Glucose intolerance in acromegaly is driven by low insulin secretion; results from an intravenous glucose tolerance test

Gadelha MR, Kasuki L, Lim DST, Fleseriu M (2019) Systemic complications of Acromegaly and the impact of the Current Treatment Landscape: an update. Endocr Rev 40:268–332. https://doi.org/10.1210/er.2018-00115

Article  PubMed  Google Scholar 

Melmed S, Kaiser UB, Lopes MB, Bertherat J, Syro LV, Raverot G, Reincke M, Johannsson G, Beckers A, Fleseriu M, Giustina A, Wass JAH, Ho KKY (2022) Clinical Biology of the Pituitary Adenoma. Endocr Rev 43:1003–1037. https://doi.org/10.1210/ENDREV/BNAC010

Article  PubMed  PubMed Central  Google Scholar 

Fleseriu M, Langlois F, Lim DST, Varlamov EV, Melmed S (2022) Acromegaly: pathogenesis, diagnosis, and management. Lancet Diabetes Endocrinol 10:804–826. https://doi.org/10.1016/S2213-8587(22)00244-3

Article  CAS  PubMed  Google Scholar 

Giustina A, Barkhoudarian G, Beckers A, Ben-Shlomo A, Biermasz N, Biller B, Boguszewski C, Bolanowski M, Bollerslev J, Bonert V, Bronstein MD, Buchfelder M, Casanueva F, Chanson P, Clemmons D, Fleseriu M, Formenti AM, Freda P, Gadelha M, Geer E, Gurnell M, Heaney AP, Ho KKY, Ioachimescu AG, Lamberts S, Laws E, Losa M, Maffei P, Mamelak A, Mercado M, Molitch M, Mortini P, Pereira AM, Petersenn S, Post K, Puig-Domingo M, Salvatori R, Samson SL, Shimon I, Strasburger C, Swearingen B, Trainer P, Vance ML, Wass J, Wierman ME, Yuen KCJ, Zatelli MC, Melmed S (2020) Multidisciplinary management of acromegaly: a consensus. Rev Endocr Metab Disord 21:667–678. https://doi.org/10.1007/s11154-020-09588-z

Article  PubMed  PubMed Central  Google Scholar 

Giustina A, Barkan A, Beckers A, Biermasz N, Biller BMK, Boguszewski C, Bolanowski M, Bonert V, Bronstein MD, Casanueva FF, Clemmons D, Colao A, Ferone D, Fleseriu M, Frara S, Gadelha MR, Ghigo E, Gurnell M, Heaney AP, Ho K, Ioachimescu A, Katznelson L, Kelestimur F, Kopchick J, Krsek M, Lamberts S, Losa M, Luger A, Maffei P, Marazuela M, Mazziotti G, Mercado M, Mortini P, Neggers S, Pereira AM, Petersenn S, Puig-Domingo M, Salvatori R, Shimon I, Strasburger C, Tsagarakis S, van der Lely AJ, Wass J, Zatelli MC, Melmed S (2020) A consensus on the diagnosis and treatment of acromegaly comorbidities: an update. J Clin Endocrinol Metab 105:E937–E946. https://doi.org/10.1210/clinem/dgz096

Article  Google Scholar 

Frara S, Maffezzoni F, Mazziotti G, Giustina A (2016) Current and emerging aspects of diabetes Mellitus in Acromegaly. Trends Endocrinol Metab 27:470–483. https://doi.org/10.1016/j.tem.2016.04.014

Article  CAS  PubMed  Google Scholar 

Albertelli M, Nazzari E, Dotto A, Grasso LF, Sciallero S, Pirchio R, Rebora A, Boschetti M, Pivonello R, Ricci Bitti S, Colao AAL, Ferone D (2021) Possible protective role of metformin therapy on colonic polyps in acromegaly: an exploratory cross-sectional study. Eur J Endocrinol 184:423–429. https://doi.org/10.1530/EJE-20-0795

Article  CAS  Google Scholar 

Moustaki M, Paschou SA, Xekouki P, Kotsa K, Peppa M, Psaltopoulou T, Kalantaridou S, Vryonidou A (2023) Secondary diabetes mellitus in acromegaly. Endocrine 81:1–15. https://doi.org/10.1007/s12020-023-03339-1

Article  CAS  PubMed  PubMed Central  Google Scholar 

Biagetti B, Aulinas A, Casteras A, Pérez-Hoyos S, Simó R (2021) HOMA-IR in acromegaly: a systematic review and meta-analysis. Pituitary 24:146–158. https://doi.org/10.1007/s11102-020-01092-6

Article  PubMed  Google Scholar 

Baldelli R, Battista C, Leonetti F, Ghiggi MR, Ribaudo MC, Paoloni A, D’Amico E, Ferretti E, Baratta R, Liuzzi A, Trischitta V, Tamburrano G (2003) Glucose homeostasis in acromegaly: effects of long-acting somatostatin analogues treatment. Clin Endocrinol (Oxf) 59:492–499. https://doi.org/10.1046/j.1365-2265.2003.01876.x

Article  CAS  PubMed  Google Scholar 

Battezzati A, Benedini S, Fattorini A, Losa M, Mortini P, Bertoli S, Lanzi R, Testolin G, Biolo G, Luzi L (2003) Insulin action on protein metabolism in acromegalic patients. Am J Physiol Endocrinol Metab 284:E823–E829. https://doi.org/10.1152/ajpendo.00020.2002

Article  CAS  PubMed  Google Scholar 

Moller N, Schmitz O, Joorgensen JO, Astrup J, Bak JF, Christensen SE, Alberti KG, Weeke J (1992) Basal- and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy. J Clin Endocrinol Metab 74:1012–1019

CAS  PubMed  Google Scholar 

Alexopoulou O, Bex M, Kamenicky P, Mvoula AB, Chanson P, Maiter D (2014) Prevalence and risk factors of impaired glucose tolerance and diabetes mellitus at diagnosis of acromegaly: a study in 148 patients. Pituitary 17:81–89. https://doi.org/10.1007/s11102-013-0471-7

Article  CAS  PubMed  Google Scholar 

Wang Z, Gao L, Guo X, Feng C, Deng K, Lian W, Feng M, Bao X, Xing B (2019) Preoperative fasting C-Peptide acts as a promising predictor of improved glucose tolerance in patients with Acromegaly after Transsphenoidal surgery: a retrospective study of 64 cases from a large Pituitary Center in China. Front Endocrinol (Lausanne) 10:736. https://doi.org/10.3389/fendo.2019.00736

Article  PubMed  Google Scholar 

Shekhawat VS, Bhansali S, Dutta P, Mukherjee KK, Vaiphei K, Kochhar R, Sinha SK, Sachdeva N, Kurpad AV, Bhat K, Mudaliar S, Bhansali A (2019) Glucose-dependent Insulinotropic polypeptide (GIP) resistance and β-cell dysfunction contribute to Hyperglycaemia in Acromegaly. Sci Rep 9:5646. https://doi.org/10.1038/s41598-019-41887-7

Article  ADS  CAS  PubMed  PubMed Central  Google Scholar 

Niculescu D, Purice M, Lichiardopol R, Coculescu M (2010) Both insulin resistance and insulin secretion are involved in the pre-diabetes of Acromegaly. Acta Endocrinol 6:35–42. https://doi.org/10.4183/aeb.2010.35

Article  CAS  Google Scholar 

Kinoshita Y, Fujii H, Takeshita A, Taguchi M, Miyakawa M, Oyama K, Yamada S, Takeuchi Y (2011) Impaired glucose metabolism in Japanese patients with acromegaly is restored after successful pituitary surgery if pancreatic -cell function is preserved. Eur J Endocrinol 164:467–473. https://doi.org/10.1530/EJE-10-1096

Article  CAS  PubMed  Google Scholar 

He W, Yan L, Wang M, Li Q, He M, Ma Z, Ye Z, Zhang Q, Zhang Y, Qiao N, Lu Y, Ye H, Lu B, Shou X, Zhao Y, Li Y, Li S, Zhang Z, Shen M, Wang Y (2019) Surgical outcomes and predictors of glucose metabolism alterations for growth hormone-secreting pituitary adenomas: a hospital-based study of 151 cases. Endocrine 63:27–35. https://doi.org/10.1007/s12020-018-1745-7

Article  CAS  PubMed  Google Scholar 

Niculescu DA, Dusceac R, Caragheorgheopol A, Popescu N, Poiana C (2019) Disposition Index in active acromegaly. Front Endocrinol (Lausanne) 10:637. https://doi.org/10.3389/fendo.2019.00637

Article  PubMed  Google Scholar 

Giustina A, Biermasz N, Casanueva FF, Fleseriu M, Mortini P, Strasburger C, van der Lely AJ, Wass J, Melmed S (2023) Consensus on criteria for acromegaly diagnosis and remission. https://doi.org/10.1007/s11102-023-01360-1. Acromegaly Consensus GroupPituitary

ElSayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, Collins BS, Hilliard ME, Isaacs D, Johnson EL, Kahan S, Khunti K, Leon J, Lyons SK, Perry M, Lou, Prahalad P, Pratley RE, Seley JJ, Stanton RC, Gabbay RA, on behalf of the American Diabetes Association (2023) 2. Classification and diagnosis of diabetes: standards of Care in Diabetes-2023. Diabetes Care 46:S19–S40. https://doi.org/10.2337/dc23-S002

Article  CAS  PubMed  Google Scholar 

Cersosimo E, Solis-Herrera C, Trautmann ME, Malloy J, Triplitt CL (2014) Assessment of pancreatic β-cell function: review of methods and clinical applications. Curr Diabetes Rev 10:2–42

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bunt JC, Krakoff J, Ortega E, Knowler WC, Bogardus C (2007) Acute insulin response is an independent predictor of type 2 diabetes mellitus in individuals with both normal fasting and 2-h plasma glucose concentrations. Diabetes Metab Res Rev 23:304–310. https://doi.org/10.1002/dmrr.686

Article  CAS  PubMed  PubMed Central  Google Scholar 

Gastaldelli A (2022) Measuring and estimating insulin resistance in clinical and research settings. Obesity 30:1549–1563. https://doi.org/10.1002/oby.23503

Article  PubMed  Google Scholar 

Espinosa-de-Los-Monteros AL, Gonzalez B, Vargas G, Sosa E, Mercado M (2011) Clinical and biochemical characteristics of acromegalic patients with different abnormalities in glucose metabolism. Pituitary 14:231–235

Article  CAS  PubMed  Google Scholar 

Ciresi A, Amato MC, Pivonello R, Nazzari E, Grasso LF, Minuto F, Ferone D, Colao A, Giordano C (2013) The metabolic profile in active acromegaly is gender-specific. J Clin Endocrinol Metab 98:E51–E59. https://doi.org/10.1210/jc.2012-2896

Article  CAS  PubMed  Google Scholar 

Niculescu D, Purice M, Coculescu M (2013) Insulin-like growth factor-I correlates more closely than growth hormone with insulin resistance and glucose intolerance in patients with acromegaly. Pituitary 16:168–174. https://doi.org/10.1007/s11102-012-0396-6

Article  CAS  PubMed  Google Scholar 

Petrossians P, Daly AF, Natchev E, Maione L, Blijdorp K, Sahnoun-Fathallah M, Auriemma R, Diallo AM, Hulting AL, Ferone D, Hana V, Filipponi S, Sievers C, Nogueira C, Fajardo-Montañana C, Carvalho D, Hana V, Stalla GK, Jaffrain-Réa ML, Delemer B, Colao A, Brue T, Neggers SJCMM, Zacharieva S, Chanson P, Beckers A (2017) Acromegaly at diagnosis in 3173 patients from the Liège Acromegaly Survey (LAS) database. Endocr Relat Cancer 24:505–518. https://doi.org/10.1530/ERC-17-0253

Article  CAS  PubMed  PubMed Central  Google Scholar 

Arosio M, Reimondo G, Malchiodi E, Berchialla P, Borraccino A, De Marinis L, Pivonello R, Grottoli S, Losa M, Cannavò S, Minuto F, Montini M, Bondanelli M, De Menis E, Martini C, Angeletti G, Velardo A, Peri A, Faustini-Fustini M, Tita P, Pigliaru F, Borretta G, Scaroni C, Bazzoni N, Bianchi A, Appetecchia M, Cavagnini F, Lombardi G, Ghigo E, Beck-Peccoz P, Colao A, Terzolo M, Italian Study Group of Acromegaly (2012) Predictors of morbidity and mortality in acromegaly: an Italian survey. Eur J Endocrinol 167:189–198. https://doi.org/10.1530/EJE-12-0084

Article  CAS  PubMed  Google Scholar 

Mestron A, Webb SM, Astorga R, Benito P, Catala M, Gaztambide S, Gomez JM, Halperin I, Lucas-Morante T, Moreno B, Obiols G, de Pablos P, Paramo C, Pico A, Torres E, Varela C, Vazquez JA, Zamora J, Albareda M, Gilabert M (2004) Epidemiology, clinical characteristics, outcome, morbidity and mortality in acromegaly based on the Spanish Acromegaly Registry (Registro Espanol De Acromegalia, REA). Eur J Endocrinol 151:439–446

Article  CAS  PubMed 

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