Pinho, S. & Frenette, P. S. Haematopoietic stem cell activity and interactions with the niche. Nat. Rev. Mol. Cell Biol. 20, 303–320 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tokoyoda, K., Hauser, A. E., Nakayama, T. & Radbruch, A. Organization of immunological memory by bone marrow stroma. Nat. Rev. Immunol. 10, 193–200 (2010).

Article  CAS  PubMed  Google Scholar 

Barreyro, L., Chlon, T. M. & Starczynowski, D. T. Chronic immune response dysregulation in MDS pathogenesis. Blood 132, 1553–1560 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mei, Y. et al. Bone marrow-confined IL-6 signaling mediates the progression of myelodysplastic syndromes to acute myeloid leukemia. J. Clin. Invest. 132, e152673 (2022). This study identifies IL-6 as an essential factor mediating progression of MDS to AML in a mouse model.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carey, A. et al. Identification of interleukin-1 by functional screening as a key mediator of cellular expansion and disease progression in acute myeloid leukemia. Cell Rep. 18, 3204–3218 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dosani, T. et al. Host-related immunodeficiency in the development of multiple myeloma. Leuk. Lymphoma 59, 1127–1132 (2018).

Article  PubMed  Google Scholar 

Zavidij, O. et al. Single-cell RNA sequencing reveals compromised immune microenvironment in precursor stages of multiple myeloma. Nat. Cancer 1, 493–506 (2020). This study identifies the changes in NK cells, memory T cells and monocytes in the bone marrow of individuals with precursor stages of MM.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brück, O. et al. Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival. Blood Adv. 4, 274–286 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Deb, G., Cicala, A., Papadas, A. & Asimakopoulos, F. Matrix proteoglycans in tumor inflammation and immunity. Am. J. Physiol. Cell Physiol. 323, C678–C693 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pirillo, C. et al. Metalloproteinase inhibition reduces AML growth, prevents stem cell loss, and improves chemotherapy effectiveness. Blood Adv. 6, 3126–3141 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Goselink, H. M., Willemze, R. & Falkenburg, J. H. F. Tumor necrosis factor alpha (TNFα) production by acute myeloid leukemic (AML) blasts results in impaired proliferation of normal hematopoietic progenitor cells (HPC). Exp. Hematol. 28, 69–70 (2000).

Article  Google Scholar 

Corradi, G. et al. Release of IFNγ by acute myeloid leukemia cells remodels bone marrow immune microenvironment by inducing regulatory T cells. Clin. Cancer Res. 28, 3141–3155 (2022).

Article  CAS  PubMed  Google Scholar 

Young, D. C. & Griffin, J. D. Autocrine secretion of GM-CSF in acute myeloblastic leukemia. Blood 68, 1178–1181 (1986).

Article  CAS  PubMed  Google Scholar 

Medzhitov, R. The spectrum of inflammatory responses. Science 374, 1070–1075 (2021).

Article  CAS  PubMed  Google Scholar 

Naik, S., Larsen, S. B., Cowley, C. J. & Fuchs, E. Two to tango: dialog between immunity and stem cells in health and disease. Cell 175, 908–920 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cosgrove, J., Hustin, L. S. P., de Boer, R. J. & Perié, L. Hematopoiesis in numbers. Trends Immunol. 42, 1100–1112 (2021).

Article  CAS  PubMed  Google Scholar 

Méndez-Ferrer, S. et al. Bone marrow niches in haematological malignancies. Nat. Rev. Cancer 20, 285–298 (2020).

Article  PubMed  PubMed Central  Google Scholar 

Beerman, I., Luis, T. C., Singbrant, S., Celso, C. L. & Méndez-Ferrer, S. The evolving view of the hematopoietic stem cell niche. Exp. Hematol. 50, 22–26 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Reynaud, D. et al. IL-6 controls leukemic multipotent progenitor cell fate and contributes to chronic myelogenous leukemia development. Cancer Cell 20, 661–673 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bernitz, J. M., Daniel, M. G., Fstkchyan, Y. S. & Moore, K. Granulocyte colony-stimulating factor mobilizes dormant hematopoietic stem cells without proliferation in mice. Blood 129, 1901–1912 (2017).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Orelio, C., Haak, E., Peeters, M. & Dzierzak, E. Interleukin-1–mediated hematopoietic cell regulation in the aorta-gonad-mesonephros region of the mouse embryo. Blood 112, 4895–4904 (2008).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mendelson, A. & Frenette, P. S. Hematopoietic stem cell niche maintenance during homeostasis and regeneration. Nat. Med. 20, 833–846 (2014).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fujisaki, J. et al. In vivo imaging of Treg cells providing immune privilege to the haematopoietic stem-cell niche. Nature 474, 216–219 (2011).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zehentmeier, S. et al. Static and dynamic components synergize to form a stable survival niche for bone marrow plasma cells. Eur. J. Immunol. 44, 2306–2317 (2014). In this study, imaging of mouse bone marrow reveals stromal cell niches for plasma cells and provides evidence for a contribution of neutrophil-derived signals.

Article  CAS  PubMed  Google Scholar 

Tokoyoda, K., Egawa, T., Sugiyama, T., Choi, B. I. & Nagasawa, T. Cellular niches controlling B lymphocyte behavior within bone marrow during development. Immunity 20, 707–718 (2004).

Article  CAS  PubMed  Google Scholar 

Jourdan, M. et al. IL-6 supports the generation of human long-lived plasma cells in combination with either APRIL or stromal cell-soluble factors. Leukemia 28, 1647–1656 (2014). This study identifies essential roles for IL-6 and APRIL in the generation and maintenance of long-lived plasma cells.

Article  CAS  PubMed  Google Scholar 

Chu, V. T. et al. Eosinophils are required for the maintenance of plasma cells in the bone marrow. Nat. Immunol. 12, 151–159 (2011). This study establishes the importance of eosinophils for plasma cell retention and survival in the bone marrow.

Article  CAS  PubMed  Google Scholar 

Matthes, T. et al. Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow. Blood 118, 1838–1844 (2011).

Article  CAS  PubMed  Google Scholar 

Cheng, Q. et al. CXCR4-CXCL12 interaction is important for plasma cell homing and survival in NZB/W mice. Eur. J. Immunol. 48, 1020–1029 (2018).

Article  CAS  PubMed  Google Scholar 

Kennel, K. B., Bozlar, M., De Valk, A. F. & Greten, F. R. Cancer-associated fibroblasts in inflammation and antitumor immunity. Clin. Cancer Res. 29, 1009–1016 (2023).

Article  CAS  PubMed  Google Scholar 

Sahai, E. et al. A framework for advancing our understanding of cancer-associated fibroblasts. Nat. Rev. Cancer 20, 174–186 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen, S. et al. Massive parallel RNA sequencing of highly purified mesenchymal elements in low-risk MDS reveals tissue-context-dependent activation of inflammatory programs. Leukemia 30, 1938–1942 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Balderman, S. R. et al. Targeting of the bone marrow microenvironment improves outcome in a murine model of myelodysplastic syndrome. Blood 127, 616–625 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Schepers, K. et al. Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell 13, 285–299 (2013).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Raaijmakers, M. H. et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 464, 852–857 (2010). This paper establishes the concept of stromal niche-induced oncogenesis in the haematopoietic system in mouse models.

Article  CAS  PubMed  PubMed Central