C-Myc protein expression indicates unfavorable clinical outcome in surgically resected small cell lung cancer

Schwendenwein A, Megyesfalvi Z, Barany N, Valko Z, Bugyik E, Lang C, et al. Molecular profiles of small cell lung cancer subtypes: therapeutic implications. Molecular therapy oncolytics. 2021;20:470–83.

Article  PubMed  PubMed Central  Google Scholar 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.

Article  PubMed  Google Scholar 

Karachaliou N, Pilotto S, Lazzari C, Bria E, de Marinis F, Rosell R. Cellular and molecular biology of small cell lung cancer: an overview. Transl Lung Cancer Res. 2016;5(1):2–15.

PubMed Central  Google Scholar 

Rudin CM, Poirier JT, Byers LA, Dive C, Dowlati A, George J, et al. Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data. Nat Rev Cancer. 2019;19(5):289–97.

Article  PubMed  PubMed Central  Google Scholar 

Megyesfalvi Z, Barany N, Lantos A, Valko Z, Pipek O, Lang C, et al. Expression patterns and prognostic relevance of subtype-specific transcription factors in surgically resected small-cell lung cancer: an international multicenter study. J Pathol. 2022;257(5):674–86.

Article  PubMed  PubMed Central  Google Scholar 

Qu S, Fetsch P, Thomas A, Pommier Y, Schrump DS, Miettinen MM, et al. Molecular subtypes of primary SCLC tumors and their associations with neuroendocrine and therapeutic markers. J Thoracic Oncol. 2022;17(1):141–53.

Article  Google Scholar 

Szeitz B, Megyesfalvi Z, Woldmar N, Valkó Z, Schwendenwein A, Bárány N, et al. In-depth proteomic analysis reveals unique subtype-specific signatures in human small-cell lung cancer. Clin Transl Med. 2022;12(9):e1060.

Article  PubMed  PubMed Central  Google Scholar 

Ireland AS, Micinski AM, Kastner DW, Guo B, Wait SJ, Spainhower KB, et al. MYC drives temporal evolution of small cell lung cancer subtypes by reprogramming neuroendocrine fate. Cancer Cell. 2020;38(1):60-78.e12.

Article  PubMed  PubMed Central  Google Scholar 

Mollaoglu G, Guthrie MR, Böhm S, Brägelmann J, Can I, Ballieu PM, et al. MYC drives progression of small cell lung cancer to a variant neuroendocrine subtype with vulnerability to aurora kinase inhibition. Cancer Cell. 2017;31(2):270–85.

Article  PubMed Central  Google Scholar 

Meyer N, Penn LZ. Reflecting on 25 years with MYC. Nat Rev Cancer. 2008;8(12):976–90.

Article  PubMed  Google Scholar 

Brägelmann J, Böhm S, Guthrie MR, Mollaoglu G, Oliver TG, Sos ML. Family matters: how MYC family oncogenes impact small cell lung cancer. Cell Cycle. 2017;16(16):1489–98.

Article  PubMed  PubMed Central  Google Scholar 

Chen J, Guanizo AC, Jakasekara WSN, Inampudi C, Luong Q, Garama DJ, et al. MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat. J Exp Clin Cancer Res. 2023;42(1):100.

Article  PubMed  PubMed Central  Google Scholar 

Grunblatt E, Wu N, Zhang H, Liu X, Norton JP, Ohol Y, et al. MYCN drives chemoresistance in small cell lung cancer while USP7 inhibition can restore chemosensitivity. Genes Dev. 2020;34(17–18):1210–26.

Article  PubMed  PubMed Central  Google Scholar 

Feng W, Dean DC, Hornicek FJ, Spentzos D, Hoffman RM, Shi H, et al. Myc is a prognostic biomarker and potential therapeutic target in osteosarcoma. Ther Adv Med Oncol. 2020;12:1758835920922055.

Article  PubMed  PubMed Central  Google Scholar 

Ambrosio MR, Lazzi S, Bello GL, Santi R, Porro LD, de Santi MM, et al. MYC protein expression scoring and its impact on the prognosis of aggressive B-cell lymphoma patients. Haematologica. 2019;104(1):e25–8.

Article  PubMed  PubMed Central  Google Scholar 

Qu J, Zhao X, Wang J, Liu X, Yan Y, Liu L, et al. MYC overexpression with its prognostic and clinicopathological significance in breast cancer. Oncotarget. 2017;8(55):93998–4008.

Article  PubMed  PubMed Central  Google Scholar 

Chen H, Liu H, Qing G. Targeting oncogenic Myc as a strategy for cancer treatment. Signal Transduct Target Ther. 2018;3(1):5.

Article  PubMed  PubMed Central  Google Scholar 

Llombart V, Mansour MR. Therapeutic targeting of “undruggable” MYC. EBioMedicine. 2022;75:103756.

Article  PubMed  Google Scholar 

Whitfield JR, Soucek L. The long journey to bring a Myc inhibitor to the clinic. J Cell Biol. 2021;220(8):e202103090.

Article  PubMed  PubMed Central  Google Scholar 

Fiorentino FP, Tokgün E, Solé-Sánchez S, Giampaolo S, Tokgün O, Jauset T, et al. Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation. Oncotarget. 2016;7(21):31014–28.

Article  PubMed  PubMed Central  Google Scholar 

Cargill KR, Stewart CA, Park EM, Ramkumar K, Gay CM, Cardnell RJ, et al. Targeting MYC-enhanced glycolysis for the treatment of small cell lung cancer. Cancer & Metabolism. 2021;9(1):33.

Article  Google Scholar 

Ganti AKP, Loo BW, Bassetti M, Blakely C, Chiang A, D’Amico TA, et al. Small cell lung cancer, Version 2.2022, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Cancer Netw. 2021;19(12):1441–64.

Article  Google Scholar 

Majeed U, Manochakian R, Zhao Y, Lou Y. Targeted therapy in advanced non-small cell lung cancer: current advances and future trends. J Hematol Oncol. 2021;14(1):108.

Article  PubMed  PubMed Central  Google Scholar 

Malhotra J, Jabbour SK, Aisner J. Current state of immunotherapy for non-small cell lung cancer. Transl Lung Cancer Res. 2017;6(2):196–211.

Article  PubMed  PubMed Central  Google Scholar 

Hsu JC, Wei CF, Yang SC, Lin PC, Lee YC, Lu CY. Lung cancer survival and mortality in Taiwan following the initial launch of targeted therapies: an interrupted time series study. BMJ Open. 2020;10(5):e033427.

Article  PubMed  PubMed Central  Google Scholar 

Wang S, Tang J, Sun T, Zheng X, Li J, Sun H, et al. Survival changes in patients with small cell lung cancer and disparities between different sexes, socioeconomic statuses and ages. Sci Rep. 2017;7(1):1339.

Article  ADS  PubMed  PubMed Central  Google Scholar 

Martucci N, Morabito A, La Rocca A, De Luca G, De Cecio R, Botti G, et al. Surgery in small-cell lung cancer. Cancers (Basel). 2021;13(3):390.

Article  PubMed  Google Scholar 

Dingemans AC, Früh M, Ardizzoni A, Besse B, Faivre-Finn C, Hendriks LE, et al. Small-cell lung cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up(☆). Ann Oncol. 2021;32(7):839–53.

Article  PubMed  Google Scholar 

Bernhardt EB, Jalal SI. Small Cell Lung Cancer. Cancer Treat Res. 2016;170:301–22.

Article  PubMed  Google Scholar 

Ju MH, Kim HR, Kim JB, Kim YH, Kim DK, Park SI. Surgical outcomes in small cell lung cancer. Korean J Thorac Cardiovasc Surg. 2012;45(1):40–4.

Article  PubMed  PubMed Central  Google Scholar 

Nakamura H, Kato Y, Kato H. Outcome of surgery for small cell lung cancer—response to induction chemotherapy predicts survival. Thorac Cardiovasc Surg. 2004;52(4):206–10.

Article  PubMed  Google Scholar 

Wheatley-Price P, Ma C, Ashcroft LF, Nankivell M, Stephens RJ, White SC, et al. The strength of female sex as a prognostic factor in small-cell lung cancer: a pooled analysis of chemotherapy trials from the Manchester Lung Group and Medical Research Council Clinical Trials Unit. Ann Oncol. 2010;21(2):232–7.

Article  PubMed  Google Scholar 

Viña J, Borrás C, Gambini J, Sastre J, Pallardó FV. Why females live longer than males: control of longevity by sex hormones. Sci Aging Knowledge Environ. 2005;2005(23):pe17.

Article  PubMed  Google Scholar 

Yang CF, Chan DY, Speicher PJ, Gulack BC, Wang X, Hartwig MG, et al. Role of Adjuvant therapy in a population-based cohort of patients with early-stage small-cell lung cancer. J Clin Oncol. 2016;34(10):1057–64.

Article  PubMed  PubMed Central  Google Scholar 

Zhou N, Bott M, Park BJ, Vallières E, Wilshire CL, Yasufuku K, et al. Predictors of survival following surgical resection of limited-stage small cell lung cancer. J Thorac Cardiovasc Surg. 2021;161(3):760-71.e2.

Article  PubMed  Google Scholar 

Thomas DC, Arnold BN, Rosen JE, Salazar MC, Blasberg JD, Detterbeck FC, et al. Defining outcomes of patients with clinical stage I small cell lung cancer upstaged at surgery. Lung Cancer. 2017;103:75–81.

Article  Google Scholar 

Takei H, Kondo H, Miyaoka E, Asamura H, Yoshino I, Date H, et al. Surgery for small cell lung cancer: a retrospective analysis of 243 patients from Japanese Lung Cancer Registry in 2004. J Thorac Oncol. 2014;9(8):1140–5.

Article  PubMed  Google Scholar 

Hoda MA, Klikovits T, Klepetko W. Controversies in oncology: surgery for small cell lung cancer? It’s time to rethink the case. ESMO Open. 2018;3(3):e000366.

Article  PubMed Central  Google Scholar 

de Koning HJ, van der Aalst CM, de Jong PA, Scholten ET, Nackaerts K, Heuvelmans MA, et al. Reduced lung-cancer mortality with volume CT screening in a randomized trial. N Engl J Med. 2020;382(6):503–13.

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