Bhate K, Williams HC. Epidemiology of acne vulgaris. Br J Dermatol. 2013;168:474–85.

Article  CAS  PubMed  Google Scholar 

Cunliffe WJ. Acne and unemployment. Br J Dermatol. 1986;115:386–386.

Article  CAS  PubMed  Google Scholar 

Ramos-e-Silva M, Ramos-e-Silva S, Carneiro S. Acne in women. Br J Dermatol. 2015;172:20–26.

Article  PubMed  Google Scholar 

Dikicier BS. Topical treatment of acne vulgaris: efficiency, side effects, and adherence rate. J Int Med Res. 2019;47:2987–92.

Article  Google Scholar 

Quanico J, Gimeno J-P, Nadal-Wollbold F, Casas C, Alvarez-Georges S, Redoules D, et al. Proteomic and transcriptomic investigation of acne vulgaris microcystic and papular lesions: Insights in the understanding of its pathophysiology. Biochim Biophys Acta Gen Subj. 2017;1861:652–63.

Article  CAS  PubMed  Google Scholar 

Zouboulis CC. Acne and sebaceous gland function. Clin Dermatol. 2005;22:360–6.

Article  Google Scholar 

Nagy I, Pivarcsi A, Kis K, Koreck A, Bodai L, McDowell A, et al. Propionibacterium acnes and lipopolysaccharide induce the expression of antimicrobial peptides and proinflammatory cytokines/ chemokines in human sebocytes. Microbes Infect. 2006;8:2195–205.

Article  CAS  PubMed  Google Scholar 

Clarke SB, Nelson AM, George RE, Thiboutot DM. Pharmacologic modulation of sebaceous gland activity: mechanisms and clinical applications. Dermatol Clin. 2007;25:137–46.

Article  CAS  PubMed  Google Scholar 

Kurokawa I, Danby FW, Ju Q, Wang X, Xiang LF, Xia L, et al. New developments in our under- standing of acne pathogenesis and treatment. Exp Dermatol. 2009;18:821–32.

Article  CAS  PubMed  Google Scholar 

Li ZJ, Choi DK, Sohn KC, Seo MS, Lee HE, Lee Y, et al. Propionibacterium acnes activates the NLRP3 inflammasome in human sebocytes. J Inves Dermatol. 2014;134:2747–65.

Article  CAS  Google Scholar 

Thaiss CA, Zmora N, Levy M, Elinav E. The microbiome and innate immunity. Nature. 2016;535:65–74.

Article  CAS  PubMed  Google Scholar 

Kieser KJ, Kagan JC. Multi-receptor detection of individual bacterial products by the innate immune system. Nat Rev Immunol. 2017;17:376–90.

Article  CAS  PubMed  PubMed Central  Google Scholar 

He Y, Hara H, Nunez G. Mechanism and regulation of NLRP3 inflammasome activation. Trends Biochem Sci. 2016;41:1012–21.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Guo H, Callaway JB, Ting JP-Y. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat Med. 2015;21:677–87.

Article  PubMed  PubMed Central  Google Scholar 

Broz P, Dixit VM. Inflammasomes: mechanism of assembly, regulation and signaling. Nat Rev Immunol. 2016;16:407–20.

Article  CAS  PubMed  Google Scholar 

Brinkmann V, Reichard U, Goosmann C, Fauler B, Uhlemann Y, Weiss DS, et al. Neutrophil extracellular traps kill bacteria. Science. 2004;303:1532–5.

Article  CAS  PubMed  Google Scholar 

Papayannopoulos V. Neutrophil extracellular traps in immunity and disease. Nat Rev Immunol. 2018;18:134–47.

Article  CAS  PubMed  Google Scholar 

Bonaventura A, Vecchie A, Abbate A, Montecucco F. Neutrophil extracellular traps and cardiovascular diseases an update. Cells. 2020;9:231.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Papayannopoulos V, Metzler KD, Hakkim A, Zychlinsky A. Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J Cell Biol. 2010;191:677–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Reeves EP, Lu H, Jacobs HL, Messina CGM, Bolsover S, Gabella G, et al. Killing activity of neutrophils is mediated through activation of proteases by K+ flux. Nature. 2002;416:291–7.

Article  CAS  PubMed  Google Scholar 

Smith CK, Vivekanandan-Giri A, Tang C, Knight JS, Mathew A, Padilla RL, et al. Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus. Arthritis Rheum. 2014;66:2532–44.

Article  CAS  Google Scholar 

Parker H, Winterbourn CC. Reactive oxidants and myeloperoxidase and their involvement in neutrophil extracellular traps. Front Immunol. 2013;3:424.

Article  PubMed  PubMed Central  Google Scholar 

Hawez A, Al-Haidari A, Madhi R, Rahman M, Thorlacius H, et al. MiR-155 regulates PAD4-dependent formation of neutrophil extracellular traps. Front Immunol. 2019;10:2462.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, et al. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015;11:189–91.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wang Y, Li M, Stadler S, Correll S, Li P, Wang D, et al. Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation. J Cell Biol. 2009;184:205–13.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Martinod K, Demers M, Fuchs TA, Wong SL, Brill A, Gallant M, et al. Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice. Proc Natl Acad Sci USA. 2013;110:8674–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kaplan MJ, Radic M. Neutrophil extracellular traps: double-edged swords of innate immunity. J Immunol. 2012;189:2689–95.

Article  CAS  PubMed  Google Scholar 

Hahn S, Giaglis S, Chowdury CS, Hosli I, Hasler P. Modulation of neutrophil NETosis: interplay between infectious agents and underlying host physiology. Semin Immunopathol. 2013;35:439–53.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wong SL, Demers M, Martinod K, Gallant M, Wang Y, Goldfine AB, et al. Diabetes primes neutrophils to undergo NETosis, which impairs wound healing. Nat Med. 2015;21:815–9.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li ZJ, Choi DK, Sohn KC, Seo MS, Lee HE, Lee Y, et al. Propionibacterium acnes activates the NLRP3 inflammasome in human sebocytes. J Invest Dermatol. 2014;134:2747–56.

Article  CAS  PubMed  Google Scholar 

James WD. Clinical practice. Acne N. Engl J Med. 2005;352:1463–72.

Article  CAS  PubMed  Google Scholar 

Brenner M, Ruzicka T, Plewig G, Thomas P, Herzer P. Targeted treatment of pyoderma gangrenosum in PAPA (pyogenic arthritis, pyoderma gangrenosum and acne) syndrome with the recombinant human interleukin-1 receptor antagonist anakinra. Br J Dermatol. 2009;161:1191–201.

Article  Google Scholar 

Braun-Falco M, Kovnerystyy O, Lohse P, Ruzicka T. Pyoderma gangrenosum, acne, and suppurative hidradenitis (PASH)—a new autoinflammatory syndrome distinct from PAPA syndrome. J Am Acad Dermatol. 2012;66:409–15.

Article  PubMed  Google Scholar 

Wendling D, Prati C, Aubin F. Anakinra treatment of SAPHO syndrome: short-term results of an open study. Ann Rheum Dis. 2012;71:1098–100.

Article  CAS  PubMed  Google Scholar