Hasel, P. & Liddelow, S. A. Astrocytes. Curr. Biol. 31, R326–R327 (2021).
Article CAS PubMed Google Scholar
Allen, N. J. & Eroglu, C. Cell biology of astrocyte–synapse interactions. Neuron 96, 697–708 (2017).
Article CAS PubMed PubMed Central Google Scholar
Nagai, J. et al. Behaviorally consequential astrocytic regulation of neural circuits. Neuron 109, 576–596 (2021).
Article CAS PubMed Google Scholar
Guttenplan, K. A. et al. Neurotoxic reactive astrocytes induce cell death via saturated lipids. Nature 599, 102–107 (2021).
Article ADS CAS PubMed Google Scholar
Di Giorgio, F. P., Carrasco, M. A., Siao, M. C., Maniatis, T. & Eggan, K. Non-cell autonomous effect of glia on motor neurons in an embryonic stem cell-based ALS model. Nat. Neurosci. 10, 608–614 (2007).
Article PubMed PubMed Central Google Scholar
Ilieva, H., Polymenidou, M. & Cleveland, D. W. Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J. Cell Biol. 187, 761–772 (2009).
Article CAS PubMed PubMed Central Google Scholar
Meyer, K. et al. Direct conversion of patient fibroblasts demonstrates non-cell autonomous toxicity of astrocytes to motor neurons in familial and sporadic ALS. Proc. Natl Acad. Sci. USA 111, 829–832 (2014).
Article ADS CAS PubMed Google Scholar
Clarke, L. E. et al. Normal aging induces A1-like astrocyte reactivity. Proc. Natl Acad. Sci. USA 115, E1896–E1905 (2018).
Article CAS PubMed PubMed Central Google Scholar
Liddelow, S. A. et al. Neurotoxic reactive astrocytes are induced by activated microglia. Nature 541, 481–487 (2017).
Article ADS CAS PubMed PubMed Central Google Scholar
Wheeler, M. A. et al. MAFG-driven astrocytes promote CNS inflammation. Nature 578, 593–599 (2020).
Article ADS CAS PubMed PubMed Central Google Scholar
Smith, H. L. et al. Astrocyte unfolded protein response induces a specific reactivity state that causes non-cell-autonomous neuronal degeneration. Neuron 105, 855–866 (2020).
Article CAS PubMed PubMed Central Google Scholar
Burda, J. E. et al. Divergent transcriptional regulation of astrocyte reactivity across disorders. Nature 606, 557–564 (2022).
Article ADS CAS PubMed PubMed Central Google Scholar
Dooves, S. et al. Astrocytes are central in the pathomechanisms of vanishing white matter. J. Clin. Invest. 126, 1512–1524 (2016).
Article PubMed PubMed Central Google Scholar
Absinta, M. et al. A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis. Nature 597, 709–714 (2021).
Article ADS CAS PubMed PubMed Central Google Scholar
Leng, K. et al. CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive states. Nat. Neurosci. 25, 1528–1542 (2022).
Yun, S. P. et al. Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease. Nat. Med. 24, 931–938 (2018).
Article CAS PubMed PubMed Central Google Scholar
Najm, F. J. et al. Drug-based modulation of endogenous stem cells promotes functional remyelination in vivo. Nature 522, 216–220 (2015).
Article ADS CAS PubMed PubMed Central Google Scholar
Foo, L. C. et al. Development of a method for the purification and culture of rodent astrocytes. Neuron 71, 799–811 (2011).
Article CAS PubMed PubMed Central Google Scholar
Pike, S. C., Welsh, N., Linzey, M. & Gilli, F. Theiler’s virus-induced demyelinating disease as an infectious model of progressive multiple sclerosis. Front. Mol. Neurosci. 15, 1019799 (2022).
Article CAS PubMed PubMed Central Google Scholar
Chastain, E. M., Duncan, D. S., Rodgers, J. M. & Miller, S. D. The role of antigen presenting cells in multiple sclerosis. Biochim. Biophys. Acta 1812, 265–274 (2011).
Article CAS PubMed Google Scholar
Chung, W. S. et al. Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways. Nature 504, 394–400 (2013).
Article ADS CAS PubMed PubMed Central Google Scholar
Grubman, A. et al. A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation. Nat. Neurosci. 22, 2087–2097 (2019).
Article CAS PubMed Google Scholar
Al-Dalahmah, O. et al. Single-nucleus RNA-seq identifies Huntington disease astrocyte states. Acta Neuropathol. Commun. 8, 19 (2020).
Article CAS PubMed PubMed Central Google Scholar
Smajic, S. et al. Single-cell sequencing of human midbrain reveals glial activation and a Parkinson-specific neuronal state. Brain 145, 964–978 (2022).
Loven, J. et al. Selective inhibition of tumor oncogenes by disruption of super-enhancers. Cell 153, 320–334 (2013).
Article CAS PubMed PubMed Central Google Scholar
Whyte, W. A. et al. Master transcription factors and mediator establish super-enhancers at key cell identity genes. Cell 153, 307–319 (2013).
Article CAS PubMed PubMed Central Google Scholar
Hnisz, D. et al. Super-enhancers in the control of cell identity and disease. Cell 155, 934–947 (2013).
Article CAS PubMed Google Scholar
Molofsky, A. V. & Deneen, B. Astrocyte development: a guide for the perplexed. Glia 63, 1320–1329 (2015).
Hartmann, K. et al. Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia. Acta Neuropathol. Commun. 7, 83 (2019).
Article PubMed PubMed Central Google Scholar
Malvaez, M. et al. HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner. Proc. Natl Acad. Sci. USA 110, 2647–2652 (2013).
Article ADS CAS PubMed PubMed Central Google Scholar
Suzuki, T. et al. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PLoS ONE 8, e68669 (2013).
Article ADS CAS PubMed PubMed Central Google Scholar
Srinivasan, R. et al. New transgenic mouse lines for selectively targeting astrocytes and studying calcium signals in astrocyte processes in situ and in vivo. Neuron 92, 1181–1195 (2016).
Article CAS PubMed PubMed Central Google Scholar
McQuown, S. C. et al. HDAC3 is a critical negative regulator of long-term memory formation. J. Neurosci. 31, 764–774 (2011).
Article CAS PubMed PubMed Central Google Scholar
Gryder, B. E. et al. Histone hyperacetylation disrupts core gene regulatory architecture in rhabdomyosarcoma. Nat. Genet. 51, 1714–1722 (2019).
Article CAS PubMed PubMed Central Google Scholar
Leus, N. G., Zwinderman, M. R. & Dekker, F. J. Histone deacetylase 3 (HDAC 3) as emerging drug target in NF-kappaB-mediated inflammation. Curr. Opin. Chem. Biol. 33, 160–168 (2016).
留言 (0)