Abou-Saleh M, Müller-Oerlinghausen B, Coppen AJ. Lithium in the episode and suicide prophylaxis and in augmenting strategies in patients with unipolar depression. Int J Bipolar Disord. 2017;5:11–9.

Article  PubMed  PubMed Central  Google Scholar 

Acharya N, Rosen S, Polzer JP, D’Souza DN, Perahia DG, Cavazzoni PA. Duloxetine: meta-analyses of suicidal behaviors and ideation in clinical trials for major depressive disorder. Clin Psychopharmacol. 2006;26:587–94.

Article  CAS  Google Scholar 

Ahearn EP, Chen P, Hertzberg M, Cornette M, Suvalsky L, Cooley-Olson D, et al. Suicide attempts in veterans with bipolar disorder during treatment with lithium, divalproex, and atypical antipsychotics. J Affect Disord. 2013;145:77–82.

Article  CAS  PubMed  Google Scholar 

Ahrens B, Müller-Oerlinghausen B. Does lithium exert an independent antisuicidal effect? Pharmacopsychiatry. 2001;34:132–6.

Article  CAS  PubMed  Google Scholar 

Ahrens B, Müller-Oerlinghausen B, Schou M, Wolf T, Alda M, Grof E, et al. Excess cardiovascular and suicide mortality of affective disorders may be reduced by lithium prophylaxis. J Affect Disord. 1995;33:67–75.

Article  CAS  PubMed  Google Scholar 

American Psychiatric Association (APA). Diagnostic and statistical manual of mental disorders 5th revision (DSM-5). Washington: American Psychiatric Publishing; 2013.

Book  Google Scholar 

Ando S, Suzuki H, Matsukawa T, Usami S, Muramatsu H, Fukunaga T, et al. Comparison of lithium levels between suicide and non-suicide fatalities: cross-sectional study. Transl Psychiatry. 2022;12:466–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Angst J, Angst F, Gerber-Werder R, Gamma A. Suicide in 406 mood-disorder patients with and without long-term medication: 40–44 years follow-up. Arch Suicide Res. 2005;9:279–300.

Article  PubMed  Google Scholar 

Araya P, Martínez C, Barros J. Lithium in drinking water as a public policy for suicide prevention: relevance and considerations. Front Public Health. 2022;10: 805774.

Article  PubMed  PubMed Central  Google Scholar 

Baldessarini RJ. Chemotherapy in psychiatry. 3rd ed. New York: Springer Press; 2013.

Book  Google Scholar 

Baldessarini RJ, Tondo L. Lithium and suicidal risk. Bipolar Disord. 2008;10:114–5.

Article  PubMed  Google Scholar 

Baldessarini RJ, Tondo L. Suicidal risks during treatment of bipolar disorder patients with lithium versus anticonvulsants. Pharmacopsychiatry. 2009;42:72–5.

Article  CAS  PubMed  Google Scholar 

Baldessarini RJ, Tondo L, Davis P, Pompili M, Goodwin FK, Hennen J. Decreased suicidal risk during long-term lithium treatment: meta-analysis. Bipolar Disord. 2006;8:625–39.

Article  CAS  PubMed  Google Scholar 

Baldessarini RJ, Tondo L, Strombom IM, Dominguez S, Fawcett J, Licinio J, et al. Ecological studies of antidepressant treatment and suicidal risks. Harv Rev Psychiatry. 2007;15:133–45.

Article  PubMed  Google Scholar 

Baldessarini RJ, Tondo L, Pinna M, Nuñez N, Vázquez GH. Suicidal risk factors in major affective disorders. Br J Psychiatry. 2019;11:1–6.

Google Scholar 

Baldessarini RJ, Vázquez GH, Tondo L. Bipolar depression: a major unsolved challenge. Int J Bipolar Disord. 2020;8:1–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Barbui C, Esposito E, Cipriani A. Selective serotonin reuptake inhibitors and risk of suicide: a systematic review of observational studies. CMAJ. 2009;180:291–7.

Article  PubMed  PubMed Central  Google Scholar 

Barjasteh-Askari F, Davoudi M, Amini H, Ghorbani M, Yaseri M, Yunesian M, et al. Relationship between suicide mortality and lithium in drinking water: systematic review and meta-analysis. J Affect Disord. 2020;264:234–41.

Article  CAS  PubMed  Google Scholar 

Barraclough B. Suicide prevention, recurrent affective disorder and lithium. Br J Psychiatry. 1972;121:391–2.

Article  CAS  PubMed  Google Scholar 

Bastiampillai T, Sharfstein SS, Allison S. Increasing the use of lithium and clozapine in US suicide prevention. JAMA Psychiat. 2017;74:423–423.

Article  Google Scholar 

Blüml V, Regier MD, Hlavin G, Rockett IRH, König F, Vyssoki B, et al. Lithium in the public water supply and suicide mortality in Texas. J Psychiatr Res. 2013;47:407–11.

Article  PubMed  Google Scholar 

Braun C, Bschor T, Franklin J, Baethge C. Suicides and suicide attempts during long-term treatment with antidepressants: meta-analysis of 29 placebo-controlled studies including 6,934 patients with major depressive disorder. Psychother Psychosom. 2016;85:171–9.

Article  PubMed  Google Scholar 

Brown EE, Gerretsen P, Pollock B, Graff-Guerrero A. Psychiatric benefits of lithium in water supplies may be due to protection from the neurotoxicity of lead exposure. Med Hypotheses. 2018;115:94–102.

Article  CAS  PubMed  Google Scholar 

Bschor T, Adli M, Alda M, Baethge C, Etain B, Glenn T. International group for the study of lithium treated patients (IGSLI). Epidemiol Psychiatr Sci. 2022;31: e84.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen PH, Tsai SY, Chen PY, Pan CH, Su SS, Chen CC, Kuo CJ. Mood stabilizers and risk of all-cause, natural, and suicide mortality in bipolar disorder: a nationwide cohort study. Acta Psychiatr Scand. 2023;147:234–47.

Article  PubMed  Google Scholar 

Ciapparelli A, Dell’Osso L, Pini S, Chiavacci MC, Fenzi M, Cassano GB. Clozapine for treatment-refractory schizophrenia, schizoaffective disorder, and psychotic bipolar disorder: a 24-month naturalistic study. J Clin Psychiatry. 2000;61:329–34.

Article  CAS  PubMed  Google Scholar 

Cipriani A, Pretty H, Hawton K, Geddes JR. Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: systematic review of randomized trials. Am J Psychiatry. 2005;162:1805–19.

Article  PubMed  Google Scholar 

Cipriani A, Hawton K, Stockton S, Geddes JR. Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. BMJ. 2013;346:f3646–58.

Article  PubMed  Google Scholar 

Coppen A, Farmer R. Suicide mortality in patients on lithium maintenance therapy. J Affect Disord. 1998;50:261–7.

Article  CAS  PubMed  Google Scholar 

Coppen A, Standish-Barry H, Bailey J, Houston G, Silcocks P, Hermon C. Does lithium reduce mortality of recurrent mood disorders? J Affect Disord. 1991;23:1–7.

Article  CAS  PubMed  Google Scholar 

Dawson EB, Moore TD, McGanity WJ. Relationship of lithium metabolism to mental hospital admissions and homicide. Dis Nerv Syst. 1972;33:546–56.

CAS  PubMed  Google Scholar 

Del Matto L, Muscas M, Murru A, Verdolini N, Anmella G, Fico G, et al. Lithium and suicide prevention in mood disorders and in the general population: systematic review. Neurosci Biobehav Rev. 2020;116:142–53.

Article  PubMed  Google Scholar 

Dervic K, Sher L, Galfalvy HC, Grunebaum M, Burke AK, Sullivan G, et al. Antisuicidal effect of lithium in bipolar disorder: is there an age-specific effect? J Affect Disord. 2023;341:8–11.

Article  CAS  PubMed  Google Scholar 

Desai-Boström AE, Andersson P, Rask-Andersen M, Jarbin H, Lundberg J, Jokinen J. Regional clozapine, ECT and lithium usage inversely associated with excess suicide rates in male adolescents. Nature Commun. 2023;14:1281–8.

Article  ADS  Google Scholar 

Fico G, Anmella G, Pacchiarotti I, Verdolini N, Sagué-Vilavella M, Corponi F, et al. The biology of aggressive behavior in bipolar disorder: systematic review. Neurosci Biobehav Rev. 2020;119:9–20.

Article  PubMed  Google Scholar 

Fitzgerald C, Christensen RHB, Simons J, Andersen PK, Benros ME, Nordentoft M, et al. Effectiveness of medical treatment for bipolar disorder regarding suicide, self-harm and psychiatric hospital admission: between- and within-individual study on Danish national data. Br J Psychiatry. 2022;221:692–700.

Article  Google Scholar 

Fornaro M, Stubbs B, De Berardis D, Perna G, Valchera A, Veronese N, et al. Atypical antipsychotics in the treatment of acute bipolar depression with mixed features: systematic review and exploratory meta-analysis of placebo-controlled clinical trials. Int J Mol Sci. 2016;17:241–54.

Article  PubMed  PubMed Central  Google Scholar 

Goodwin FK, Fireman B, Simon GE, Hunkeler EM, Lee J, Revicki D. Suicide risk in bipolar disorder during treatment with lithium and divalproex. JAMA. 2003;290:1467–73.

Article  CAS  PubMed  Google Scholar 

Griffiths JJ, Zarate CA Jr, Rasimas JJ. Existing and novel biological therapeutics in suicide prevention. Focus (am Psychiatr Publ). 2023;21:225–32.

PubMed  Google Scholar 

Guzzetta F, Tondo L, Centorrino F, Baldessarini RJ. Lithium treatment reduces suicide risk in recurrent major depressive disorder. J Clin Psychiatry. 2007;68:380–3.

Article  PubMed