Abirami A, Nagarani G, Siddhuraju P (2014) In vitro antioxidant, anti-diabetic, cholinesterase and tyrosinase inhibitory potential of fresh juice from Citrus hystrix and C. maxima fruits. Food Sci Hum Wellness 3:16–25

Google Scholar 

Agnel AJN, Shobana G, Keerthana K (2018) Wound healing efficacy of herbal ointment containing Oldenlandia herbacea Roxb. on excision wounded animals. Int Res J Pharmacol 9:95–99

CAS  Google Scholar 

Aguiar AA, Bastos EGP, Soares IM et al (2020) Antiproliferative effect of Amburana cearensis seed extracts on human cancer cell lines. Afr J Biotechnol 19:56–64

Google Scholar 

Ahamad SH, Norio A, Nordin HJ (1996) Constituents of Hedyotis herbacea. Biochem Syst Ecol 24:273

Google Scholar 

Ahmad R, Ali AM, Israf DA et al (2005) Antioxidant, radical-scavenging, anti-inflammatory, cytotoxic and antibacterial activities of methanolic extracts of some Hedyotis species. Life Sci 76:1953–1964

CAS  PubMed  Google Scholar 

Ahmad R, Shaari K, Lajis NH et al (2005) Anthraquinones from Hedyotis capitellata. Phytochemistry 66:1141–1147

CAS  PubMed  Google Scholar 

Al Bashera M, Mosaddik A, El-Saber Batiha G et al (2021) In vivo and in vitro evaluation of preventive activity of inflammation and free radical scavenging potential of plant extracts from Oldenlandia corymbosa L. Appl Sci 11:9073

CAS  Google Scholar 

Al-Shuhaib MBS, Hashim HO, Al-Shuhaib JMB, Obayes DH (2022) Artecanin of Laurus nobilis is a novel inhibitor of SARS-CoV-2 main protease with highly desirable druglikeness. J Biomol Struct Dyn 41:2355–2367

PubMed  Google Scholar 

Anbarasu K, Manisenthil KKT, Ramachandran S (2011) Antipyretic, anti-inflammatory and analgesic properties of nilavembu kudineer choornam: a classical preparation used in the treatment of chikungunya fever. Asian Pac J Trop Med 4:819–823

CAS  PubMed  Google Scholar 

Anh NTH, Tam KT, Van Tuan N et al (2019) Chemical constituents of Hedyotis ampliflora. Chem Nat Compd 55:379–381

CAS  Google Scholar 

Anuja GI, Shine VJ, Suja SR (2018) In vitro anti-inflammatory and free radical scavenging properties of Oldenlandia auricularia. Toxicol Environ Chem 100:573–582

CAS  Google Scholar 

Archana V, Thomas NN, Rauf AA, Edwin BT (2020) Fatty acid derivative of methanol extract of Oldenlandia corymbosa: a potential compound against K. pneuminiae and mcf-cell lines. Int J Res Appl Sci Biotechnol 7:46–52

Google Scholar 

Archana V, Thomas NN, Lakshmi S et al (2021) Pharmaceutical properties of Oldenlandia corymbosa Linn. Mater Today Proc 41:698–702

CAS  Google Scholar 

Artanti N, Hanafi M, Andriyani R et al (2015) Isolation of an anti-cancer asperuloside from Hedyotis corymbosa L. J Trop Life Sci 5:88–91

Google Scholar 

Arun P, Purushotham KG, Jayarani J, Kumari V (2010) Invitro antibacterial activity of oldenlandia umbellata an Indian medicinal plant. J Pharm Sci Technol 2:198–201

Google Scholar 

Attah FA, Mbanu AE, Chukwudulue UM et al (2022) Ethnopharmacology, phytochemistry and a new chemotaxonomic marker in Oldenlandia affinis (Roem. & Schult.) DC. Rubiaceae. Phys Sci Rev. https://doi.org/10.1515/psr-2021-0196

Aziz MA, Nime MJ, Rahman MH et al (2023) Studies on antioxidant and antineoplastic potentials of Oldenlandia corymbosa Linn. leaves. J Fundam Appl Pharm Sci 3:83–98

Google Scholar 

Babu KA, Sivakrishnan S, Jasemine S (2023) Determination of allyl isothiocyanate from Hedyotis herbacea and its in silico screening for wound healing activity. Trop J Pharm Res 22:383–388

CAS  Google Scholar 

Banerjee A, Sane R, Mangaonkar K et al (2006) Quantitation of oleanolic acid in Oldenlandia corymbosa L. whole-plant powder by high-performance thin-layer chromatography. JPC-J Planar Chromat TLC 19:68–72

CAS  Google Scholar 

Bazan HA, Bhattacharjee S, Burgos C et al (2020) A novel pipeline of 2-(benzenesulfonamide)-N-(4-hydroxyphenyl) acetamide analgesics that lack hepatotoxicity and retain antipyresis. Eur J Med Chem 202:112600

CAS  PubMed  PubMed Central  Google Scholar 

Behera SK, Rajasekaran C, Payas S et al (2018) In vitro flowering in Oldenlandia umbellata L. J Ayurveda Integr Med 9:99–103

PubMed  Google Scholar 

Braun DE, Bhardwaj RM, Florence AJ et al (2013) Complex polymorphic system of gallic acid five monohydrates, three anhydrates, and over 20 solvates. Cryst Growth Des 13:19–23

CAS  PubMed  Google Scholar 

Cai Q, Lin J, Wei L et al (2012) Hedyotis diffusa Willd inhibits colorectal cancer growth in vivo via inhibition of STAT3 signaling pathway. Int J Mol Sci 13:6117–6128

CAS  PubMed  PubMed Central  Google Scholar 

Chan EWC, Soon CY, Tan JBL et al (2019) Ursolic acid: an overview on its cytotoxic activities against breast and colorectal cancer cells. J Integr Med 17:155–160

PubMed  Google Scholar 

Chang C-H, Lin C-H, Liu C-Y et al (2020) Efficacy and cognitive effect of sarcosine (N-methylglycine) in patients with schizophrenia: a systematic review and meta-analysis of double-blind randomised controlled trials. J Psychopharmacol 34:495–505

PubMed  Google Scholar 

Chang YS, Ho Y-L, Wu H-Y, Wu K-C (2023) Comparative study of Scleromitrion diffusum and Oldenlandia corymbosa: microscopy, TLC, HPLC and antioxidant activity. Authorea Prepr. https://doi.org/10.22541/au.167507110.03147176/v1

Chattopadhyay R (2003) Possible mechanism of hepatoprotective activity of Azadirachta indica leaf extract: part II. J Ethnopharmacol 89:217–219

CAS  PubMed  Google Scholar 

Chellappan BM, Venkatachalam G, Reddy CU et al (2022) GC-MS Profiling and in vitro assessment of antioxidant and neuroprotective properties of ethanolic and acetone extracts of Oldenlandia corymbosa L. Asian J Biol Life Sci 11:189

Google Scholar 

Chen W (2005) Extracting and identifying of ursolic acid from Hedyotis corymbosa Lam. Jiangxi Shifan Daxue Xuebao. Ziran Kexueban 29:126–128

CAS  Google Scholar 

Chen J-Y, Lin C-C, Namba T (1992) Development of natural crude drug resources from Taiwan (X) Pharmacognostical studies on the Chinese crude drug “Han-lian-cao.” Am J Chin Med 20:51–64

CAS  PubMed  Google Scholar 

Chen Y-H, Chang F-R, Wu C-C et al (2006) New cytotoxic 6-oxygenated 8, 9-dihydrofurocoumarins, hedyotiscone A-C, from Hedyotis biflora. Planta Med 72:75–78

CAS  PubMed  Google Scholar 

Chen X-Z, Cao Z-Y, Chen T-S et al (2012) Water extract of Hedyotis Diffusa Willd suppresses proliferation of human HepG2 cells and potentiates the anticancer efficacy of low-dose 5-fluorouracil by inhibiting the CDK2-E2F1 pathway. Oncol Rep 28:742–748

CAS  PubMed  Google Scholar 

Chen R, He J, Tong X et al (2016) The Hedyotis diffusa Willd. (Rubiaceae): a review on phytochemistry, pharmacology, quality control and pharmacokinetics. Molecules 21:710

PubMed  PubMed Central  Google Scholar 

Chen H, Shang X, Yuan H et al (2022) Total flavonoids of Oldenlandia diffusa (Willd.) Roxb. suppresses the growth of hepatocellular carcinoma through endoplasmic reticulum stress-mediated autophagy and apoptosis. Front Pharmacol 13:1019670

CAS  PubMed  PubMed Central  Google Scholar 

Chimkode R, Patil MB, Jalalpure S, Pasha TY (2009) A study of hepatoprotective activity of Hedyotis corymbosa. Linn, in albino rats. Anc Sci Life 28:32

PubMed  PubMed Central  Google Scholar 

Chung T-W, Choi H, Lee J-M et al (2017) Oldenlandia diffusa suppresses metastatic potential through inhibiting matrix metalloproteinase-9 and intercellular adhesion molecule-1 expression via p38 and ERK1/2 MAPK pathways and induces apoptosis in human breast cancer MCF-7 cells. J Ethnopharmacol 195:309–317

CAS  PubMed  Google Scholar 

Chunyan Y, Wei L, Yuhe L et al (2004) Anti-tumor effects of Oldenlandia Diffusa on multidrug resistance of human hepatic cancer cell Bel-7402 in vitro. J Beihua Univ (Natural Sci) 5:221–223

Dai S, Meng X, Cai X et al (2021) Therapeutic effect of ursolic acid on fetal development in pregnant rats with gestational diabetes mellitus via AGEs-RAGE signaling pathway. J Food Biochem 45:e13651

CAS  PubMed  Google Scholar 

Dajas F (2012) Life or death: neuroprotective and anticancer effects of quercetin. J Ethnopharmacol 143:383–396

CAS  PubMed  Google Scholar 

Danlami U, Danhalilu RL (2015) Antibacterial, proximate and antioxidant studies of Oldenlandia Herbacea extract. J Pharm Biol Sci 3:61

Google Scholar 

Das S, Mondal N, Mondal S et al (2019) Botanical features, phytochemical and pharmacological overviews of Oldenlandia corymbosa Linn.: a brief review. Pharma Innov J 8:464–468

CAS  Google Scholar 

Datta S, Sinha BK, Bhattacharjee S, Seal T (2019) Nutritional composition, mineral content, antioxidant activity and quantitative estimation of water soluble vitamins and phenolics by RP-HPLC in some lesser used wild edible plants. Heliyon 5:e01431

PubMed  PubMed Central  Google Scholar 

Datta PC, Sen A (1969) Pharmacognosy of Oldenlandia corymbosa Linn. Q J Crude Drug Res 9:1365–1371

Google Scholar 

De S, Suresh R, Babu AMSS, Aneela S (2017) In-vivo hepatoprotective activity of methanolic extracts of Sphaeranthus amaranthoides and Oldenlandia umbellate. Pharmacogn J 9:98–101

CAS  Google Scholar 

De Padua LS, Bunyapraphatsara N, Lemmens R (1999) Plant resources of South-East Asia. Backhuys Publ, Leiden

Google Scholar 

Deng W, Hu B, Dai C-L et al (2013) Anticancer activity of Oldenlandia Diffusa & Viola Philippica Car. J Can Res Updates 2:87–94

Google Scholar 

Denni M, Daniel M, Sane R (2011) Seasonal and geographical variations in the HPTLC fingerprints of Hedyotis corymbosa. J Med Aromat Plant Sci 33:133–138

Google Scholar 

Denni M, Mammen D, Ramesh S (2012) Pharmacognosy of Hedyotis corymbosa (L.) Lam. Glob J Pharm Res 1:584–589

Google Scholar 

Denthamil Selvan P, Vellavan DS, Sakunthala P (2015) Analysis of phytochemical component and nutrients component in ethanol extracted Oldenlandia corymbosa. World J Pharm Res 4:1960–1967

Google Scholar 

Ding X, Bai D, Qian J (2014) Novel cyclotides from Hedyotis biflora inhibit proliferation and migration of pancreatic cancer cell in vitro and in vivo. Med Chem Res 23:1406–1413

CAS  Google Scholar 

Divya M, Shanti G, Amalraj S et al (2023) Evaluation of in vitro enzyme inhibitory, anti-inflammatory, antioxidant, and antibacterial activities of Oldenlandia corymbosa L. and Oldenlandia umbellata L. whole plant extracts. Pharmacol Res Chinese Med 8:100286

Google Scholar 

Dodiya T, Jain V (2018) Screening of behavioural and antidepressant activity of Oldenlandia Corymbosa. Int J Res Ayurveda Pharm 9:201–204

CAS  Google Scholar 

Ezeabara CA, Egwuoba GC (2016) Comparative screening of phytochemical and proximate constituents of leaf, stem and root of Oldenlandia corymbosa L. and Oldenlandia herbacea (L.) Roxb. Am J Life Sci Res 4:113–118

Google Scholar 

Feng J, Jin Y, Peng J et al (2017) Hedyotis diffusa willd extract suppresses colorectal cancer growth through multiple cellular pathways. Oncol Lett 14:8197–8205

PubMed  PubMed Central  Google Scholar 

Ganbold M (2010) Cytotoxicity of the Chinese herbal remedy ’Oldenlandia diffusa’ and its anti-cancer effective constituents. Kingston University London, UK. Available from https://eprints.kingston.ac.uk/id/eprint/20412/

Gao X, Li C, Tang Y-L et al (2016) Effect of Hedyotis diffusa water extract on protecting human hepatocyte cells (LO2) from H2O2-induced cytotoxicity. Pharm Biol 54:1148–1155

CAS