Lam, C. S. P. et al. Sex differences in heart failure. Eur. Heart J. 40, 3859–3868c (2019).
Vaduganathan, M. et al. Do women and men respond similarly to therapies in contemporary heart failure clinical trials? JACC Heart Fail. 7, 267–271 (2019).
Article PubMed PubMed Central Google Scholar
Butler, J. et al. Systolic blood pressure and incident heart failure in the elderly. The Cardiovascular Health Study and the Health, Ageing and Body Composition Study. Heart 97, 1304–1311 (2011).
He, J. et al. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. Arch. Intern. Med. 161, 996–1002 (2001).
Article CAS PubMed Google Scholar
Magnussen, C. et al. Sex-specific epidemiology of heart failure risk and mortality in Europe: results from the biomarCaRE consortium. JACC Heart Fail. 7, 204–213 (2019).
Savji, N. et al. The association of obesity and cardiometabolic traits with incident HFpEF and HFrEF. JACC Heart Fail. 6, 701–709 (2018).
Article PubMed PubMed Central Google Scholar
Uijl, A. et al. Risk factors for incident heart failure in age- and sex-specific strata: a population-based cohort using linked electronic health records. Eur. J. Heart Fail. 21, 1197–1206 (2019).
Lala, A. et al. Sex differences in heart failure. J. Card. Fail. 28, 477–498 (2022).
Ho, J. E. et al. Predicting heart failure with preserved and reduced ejection fraction: the international collaboration on heart failure subtypes. Circ. Heart Fail. 9, e003116 (2016).
Paulus, W. J. & Tschope, C. A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation. J. Am. Coll. Cardiol. 62, 263–271 (2013).
Sorimachi, H. et al. Pathophysiologic importance of visceral adipose tissue in women with heart failure and preserved ejection fraction. Eur. Heart J. 42, 1595–1605 (2021).
Stolfo, D. et al. Sex-based differences in heart failure across the ejection fraction spectrum: phenotyping, and prognostic and therapeutic implications. JACC Heart Fail. 7, 505–515 (2019).
Templin, C. et al. Clinical features and outcomes of takotsubo (stress) cardiomyopathy. N. Engl. J. Med. 373, 929–938 (2015).
Article CAS PubMed Google Scholar
Sliwa, K. et al. Clinical characteristics of patients from the worldwide registry on peripartum cardiomyopathy (PPCM): EURObservational Research Programme in conjunction with the Heart Failure Association of the European Society of Cardiology Study Group on PPCM. Eur. J. Heart Fail. 19, 1131–1141 (2017).
Article CAS PubMed Google Scholar
Denfeld, Q. E. et al. Characterizing sex differences in physical frailty phenotypes in heart failure. Circ. Heart Fail. 14, e008076 (2021).
Article CAS PubMed PubMed Central Google Scholar
Dewan, P. et al. Differential impact of heart failure with reduced ejection fraction on men and women. J. Am. Coll. Cardiol. 73, 29–40 (2019).
Ravera, A. et al. Quality of life in men and women with heart failure: association with outcome, and comparison between the Kansas City Cardiomyopathy Questionnaire and the EuroQol 5 dimensions questionnaire. Eur. J. Heart Fail. 23, 567–577 (2021).
McDonagh, T. A. et al. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. Heart J. 42, 3599–3726 (2021).
Article CAS PubMed Google Scholar
Kittleson, M. M. et al. 2023 ACC expert consensus decision pathway on management of heart failure with preserved ejection fraction: a report of the American College of Cardiology Solution Set Oversight Committee. J. Am. Coll. Cardiol. 81, 1835–1878 (2023).
McDonagh, T. A. et al. 2023 Focused update of the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur. Heart J. 44, 3627–3639 (2023).
Article CAS PubMed Google Scholar
Soldin, O. P. & Mattison, D. R. Sex differences in pharmacokinetics and pharmacodynamics. Clin. Pharmacokinet. 48, 143–157 (2009).
Article CAS PubMed PubMed Central Google Scholar
Tamargo, J. et al. Gender differences in the effects of cardiovascular drugs. Eur. Heart J. Cardiovasc. Pharmacother. 3, 163–182 (2017).
Article CAS PubMed Google Scholar
Soldin, O. P., Chung, S. H. & Mattison, D. R. Sex differences in drug disposition. J. Biomed. Biotechnol. 2011, 187103 (2011).
Article PubMed PubMed Central Google Scholar
Anderson, G. D. Sex differences in drug metabolism: cytochrome P-450 and uridine diphosphate glucuronosyltransferase. J. Gend. Specif. Med. 5, 25–33 (2002).
Greenblatt, D. J. & von Moltke, L. L. Gender has a small but statistically significant effect on clearance of CYP3A substrate drugs. J. Clin. Pharmacol. 48, 1350–1355 (2008).
Article CAS PubMed Google Scholar
McDonough, A. A., Harris, A. N., Xiong, L. I. & Layton, A. T. Sex differences in renal transporters: assessment and functional consequences. Nat. Rev. Nephrol. 20, 21–36 (2023).
Bairey Merz, C. N. et al. Sex and the kidneys: current understanding and research opportunities. Nat. Rev. Nephrol. 15, 776–783 (2019).
Vree, T. B. et al. Lack of male-female differences in disposition and esterase hydrolysis of ramipril to ramiprilat in healthy volunteers after a single oral dose. ScientificWorldJournal 3, 1344–1358 (2003).
Article PubMed PubMed Central Google Scholar
Michel, M. C., Foster, C., Brunner, H. R. & Liu, L. A systematic comparison of the properties of clinically used angiotensin II type 1 receptor antagonists. Pharmacol. Rev. 65, 809–848 (2013).
Vachharajani, N. N., Shyu, W. C., Smith, R. A. & Greene, D. S. The effects of age and gender on the pharmacokinetics of irbesartan. Br. J. Clin. Pharmacol. 46, 611–613 (1998).
Article CAS PubMed PubMed Central Google Scholar
Miller, J. A. et al. Gender differences in the renal response to renin-angiotensin system blockade. J. Am. Soc. Nephrol. 17, 2554–2560 (2006).
Article CAS PubMed Google Scholar
Luzier, A. B. et al. Gender-related effects on metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers. Clin. Pharmacol. Ther. 66, 594–601 (1999).
Article CAS PubMed Google Scholar
Thurmann, P. A. et al. Tolerability of β-blockers metabolized via cytochrome P450 2D6 is sex-dependent. Clin. Pharmacol. Ther. 80, 551–553 (2006).
Labbe, L. et al. Effect of gender, sex hormones, time variables and physiological urinary pH on apparent CYP2D6 activity as assessed by metabolic ratios of marker substrates. Pharmacogenetics 10, 425–438 (2000).
Article CAS PubMed Google Scholar
Eugene, A. R. Metoprolol dose equivalence in adult men and women based on gender differences: pharmacokinetic modeling and simulations. Med. Sci. 4, 18 (2016).
McMurray, J. J. V. et al. Effects of sacubitril-valsartan versus valsartan in women compared with men with heart failure and preserved ejection fraction: insights from PARAGON-HF. Circulation 141, 338–351 (2020).
Berg, D. D. et al. Efficacy and safety of sacubitril/valsartan by dose level achieved in the PIONEER-HF Trial. JACC Heart Fail. 8, 834–843 (2020).
Article PubMed PubMed Central Google Scholar
Wikstrand, J. et al. Dose of metoprolol CR/XL and clinical outcomes in patients with heart failure: analysis of the experience in metoprolol CR/XL randomized intervention trial in chronic heart failure (MERIT-HF). J. Am. Coll. Cardiol. 40, 491–498 (2002).
Article CAS PubMed Google Scholar
Lam, C. S. P. et al. Age, sex, and outcomes in heart failure with reduced EF: insights from the VICTORIA trial. JACC Heart Fail. 11, 1246–1257 (2023).
Granger, C. B. et al. Effects of candesartan in patients with chronic heart failure and reduced left-ventricular systolic function intolerant to angiotensin-converting-enzyme inhibitors: the CHARM-Alternative trial. Lancet 362, 772–776 (2003).
留言 (0)