Cadmium-induced lung injury is associated with oxidative stress, apoptosis, and altered SIRT1 and Nrf2/HO-1 signaling; protective role of the melatonin agonist agomelatine

Abraham NG, Lutton JD, Levere RD (1985) Heme metabolism and erythropoiesis in abnormal iron states: role of δ-aminolevulinic acid synthase and heme oxygenase. Exp Hematol 13:838–843

CAS  PubMed  Google Scholar 

Aguiar CC, Almeida AB, Araújo PV, Vasconcelos GS, Chaves EM, do Vale OC, Macêdo DS, Leal LK, de Barros Viana GS, Vasconcelos SM (2013) Effects of agomelatine on oxidative stress in the brain of mice after chemically induced seizures. Cell Mol Neurobiol 33:825–835

PubMed  Google Scholar 

Alam SI, Kim MW, Shah FA, Saeed K, Ullah R, Kim MO (2021) Alpha-linolenic acid impedes cadmium-induced oxidative stress, neuroinflammation, and neurodegeneration in mouse brain. Cells 10:2274

Alruhaimi RS, Hassanein EHM, Abd El-Aziz MK, Siddiq Abduh M, Bin-Ammar A, Kamel EM, Mahmoud AM (2023) The melatonin receptor agonist agomelatine protects against acute pancreatitis induced by cadmium by attenuating inflammation and oxidative stress and modulating Nrf2/HO-1 pathway. Int Immunopharmacol 124:110833

Ashizawa A, Faroon O, Ingerman L, Jenkins K, Tucker P, Wright S (2012) Toxicological profile for cadmium. U.S. Department of Health and Human Services, Public Health Service, Agency for Toxic Substances and Disease Registry, Atlanta

Bakr AG, Hassanein EHM, Ali FEM, El-Shoura EAM (2022) Combined apocynin and carvedilol protect against cadmium-induced testicular damage via modulation of inflammatory response and redox-sensitive pathways. Life Sci 311:121152

CAS  PubMed  Google Scholar 

Bedard K, Krause KH (2007) The NOX family of ROS-generating NADPH oxidases: physiology and pathophysiology. Physiol Rev 87:245–313

CAS  PubMed  Google Scholar 

Bernard A (2008) Cadmium & its adverse effects on human health. Indian J Med Res 128:557–564

CAS  PubMed  Google Scholar 

Cadenas C, Franckenstein D, Schmidt M, Gehrmann M, Hermes M, Geppert B, Schormann W, Maccoux LJ, Schug M, Schumann A, Wilhelm C, Freis E, Ickstadt K, Rahnenführer J, Baumbach JI, Sickmann A, Hengstler JG (2010) Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer. Breast Cancer Res 12:R44

PubMed  PubMed Central  Google Scholar 

Cankara FN, Günaydın C, Çelik ZB, Şahin Y, Pekgöz Ş, Erzurumlu Y, Gülle K (2021) Agomelatine confers neuroprotection against cisplatin-induced hippocampal neurotoxicity. Metab Brain Dis 36:339–349

CAS  PubMed  Google Scholar 

Casalino E, Sblano C, Landriscina C (1997) Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation. Arch Biochem Biophys 346:171–179

CAS  PubMed  Google Scholar 

Cuypers A, Plusquin M, Remans T, Jozefczak M, Keunen E, Gielen H, Opdenakker K, Nair AR, Munters E, Artois TJ (2010) Cadmium stress: an oxidative challenge. Biometals 23:927–940

CAS  PubMed  Google Scholar 

de Lima EC, de Moura CFG, Silva MJD, Vilegas W, Santamarina AB, Pisani LP, de Oliveira F, Ribeiro DA (2020) Therapeutical properties of Mimosa caesalpiniifolia in rat liver intoxicated with cadmium. Environ Sci Pollut Res Int 27:10981–10989

PubMed  Google Scholar 

de Souza PF, Diamante MA, Dolder H (2010) Testis response to low doses of cadmium in Wistar rats. Int J Exp Pathol 91:125–131

Google Scholar 

Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–77

CAS  PubMed  Google Scholar 

Eraslan E, Tanyeli A, Güler MC, Kurt N, Yetim Z (2020) Agomelatine prevents indomethacin-induced gastric ulcer in rats. Pharmacol Rep 72:984–991

CAS  PubMed  Google Scholar 

Fasano C, Disciglio V, Bertora S, Lepore Signorile M, Simone C (2019) FOXO3a from the nucleus to the mitochondria: a round trip in cellular stress response. Cells 8:1110

Fulcher K, Gibb H (2014) Setting the research agenda on the health effects of chemicals. Int J Environ Res Public Health 11:1049–1057

CAS  PubMed  PubMed Central  Google Scholar 

Furukawa M, Xiong Y (2005) BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase. Mol Cell Biol 25:162–171

CAS  PubMed  PubMed Central  Google Scholar 

Galano A, Reiter RJ (2018) Melatonin and its metabolites vs oxidative stress: from individual actions to collective protection. J Pineal Res 65:e12514

PubMed  Google Scholar 

Greer EL, Brunet A (2005) FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24:7410–7425

CAS  PubMed  Google Scholar 

Guarente L (2013) Calorie restriction and sirtuins revisited. Genes Dev 27:2072–2085

CAS  PubMed  PubMed Central  Google Scholar 

Haigis MC, Guarente LP (2006) Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction. Genes Dev 20:2913–2921

CAS  PubMed  Google Scholar 

Handan BA, De Moura CFG, Cardoso CM, Santamarina AB, Pisani LP, Ribeiro DA (2020) Protective effect of grape and apple juices against cadmium intoxication in the kidney of rats. Drug Research 70:503–511

CAS  PubMed  Google Scholar 

Hassanein EHM, Sayed AM, Hussein OE, Mahmoud AM (2020) Coumarins as modulators of the Keap1/Nrf2/ARE signaling pathway. Oxid Med Cell Longev 2020:1675957

PubMed  PubMed Central  Google Scholar 

Hozayen WG, Mahmoud AM, Desouky EM, El-Nahass E-S, Soliman HA, Farghali AA (2019) Cardiac and pulmonary toxicity of mesoporous silica nanoparticles is associated with excessive ROS production and redox imbalance in Wistar rats. Biomed Pharmacother 109:2527–2538

CAS  PubMed  Google Scholar 

Ikediobi CO, Badisa VL, Ayuk-Takem LT, Latinwo LM, West J (2004) Response of antioxidant enzymes and redox metabolites to cadmium-induced oxidative stress in CRL-1439 normal rat liver cells. Int J Mol Med 14:87–92

CAS  PubMed  Google Scholar 

Kamel MY, Ahmed SM, Abdelzaher WY, Welson NN, Abdel-Aziz AM (2022) Role of IL-6/STAT3 pathway in mediating the protective effect of agomelatine against methotrexate-induced lung/intestinal tissues damage in rats. Immunopharmacol Immunotoxicol 44:35–46

CAS  PubMed  Google Scholar 

Kato K, Hecker L (2020) NADPH oxidases: Pathophysiology and therapeutic potential in age-associated pulmonary fibrosis. Redox Biol 33:101541

CAS  PubMed  PubMed Central  Google Scholar 

Keen JH, Habig WH, Jakoby WB (1976) Mechanism for the several activities of the glutathione S-transferases. J Biol Chem 251:6183–6188

CAS  PubMed  Google Scholar 

Köse D, Yüksel TN, Halıcı Z, Çadırcı E, Gürbüz MA (2021) The effects of agomelatine treatment on lipopolysaccharide-induced septic lung injuries in rats. Eurasian J Med 53:127–131

PubMed  PubMed Central  Google Scholar 

Larson-Casey JL, Gu L, Fiehn O, Carter AB (2020) Cadmium-mediated lung injury is exacerbated by the persistence of classically activated macrophages. J Biol Chem 295:15754–15766

CAS  PubMed  PubMed Central  Google Scholar 

Lawrence RA, Burk RFJB, communications br (1976) Glutathione peroxidase activity in selenium-deficient rat liver. 71: 952-958

Lee IT, Yang CM (2012) Role of NADPH oxidase/ROS in pro-inflammatory mediators-induced airway and pulmonary diseases. Biochem Pharmacol 84:581–590

CAS  PubMed  Google Scholar 

Li L, Zhang S, Xin Y, Sun J, Xie F, Yang L, Chen Z, Chen H, Liu F, Xuan YJSR (2018) Role of Quzhou Fructus Aurantii extract in preventing and treating acute lung injury and inflammation. 8: 1-11

Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) Method. Methods (san Diego, Calif) 25:402–408

CAS  PubMed  Google Scholar 

Lu SC (2013) Glutathione synthesis. Biochim Biophys Acta 1830:3143–3153

CAS  PubMed  Google Scholar 

Ma MW, Wang J, Zhang Q, Wang R, Dhandapani KM, Vadlamudi RK, Brann DW (2017) NADPH oxidase in brain injury and neurodegenerative disorders. Mol Neurodegener 12:7

PubMed  PubMed Central  Google Scholar 

Mahlooji MA, Heshmati A, Kheiripour N, Ghasemi H, Asl SS, Solgi G, Ranjbar A, Hosseini A (2022) Evaluation of protective effects of curcumin and nanocurcumin on aluminium phosphide-induced subacute lung injury in rats: modulation of oxidative stress through SIRT1/FOXO3 signalling pathway. Drug Res (stuttg) 72:100–108

CAS  PubMed  Google Scholar 

Mahmoud AM, Abd El-Ghafar OAM, Alzoghaibi MA, Hassanein EHM (2021) Agomelatine prevents gentamicin nephrotoxicity by attenuating oxidative stress and TLR-4 signaling, and upregulating PPARγ and SIRT1. Life Sci 278:119600

CAS  PubMed  Google Scholar 

Marklund S, Marklund G (1974) Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem 47:469–474

CAS  PubMed  Google Scholar 

Mihara M, Uchiyama M (1978) Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Anal Biochem 86:271–278

CAS  PubMed  Google Scholar 

Mortada WI, Sobh MA, El-Defrawy MM, Farahat SE (2002) Reference intervals of cadmium, lead, and mercury in blood, urine, hair, and nails among residents in Mansoura City, Nile Delta. Egypt Environ Res 90:104–110

CAS  PubMed  Google Scholar 

Olmos Y, Sanchez-Gomez FJ, Wild B, Garcia-Quintans N, Cabezudo S, Lamas S, Monsalve M (2013) SirT1 regulation of antioxidant genes is dependent on the formation of a FoxO3a/PGC-1alpha complex. Antioxid Redox Signal 19:1507–1521

CAS  PubMed  PubMed Central  Google Scholar 

Pappas RS (2011) Toxic elements in tobacco and in cigarette smoke: inflammation and sensitization. Metallomics : Integr Biometal Sci 3:1181–1198

CAS  Google Scholar 

Paulis L, Simko F, Laudon M (2012) Cardiovascular effects of melatonin receptor agonists. Expert Opin Investig Drugs 21:1661–1678

CAS  PubMed  Google Scholar 

Pinheiro Júnior JEG, Moraes PZ, Rodriguez MD, Simões MR, Cibin F, Pinton S, Barbosa Junior F, Peçanha FM, Vassallo DV, Miguel M, Wiggers GA (2020) Cadmium exposure activates NADPH oxidase, renin-angiotensin system and cyclooxygenase 2 pathways in arteries, inducing hypertension and vascular damage. Toxicol Lett 333:80–89

PubMed  Google Scholar 

Rafati Rahimzadeh M, Rafati Rahimzadeh M, Kazemi S, Moghadamnia AA (2017) Cadmium toxicity and treatment: an update. Caspian J Intern Med 8:135–145

PubMed  PubMed Central  Google Scholar 

Rani A, Kumar A, Lal A, Pant M (2014) Cellular mechanisms of cadmium-induced toxicity: a review. Int J Environ Health Res 24:378–399

CAS 

留言 (0)

沒有登入
gif