New light on ω-3 polyunsaturated fatty acids and diabetes debate: a population pharmacokinetic-pharmacodynamic modelling and intake threshold study

Collaborators GBDDitA. Burden of diabetes and hyperglycaemia in adults in the Americas, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Diabetes Endocrinol. 2022;10:655–67.

Article  Google Scholar 

Delpino FM, Figueiredo LM, da Silva BGC, da Silva TG, Mintem GC, Bielemann RM, et al. Omega-3 supplementation and diabetes: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2022;62:4435–48.

Article  CAS  Google Scholar 

Downer S, Berkowitz SA, Harlan TS, Olstad DL, Mozaffarian D. Food is medicine: actions to integrate food and nutrition into healthcare. BMJ. 2020;369:m2482.

Article  Google Scholar 

Kazemian P, Kazemi-Bajestani SM, Alherbish A, Steed J, Oudit GY. The use of omega-3 poly-unsaturated fatty acids in heart failure: a preferential role in patients with diabetes. Cardiovasc Drugs Ther. 2012;26:311–20.

Article  CAS  Google Scholar 

Duran AM, Beeson WL, Firek A, Cordero-MacIntyre Z, De Leon M. Dietary omega-3 polyunsaturated fatty-acid supplementation upregulates protective cellular pathways in patients with type 2 diabetes exhibiting improvement in painful diabetic neuropathy. Nutrients. 2022;14:761.

Article  CAS  Google Scholar 

Gortan Cappellari G, Semolic A, Ruozi G, Barbetta D, Bortolotti F, Vinci P, et al. n-3 PUFA dietary lipid replacement normalizes muscle mitochondrial function and oxidative stress through enhanced tissue mitophagy and protects from muscle wasting in experimental kidney disease. Metabolism. 2022;133:155242.

Article  CAS  Google Scholar 

Chen C, Yang Y, Yu X, Hu S, Shao S. Association between omega-3 fatty acids consumption and the risk of type 2 diabetes: A meta-analysis of cohort studies. J Diabetes Investig. 2017;8:480–8.

Article  CAS  Google Scholar 

Djuricic I, Calder PC. Polyunsaturated fatty acids and metabolic health: novel insights. Curr Opin Clin Nutr Metab Care. 2022;25:436–42.

Article  CAS  Google Scholar 

Group ASC, Bowman L, Mafham M, Wallendszus K, Stevens W, Buck G, et al. Effects of n-3 fatty acid supplements in diabetes mellitus. N. Engl J Med. 2018;379:1540–50.

Article  Google Scholar 

Glauber H, Wallace P, Griver K, Brechtel G. Adverse metabolic effect of omega-3 fatty acids in non-insulin-dependent diabetes mellitus. Ann Intern Med. 1988;108:663–8.

Article  CAS  Google Scholar 

Vessby B, Karlstrom B, Boberg M, Lithell H, Berne C. Polyunsaturated fatty acids may impair blood glucose control in type 2 diabetic patients. Diabet Med. 1992;9:126–33.

Article  CAS  Google Scholar 

Jager S, Cuadrat R, Hoffmann P, Wittenbecher C, Schulze MB. Desaturase activity and the risk of type 2 diabetes and coronary artery disease: a Mendelian randomization study. Nutrients. 2020;12:2261.

Article  Google Scholar 

Chevalier L, Plourde M. Comparison of pharmacokinetics of omega-3 fatty acid supplements in monoacylglycerol or ethyl ester in humans: a randomized controlled trial. Eur J Clin Nutr. 2021;75:680–8.

Article  CAS  Google Scholar 

Bird JK, Calder PC, Eggersdorfer M. The role of n-3 long chain polyunsaturated fatty acids in cardiovascular disease prevention, and interactions with statins. Nutrients. 2018;10:775.

Article  Google Scholar 

Illner AK, Freisling H, Boeing H, Huybrechts I, Crispim SP, Slimani N. Review and evaluation of innovative technologies for measuring diet in nutritional epidemiology. Int J Epidemiol. 2012;41:1187–203.

Article  Google Scholar 

Djousse L, Biggs ML, Lemaitre RN, King IB, Song X, Ix JH, et al. Plasma omega-3 fatty acids and incident diabetes in older adults. Am J Clin Nutr. 2011;94:527–33.

Article  CAS  Google Scholar 

Tuntland T, Ethell B, Kosaka T, Blasco F, Zang RX, Jain M, et al. Implementation of pharmacokinetic and pharmacodynamic strategies in early research phases of drug discovery and development at Novartis Institute of Biomedical Research. Front Pharm. 2014;5:174.

Article  Google Scholar 

Grit GF, Martson AG, Knoester M, Toren-Wielema ML, Touw DJ. Shedding a light on ccyclovir pharmacodynamics: a retrospective analysis on pharmacokinetic/pharmacodynamic modelling of acyclovir for the treatment of Varicella zoster virus Infection in immunocompromised patients: a pilot study. Pharmaceutics. 2022;14:2311.

Article  CAS  Google Scholar 

Rosario M, Dirks NL, Gastonguay MR, Fasanmade AA, Wyant T, Parikh A, et al. Population pharmacokinetics-pharmacodynamics of vedolizumab in patients with ulcerative colitis and Crohn’s disease. Aliment Pharm Ther. 2015;42:188–202.

Article  CAS  Google Scholar 

Agema BC, Oosten AW, Sassen SDT, Rietdijk WJR, van der Rijt CCD, Koch BCP, et al. Population pharmacokinetics of oxycodone and metabolites in patients with cancer-related pain. Cancers. 2021;13:2768.

Article  CAS  Google Scholar 

Byrne CJ, Roberts JA, McWhinney B, Ryder SA, Fennell JP, O’Byrne P, et al. Population pharmacokinetics of teicoplanin and attainment of pharmacokinetic/pharmacodynamic targets in adult patients with haematological malignancy. Clin Microbiol Infect. 2017;23:674.e7–e13.

Article  CAS  Google Scholar 

Madar AA, Heen E, Hopstock LA, Carlsen MH, Meyer HE. Iodine intake in Norwegian women and men: the population-based Tromso Study 2015-2016. Nutrients. 2020;12:3246.

Article  CAS  Google Scholar 

Naghshi S, Aune D, Beyene J, Mobarak S, Asadi M, Sadeghi O. Dietary intake and biomarkers of alpha linolenic acid and risk of all cause, cardiovascular, and cancer mortality: systematic review and dose-response meta-analysis of cohort studies. BMJ. 2021;375:n2213.

Article  Google Scholar 

Byers JP, Sarver JG Chapter 10 - Pharmacokinetic Modeling. In: Hacker M, Messer W, Bachmann K, editors. Pharmacology. San Diego: Academic Press; 2009. p. 201–77.

Foster DM, Vicini P. Noncompartmental and compartmental approaches to pharmacokinetic data analysis. In: Huang SM, Lertora JJL, Vicini P, Atkinson AJ, editors. Atkinson’s principles of clinical pharmacology. San Diego: Academic Press; 2022. p. 113–35.

Rajpoot K, Tekade RK, Sharma MC, Safavi M, Tekade M. Pharmacokinetics modeling in drug delivery. In: Tekade RK, editor. Advances in pharmaceutical product development and research, biopharmaceutics and pharmacokinetics considerations. San Diego: Academic Press; 2021. p. 279–334.

Shimada H, Nilsson C, Noda Y, Kim H, Lundstrom T, Yajima T. Effects of food on the pharmacokinetics of omega-3-carboxylic acids in healthy Japanese male subjects: a phase I, randomized, open-label, three-period, crossover trial. J Atheroscler Thromb. 2017;24:980–7.

Article  CAS  Google Scholar 

Samimi M, Jamilian M, Asemi Z, Esmaillzadeh A. Effects of omega-3 fatty acid supplementation on insulin metabolism and lipid profiles in gestational diabetes: Randomized, double-blind, placebo-controlled trial. Clin Nutr. 2015;34:388–93.

Article  CAS  Google Scholar 

Mostad IL, Bjerve KS, Bjorgaas MR, Lydersen S, Grill V. Effects of n-3 fatty acids in subjects with type 2 diabetes: reduction of insulin sensitivity and time-dependent alteration from carbohydrate to fat oxidation. Am J Clin Nutr. 2006;84:540–50.

Article  CAS  Google Scholar 

Collaborators GBDD. Health effects of dietary risks in 195 countries, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2019;393:1958–72.

Article  Google Scholar 

Donadio JV, Grande JP. The role of fish oil/omega-3 fatty acids in the treatment of IgA nephropathy. Semin Nephrol. 2004;24:225–43.

Article  CAS  Google Scholar 

Hamazaki T, Colleran H, Hamazaki K, Matsuoka Y, Itomura M, Hibbeln J. The safety of fish oils for those whose risk of injury is high. Mil Med. 2014;179:134–7.

Article  Google Scholar 

Abdelhamid AS, Brown TJ, Brainard JS, Biswas P, Thorpe GC, Moore HJ, et al. Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease. Cochrane Database Syst Rev. 2020;3:Cd003177.

Google Scholar 

Akintoye E, Sethi P, Harris WS, Thompson PA, Marchioli R, Tavazzi L, et al. Fish oil and perioperative bleeding. Circ Cardiovasc Qual Outcomes. 2018;11:e004584.

Article  Google Scholar 

Wiseman M. The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Proc Nutr Soc. 2008;67:253–6.

Article  Google Scholar 

Manson JE, Cook NR, Lee IM, Christen W, Bassuk SS, Mora S, et al. Marine n-3 fatty acids and prevention of cardiovascular disease and cancer. N. Engl J Med. 2019;380:23–32.

Article  CAS  Google Scholar 

Huang R, Yan L, Lei Y. The relationship between high-density lipoprotein cholesterol (HDL-C) and glycosylated hemoglobin in diabetic patients aged 20 or above: a cross-sectional study. BMC Endocr Disord. 2021;21:198.

Article  CAS  Google Scholar 

Sacks FM, Andraski AB. Dietary fat and carbohydrate affect the metabolism of protein-based high-density lipoprotein subspecies. Curr Opin Lipido. 2022;33:1–15.

Article  CAS  Google Scholar 

Chen C, Yu X, Shao S. Effects of omega-3 fatty acid supplementation on glucose control and lipid levels in type 2 diabetes: a meta-analysis. PLoS ONE. 2015;10:e0139565.

Article  Google Scholar 

Enzenbach C, Kröger J, Zietemann V, Jansen EH, Fritsche A, Döring F, et al. Erythrocyte membrane phospholipid polyunsaturated fatty acids are related to plasma C-reactive protein and adiponectin in middle-aged German women and men. Eur J Nutr. 2011;50:625–36.

Article  CAS  Google Scholar 

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