Ashina M, Katsarava Z, Do TP, Buse DC, Pozo-Rosich P, Özge A et al (2021) Migraine: epidemiology and systems of care. Lancet 397(10283):1485–1495. https://doi.org/10.1016/S0140-6736(20)32160-7. PMID: 33773613
GBD 2019 Diseases and Injuries Collaborators (2020) Diseases. Lancet. 396(10258):1204–22. https://doi.org/10.1016/S0140-6736(20)30925-9. PMID 33069326
Steiner TJ, Stovner LJ, Jensen R, Uluduz D, Katsarava Z, Lifting The Burden: the Global Campaign against Headache (2020) Migraine remains second among the world’s causes of disability, and first among young women: findings from GBD2019. J Headache Pain. 21(1):137. https://doi.org/10.1186/s10194-020-01208-0. PMID 33267788
Article CAS PubMed PubMed Central Google Scholar
(2018) Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition. Cephalalgia 38(1):1–211. https://doi.org/10.1177/0333102417738202. PMID: 29368949
Andreou AP, Edvinsson L (2019) Mechanisms of migraine as a chronic evolutive condition. J Headache Pain 20(1):117. https://doi.org/10.1186/s10194-019-1066-0. PMID: 31870279
Article PubMed PubMed Central Google Scholar
Dodick D, Silberstein S (2006) Central sensitization theory of migraine: clinical implications. Headache 46(Suppl 4):S182–S191. https://doi.org/10.1111/j.1526-4610.2006.00602.x. PMID17078850
Edvinsson L, Haanes KA, Warfvinge K (2019) Does inflammation have a role in migraine? Nat Rev Neurol 15(8):483–490. https://doi.org/10.1038/s41582-019-0216-y. PMID: 31263254
Saijo K, Glass CK (2011) Microglial cell origin and phenotypes in health and disease. Nat Rev Immunol 11(11):775–787. https://doi.org/10.1038/nri3086. PMID: 22025055
Article CAS PubMed Google Scholar
Prinz M, Jung S, Priller J (2019) Microglia biology: one century of evolving concepts. Cell 179(2):292–311. https://doi.org/10.1016/j.cell.2019.08.053. PMID: 31585077
Article CAS PubMed Google Scholar
Liu L, Xu Y, Dai H, Tan S, Mao X, Chen Z (2020) Dynorphin activation of kappa Opioid receptor promotes microglial polarization toward M2 phenotype via TLR4/NF-κB pathway. Cell Biosci 10:42. https://doi.org/10.1186/s13578-020-00387-2. PMID: 32206297
Article CAS PubMed PubMed Central Google Scholar
Sudershan A, Younis M, Sudershan S, Kumar P (2023) Migraine as an inflammatory disorder with microglial activation as a prime candidate. Neurol Res 45(3):200–215. https://doi.org/10.1080/01616412.2022.2129774. PMID: 36197286
Article CAS PubMed Google Scholar
Thuraiaiyah J, Erritzøe-Jervild M, Al-Khazali HM, Schytz HW, Younis S (2022) The role of cytokines in migraine: a systematic review. Cephalalgia 42(14):1565–1588. https://doi.org/10.1177/03331024221118924. PMID: 35962530
Kursun O, Yemisci M, van den Maagdenberg AMJM, Karatas H (2021) Migraine and neuroinflammation: the inflammasome perspective. J Headache Pain 22(1):55. https://doi.org/10.1186/s10194-021-01271-1. PMID: 34112082
Article PubMed PubMed Central Google Scholar
Jing F, Zou Q, Wang Y, Cai Z, Tang Y (2021) Activation of microglial GLP-1R in the trigeminal nucleus caudalis suppresses central sensitization of chronic migraine after recurrent nitroglycerin stimulation. J Headache Pain 22(1):86. https://doi.org/10.1186/s10194-021-01302-x. PMID: 34325647
Article CAS PubMed PubMed Central Google Scholar
Barbiroli B, Montagna P, Cortelli P, Funicello R, Iotti S, Monari L et al (1992) Abnormal brain and muscle energy metabolism shown by 31P magnetic resonance spectroscopy in patients affected by migraine with aura. Neurology 42(6):1209–1214. https://doi.org/10.1212/wnl.42.6.1209. PMID: 1603349
Article CAS PubMed Google Scholar
Lodi R, Kemp GJ, Montagna P, Pierangeli G, Cortelli P, Iotti S et al (1997) Quantitative analysis of skeletal muscle bioenergetics and proton efflux in migraine and cluster headache. J Neurol Sci 146(1):73–80. https://doi.org/10.1016/s0022-510x(96)00287-0. PMID: 9077499
Article CAS PubMed Google Scholar
Lodi R, Montagna P, Soriani S, Iotti S, Arnaldi C, Cortelli P et al (1997) Deficit of brain and skeletal muscle bioenergetics and low brain magnesium in juvenile migraine: an in vivo 31P magnetic resonance spectroscopy interictal study. Pediatr Res 42(6):866–871. https://doi.org/10.1203/00006450-199712000-00024. PMID: 9396571
Article CAS PubMed Google Scholar
Schulz UG, Blamire AM, Corkill RG, Davies P, Styles P, Rothwell PM (2007) Association between cortical metabolite levels and clinical manifestations of migrainous aura: an MR-spectroscopy study. Brain 130(12):3102–3110. https://doi.org/10.1093/brain/awm165. PMID: 17956910
Article CAS PubMed Google Scholar
Welch KM, Levine SR, D’Andrea G, Schultz LR, Helpern JA (1989) Preliminary observations on brain energy metabolism in migraine studied by in vivo phosphorus 31 NMR spectroscopy. Neurology 39(4):538–541. https://doi.org/10.1212/wnl.39.4.538. PMID: 2927679
Article CAS PubMed Google Scholar
Reyngoudt H, Paemeleire K, Descamps B, De Deene Y, Achten E (2011) 31P-MRS demonstrates a reduction in high-energy phosphates in the occipital lobe of migraine without aura patients. Cephalalgia 31(12):1243–1253. https://doi.org/10.1177/0333102410394675. PMID: 21289000
Lisicki M, D’Ostilio K, Coppola G, Scholtes F, de Maertens Noordhout A, Parisi V et al (2018) Evidence of an increased neuronal activation-to-resting glucose uptake ratio in the visual cortex of migraine patients: a study comparing (18) FDG-PET and visual evoked potentials. J Headache Pain. 19(1):49. https://doi.org/10.1186/s10194-018-0877-8. PMID: 29978429
Article PubMed PubMed Central Google Scholar
Gross EC, Lisicki M, Fischer D, Sándor PS, Schoenen J (2019) The metabolic face of migraine - from pathophysiology to treatment. Nat Rev Neurol 15(11):627–643. https://doi.org/10.1038/s41582-019-0255-4. PMID: 31586135
Article CAS PubMed Google Scholar
Herzig S, Shaw RJ (2018) AMPK: guardian of metabolism and mitochondrial homeostasis. Nat Rev Mol Cell Biol 19(2):121–135. https://doi.org/10.1038/nrm.2017.95. PMID: 28974774
Article CAS PubMed Google Scholar
Xu X, Ding G, Liu C, Ding Y, Chen X, Huang X et al (2022) Nuclear UHRF1 is a gate-keeper of cellular AMPK activity and function. Cell Res 32(1):54–71. https://doi.org/10.1038/s41422-021-00565-y. PMID: 34561619
Article CAS PubMed Google Scholar
Xiang HC, Lin LX, Hu XF, Zhu H, Li HP, Zhang RY et al (2019) AMPK activation attenuates inflammatory pain through inhibiting NF-κB activation and IL-1β expression. J Neuroinflammation 16(1):34. https://doi.org/10.1186/s12974-019-1411-x. PMID: 30755236
Article PubMed PubMed Central Google Scholar
Corton JM, Gillespie JG, Hawley SA, Hardie DG (1995) 5-aminoimidazole-4-carboxamide ribonucleoside. A specific method for activating AMP-activated protein kinase in intact cells? Eur J Biochem. 229(2):558–65. https://doi.org/10.1111/j.1432-1033.1995.tb20498.x. PMID: 7744080
Article CAS PubMed Google Scholar
Sullivan JE, Brocklehurst KJ, Marley AE, Carey F, Carling D, Beri RK (1994) Inhibition of lipolysis and lipogenesis in isolated rat adipocytes with AICAR, a cell-permeable activator of AMP-activated protein kinase. FEBS Lett 353(1):33–36. https://doi.org/10.1016/0014-5793(94)01006-4. PMID: 7926017
Article CAS PubMed Google Scholar
Achanta LB, Thomas DS, Housley GD, Rae CD (2023) AMP-activated protein kinase activators have compound and concentration-specific effects on brain metabolism. J Neurochem. https://doi.org/10.1111/jnc.15815. PMID: 36977628
Hill JL, Kobori N, Zhao J, Rozas NS, Hylin MJ, Moore AN et al (2016) Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcome. J Neurochem 139(1):106–119. https://doi.org/10.1111/jnc.13726. PMID: 27379837
Article CAS PubMed PubMed Central Google Scholar
Prasad R, Giri S, Nath N, Singh I, Singh AK (2006) 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside attenuates experimental autoimmune encephalomyelitis via modulation of endothelial-monocyte interaction. J Neurosci Res 84(3):614–625. https://doi.org/10.1002/jnr.20953. PMID: 16770773
Article CAS PubMed Google Scholar
Yu HY, Cai YB, Liu Z (2015) Activation of AMPK improves lipopolysaccharide-induced dysfunction of the blood-brain barrier in mice. Brain Inj 29(6):777–784. https://doi.org/10.3109/02699052.2015.1004746. PMID: 25794165
Fu L, Huang L, Cao C, Yin Q, Liu J (2016) Inhibition of AMP-activated protein kinase alleviates focal cerebral ischemia injury in mice: interference with mTOR and autophagy. Brain Res 1650:103–111. https://doi.org/10.1016/j.brainres.2016.08.035. PMID: 27569585
Article CAS PubMed Google Scholar
Ammar RA, Mohamed AF, Kamal MM, Safar MM, Abdelkader NF (2022) Neuroprotective effect of liraglutide in an experimental mouse model of multiple sclerosis: role of AMPK/SIRT1 signaling and NLRP3 inflammasome. Inflammopharmacology 30(3):919–934. https://doi.org/10.1007/s10787-022-00956-6. PMID: 35364735
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