Agency for Toxic Substances and Disease Registry [WWW Document], 2022. URL https://www.atsdr.cdc.gov/index.html (Accessed 11.12.22).

Averina M, Brox J, Huber S, Furberg A-S, Sørensen M (2019) Serum perfluoroalkyl substances (PFAS) and risk of asthma and various allergies in adolescents. The Tromsø study Fit Futures in Northern Norway. Environ Res 169:114–121. https://doi.org/10.1016/j.envres.2018.11.005

Article  CAS  PubMed  Google Scholar 

Bobb JF, Valeri L, Claus Henn B, Christiani DC, Wright RO, Mazumdar M, Godleski JJ, Coull BA (2015) Bayesian kernel machine regression for estimating the health effects of multi-pollutant mixtures. Biostat Oxf Engl 16:493–508. https://doi.org/10.1093/biostatistics/kxu058

Article  MathSciNet  Google Scholar 

Bobb JF, Claus Henn B, Valeri L, Coull BA (2018) Statistical software for analyzing the health effects of multiple concurrent exposures via Bayesian kernel machine regression. Environ Health Glob Access Sci Source 17:67. https://doi.org/10.1186/s12940-018-0413-y

Article  Google Scholar 

Braun JM, Gennings C, Hauser R, Webster TF (2016) What can epidemiological studies tell us about the impact of chemical mixtures on human health? Environ Health Perspect 124:A6-9. https://doi.org/10.1289/ehp.1510569

Article  PubMed  PubMed Central  Google Scholar 

Buck RC, Franklin J, Berger U, Conder JM, Cousins IT, de Voogt P, Jensen AA, Kannan K, Mabury SA, van Leeuwen SPJ (2011) Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins. Integr Environ Assess Manag 7:513–541. https://doi.org/10.1002/ieam.258

Article  CAS  PubMed  PubMed Central  Google Scholar 

Calafat AM, Wong L-Y, Kuklenyik Z, Reidy JA, Needham LL (2007) Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003–2004 and comparisons with NHANES 1999–2000. Environ Health Perspect 115:1596–1602. https://doi.org/10.1289/ehp.10598

Article  CAS  PubMed  PubMed Central  Google Scholar 

Carrico C, Gennings C, Wheeler DC, Factor-Litvak P (2015) Characterization of weighted quantile sum regression for highly correlated data in a risk analysis setting. J Agric Biol Environ Stat 20:100–120. https://doi.org/10.1007/s13253-014-0180-3

Article  MathSciNet  PubMed  Google Scholar 

D’Agostino LA, Mabury SA (2014) Identification of novel fluorinated surfactants in aqueous film forming foams and commercial surfactant concentrates. Environ Sci Technol 48:121–129. https://doi.org/10.1021/es403729e

Article  CAS  PubMed  Google Scholar 

D’eon JC, Mabury SA (2011) Is indirect exposure a significant contributor to the burden of perfluorinated acids observed in humans? Environ Sci Technol 45:7974–7984. https://doi.org/10.1021/es200171y

Article  CAS  PubMed  Google Scholar 

De Silva AO, Armitage JM, Bruton TA, Dassuncao C, Heiger-Bernays W, Hu XC, Kärrman A, Kelly B, Ng C, Robuck A, Sun M, Webster TF, Sunderland EM (2021) PFAS exposure pathways for humans and wildlife: a synthesis of current knowledge and key gaps in understanding. Environ Toxicol Chem 40:631–657. https://doi.org/10.1002/etc.4935

Article  CAS  PubMed  PubMed Central  Google Scholar 

Dong G-H, Tung K-Y, Tsai C-H, Liu M-M, Wang D, Liu W, Jin Y-H, Hsieh W-S, Lee YL, Chen P-C (2013) Serum polyfluoroalkyl concentrations, asthma outcomes, and immunological markers in a case-control study of Taiwanese children. Environ Health Perspect 121:507–513. https://doi.org/10.1289/ehp.1205351

Article  PubMed  PubMed Central  Google Scholar 

Fromme H, Tittlemier SA, Völkel W, Wilhelm M, Twardella D (2009) Perfluorinated compounds–exposure assessment for the general population in Western countries. Int J Hyg Environ Health 212:239–270. https://doi.org/10.1016/j.ijheh.2008.04.007

Article  CAS  PubMed  Google Scholar 

Goldman LR (1995) Children--unique and vulnerable. Environmental risks facing children and recommendations for response. Environ Health Perspect 103(Suppl 6):13–18. https://doi.org/10.1289/ehp.95103s613

Guo J, Huang S, Yang L, Zhou J, Xu X, Lin S, Li H, Xie X, Wu S (2023) Association between polyfluoroalkyl substances exposure and sex steroids in adolescents: the mediating role of serum albumin. Ecotoxicol Environ Saf 253:114687. https://doi.org/10.1016/j.ecoenv.2023.114687

Article  CAS  PubMed  Google Scholar 

Hu XC, Tokranov AK, Liddie J, Zhang X, Grandjean P, Hart JE, Laden F, Sun Q, Yeung LWY, Sunderland EM (2019) Tap water contributions to plasma concentrations of poly- and perfluoroalkyl substances (PFAS) in a Nationwide Prospective Cohort of U.S. Women. Environ Health Perspect 127:67006. https://doi.org/10.1289/EHP4093

Article  PubMed  Google Scholar 

Hu P, Pan C, Su W, Vinturache A, Hu Y, Dong X, Ding G (2022) Associations between exposure to a mixture of phenols, parabens, and phthalates and sex steroid hormones in children 6–19 years from NHANES, 2013–2016. Sci Total Environ 822:153548. https://doi.org/10.1016/j.scitotenv.2022.153548

Article  CAS  PubMed  Google Scholar 

Humblet O, Diaz-Ramirez LG, Balmes JR, Pinney SM, Hiatt RA (2014) Perfluoroalkyl chemicals and asthma among children 12–19 years of age: NHANES (1999–2008). Environ Health Perspect 122:1129–1133. https://doi.org/10.1289/ehp.1306606

Article  PubMed  PubMed Central  Google Scholar 

Immunotoxicity Associated with Exposure to Perfluorooctanoic Acid (PFOA) or Perfluorooctane Sulfonate (PFOS) [WWW Document], 2016. URL https://ntp.niehs.nih.gov/whatwestudy/assessments/noncancer/completed/pfoa/ (accessed 5.5.23).

Jackson-Browne MS, Eliot M, Patti M, Spanier AJ, Braun JM (2020) PFAS (per- and polyfluoroalkyl substances) and asthma in young children: NHANES 2013–2014. Int J Hyg Environ Health 229:113565. https://doi.org/10.1016/j.ijheh.2020.113565

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kuczmarski RJ, Ogden CL, Guo SS, Grummer-Strawn LM, Flegal KM, Mei Z, Wei R, Curtin LR, Roche AF, Johnson CL (2002) 2000 CDC Growth Charts for the United States: methods and development. Vital Health Stat 11:1–190

Google Scholar 

Kvalem HE, Nygaard UC, Lødrup Carlsen KC, Carlsen KH, Haug LS, Granum B (2020) Perfluoroalkyl substances, airways infections, allergy and asthma related health outcomes - implications of gender, exposure period and study design. Environ Int 134:105259. https://doi.org/10.1016/j.envint.2019.105259

Article  CAS  PubMed  Google Scholar 

Liew Z, Goudarzi H, Oulhote Y (2018) Developmental exposures to Perfluoroalkyl Substances (PFASs): an update of associated health outcomes. Curr Environ Health Rep 5:1–19. https://doi.org/10.1007/s40572-018-0173-4

Article  CAS  PubMed  PubMed Central  Google Scholar 

Luo Y, Deji Z, Huang Z (2020) Exposure to perfluoroalkyl substances and allergic outcomes in children: a systematic review and meta-analysis. Environ Res 191:110145. https://doi.org/10.1016/j.envres.2020.110145

Article  CAS  PubMed  Google Scholar 

NHANES - About the National Health and Nutrition Examination Survey [WWW Document], 2022. URL https://www.cdc.gov/nchs/nhanes/about_nhanes.htm (accessed 5.9.23).

NHANES Tutorials - Weighting Module [WWW Document], n.d. URL https://wwwn.cdc.gov/nchs/nhanes/tutorials/Weighting.aspx (Accessed 5.14.23).

Olsen GW, Burris JM, Ehresman DJ, Froehlich JW, Seacat AM, Butenhoff JL, Zobel LR (2007) Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers. Environ Health Perspect 115:1298–1305. https://doi.org/10.1289/ehp.10009

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pan Z, Guo Y, Zhou Q, Wang Q, Pan S, Xu S, Li L (2023) Perfluoroalkyl substance exposure is associated with asthma and innate immune cell count in US adolescents stratified by sex. Environ Sci Pollut Res Int 30:52535–52548. https://doi.org/10.1007/s11356-023-26065-7

Article  CAS  PubMed  Google Scholar 

R Core Team (2022) R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria: 4.2.2. URL https://www.R-project.org/., 2022

Rappazzo KM, Coffman E, Hines EP (2017) Exposure to perfluorinated alkyl substances and health outcomes in children: a systematic review of the epidemiologic literature. Int J Environ Res Public Health 14:691. https://doi.org/10.3390/ijerph14070691

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rotander A, Karrman A, Toms LML, Kay M, Mueller JF, Gomez Ramos MJ (2015) Novel fluorinated surfactants tentatively identified in firefighters using liquid chromatography quadrupole time-of-flight tandem mass spectrometry and a case-control approach. Environ Sci Technol. https://doi.org/10.1021/es503653n

Article  PubMed  Google Scholar 

Sarigiannis DA, Hansen U (2012) Considering the cumulative risk of mixtures of chemicals - a challenge for policy makers. Environ Health Glob Access Sci Source 11(Suppl 1):S18. https://doi.org/10.1186/1476-069X-11-S1-S18

Article  Google Scholar 

Stein CR, McGovern KJ, Pajak AM, Maglione PJ, Wolff MS (2016) Perfluoroalkyl and polyfluoroalkyl substances and indicators of immune function in children aged 12–19 y: National Health and Nutrition Examination Survey. Pediatr Res 79:348–357. https://doi.org/10.1038/pr.2015.213

Article  CAS  PubMed  Google Scholar 

Timmermann CAG, Budtz-Jørgensen E, Jensen TK, Osuna CE, Petersen MS, Steuerwald U et al (2017) Association between perfluoroalkyl substance exposure and asthma and allergic disease in children as modified by MMR vaccination. J Immunotoxicol 14(1):39–49. https://doi.org/10.1080/1547691X.2016.1254306

Article  CAS  PubMed  PubMed Central  Google Scholar 

Torén K, Brisman J, Järvholm B (1993) Asthma and asthma-like symptoms in adults assessed by questionnaires. A literature review. Chest 104:600–608. https://doi.org/10.1378/chest.104.2.600

Article  PubMed  Google Scholar 

Wang Y, Liu J, Li J, Zhao Y, Wu Y (2019) Dietary exposure of chinese adults to perfluoroalkyl acids via animal-origin foods: Chinese total diet Study (2005–2007 and 2011–2013). J Agric Food Chem 67:6048–6055. https://doi.org/10.1021/acs.jafc.9b01108

Article  CAS  PubMed  Google Scholar 

Wang L-Q, Liu T, Yang S, Sun L, Zhao Z-Y, Li L-Y, She Y-C, Zheng Y-Y, Ye X-Y, Bao Q, Dong G-H, Li C-W, Cui J (2021) Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome. Na