Stovner LJ, Hagen K, Linde M, Steiner TJ. The global prevalence of headache: an update, with analysis of the influences of methodological factors on prevalence estimates. J Headache Pain. 2022;23:34. https://doi.org/10.1186/s10194-022-01402-2.

Article  PubMed  PubMed Central  Google Scholar 

WHO. Headache disorders. https://www.who.int/news-room/fact-sheets/detail/headache-disorders. Accessed 28 Aug 2023.

ICHD 3. Cephalalgia 2018; 38: 1–211 The International Classification of Headache Disorders 3rd Edition (ICHD-3). https://ihs-headache.org/en/resources/guidelines/. Accessed 26 Aug 2023.

Linde M, Gustavsson A, Stovner LJ, et al. The cost of headache disorders in Europe: the Eurolight project. Eur J Neurol. 2012;19(5):703–11. https://doi.org/10.1111/j.1468-1331.2011.03612.x.

Article  CAS  PubMed  Google Scholar 

Martelletti P, Schwedt TJ, Vo P, et al. Healthcare resource use and indirect costs associated with migraine in Italy: results from the My Migraine Voice survey. J Med Econ. 2021;24(1):717–26.

Article  PubMed  Google Scholar 

Barbanti P, Egeo G, Aurilia C, et al. The first report of the Italian Migraine Registry (I-GRAINE). Neurol Sci. 2022;43(9):5725–8. https://doi.org/10.1007/s10072-022-06214-5.

Article  PubMed  Google Scholar 

Negro A, Sciattella P, Rossi D, et al. Cost of chronic and episodic migraine patients in continuous treatment for two years in a tertiary level headache centre. J Headache Pain. 2019;20(1):120.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vo P, Swallow E, Wu E. Real-world migraine-related healthcare resource utilization and costs associated with improved vs. worsened/stable migraine: a panel-based chart review in France, Germany, Italy, and Spain. J Med Econ. 2021;24(1):900–7.

Article  PubMed  Google Scholar 

Lipton RB, Fanning KM, Serrano D, et al. Ineffective acute treatment of episodic migraine is associated with new-onset chronic migraine. Neurology. 2015;84:688–95.

Article  PubMed  PubMed Central  Google Scholar 

Zobdeh F, ben Kraiem A, Attwood MM, et al. Pharmacological treatment of migraine: drug classes, mechanisms of action, clinical trials, and new treatments. Br J Pharmacol. 2021;178:4588–607. https://doi.org/10.1111/bph.15657.

Article  CAS  PubMed  Google Scholar 

Barbanti P, Egeo G, Mitsikostas DD, et al. Trigeminal-targeted treatments in migraine: is 60% the magic number? Headache. 2019;59(9):1659–61.

Article  PubMed  Google Scholar 

Straube A, Aicher B, Fiebich BL, et al. Combined analgesics in (headache) pain therapy: shotgun approach or precise multi-target therapeutics? BMC Neurol. 2011;11:43.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Iacobucci G. NICE recommends rimegepant for treating acute migraine in adults. BMJ. 2023;382:p2104. https://doi.org/10.1136/bmj.p2104. 

Lipton RB, Sagar M, Dawn CB, et al. Predicting inadequate response to acute migraine medication. Results from the American Migraine Prevalence and Prevention (AMPP) Study. Headache. 2016;56:1635–48.

Article  PubMed  Google Scholar 

Derry CJ, Derry S, Moore RA. Sumatriptan (oral route of administration) for acute migraine attacks in adults. Cochrane Database Syst Rev. 2012. https://doi.org/10.1002/14651858.CD008615.pub2.

Article  PubMed  PubMed Central  Google Scholar 

Geraud G, Keywood C, Senard JM. Migraine headache recurrence: relationship to clinical, pharmacological, and pharmacokinetic properties of triptans. Headache. 2003;43:376–88.

Article  PubMed  Google Scholar 

Schwedt TJ, Reed Alam A, Factors LM, associated with acute medicaton overuse in people with migraine: results from the, et al. migraine in America Symptoms and Treatment (MAST) study. Headache. 2017;2018(19):38. https://doi.org/10.1186/s10194-018-0865-z.

Article  Google Scholar 

Xu X, Ji Q, Shen M. Patient preferences and values in decision making for migraines: a systematic literature review pain research and management. Pain Res Manag. 2021;2021:9919773. https://doi.org/10.1155/2021/9919773.

Article  PubMed  PubMed Central  Google Scholar 

Tonini MC, Fiorencis A, Innacchero R, et al. Narrative Medicine to integrate patients’, caregivers’, and clinicians’ migraine experiences: the DRONE multicentre project. Neurol Sci. 2021;42:5277–88. https://doi.org/10.1007/s10072-021-05227-w.

Article  PubMed  PubMed Central  Google Scholar 

Rasmussen, Jensen R, Schroll M, et al. Epidemiology of headache in a general population—a prevalence study. J Clin Epidemiol. 1991;44:1147–57.

Article  CAS  PubMed  Google Scholar 

Curto M, Capi M, Martelletti P, et al. How do you choose the appropriate migraine pharmacotherapy for an elderly person? Expert Opin Pharmacother. 2019;20(1):1–3. https://doi.org/10.1080/14656566.2018.1543660.

Article  PubMed  Google Scholar 

Haan J, Hollander J, Ferrari MD, et al. Migraine in the elderly: a review. Cephalalgia. 2007;27:97–106. https://doi.org/10.1111/j.1468-2982.2006.01250.x.

Article  CAS  PubMed  Google Scholar 

Sarchielli P, Mancini ML, Calabresi P, et al. Practical considerations for the treatment of elderly patients with migraine drugs. Aging. 2006;23(6):461–89.

CAS  Google Scholar 

Martin VT, Ahmed Z, Hochstetler HM, et al. Tolerability and safety of lasmiditan treatment in elderly patients with migraine: post hoc analyses from randomized studies. Clin Ther. 2021;43(6):1066–78.

Article  CAS  PubMed  Google Scholar 

Lasmiditan summary of product characteristics. https://www.ema.europa.eu/en/documents/product-information/rayvow-epar-product-information_en.pdf. Accessed 25 Feb 2024.

Tepper SJ, Millson D. Safety profile of the triptans. Expert Opin Drug Saf. 2003;2(2):123–32.

Article  CAS  PubMed  Google Scholar 

Peterson GM. Selecting nonprescription analgesics. Am J Ther. 2005;12(1):67–79.

Article  PubMed  Google Scholar 

van der Heijden LT, Mian P, Hias J, et al. Highly variable paracetamol pharmacokinetics after multiple oral dosing in frail older people: a population pharmacokinetic analysis. Drugs Aging. 2022;39:83–95. https://doi.org/10.1007/s40266-021-00912-z.

Article  CAS  PubMed  Google Scholar 

Ward N, Whitney C, Avery D, et al. The analgesic effects of caffeine in headache. Pain. 1991;44:151–5.

Article  PubMed  Google Scholar 

Kalkman DN, Couturier EG, El Bouziani A, et al. Migraine and cardiovascular disease: what cardiologists should know. Eur Heart J. 2023;44:2815–28.https://www.acc.org/latest-in-cardiology/ten-points-to-remember/2023/08/15/14/43/migraine-and-cardiovascular-disease.

Schurks M, Rist PM, Bigal ME, et al. Migraine and cardiovascular disease: systematic review and meta-analysis. BMJ. 2009;339:b3914. https://doi.org/10.1136/bmj.b3914.

Article  PubMed  PubMed Central  Google Scholar 

Mahmoud AN, Mentias A, Elgendy AY, et al. Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1 152 407 subjects. BMJ Open. 2018;8:e020498. https://doi.org/10.1136/bmjopen-2017-020498.

Article  PubMed  PubMed Central  Google Scholar 

Kurth T, Schurks M, Logroscino G, et al. Migraine frequency and risk of cardiovascular disease in women. Neurology. 2009;73:581–8. https://doi.org/10.1212/WNL.0b013e3181ab2c20.

Article  PubMed  PubMed Central  Google Scholar 

Etminan M, Takkouche B, Isorna FC, et al. Risk of ischaemic stroke in people with migraine: systematic review and meta-analysis of observational studies. BMJ. 2005. https://doi.org/10.1136/bmj.38302.504063.8F.

Article  PubMed  PubMed Central  Google Scholar 

Visseren FLJ, Mach F, Smulders YM, et al. ESC guidelines on cardiovascular disease prevention in clinical practice: developed by the task force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies with the special contribution of the European Association of Preventive Cardiology (EAPC). Eur Heart J. 2021;2021(42):3227–337. https://doi.org/10.1093/eurheartj/ehab484.

Article  Google Scholar 

Buse DC, Reed ML, Fanning KM, et al. Cardiovascular events, conditions, and procedures among people with episodic migraine in the US population: results from the American Migraine Prevalence and Prevention (AMPP) Study. Headache. 2017;57:31–44.

Article  PubMed  Google Scholar 

Robbins MS. Diagnosis and management of headache: a review. JAMA. 2021;325:1874–85. https://doi.org/10.1001/jama.2021.1640.

Article  PubMed  Google Scholar 

Kalkman DN, Couturier EGM, El Bouziani A, et al. Migraine and cardiovascular disease: what cardiologists should know. Eur Heart J. 2023;44:2815–28.

Article  CAS  PubMed  Google Scholar 

Palmer H. A risk-benefit assessment of paracetamol (acetaminophen) combined with caffeine. Pain Med. 2010;11:951–65.

Article  PubMed  Google Scholar 

Lopez-Garcia E, van Dam RM, Willett WC, et al. Coffee consumption and coronary heart disease in men and women: a prospective cohort study. Circulation. 2006;113:2045–53.

Article  PubMed  Google Scholar 

Cefalee nell’adulto Linee guida nazionali di riferimento per la prevenzione e la terapia. Age.na.s. 2011. https://www.asp.cz.it/files/old/CEFALEA%20NELL'ADUL