Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022;72(1):7–33.

Article  PubMed  Google Scholar 

Martini N, Melamed MR. Multiple primary lung cancers. J Thorac Cardiovasc Surg. 1975;70(4):606–12.

Article  CAS  PubMed  Google Scholar 

Stella F, Luciano G, Dell’ Amore A, Greco D, Ammari C, Giunta D, et al. Pulmonary metastases from NSCLC and MPLC (multiple primary lung cancers): management and outcome in a single centre experience. Heart Lung Circ. 2016;25(2):191–5.

Article  PubMed  Google Scholar 

Travis WD, Brambilla E, Burke AP, Marx A, Nicholson AG. Introduction to the 2015 World Health Organization Classification of Tumors of the lung, Pleura, Thymus, and heart. J Thorac Oncology: Official Publication Int Association Study Lung Cancer. 2015;10(9):1240–2.

Article  Google Scholar 

Alvarez Moreno JC, Aljamal AA, Bahmad HF, Febres-Aldana CA, Rassaei N, Recine M, et al. Correlation between spread through air spaces (STAS) and other clinicopathological parameters in lung cancer. Pathol Res Pract. 2021;220:153376.

Article  PubMed  Google Scholar 

Xie H, Su H, Zhu E, Gu C, Zhao S, She Y, et al. Morphological subtypes of Tumor Spread through Air spaces in Non-small Cell Lung Cancer: prognostic heterogeneity and its underlying mechanism. Front Oncol. 2021;11:608353.

Article  PubMed  PubMed Central  Google Scholar 

Tian Y, Feng J, Jiang L, Ning J, Gu Z, Huang J, et al. Integration of clinicopathological and mutational data offers insight into lung cancer with tumor spread through air spaces. Annals Translational Med. 2021;9(12):985.

Article  CAS  Google Scholar 

Cao L, Jia M, Sun PL, Gao H. Histopathologic features from preoperative biopsies to predict spread through air spaces in early-stage lung adenocarcinoma: a retrospective study. BMC Cancer. 2021;21(1):913.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Chen D, Mao Y, Wen J, She Y, Zhu E, Zhu F, et al. Tumor Spread through Air spaces in Non-small Cell Lung Cancer: a systematic review and Meta-analysis. Ann Thorac Surg. 2019;108(3):945–54.

Article  PubMed  Google Scholar 

Wang S, Hao J, Qian C, Wang H. Tumor Spread through Air Spaces is a survival predictor in Non-small-cell Lung Cancer. Clin Lung Cancer. 2019;20(5):e584–e91.

Article  CAS  PubMed  Google Scholar 

Liu H, Yin Q, Yang G, Qie P. Prognostic impact of Tumor Spread through Air spaces in Non-small Cell Lung cancers: a Meta-Analysis including 3564 patients. Pathol Oncol Research: POR. 2019;25(4):1303–10.

Article  PubMed  Google Scholar 

Chen D, Wang X, Zhang F, Han R, Ding Q, Xu X, et al. Could tumor spread through air spaces benefit from adjuvant chemotherapy in stage I lung adenocarcinoma? A multi-institutional study. Therapeutic Adv Med Oncol. 2020;12:1758835920978147.

CAS  Google Scholar 

Mantovani S, Pernazza A, Bassi M, Amore D, Vannucci J, Poggi C, et al. Prognostic impact of spread through air spaces in lung adenocarcinoma. Interact Cardiovasc Thorac Surg. 2022;34(6):1011–5.

Article  PubMed  Google Scholar 

Zeng H, Tan FW, Yuan ZL, Ren JY, Xu JX, Xue Q. [Analysis of the effect of spread through air spaces on postoperative recurrence-free survival in patients with stage pT1N0M0 lung adenocarcinoma of different tumor size]. Zhonghua Yi Xue Za Zhi. 2022;102(19):1430–6.

CAS  PubMed  Google Scholar 

Wang J, Zhang T, Ding H, Dong G, Xu L, Jiang F. [Research Progress in distinguishing methods of simultaneous multiple primary Lung Cancer and Intrapulmonary Metastasis]. Zhongguo Fei ai Za Zhi = Chinese. J lung cancer. 2021;24(5):365–71.

Google Scholar 

Blaauwgeers H, Flieder D, Warth A, et al. A prospective study of loose tissue fragments in non-small cell lung cancer resection specimens: an alternative view to spread through Air spaces. Am J Surg Pathol. 2017;41(9):1226–30.

Article  PubMed  Google Scholar 

Warth A. Spread through air spaces (STAS): a comprehensive update. Transl Lung Cancer Res. 2017;6(5):501–7.

Article  PubMed  PubMed Central  Google Scholar 

Warth A, Muley T, Kossakowski CA, et al. Prognostic impact of intra alveolar tumor spread in pulmonary adenocarcinoma. Am J Surg Pathol. 2015;39(6):793–801.

Article  PubMed  Google Scholar 

Dai C, Xie H, Su H, et al. Tumor spread through air spaces affects therecurrence and overall survival in patients with lung adenocarcinoma > 2 to 3 cm. J Thorac Oncol. 2017;12(7):1052–60.

Article  PubMed  Google Scholar 

Han YB, Kim H, Mino-Kenudson M, et al. Tumor spread through air spaces (STAS): prognostic significance of grading in non-small cell lung cancer. Mod Pathol. 2021;34(3):549–61.

Article  PubMed  Google Scholar 

Hattori A, Takamochi K, Oh S, Suzuki K. Prognostic classification of multiple primary lung cancers based on a ground-glass opacity component. Ann Thorac Surg. 2020;109(2):420–7.

Article  PubMed  Google Scholar 

Dai C, Xie H, Su H, She Y, Zhu E, Fan Z, et al. Tumor Spread through Air Spaces affects the recurrence and overall survival in patients with lung adenocarcinoma > 2 to 3 cm. J Thorac Oncology: Official Publication Int Association Study Lung Cancer. 2017;12(7):1052–60.

Article  Google Scholar 

Kadota K, Nitadori JI, Sima CS, Ujiie H, Rizk NP, Jones DR, et al. Tumor Spread through Air Spaces is an important pattern of Invasion and impacts the frequency and location of recurrences after Limited Resection for Small Stage I Lung Adenocarcinomas. J Thorac Oncology: Official Publication Int Association Study Lung Cancer. 2015;10(5):806–14.

Article  CAS  Google Scholar 

Jung W, Chung JH, Yum S, Kim K, Lee CT, Jheon S, et al. The differential prognostic impact of spread through air spaces in early-stage lung adenocarcinoma after lobectomy according to the pT descriptor. J Thorac Cardiovasc Surg. 2022;163(1):277–84. e1.

Article  PubMed  Google Scholar 

Jin Y, Sun PL, Park SY, Kim H, Park E, Kim G, et al. Frequent aerogenous spread with decreased E-cadherin expression of ROS1-rearranged lung cancer predicts poor disease-free survival. Lung cancer (Amsterdam Netherlands). 2015;89(3):343–9.

Article  PubMed  Google Scholar 

Suzuki K, Watanabe SI, Wakabayashi M, Saji H, Aokage K, Moriya Y, et al. A single-arm study of sublobar resection for ground-glass opacity dominant peripheral lung cancer. J Thorac Cardiovasc Surg. 2022;163(1):289–301e2.

Article  PubMed  Google Scholar