Mucosal T-cell responses to chronic viral infections: Implications for vaccine design

Krausgruber T, Fortelny N, Fife-Gernedl V, Senekowitsch M, Schuster LC, Lercher A, et al. Structural cells are key regulators of organ-specific immune responses. Nature .2020;583:296–302.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Seo GY, Giles DA, Kronenberg M. The role of innate lymphoid cells in response to microbes at mucosal surfaces. Mucosal Immunol. 2020;13:399–412.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cohen JI. Herpesvirus latency. J Clin Invest. 2020;130:3361–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Busman-Sahay K, Starke CE, Nekorchuk MD, Estes JD. Eliminating HIV reservoirs for a cure: the issue is in the tissue. Curr Opin HIV Aids. 2021;16:200–8.

Article  PubMed  PubMed Central  Google Scholar 

Han S, Tay JK, Loh CJL, Chu AJM, Yeong JPS, Lim CM, et al. Epstein-barr virus epithelial cancers-a comprehensive understanding to drive novel therapies. Front Immunol. 2021;12:734293.

Article  CAS  PubMed  PubMed Central  Google Scholar 

zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer. 2002;2:342–50.

Article  CAS  PubMed  Google Scholar 

Spyridopoulos I, Martin-Ruiz C, Hilkens C, Yadegarfar ME, Isaacs J, Jagger C, et al. CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study. Aging Cell. 2016;15:389–92.

Article  CAS  PubMed  Google Scholar 

Clement M. The association of microbial infection and adaptive immune cell activation in Alzheimer’s disease. Discovery Immunology. 2023;2:kyad015.

Thomasini RL, Pereira DS, Pereira FSM, Mateo EC, Mota TN, Guimarães GG, et al. Aged-associated cytomegalovirus and Epstein-Barr virus reactivation and cytomegalovirus relationship with the frailty syndrome in older women. PLoS One. 2017;12:e0180841.

Article  PubMed  PubMed Central  Google Scholar 

Boeckh M, Nichols WG, Papanicolaou G, Rubin R, Wingard JR, Zaia J. Cytomegalovirus in hematopoietic stem cell transplant recipients: Current status, known challenges, and future strategies. Biol Blood Marrow Transplant. 2003;9:543–58.

Article  PubMed  Google Scholar 

Jabs DA, Van Natta ML, Holland GN, Danis R. Cytomegalovirus retinitis in patients with acquired immunodeficiency syndrome after initiating antiretroviral therapy. Am J Ophthalmol. 2017;174:23–32.

Article  PubMed  Google Scholar 

Jacobson MA, Mills J. Serious cytomegalovirus disease in the acquired immunodeficiency syndrome (AIDS). Clinical findings, diagnosis, and treatment. Ann Intern Med. 1988;108:585–94.

Article  CAS  PubMed  Google Scholar 

Maidji E, Somsouk M, Rivera JM, Hunt PW, Stoddart CA. Replication of CMV in the gut of HIV-infected individuals and epithelial barrier dysfunction. PLoS Pathog. 2017;13:e1006202.

Article  PubMed  PubMed Central  Google Scholar 

Manicklal S, Emery VC, Lazzarotto T, Boppana SB, Gupta RK. The “silent” global burden of congenital cytomegalovirus. Clin Microbiol Rev. 2013;26:86–102.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pass RF, Arav-Boger R. Maternal and fetal cytomegalovirus infection: diagnosis, management, and prevention. F1000Res .2018;7:255.

Article  PubMed  PubMed Central  Google Scholar 

Retzler J, Hex N, Bartlett C, Webb A, Wood S, Star C, et al. Economic cost of congenital CMV in the UK. Arch Dis Child. 2019;104:559–63.

Article  PubMed  Google Scholar 

Mocarski E, Courcelle C. Cytomegaloviruses and Their Replication. Fields Virology. 4 ed. Philadelphia: Lippincott Williams & Wilkins; 2001.

Stagno S, Cloud GA. Working parents: the impact of day care and breast-feeding on cytomegalovirus infections in offspring. Proc Natl Acad Sci USA. 1994;91:2384–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

De Cock KM, Brun-Vézinet F, Soro B. HIV-1 and HIV-2 infections and AIDS in West Africa. Aids .1991;5:S21–8.

PubMed  Google Scholar 

Kelly MN, Shellito JE. Current understanding of Pneumocystis immunology. Future Microbiol. 2010;5:43–65.

Article  CAS  PubMed  Google Scholar 

World Health Organisation. HIV statistics, globally and by WHO region, 2023. Geneva; 2023.

McDonald D, Wu L, Bohks SM, KewalRamani VN, Unutmaz D, Hope TJ. Recruitment of HIV and its receptors to dendritic cell-T cell junctions. Science .2003;300:1295–7.

Article  CAS  PubMed  Google Scholar 

Wiley RD, Gummuluru S. Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection. Proc Natl Acad Sci USA. 2006;103:738–43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Turville SG, Santos JJ, Frank I, Cameron PU, Wilkinson J, Miranda-Saksena M, et al. Immunodeficiency virus uptake, turnover, and 2-phase transfer in human dendritic cells. Blood .2004;103:2170–9.

Article  CAS  PubMed  Google Scholar 

Mehandru S, Poles MA, Tenner-Racz K, Horowitz A, Hurley A, Hogan C, et al. Primary HIV-1 infection is associated with preferential depletion of CD4+ T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med. 2004;200:761–70.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman GJ, et al. CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med. 2004;200:749–59.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Brenchley JM, Price DA, Schacker TW, Asher TE, Silvestri G, Rao S, et al. Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med. 2006;12:1365–71.

Article  CAS  PubMed  Google Scholar 

Sankaran S, George MD, Reay E, Guadalupe M, Flamm J, Prindiville T, et al. Rapid onset of intestinal epithelial barrier dysfunction in primary human immunodeficiency virus infection is driven by an imbalance between immune response and mucosal repair and regeneration. J Virol. 2008;82:538–45.

Article  CAS  PubMed  Google Scholar 

Giorgi JV, Lyles RH, Matud JL, Yamashita TE, Mellors JW, Hultin LE, et al. Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection. J Acquir Immune Defic Syndr. 2002;29:346–55.

Article  PubMed  Google Scholar 

Pilcher CD, Joaki G, Hoffman IF, Martinson FE, Mapanje C, Stewart PW, et al. Amplified transmission of HIV-1: comparison of HIV-1 concentrations in semen and blood during acute and chronic infection. Aids .2007;21:1723–30.

Article  PubMed  Google Scholar 

Houzet L, Matusali G, Dejucq-Rainsford N. Origins of HIV-infected leukocytes and virions in semen. J Infect Dis. 2014;210:S622–30.

Article  PubMed  Google Scholar 

Barreto-de-Souza V, Arakelyan A, Margolis L, Vanpouille C. HIV-1 vaginal transmission: cell-free or cell-associated virus? Am J Reprod Immunol. 2014;71:589–99.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clemetson DB, Moss GB, Willerford DM, Hensel M, Emonyi W, Holmes KK, et al. Detection of HIV DNA in cervical and vaginal secretions. Prevalence and correlates among women in Nairobi, Kenya. JAMA .1993;269:2860–4.

Article  CAS  PubMed  Google Scholar 

Kordy K, Tobin NH, Aldrovandi GM. HIV and SIV in body fluids: from breast milk to the genitourinary tract. Curr Immunol Rev. 2019;15:139–52.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Clement M, Humphreys IR. Cytokine-mediated induction and regulation of tissue damage during cytomegalovirus infection. Front Immunol. 2019;10:78.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hillaire ML, Rimmelzwaan GF, Kreijtz JH. Clearance of influenza virus infections by T cells: risk of collateral damage? Curr Opin Virol. 2013;3:430–7.

Article  CAS  PubMed  Google Scholar 

Zangger N, Oderbolz J, Oxenius A. CD4 T cell-mediated immune control of cytomegalovirus infection in murine salivary glands. Pathogens. 2021;10:1531.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cavanaugh VJ, Deng Y, Birkenbach MP, Slater JS, Campbell AE. Vigorous innate and virus-specific cytotoxic T-lymphocyte responses to murine cytomegalovirus in the submaxillary salivary gland. J Virol. 2003;77:1703–17.

Article  CAS  PubMed  PubMed Central  Google Scholar 

留言 (0)

沒有登入
gif