, dysphagia, weight loss (> 5kg in 3 months)

CP, HT, DB2, current

ATC, RT for cT1N0 glottic LSCC (4 years)

Fixed right hemilarynx

No exophytic lesion

Neck CT, PET–CT, endoscopy

Biopsies: SCC

cT3N0M0

LSCC

Primary: total laryngectomy

Alternative: CTh/immunotherapy.

4

M

55

Dysphonia (2 months)

HT, current TC

TLM for cT1a glottis

LSCC (6 months)

Exophytic lesion of the right vocal cord

Normal laryngeal mobility

Neck CT and PET–CT

No biopsy regarding morphological lesion

cT1aN0M0

LSCC (recurrence)

Primary: TLM or RT

Alternative: –

5

M

56

Dysphagia (6 months)

Current TC

Exophytic lesion of right ary—epiglottic fold and epiglottis

Normal vocal cord exam

Neck CT, PET–CT

Endoscopy, biopsy: LSCC

cT2N1M0

Supraglottic LSCC

Primary: TORS supraglottic laryngectomy and neck dissections or RT

Alternative: –

6

F

56

Throat pain, globus (6 months)

Thyroidectomy (1 year) for medullar cancer, bilateral neck dissection

Right oropharyngeal wall mass

Neck MRI, PET–CT

Calcitonin biology

Neck recurrence of medullar thyroid cancer (parapharyngeal space)

Primary: TORS node surgery, or targeted therapy

Alternative: CTh

7

M

75

Throat pain, dysphagia, weight loss (>7kg–3 months)

HT, current ATC

RT for cT2N2 OSCC (5 years)

Left oropharyngeal wall exophytic lesion, ipsilateral neck nodes

Neck MRI, PET–CT, endoscopy

Biopsies: SCC

cT4aN2M1

OSCC spinal bone metastases

Primary: chemotherapy

Alternative: immunotherapy bone radiation

8

F

70

Dysphagia, throat pain (3 months)

HT, no ATC

Right base of tongue ulcerative lesion

Neck MRI, PET–CT, endoscopy

Biopsies: SCC

cT2N0M0

OSCC

Primary: TORS and ipsi-lateral neck dissection or RT

Alternative: CTh

9

M

70

Dysphonia (4 months)

Current TC

Radiotherapy for cT3

Supraglottic cancer

Exophytic lesion of the left vocal cord and anterior commissure of the larynx

Neck CT, PET–CT, endoscopy

cT2N0M0

Supraglottic LSCC (recurrence)

Primary: partial laryngectomy

Alternative: CTh/immunotherapy.

10

M

50

Neck mass (6 months)

None

Right neck node 2cm

Endoscopy: normal

Neck MRI, PET–CT, endoscopy

Fine-needle aspiration biopsy

cTxN1M0

SCC

Primary: TORS tonsillectomy Neck dissection, no post-RT or RT

Alternative: CTh

11

F

49

Throat pain (4 months)

None

Ulceration lesion in left tonsil and left neck adenopathy

Neck MRI, PET–CT

Biopsies: SCC

HPV detection

cT2N1M0

OSCC

cT2N0M0

Primary: TORS tonsillectomy neck dissection, no post-RT or RT

Alternative: CTh

12

M

62

Left parotid gland nodules

HT, left superficial parotidectomy for pleomorphic adenoma (10 years)

Left parotid node, no facial palsy, no adenopathy

Neck MRI

Fine-needle aspiration biopsy

HPV detection

Parotid carcinoma

Primary: parotidectomy neck dissection, postoperative RT or RT

Alternative: CRT

13

F

55

Right facial nerve paralysis, nodules (3 weeks)

Parotidectomy and RT for a right adeno-carcinoma (4 years)

Right facial nerve paralysis Parotid region nodules

No lymph adenopathy

Neck MRI, PET–CT

Chest CT

Fine-needle aspiration biopsy

cT1N0M0

Recurrence of Adenocarcinoma

Primary: parotidectomy free flap, reinnervation

Alternative: CTh/immunotherapy.

14

M

55

Right EU-Tirads 5 thyroid nodule (8 months)

None

Normal, endoscopy normal

No vocal fold paralysis

Fine-needle aspiration biopsy

Ultrasonography

cT1N0M0

papillary carcinoma

Primary: lobectomy

Alternative: iodine

15

M

55

Right sublingual gland nodule (6 months)

HT, current TC

Right sublingual nodule, Examination: normal

Neck MRI

Fine-needle aspiration

cT1N0M0 muco-epidermoid carcinoma

Primary: sublingual surgery, low grade cancer, no postoperative RT

Alternative: RT

16

F

51

Oral cavity pain, and tongue ulceration (6 months)

Current TC

Right tongue ulceration of 1cm (latero-posterior)

Neck/oral MRI, PET–CT

Endoscopy and biopsy

cT1N0M0

Oral SCC

Primary: partial glossectomy Sentinel node dissection or RT

Alternative: CTh

17

M

53

Oral cavity pain, ulceration of inferior tongue part and oral cavity floor (7 months)

HT, current ATC

Left tongue and oral cavity floor lesion, left neck nodes

Neck MRI, CT, PET–CT

Biopsies: SCC

HPV detection

cT2N2aM0

Oral SCC

Primary: partial glossectomy, neck dissection, FAMM, or RT

Alternative: CTh

18

F

45

Epistaxis, diplopia, Right deafness, neck nodes (5 months)

None

Right exophytic nasopharyngeal lesion and right chronic otitis

Multiple cervical nodes

MRI, Neck CT, PET–CT

Biopsy

Audiometry, tympanometry

cT4N2cM0

UCNT

Primary: induction CTh and CRT

Alternative: CRT

19

F

58

Aphagia, weight loss throat pain (6 months)

Past TC, CRT for a cT4N2M0 HSCC (2 years)

Laryngopharyngeal edema and saliva, no neck node

Neck CT, MRI, PET–CT

Biopsies: SCC

pT2N0M0

HLSCC (recurrence)

Primary: salvage pharyngo-laryngectomy and neck dissections

Alternative: CTh/immunotherapy.

20

M

67

Unilateral epistaxis and obstruction, diplopia

HT

Exophytic lesion in right nasal cavity, no neck node

Nasal CT, MRI, PET–CT

Biopsy

cT2N0M0

Ethmoid Intestinal-type

Adenocarcinoma

Primary: endoscopic nasal surgery, postoperative RT

Alternative: CRT