Stress Biomarkers Transferred Into the Female Reproductive Tract by Seminal Plasma Are Associated with ICSI Outcomes

European IVF Monitoring Consortium (EIM), for the European Society of Human Reproduction and Embryology (ESHRE); Wyns C, De Geyter C, Calhaz-Jorge C, Kupka MS, Motrenko T, Smeenk J, et al. ART in Europe, 2018: results generated from European registries by ESHRE. Hum Reprod Open. 2022;2022(3):hoac022. https://doi.org/10.1093/hropen/hoac022.

Schjenken JE, Robertson SA. The female response to seminal fluid. Physiol Rev. 2020;100(3):1077–117. https://doi.org/10.1152/physrev.00013.2018.

Article  CAS  PubMed  Google Scholar 

Chen JC, Johnson BA, Erikson DW, Piltonen TT, Barragan F, Chu S, et al. Seminal plasma induces global transcriptomic changes associated with cell migration, proliferation and viability in endometrial epithelial cells and stromal fibroblasts. Hum Reprod. 2014;29(6):1255–70. https://doi.org/10.1093/humrep/deu047.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Rodriguez-Caro H, Dragovic R, Shen M, Dombi E, Mounce G, Field K, et al. In vitro decidualisation of human endometrial stromal cells is enhanced by seminal fluid extracellular vesicles. J Extracell Vesicles. 2019;8(1):1565262.  https://doi.org/10.1080/20013078.2019.1565262.

George AF, Jang KS, Nyegaard M, Neidleman J, Spitzer TL, Xie G, et al. Seminal plasma promotes decidualization of endometrial stromal fibroblasts in vitro from women with and without inflammatory disorders in a manner dependent on interleukin-11 signaling. Hum Reprod. 2020;35(3):617–40. https://doi.org/10.1093/humrep/deaa015.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Moharrami T, Ai J, Ebrahimi-Barough S, Nouri M, Ziadi M, Pashaiefar H, et al. Influence of follicular fluid and seminal plasma on the expression of endometrial receptivity genes in endometrial cells. Cell J. 2020;22(4):457–66. https://doi.org/10.22074/cellj.2021.6851.

Ata B, Abou-Setta AM, Seyhan A, Buckett W. Application of seminal plasma to female genital tract prior to embryo transfer in assisted reproductive technology cycles (IVF, ICSI and frozen embryo transfer). Cochrane Database Syst Rev. 2018;(2):CD011809. https://doi.org/10.1002/14651858.CD011809.pub2.

Clarke RN, Klock SC, Geoghegan A, Travassos DE. Relationship between psychological stress and semen quality among in-vitro fertilization patients. Hum Reprod. 1999;14(3):753–8. https://doi.org/10.1093/humrep/14.3.753.

Article  CAS  PubMed  Google Scholar 

Holter H, Anderheim L, Bergh C, Möller A. First IVF treatment – short-term impact on psychological well-being and the marital relationship. Hum Reprod. 2006;21(12):3295–302. https://doi.org/10.1093/humrep/del288.

Article  CAS  PubMed  Google Scholar 

Peterson BD, Newton CR, Feingold T. Anxiety and sexual stress in men and women undergoing infertility treatment. Fertil Steril. 2007;88(4):911–4. https://doi.org/10.1016/j.fertnstert.2006.12.023.

Article  PubMed  Google Scholar 

Ying L, Wu LH, Loke AY. Gender differences in emotional reactions to in vitro fertilization treatment: a systematic review. J Assist Reprod Genet. 2016;33(2):167–79. https://doi.org/10.1007/s10815-015-0638-4.

Article  PubMed  Google Scholar 

Martins MV, Basto-Pereira M, Pedro J, Peterson B, Almeida V, Schmidt L, et al. Male psychological adaptation to unsuccessful medically assisted reproduction treatments: a systematic review. Hum Reprod Update. 2016;22(4):466–78. https://doi.org/10.1093/humupd/dmw009.

Article  PubMed  Google Scholar 

Haimovici F, Anderson JL, Bates GW, Racowsky C, Ginsburg ES, Simovici D, et al. Stress, anxiety, and depression of both partners in infertile couples are associated with cytokine levels and adverse IVF outcome. Am J Reprod Immunol. 2018;79(4):e12832. https://doi.org/10.1111/aji.12832.

Article  CAS  PubMed  Google Scholar 

Cao D, Bai C, Zhang G. Psychological distress among infertility patients: a network analysis. Front Psychol. 2022;13:906226. https://doi.org/10.3389/fpsyg.2022.906226.

Zhang L, Shao H, Huo M, Chen J, Tao M, Liu Z. Prevalence and associated risk factors for anxiety and depression in infertile couples of ART treatment: a cross-sectional study. BMC Psychiatry. 2022;22(1):616. https://doi.org/10.1186/s12888-022-04256-9.

Article  PubMed  PubMed Central  Google Scholar 

Selye H. Confusion and controversy in the stress field. J Human Stress. 1975;1(2):37–44. https://doi.org/10.1080/0097840X.1975.9940406.

Article  CAS  PubMed  Google Scholar 

Nikolaeva M, Arefieva A, Babayan A, Chagovets V, Kitsilovskaya N, Starodubtseva N, et al. Immunoendocrine markers of stress in seminal plasma at IVF/ICSI failure: a preliminary study. Reprod Sci. 2021;28(1):144–58. https://doi.org/10.1007/s43032-020-00253-z.

Article  CAS  PubMed  Google Scholar 

Kvetnansky R, Lu X, Ziegler MG. Stress-triggered changes in peripheral catecholaminergic systems. Adv Pharmacol. 2013;68:359–97. https://doi.org/10.1016/B978-0-12-411512-5.00017-8.

Article  CAS  PubMed  Google Scholar 

Wortsman J. Role of epinephrine in acute stress. Endocrinol Metab Clin North Am. 2002;31(1):79–106. https://doi.org/10.1016/s0889-8529(01)00024-x.

Article  CAS  PubMed  Google Scholar 

Nater U, Rohleder N, Gaab J, Berger S, Jud A, Kirschbaum C, et al. Human salivary alpha-amylase reactivity in a psychosocial stress paradigm. Int J Psychophysiol. 2005;55:333–42. https://doi.org/10.1016/j.ijpsycho.2004.09.009.

Article  PubMed  Google Scholar 

Elenkov IJ, Wilder RL, Chrousos GP, Vizi ES. The sympathetic nerve – an integrative interface between two supersystems: the brain and the immune system. Pharmacol Rev. 2000;52(4):595–638.

CAS  PubMed  Google Scholar 

von Majewski K, Kraus O, Rhein C, Lieb M, Erim Y, Rohleder N. Acute stress responses of autonomous nervous system, HPA axis, and inflammatory system in posttraumatic stress disorder. Transl Psychiatry. 2023;13(1):36. https://doi.org/10.1038/s41398-023-02331-7.

Article  CAS  Google Scholar 

Dhabhar FS, McEwen BS. Enhancing versus suppressive effects of stress hormones on skin immune function. Proc Natl Acad Sci USA. 1999;96(3):1059–64. https://doi.org/10.1073/pnas.96.3.1059.

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Kunz-Ebrecht SR, Mohamed-Ali V, Feldman PJ, Kirschbaum C, Steptoe A. Cortisol responses to mild psychological stress are inversely associated with proinflammatory cytokines. Brain Behav Immun. 2003;17(5):373–83. https://doi.org/10.1016/s0889-1591(03)00029-1.

Article  CAS  PubMed  Google Scholar 

Marsland AL, Walsh C, Lockwood K, John-Henderson NA. The effects of acute psychological stress on circulating and stimulated inflammatory markers: a systematic review and meta-analysis. Brain Behav Immun. 2017;64:208–19.  https://doi.org/10.1016/j.bbi.2017.01.011.

Rohleder N. Stress and inflammation - the need to address the gap in the transition between acute and chronic stress effects. Psychoneuroendocrinology. 2019;105:164–71. https://doi.org/10.1016/j.psyneuen.2019.02.021.

Article  PubMed  Google Scholar 

Sugama S, Conti B. Interleukin-18 and stress. Brain Res Rev. 2008;58(1):85–95. https://doi.org/10.1016/j.brainresrev.2007.11.003.

Article  CAS  PubMed  Google Scholar 

Exton MS, Krüger TH, Bursch N, Haake P, Knapp W, Schedlowski M, et al. Endocrine response to masturbation-induced orgasm in healthy men following a 3-week sexual abstinence. World J Urol. 2001;19(5):377–82. https://doi.org/10.1007/s003450100222.

Article  CAS  PubMed  Google Scholar 

Krüger TH, Haake P, Chereath D, Knapp W, Janssen OE, Exton MS, et al. Specificity of the neuroendocrine response to orgasm during sexual arousal in men. J Endocrinol. 2003;177(1):57–64. https://doi.org/10.1677/joe.0.1770057.

Article  PubMed  Google Scholar 

Fait G, Vered Y, Yogev L, Gamzu R, Lessing JB, Paz G, et al. High levels of catecholamines in human semen: a preliminary study. Andrologia. 2001;33(6):347–50. https://doi.org/10.1046/j.1439-0272.2001.00461.x.

Article  CAS  PubMed  Google Scholar 

Clement P, Giuliano F. Physiology and pharmacology of ejaculation. Basic Clin Pharmacol Toxicol. 2016;119(Suppl 3):18–25. https://doi.org/10.1111/bcpt.12546.

Article  CAS  PubMed  Google Scholar 

Soni KK, Jeong HS, Jang S. Neurons for ejaculation and factors affecting ejaculation. Biology (Basel). 2022;11(5):686. https://doi.org/10.3390/biology11050686.

Article  PubMed  Google Scholar 

Stein RA. Cardiovascular response to sexual activity. Am J Cardiol. 2000;86(2A):27F-29F. https://doi.org/10.1016/s0002-9149(00)00888-2.

Article  CAS  PubMed  Google Scholar 

Courtois F, Dubray S. The neurophysiology of orgasm. Curr Sex Health Rep. 2014;6:201–10. https://doi.org/10.1007/s11930-014-0026-6.

Article  Google Scholar 

McEwen BS. Stress, adaptation, and disease: allostasis and allostatic load. Ann NY Acad Sci. 1998;840:33–44. https://doi.org/10.1111/j.1749-6632.1998.tb09546.x.

Article  ADS  CAS  PubMed  Google Scholar 

Kvetnansky R, Sabban EL, Palkovits M. Catecholaminergic systems in stress: structural and molecular genetic approaches. Physiol Rev. 2009;89(2):535–606. https://doi.org/10.1152/physrev.00042.2006.

Article  CAS  PubMed  Google Scholar 

Gardner DK, Schoolcraft WB. In vitro culture of human blastocyst. In: Jansen R, Mortimer D, editors. Towards reproductive certainty: fertility and genetics beyond. Carnforth: The Parthenon Publishing Group; 1999. p. 377–88.

Google Scholar 

World Health Organization. WHO laboratory manual for the examination and processing of human semen. 5th ed. Geneva: World Health Organization; 2010.

Google Scholar 

Hacker-Klom UB, Göhde W, Nieschlag E, Behre HM. DNA flow cytometry of human semen. Hum Reprod. 1999;14(10):2506–12. https://doi.org/10.1093/humrep/14.10.2506.

Article  CAS  PubMed  Google

留言 (0)

沒有登入
gif